Protein ADAM17 map

Identifiers
ADAM metallopeptidase domain 17
HUGO:ADAM17, HGNC:195, ENTREZ:6868, UNIPROT:P78536, GENECARDS:GC02M009580
HUGO:ADAM17

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:19726682
PMID:19704010
 NATURAL_KILLER  map
PMID:18676862
Tumor-Associated MICA Is shed by ADAM10 and ADAM17 proteases.
ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-??) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-??), and is of known physiological importance.

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. ADAM17@TUMOR_CELL_AS_INDUCTOR map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. TNF@INNATE_IMMUNE_CELL_Cytosol map → map TNF@default map