Identifiers
matrix metallopeptidase 14
HUGO:MMP14 hgnc_id:HGNC:7160 HGNC:7160 ENTREZ:4323 UNIPROT:P50281
HUGO:MMP14
matrix metallopeptidase 14 (membrane-inserted)
HUGO:MMP14, HGNC:7160, ENTREZ:4323, UNIPROT:P50281, GENECARDS:GC14P023305??
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MATRIX_REGULATION
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
Innate Immunity / TUMOR_GROWTH
References
CASCADE:TNF
CASCADE:INTEGRIN
PMID:11112697
TNF-?? upregulates MT1-MMP mRNA in organ-cultured human skin and dermal fibroblasts in a collagen environment
NF-??B inhibitor, SN50, blocks TNF-?? and collagen mediated MT1-MMP expression and pro-MMP-2 activation.
PMID:18037882
MT1-MMP (MMP14) is required to mediate matrix proteolysis during collective invasion
PMID:23737743
The characterization of ECM degradation by MT1-MMP indicate a dynamic nature of MMP14 (MT1-MMP) at invadopodia and its importance in the degradation of the ECM
MACROPHAGE
MDSC
PMID:22880008
Classical activation of macrophages derived in vitro from un-fractionated CD16(+/-) or negatively-selected CD16(-) macrophages up-regulated MMP-1, -3, -7, -10, -12, -14 and -25 and decreased TIMP-3 steady-state mRNA levels.
By contrast, alternative activation decreased MMP-2, -8 and -19 but increased MMP -11, -12, -25 and TIMP-3 steady-state mRNA levels. Up-regulation of MMPs during classical activation depended on mitogen activated protein kinases, phosphoinositide-3-kinase and inhibitor of ??B kinase-2. Effects of interferon?? depended on janus kinase-2.
PMID:18633355
MDSC isolated from murine tumours express higher levels of various MMPs (MMP2, MMP9, MMP13 and MMP14 than MDSC from healthy mice