Identifiers
phospholipase A2, group IVA (cytosolic, calcium-dependent)
HUGO:PLA2G4A HGNC:9035 ENTREZ:5321 UNIPROT:P47712
HUGO:PLA2G4A
PLA2G4
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / NECROPTOSIS
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
phospholipase A2, group IVA (cytosolic, calcium-dependent)
NATURAL_KILLER
CASCADE:Fc_gamma_RIII
PMID:9120268, PMID:9973479
ERK2 activates Phospholipase A2 group IIA (sPLA2 and cPLA2) by phosphorylation downstream of CD16 activation, but CDl6-induced degranulation in human NK cells is
dependent on ERK activation, but not on sPLA, or cPLA.
PMID:8388321
Arachidonic acid (AA) release via phospholipase A2 (PLA2) activation has positive influence on both NK and ADCC activities of natural killers.
Results supported the notion that KSR1 coupled activated ERK1/2 selectively to its substrate cPLA2 (PLA2G4A) in response to signals generated at lipid rafts.
PMID:19114553