Protein MMP11 map

Identifiers
HUGO:MMP11

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / TUMOR_GROWTH  map

References
 MACROPHAGE  map
PMID:22880008
Classical activation of macrophages derived in vitro from un-fractionated CD16(+/-) or negatively-selected CD16(-) macrophages up-regulated MMP-1, -3, -7, -10, -12, -14 and -25 and decreased TIMP-3 steady-state mRNA levels.
By contrast, alternative activation decreased MMP-2, -8 and -19 but increased MMP -11, -12, -25 and TIMP-3 steady-state mRNA levels. Up-regulation of MMPs during classical activation depended on mitogen activated protein kinases, phosphoinositide-3-kinase and inhibitor of ??B kinase-2. Effects of interferon?? depended on janus kinase-2.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MMP11@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MMP11@INNATE_IMMUNE_CELL_Cytosol map → map MATRIX_REMODELLING@default map
    As Catalyser: