Identifiers
HUGO:HRAS
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
HUGO:HRAS, HGNC:5173, ENTREZ:3265, GENECARDS:GC11M000522, UNIPROT:P01112
HRAS1
HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_NON_CANONICAL
References
PMID:16102570 PMID:9846483 PMID:7510700 PMID:24027568 PMID:14764585
PMID:9069260
Activated HRAS (GTP bound forn) is associated with the plasma membrane.
Inactive RAF1 is associated in the cytoplasm with YWHAB via S259 phosphorylation site and also binding site.
RAF1 has a RAS-binding Cysteine-rich domain (CRD) and an additional RAS-binding domain (RBD).
RAF1 binds activated HRAS via the RBD. This binding displaces YWHAB from Ser259 and unmasks the CRD.
NATURAL_KILLER
CASCADE:Fc_gamma_RIII
PMID:8551221, PMID:10358164
CD16 and IL-2R Triggering Activate p21RAS in Human NK Cells via LAT/SHC/GRB2/sos pathway.
Phosphorylated Shc interacts with Grb2, which, in turn, interacts with Sos.
PMID:9763606
Cross-linking of ??1 Integrins on Human NK Cells Induces Shc Tyrosine Phosphorylation and Grb2 Association via Pyk-2end
resulted in RAS/ERK activation.