Identifiers
HUGO:ADGRB1

References
PMID:17960134
ELMO/Dock180/Rac proteins are a conserved signalling module for promoting the internalization of apoptotic cell corpses; ELMO and Dock180 function together as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac, and thereby regulate the phagocyte actin cytoskeleton during engulfment.
phosphatidylserine, a key 'eat-me' signal exposed on apoptotic cells, as a ligand for BAI1. The thrombospondin type 1 repeats within the extracellular region of BAI1 mediate direct binding to phosphatidylserine. As with intracellular signalling, BAI1 forms a trimeric complex with ELMO and Dock180, and functional studies suggest that BAI1 cooperates with ELMO/Dock180/Rac to promote maximal engulfment of apoptotic cells by macrophages.

1. ADGRB1@INNATE_IMMUNE_CELL_Membrane

1. ADGRB1:​PtdSer@INNATE_IMMUNE_CELL_Membrane

1. PtdSer@TUMOR_CELL_AS_INDUCTOR_Membrane + ADGRB1@INNATE_IMMUNE_CELL_Membrane → ADGRB1:​PtdSer@INNATE_IMMUNE_CELL_Membrane