Protein CCL22 map

Identifiers
HUGO:CCL22

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / TREG_MODULATORS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
PMID:21339327
The Th2 chemoattractants thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22) were secreted as expected by TSLP-treated DCs and, importantly, by DCs conditioned with the supernatant of activated CAFs
PMID:18514095; PMID:18514095
MDC/CCL22 expression in the stroma was not attributable to fibroblasts
PMID:24127572
CCL17 and CCL22 have common receptor ccr4
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans.
 NEUTROPHIL  map
PMID:26966341, PMID:24501019
TANs from established tumors produce CCL17 or CCL22, recruiting immunosuppressive regulatory T cells (Tregs) with defective cytotoxic functions into the tumor and leading to suppression of antitumoral immunity

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CCL22@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CCL22@INNATE_IMMUNE_CELL_Cytosol map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: