Protein MICB
Identifiers
HUGO:MICB
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity
/ IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
References
NATURAL_KILLER
CASCADE:NKG2D
DENDRITIC_CELL
CASCADE:IL15
CASCADE:IFNAB
PMID:??10426993, PMID:??11491531
NKG2D is an activating receptor that initiates NK and T cell???mediated cytotoxicity against transfectants and tumors expressing its ligands,??? ???MICA and MICB.???
Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- MICB@INNATE_IMMUNE_CELL_Cytosol
In compartment: TUMOR_CELL_AS_INDUCTOR
- MICB@TUMOR_CELL_AS_INDUCTOR
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
- MICB@TUMOR_CELL_AS_INDUCTOR_Membrane
Participates in complexes:
Participates in reactions:
As Reactant or Product:- MICB@INNATE_IMMUNE_CELL_Cytosol
→
MICB@TUMOR_CELL_AS_INDUCTOR_Membrane
- MICB@INNATE_IMMUNE_CELL_Cytosol
→
IMMUNE_ACTIVATION@default
- MICB@TUMOR_CELL_AS_INDUCTOR
→
MICB@TUMOR_CELL_AS_INDUCTOR_Membrane
- rMICB@TUMOR_CELL_AS_INDUCTOR
→
MICB@TUMOR_CELL_AS_INDUCTOR
- rMICB@INNATE_IMMUNE_CELL_Cytosol
→
MICB@INNATE_IMMUNE_CELL_Cytosol
As Catalyser:- GRB2@INNATE_IMMUNE_CELL_Cytosol
+ DAP10:NKG2D*@INNATE_IMMUNE_CELL_Membrane
→
DAP10|pho:GRB2:NKG2D*@INNATE_IMMUNE_CELL_Membrane