Identifiers
PRKCA_B_E_G*
protein kinase C, alpha
HUGO:PRKCA, HGNC:9393, ENTREZ:5578, UNIPROT:P17252, GENECARDS:GC17P064298 ??
protein kinase C, beta
HUGO:PRKCB, HGNC:9395, ENTREZ:5579, UNIPROT:P05771, GENECARDS:GC16P023847 ??
protein kinase C, epsilon
HUGO:PRKCE, HGNC:9401, ENTREZ:5581, UNIPROT:Q02156, GENECARDS:GC02P045790
protein kinase C, gamma
HUGO:PRKCG, HGNC:9402, ENTREZ:5582, UNIPROT:P05129, GENECARDS:GC19P054382
protein kinase C, zeta
HUGO:PRKCZ HGNC:9412 ENTREZ:5590 UNIPROT:Q05513
HUGO:PRKCA, HGNC:9393, ENTREZ:5578, UNIPROT:P17252
HUGO:PRKCB, HGNC:9395, ENTREZ:5579, UNIPROT:P05771
HUGO:PRKCG, HGNC:9402, ENTREZ:5582, UNIPROT:P05129
protein kinase C, delta
HUGO:PRKCD, HGNC:9399, ENTREZ:5580, UNIPROT:Q05655
HUGO:PRKCE, HGNC:9401, ENTREZ:5581, UNIPROT:Q02156
protein kinase C, eta
HUGO:PRKCH, HGNC:9403, ENTREZ:5583, UNIPROT:P24723
protein kinase C, theta
HUGO:PRKCQ, HGNC:9410, ENTREZ:5588, UNIPROT:Q04759
protein kinase C, iota
HUGO:PRKCI, HGNC:9404, ENTREZ:5584, UNIPROT:P41743
HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG HUGO:PRKCZ HGNC:9412 ENTREZ:5590 UNIPROT:Q05513 GENECARDS:PRKCZ HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI
PKCA
PKCB PRKCB1 PRKCB2 "protein kinase C beta 1"
PKCG SCA14
HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA
HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB
HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG
HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD
HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE
HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH
HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI
HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / GAP_JUNCTIONS
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / INTEGRINS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / PI3K_AKT_MTOR
Survival / WNT_NON_CANONICAL
References
PRKCA_B_E_G*
protein kinase C, alpha
PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA
protein kinase C, beta
PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB
protein kinase C, epsilon
PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE
protein kinase C, gamma
PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG
protein kinase C, zeta
PRKCZ REACTOME:58219 KEGG:5590 ATLASONC:GC_PRKCZ WIKI:PRKCZ
protein kinase C, delta
PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD
protein kinase C, eta
PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH
protein kinase C, theta
PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ
protein kinase C, iota
PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI
PKCA
PKCB PRKCB1 PRKCB2 ???protein kinase C beta 1???
PKCG SCA14
CASCADE:GAST
PMID:24584707
Receptor activation of PLC induces the breakdown of membrane phosphatidylinositol4,5-bisphosphate (PIP2), leading to the formation of two second messengers, IP3 and 1,2-diacylglycerol (DG) [6] and [88]. IP3 induces Ca2+ release from the internal storage pool [6], or probably affects membrane ion channels [57], and DG activates the protein kinase C (PKC) enzyme system
GJA1 is so-called Connexin 43
PMID:16492141
Binding partners proteins of Connexin 43 (GJA1):
-Kinases: v-Src, c-Src, PKC, PKA, MAPK, Casein kinase 1, Cdc2 kinase
-TIGHT_JUNCTIONS scaffold proteins: ZO1, ZO2, caveolin 1
-Cytoskeleton: b-catenin, a-tubulin, b-tubulin
-Others: Drebrin, NOV, CIP85
PMID:10871288
Interaction between Connexin 43 (GJA1) and PKC (alpha, betat and gamma subunits)
The 3 subunits phosphorylate GJA1 at Ser368 and reduce Gap junctions activity.
PMID:10679481
Fibroblast growth factor-2 (FGF-2)decreases cardiomyocyte GJ permeability by stimulating phosphorylation of connexin-43
FGF-2 activates receptors linked to PKC and MAPK
In immunoprecipitation experiments using specific anti-Cx43 antibodies, PKCE but not PKCA coprecipitated with Cx43.
FGF-2 increased levels of coprecipitated PKCE, suggesting increased association between PKCE and Cx43 on stimulation.
To conclude, PKC mediates the FGF-2???induced effects on cardiac GJs and that PKC likely interacts with and phosphorylates cardiac Cx43 at sites of intercellular contact
PMID:20647370, PMID:21720730, PMID:21715253, PMID:21720730, PMID:21441608
REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA
REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB
REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE
REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG
REACTOME:58219 KEGG:5590 ATLASONC:GC_PRKCZ WIKI:PRKCZ
REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD
REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH
REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ
REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI
NATURAL_KILLER
CASCADE:LFA1
PMID:24343663, PMID:9712030, PMID:10591186
The phosphorylation of the Ser329 of DNAM-1 by protein kinase C (PKC) was shown to
be critical for DNAM-1-mediated intracellular signalling and functions
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
PMID:15567848
PMID:11313945
PMID:11940581
Only PKC alpha and delta
PMID:21386996