Identifiers
HUGO:BCL3
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / MIRNA_TF_IMMUNOSUPPRESSIVE
References
PMID:15465827
BCL3 inhibits expression of IL1A, IL1B,TNF and positively regulates
IL-10 expression. BCL3 forms complex with HDAC1 and
repression of the TNF promoter by BCL3
requires Histone Deacetylase Activity.
PMID:12907458
Bcl-3??? ???interacted with NF-??B p50,
both Bcl-3??? ???and p50??? ???were recruited to the TNF promoter,
BCL3??? ??? and??? ???p50??? ???NFkB recruitment to??? ???TNF ???promoter
prevents binding of??? ???p65/p50??? ???NFkB??? ???heterodimers
to??? ???TNF promotor and suppresses??? ???TNF ???expression
downstream of??? ???IL10.
NFkB p50 is needfull for BCL3 expression .
PMID:12907458, PMID:22323479
STAT3 directly up-regulates BCL3 expression downstream of IL10 .
References
in_re1092( Innate Immunity ):
PMID:12907458, PMID:12907458
STAT3??? ??? directly??? ???up-regulates??? ???BCL3??? ???expression
downstream of??? ???IL10.
PMID:15465827
NFkB p50 is needfull for BCL3 expression.