Protein ITGB3 map

Identifiers
integrin subunit beta 3
HUGO:ITGB3 hgnc_id:HGNC:6156 HGNC:6156 ENTREZ:3690 UNIPROT:P05106
HUGO:ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
GP3A
HUGO:ITGB3 HGNC:6156 ENTREZ:3690 UNIPROT:P05106 GENECARDS:GC17P045331

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / INTEGRINS  map
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
CASCADE:INTEGRIN
PMID:18353785
TGF??1-induced ??3 Integrin Expression Is Dependent on ??v??3 Activation
 DENDRITIC_CELL  map
CASCADE:INTEGRIN_AVB3
PMID:9295024, PMID:9763615
Dendritic cells phagocytose apoptotic cells via alphavbeta5, alphavbeta3, and CD36.
The interaction between apoptotic bodies and dendritic cells elicits a rise in intracellular free calcium concentration ([Ca2+]i) which is essential for the process of engulfment.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ITGAV:​ITGB3@INNATE_IMMUNE_CELL_Membrane map
  2. ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. PtdSer@TUMOR_CELL_AS_INDUCTOR_Membrane map + MFGE8@TUMOR_CELL_AS_INDUCTOR_Membrane map + ITGAV:​ITGB3@INNATE_IMMUNE_CELL_Membrane map → map ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane map
  2. ITGAV:​ITGB3:​MFGE8:​PtdSer@INNATE_IMMUNE_CELL_Membrane map → map EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. Tumor_antigen@TUMOR_CELL_AS_EFFECTOR map → map Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map