Protein IRAK3 map

Identifiers
HUGO:IRAK3

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:12150927
IRAK3 (IRAK-M) is a negative regulator of Toll-like receptor signaling
in macrophages. It prevented dissociation of IRAK and IRAK-4 from MyD88 and formation of IRAK-TRAF6 complexes.

IRAK3@INNATE_IMMUNE_CELL_Cytosol

References
in_re695( Innate Immunity  map ):
PMID:14660645, PMID:18264787, PMID:12620219
IRAK-1 interacts with the downstream adaptor TRAF6,
resulting in formation of a complex that also includes TAK1 and TAB2.
IRAK-1 mediates the translocation of TRAF6, TAK1, and TAB2 to the cytosol,
where they form a multiprotein complex with other cytosolic proteins,
which are needed for stimulation of TAK1 kinase activity.
PMID:12150927
IRAK3 (IRAK-M) is a negative regulator of Toll-like receptor signaling
in macrophages. It prevented dissociation of IRAK and IRAK-4 from MyD88 and formation of IRAK-TRAF6 complexes.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IRAK3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rIRAK3@INNATE_IMMUNE_CELL_Cytosol map → map IRAK3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. TRAF6@INNATE_IMMUNE_CELL_Cytosol map → map TRAF6@INNATE_IMMUNE_CELL_Cytosol map