Protein PTPN2 map

Identifiers
HUGO:PTPN2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:19833085, PMID:15699106, PMID:12138178
Inactivation of nuclear STAT1 occurs rapidly following binding to chromatin and activation of target gene transcription.
Subsequently STAT1 is dephosphorylated by phosphatases such as PTPN2 (TCP45) and PTPN11 (SHP2), and dephosphorylated STAT1
returns to cytoplasm, where it can potentially serve as the substrate for subsequent rounds of activation and inactivation.
PMID:19833085
Probably, acetylation of STAT1 on lysine residues 410 and 413 in the nucleus results in enhanced interaction with TCP45 (PTPN2) and increased dephosphorylation

PTPN2@INNATE_IMMUNE_CELL_Cytosol

References
in_re709( Innate Immunity  map ):
PMID:19833085, PMID:15699106, PMID:12138178, PMID:12270932
Inactivation of nuclear STAT1 occurs rapidly following binding to chromatin and activation of target gene transcription.
Subsequently STAT1 is dephosphorylated by phosphatases such as PTPN2 (TCP45) and PTPN11 (SHP2), and dephosphorylated STAT1
returns to cytoplasm, where it can potentially serve as the substrate for subsequent rounds of activation and inactivation.
PMID:19833085
Probably, acetylation of STAT1 on lysine residues 410 and 413 in the nucleus results in enhanced interaction with TCP45 (PTPN2) and increased dephosphorylation
in_re712( Innate Immunity  map ):
PMID:19833085, PMID:15699106, PMID:15699106, PMID:15699106

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PTPN2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. STAT1|​pho|​ace@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​ace@INNATE_IMMUNE_CELL_Cytosol map
      2. STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map STAT1@INNATE_IMMUNE_CELL_Cytosol map