Protein HAVCR1 map

Identifiers
HUGO:HAVCR1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
 MACROPHAGE  map
 DENDRITIC_CELL  map
CASCADE:HAVCR1
PMID:18082433
TIM-4 is expressed on human and mouse macrophages and dendritic cells, and both TIM-4 and TIM-1(HAVCR1) specifically bound phosphatidylserine (PS) on the surface of apoptotic cells but not any other phospholipid tested. TIM-4(+) peritoneal macrophages, TIM-1(+) kidney cells, and TIM-4- or TIM-1-transfected cells efficiently phagocytosed apoptotic cells, and phagocytosis could be blocked by TIM-4 or TIM-1 monoclonal antibodies.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. HAVCR1@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. HAVCR1:​PtdSer@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. HAVCR1:​PtdSer@INNATE_IMMUNE_CELL_Membrane map → map EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
  2. PtdSer@TUMOR_CELL_AS_INDUCTOR_Membrane map + HAVCR1@INNATE_IMMUNE_CELL_Membrane map → map HAVCR1:​PtdSer@INNATE_IMMUNE_CELL_Membrane map
As Catalyser: