Atlas of Cancer Signalling Networks -- Institut Curie -- About

About ACSN

ACSN team

ACSN is developed at institut Curie by the "Computational Systems Biology of Cancer" group from the Department "U900 Institut Curie - INSERM - Mines ParisTech".

Emmanuel Barillot
Eric Bonnet
Laurence Calzone
David Cohen
Mathurin Dorel
Simon Fourquet
Luca Grieco
Maria Kondratova
Inna Kuperstein
Hien Anh Nguyen
Stuart Pook
Jean-Marie Ravel
Christophe Russo
Eric Viara
Andrei Zinovyev

ACSN contributors

Boris Zhivotovski , Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Stockholm, Sweden.
Denis Thieffry, Ecole Normale Supérieure - Département de Biologie, IBENS - UMR ENS - CNRS 8197 - INSERM 1024, Paris France.
Thierry Dubois, Institut Curie, Department of Translational Research, Paris, France.
Gordon Tucker, Oncology Research and Development Unit, Institut de Recherches SERVIER, Croissy-sur-Seine, France.
Francisco Cruzalegui, Oncology Research and Development Unit, Institut de Recherches SERVIER, Croissy-sur-Seine, France.
Jean Paul THIERY, Institute of Molecular Cell Biology, A*STAR, Cancer Science Institute, National University of Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore.
Philippe Chavrier, Institut Curie, Membrane and Cytoskeleton Dynamics, CNRS UMR 144, Paris, France.
Anne-Vincent Salomon, Institut Curie, Genetic and Biology of Cancers Curie Institute, INSERM UMR830, Paris, France.
François Radvanyi and Simon Saule, Institut Curie, SUBCELLULAR STRUCTURE AND CELLULAR DYNAMICS, CNRS, UMR 144, Institut Curie, Paris, France.
Janet Hall, Institut Curie, Génotoxicologie, signalisation et radiothérapie expérimentale, Inserm U612, Orsay, France.
Marie Dutreix, Cyril Buhler, Amélie Croset, Maria Quanz, Institut Curie, RECOMBINATION, REPAIR AND CANCER : FROM MOLECULE TO PATIENT UMR "ETIC", Orsay, France.
Marc-Henri Stern, Institut Curie, INSERM Unit 830, Translational Research Department, Genetics and biology of hereditary breast cancers.
Mounira Amor-Guéret, Institut Curie, Centre de Recherche, Stress Génotoxiques et Cancer, UMR 3348 CNRS, Orsay, France.
Wolf Heyer Departments of Microbiology and of Molecular and Cellular Biology, University of California, Davis, USA.
Jean-Pierre de Villartay, Fondation Imagine Paris, FRANCE.
Fillipo Roselli and Murat Saparbaev, Institut Gustave Roussy, UMR 8200 GENOMES AND CANCERS RESEARCH UNIT, Villejuif Cedex -France.
Patricia Kannouche, Institut Gustave Roussy, UMR 8200 STABILITÉ GÉNÉTIQUE ET ONCOGENÈSE, Villejuif Cedex -France.

ACSN funding

This work is supported by:

APO-SYS EU FP7 project under grant agreement n° HEALTH-F4-2007-200767 (Apoptosis map).
ASSET EU FP7 project under grant agreement n° FP7-HEALTH-2010-259348.
INCA LABEL Cancéropole Ile-de-France 2011-1-LABEL-1 grant.
INVADE grant from ITMO Cancer (Call Systems Biology 2012, EMT and Cell Motility map).
Servier - Institut Curie Alliance (DNA repair map).
The grant “Projet Incitatif et Collaboratif Computational Systems Biology Approach for Cancer” from Institut Curie (DNA repair map).
Agilent Thought Leader Award #3273.
Ligue Nationale Contre le Cancer (Equipe labellisée).
INSERM (U900 budget).
Institut Curie (U900 budget).
COMeT grant from ITMO Cancer (Call Systems Biology 2014, Immunology maps).

Citing us

By using the Atlas (through the web interface, or the files you can download), you agree to cite it in any communication by refering to our main paper:

Kuperstein I, Bonnet E, Nguyen HA, Cohen D, Viara E, Grieco L, Fourquet S, Calzone L, Russo C, Kondratova M, Dutreix M, Barillot E, Zinovyev A. Atlas of Cancer Signalling Network: a systems biology resource for integrative analysis of cancer data with Google Maps. Oncogenesis. 2015 Jul 20;4:e160. doi: 10.1038/oncsis.2015.19. Pubmed ID: 26192618.

Related work

Bonnet E, Viara E, Kuperstein I, Calzone L, Cohen DP, Barillot E, Zinovyev A. NaviCell Web Service for network-based data visualization. Nucleic Acids Res. 2015 Jul 1;43(W1):W560-5. doi: 10.1093/nar/gkv450. Pubmed ID: 25958393.

Kuperstein I, Cohen DP, Pook S, Viara E, Calzone L, Barillot E, Zinovyev A. NaviCell: a web-based environment for navigation, curation and maintenance of large molecular interaction maps. BMC Syst Biol. 2013 Oct 7;7:100. doi: 10.1186/1752-0509-7-100. Pubmed ID: 24099179.

Czerwinska U, Calzone L, Barillot E, Zinovyev A. DeDaL: Cytoscape 3 app for producing and morphing data-driven and structure-driven network layouts. BMC Syst Biol. 2015 Aug 14;9:46. doi: 10.1186/s12918-015-0189-4. Pubmed ID: 26271256.

Vera-Licona P, Bonnet E, Barillot E, Zinovyev A. OCSANA: optimal combinations of interventions from network analysis. Bioinformatics. 2013 Jun 15;29(12):1571-3. doi: 10.1093/bioinformatics/btt195. Pubmed ID: 23626000.

Bonnet E, Calzone L, Rovera D, Stoll G, Barillot E, Zinovyev A. BiNoM 2.0, a Cytoscape plugin for accessing and analyzing pathways using standard systems biology formats. BMC Syst Biol. 2013 Mar 1;7:18. doi: 10.1186/1752-0509-7-18. Pubmed ID: 23453054.

Acknowledgements

We thank the computer team of the Institut Curie and in particular Camille Barette for his help to set up and maintain the ACSN web site. We also thank the many colleagues who tested ACSN, and in particular Philippe Hupé.

Contact

Questions? Comments? Write us at acsn at curie dot fr .