Protein ARHGEF2 map

Identifiers
Rho/Rac guanine nucleotide exchange factor (GEF) 2
HUGO:ARHGEF2, HGNC:682, ENTREZ:9181, GENECARDS:GC01M155916, UNIPROT:Q92974
HUGO:ARHGEF2

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:18287519
GEF-H1(so-called ARHGEF2) is a microtubule-associated guanine nucleotide exchange factor that activates RhoA upon release from microtubules.
 DENDRITIC_CELL  map
PMID:16917499
TIKAM1(TRIF) is an adaptor of TLR signaling, TLR signaling via ARHGEF2 (GEFH1)and RHOB regulates MHCII surface expression.
Just TRIF-dependent but Myd88-independent pathway enhanced the RhoB activity in DC after LPS stimulation.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ARHGEF2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. ARHGEF2@INNATE_IMMUNE_CELL_Cytosol map → map ARHGEF2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. GDP:​RHOB@INNATE_IMMUNE_CELL_Cytosol map + GTP@INNATE_IMMUNE_CELL_Cytosol map → map GTP:​RHOB@INNATE_IMMUNE_CELL_Cytosol map + GDP@INNATE_IMMUNE_CELL_Cytosol map