Identifiers
transforming growth factor, beta 3
HUGO:TGFB3, HGNC:11769, ENTREZ:7043, UNIPROT:P10600, GENECARDS:GC14M076424
HUGO:TGFB3
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
PMID:20519943
PMID:17934056
PMID:16474430
PMID:14557817
PMID:11790723
Whereas TGFB1 and 2 are proscarring growth factors, TGFB3 is antiscarring
TGFB1, 2, and 3 are embryonically expressed in skin and up-regulated at adult wound sites
Overlapping expression patterns of HIF1A and TGFB3 in vivo
TGFB1 mRNA expression was serum- but not hypoxia-inducible.
In contrast, TGFB3 mRNA expression was hypoxia-inducible, but not serum- inducible
TGFB3 might be a HIF1A target gene
CASCADE:TGFB
PMID:24132110
TGFB has been identified as a factor that inhibits the functional maturation of this cell population9. Immature NK cells do not respond to foreign antigens, thus exposure of NK cells to TGF?? will impair the recognition and the clearance of tumour cells. The inhibition of maturation also prevents the systemic effects of NK cells,
for example, activation of antigen-presenting dendritic cells and inhibition of interferon-?? (IFN??) secretion, which drives T helper 1 cell (TH1 cell) maturation
TGFB1, TGFB2, TGFB3 ligands bind to the type 2 TGF?? receptor (TGFBR2), which causes recruitment and phosphorylation of TGFBR1, resulting in downstream signalling activation.