Gene FGF2 map

Identifiers
HUGO:FGF2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_PRODUCTION  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
CASCADE:PGDF
PMID:18232728
FGF-2 Functionally Contributes to the Angiogenic Phenotype
. FGF-2 and FGF-7 are expressed by CAFs and Repressed by Specific Inhibition of PDGF Receptor Signaling
PMID:21098712; PMID:22652804; PMID:17637743; PMID:25374926
TGFB induces FGF2 expression and secretion in fibroblasts via SMAD3 and MAPK pathways (erk,p38)
 MACROPHAGE  map
 MDSC  map
PMID:18776941
Myeloid-derived suppressor cells and macrophages isolated from mouse tumors displayed activated Stat3 and induced angiogenesis in an in vitro tube formation assay via Stat3 induction of angiogenic factors, including VEGF and bFGF.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gFGF2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gFGF2@INNATE_IMMUNE_CELL_Cytosol map → map rFGF2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: