Protein IL12p35* map

Identifiers
HUGO:IL12A

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION  map

References
PMID:21240265
High expression of IRF5 was characteristic of M1 macrophages, in which it directly activated transcription of the genes encoding interleukin 12 subunit p40 (IL-12p40), IL-12p35 and IL-23p19 and repressed the gene encoding IL-10.

IL12p35*@INNATE_IMMUNE_CELL_Cytosol

References
in_re566( Innate Immunity  map ):
PMID:17404308
CSF2 have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL12p35*@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. IL12p35*@INNATE_IMMUNE_CELL_Cytosol map → map IL12*@INNATE_IMMUNE_CELL_Cytosol map
    2. rIL12p35*@INNATE_IMMUNE_CELL_Cytosol map → map IL12p35*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: