Protein MMP10 map

Identifiers
HUGO:MMP10
matrix metallopeptidase 10 (stromelysin 2)
HUGO:MMP10, HGNC:7156, ENTREZ:4319, UNIPROT:P09238, GENECARDS:GC11M102641??

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MATRIX_REGULATION  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
PMID:19509166
FGFR2, WNT2, WNT5A, WISP1, MMP1, MMP10, IGFBP2, IL8, FZD9, CD14, IL32, CXCL14, PKP2 are upregulated in CAFs, ISL1, HIST1H4K, BRCA2, BRCA1, CCNA2, CCNB2, and CDC2 are downregulated
 MACROPHAGE  map
PMID:22880008
Classical activation of macrophages derived in vitro from un-fractionated CD16(+/-) or negatively-selected CD16(-) macrophages up-regulated MMP-1, -3, -7, -10, -12, -14 and -25 and decreased TIMP-3 steady-state mRNA levels.
By contrast, alternative activation decreased MMP-2, -8 and -19 but increased MMP -11, -12, -25 and TIMP-3 steady-state mRNA levels. Up-regulation of MMPs during classical activation depended on mitogen activated protein kinases, phosphoinositide-3-kinase and inhibitor of ??B kinase-2. Effects of interferon?? depended on janus kinase-2.
PMID:23691065
Macrophage migration and invasion is regulated by MMP10 expression.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MMP10@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MMP10@INNATE_IMMUNE_CELL_Cytosol map → map MATRIX_REMODELLING@default map
    2. MMP10@INNATE_IMMUNE_CELL_Cytosol map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: