Identifiers
transforming growth factor, beta 2
HUGO:TGFB2, HGNC:11768, ENTREZ:7042, UNIPROT:P61812, GENECARDS:GC01P218519
HUGO:TGFB2
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
PMID:20519943
PMID:17934056
PMID:16474430
PMID:14557817
CASCADE:TGFB
PMID:24132110
TGFB has been identified as a factor that inhibits the functional maturation of this cell population9. Immature NK cells do not respond to foreign antigens, thus exposure of NK cells to TGF?? will impair the recognition and the clearance of tumour cells. The inhibition of maturation also prevents the systemic effects of NK cells,
for example, activation of antigen-presenting dendritic cells and inhibition of interferon-?? (IFN??) secretion, which drives T helper 1 cell (TH1 cell) maturation
TGFB1, TGFB2, TGFB3 ligands bind to the type 2 TGF?? receptor (TGFBR2), which causes recruitment and phosphorylation of TGFBR1, resulting in downstream signalling activation.