{"c_s390": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s390\"]) } catch (e) {}; return false;' title=\"c_s390 1 modifs\">ATM</a> <a href='javascript_required.html' onclick='try { show_blog(661); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Ataxia telangiectasia mutated<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=ATM' target='_blank'>HUGO:ATM</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=795' target='_blank'>HGNC:795</a> <a href='http://www.ncbi.nlm.nih.gov/gene/472' target='_blank'>ENTREZ:472</a> <a href='http://www.expasy.org/uniprot/Q13315' target='_blank'>UNIPROT:Q13315</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATM' target='_blank'>GENECARDS:ATM</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=85553' target='_blank'>REACTOME:85553</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:472' target='_blank'>KEGG:472</a> <a href='http://atlasgeneticsoncology.org//Genes/ATM123.html' target='_blank'>ATLASONC:ATM123</a> <a href='http://wikipedia.org/wiki/ATM' target='_blank'>WIKI:ATM</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;MITOCH_METABOLISM&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/MITOCH_METABOLISM/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_PHASE_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_PHASE_CHECKPOINT/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;MAPK&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/MAPK/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>ATM|Ser 1981_pho<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re141(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15829956' target='_blank'>PMID:15829956</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>Auto-phosphorylation catalysed by E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15024084' target='_blank'>PMID:15024084</a><BR>Autophosphorylation of ATM within dimeric ATM complexes<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12556884' target='_blank'>PMID:12556884</a><BR>c_re158(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>MDM2 phosphorylation by ATM inhibits its interaction with p53<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>Phosphorylation at Ser395<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11331603' target='_blank'>PMID:11331603</a><BR>c_re159:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12861053' target='_blank'>PMID:12861053</a><BR>c_re622(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s390\"]); } catch (e) {}; return false;' title=\"c_s390 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR></p></span>",
"c_s378": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s378\"]) } catch (e) {}; return false;' title=\"c_s378 1 modifs\">ATR</a> <a href='javascript_required.html' onclick='try { show_blog(1167); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Ataxia telangiectasia and Rad3 related<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=ATR' target='_blank'>HUGO:ATR</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=882' target='_blank'>HGNC:882</a> <a href='http://www.ncbi.nlm.nih.gov/gene/545' target='_blank'>ENTREZ:545</a> <a href='http://www.expasy.org/uniprot/Q13535' target='_blank'>UNIPROT:Q13535</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=ATR' target='_blank'>GENECARDS:ATR</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=405632' target='_blank'>REACTOME:405632</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:545' target='_blank'>KEGG:545</a> <a href='http://atlasgeneticsoncology.org//Genes/ATRID728ch3q23.html' target='_blank'>ATLASONC:ATRID728ch3q23</a> <a href='http://wikipedia.org/wiki/ATR' target='_blank'>WIKI:ATR</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_PHASE_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_PHASE_CHECKPOINT/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>ATR<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re132(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15024084' target='_blank'>PMID:15024084</a><BR>ATM phosphorylates p53 in case of DNA double-strand breaks. ATR phosphorylates p53 in case of other types of DNA damages.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>E2F1 stimulates ATM to phosphorylate p53 (and Chk2)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9843217' target='_blank'>PMID:9843217</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9733515' target='_blank'>PMID:9733515</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9733514' target='_blank'>PMID:9733514</a><BR>c_re142(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation by ATR at Ser-317 et Ser-345<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15190204' target='_blank'>PMID:15190204</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10859163' target='_blank'>PMID:10859163</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11090622' target='_blank'>PMID:11090622</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11390642' target='_blank'>PMID:11390642</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15279789' target='_blank'>PMID:15279789</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12781359' target='_blank'>PMID:12781359</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15272308' target='_blank'>PMID:15272308</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12766152' target='_blank'>PMID:12766152</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16431910' target='_blank'>PMID:16431910</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10859164' target='_blank'>PMID:10859164</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16360315' target='_blank'>PMID:16360315</a><BR>c_re622(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s378\"]); } catch (e) {}; return false;' title=\"c_s378 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR></p></span>",
"s627": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s718\"]) } catch (e) {}; return false;' title=\"c_s718 1 modifs\">CDK2</a> <a href='javascript_required.html' onclick='try { show_blog(3919); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK2' target='_blank'>HUGO:CDK2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1771' target='_blank'>HGNC:1771</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1017' target='_blank'>ENTREZ:1017</a> <a href='http://www.expasy.org/uniprot/P24941' target='_blank'>UNIPROT:P24941</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK2' target='_blank'>GENECARDS:CDK2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87018' target='_blank'>REACTOME:87018</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1017' target='_blank'>KEGG:1017</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK2.html' target='_blank'>ATLASONC:GC_CDK2</a> <a href='http://wikipedia.org/wiki/CDK2' target='_blank'>WIKI:CDK2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s627\"]) } catch (e) {}; return false;' title=\"s627 1 modifs\">CDK2</a>|Thr160_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s628\"]) } catch (e) {}; return false;' title=\"s628 1 modifs\">CyclinA*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinA*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APC&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APC/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re258(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10548110' target='_blank'>PMID:10548110</a><BR>CYCLINB phosphorylates CDH1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11598127' target='_blank'>PMID:11598127</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>,",
"c_s377": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s377\", \"c_s207\"]) } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\">CHEK2</a> <a href='javascript_required.html' onclick='try { show_blog(1221); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>CHK2 checkpoint homolog (S. pombe)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CHEK2' target='_blank'>HUGO:CHEK2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=16627' target='_blank'>HGNC:16627</a> <a href='http://www.ncbi.nlm.nih.gov/gene/11200' target='_blank'>ENTREZ:11200</a> <a href='http://www.expasy.org/uniprot/O96017' target='_blank'>UNIPROT:O96017</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHEK2' target='_blank'>GENECARDS:CHEK2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87288' target='_blank'>REACTOME:87288</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:11200' target='_blank'>KEGG:11200</a> <a href='http://atlasgeneticsoncology.org//Genes/CHEK2ID312.html' target='_blank'>ATLASONC:CHEK2ID312</a> <a href='http://wikipedia.org/wiki/CHEK2' target='_blank'>WIKI:CHEK2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_PHASE_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_PHASE_CHECKPOINT/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CDC25&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CDC25/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>CHEK2|Thr68_pho<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re130(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\"]); } catch (e) {}; return false;' title=\"c_s377 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation initiated by E2F1.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15024084' target='_blank'>PMID:15024084</a><BR>E2F1 stimulates ATM to phosphorylate p53 (and Chk2)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12773400' target='_blank'>PMID:12773400</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10973490' target='_blank'>PMID:10973490</a><BR>c_re132(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\"]); } catch (e) {}; return false;' title=\"c_s377 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>ATM phosphorylates p53 in case of DNA double-strand breaks. ATR phosphorylates p53 in case of other types of DNA damages.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9843217' target='_blank'>PMID:9843217</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9733515' target='_blank'>PMID:9733515</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9733514' target='_blank'>PMID:9733514</a><BR>c_re135:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\"]); } catch (e) {}; return false;' title=\"c_s377 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15024084' target='_blank'>PMID:15024084</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>c_re265(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\"]); } catch (e) {}; return false;' title=\"c_s377 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Inactivated by phosphorylation by CHEK1 and CHEK2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12478465' target='_blank'>PMID:12478465</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9278512' target='_blank'>PMID:9278512</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9836640' target='_blank'>PMID:9836640</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9889122' target='_blank'>PMID:9889122</a><BR>Phosphorylation by CYCLINB-CDC2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11313986' target='_blank'>PMID:11313986</a><BR>c_re621(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\"]); } catch (e) {}; return false;' title=\"c_s377 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR></p></span>",
"c_s207": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s377\", \"c_s207\"]) } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\">CHEK2</a> <a href='javascript_required.html' onclick='try { show_blog(1221); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>CHK2 checkpoint homolog (S. pombe)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CHEK2' target='_blank'>HUGO:CHEK2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=16627' target='_blank'>HGNC:16627</a> <a href='http://www.ncbi.nlm.nih.gov/gene/11200' target='_blank'>ENTREZ:11200</a> <a href='http://www.expasy.org/uniprot/O96017' target='_blank'>UNIPROT:O96017</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CHEK2' target='_blank'>GENECARDS:CHEK2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87288' target='_blank'>REACTOME:87288</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:11200' target='_blank'>KEGG:11200</a> <a href='http://atlasgeneticsoncology.org//Genes/CHEK2ID312.html' target='_blank'>ATLASONC:CHEK2ID312</a> <a href='http://wikipedia.org/wiki/CHEK2' target='_blank'>WIKI:CHEK2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_PHASE_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_PHASE_CHECKPOINT/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CDC25&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CDC25/index.html\", [\"c_s377\", \"c_s207\"]); } catch (e) {}; return false;' title=\"c_s377 c_s207 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>CHEK2<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re130(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s207\"]); } catch (e) {}; return false;' title=\"c_s207 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation initiated by E2F1.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15024084' target='_blank'>PMID:15024084</a><BR>E2F1 stimulates ATM to phosphorylate p53 (and Chk2)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12773400' target='_blank'>PMID:12773400</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10973490' target='_blank'>PMID:10973490</a><BR>c_re621(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s207\"]); } catch (e) {}; return false;' title=\"c_s207 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR></p></span>",
"c_s221": "<span class='bubble'></span>",
"s628": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s718\"]) } catch (e) {}; return false;' title=\"c_s718 1 modifs\">CyclinA*</a> <a href='javascript_required.html' onclick='try { show_blog(1818); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin A1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNA1' target='_blank'>HUGO:CCNA1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1577' target='_blank'>HGNC:1577</a> <a href='http://www.ncbi.nlm.nih.gov/gene/8900' target='_blank'>ENTREZ:8900</a> <a href='http://www.expasy.org/uniprot/P78396' target='_blank'>UNIPROT:P78396</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNA1' target='_blank'>GENECARDS:CCNA1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87205' target='_blank'>REACTOME:87205</a> <a href='http://atlasgeneticsoncology.org//Genes/CCNA1ID949ch13q13.html' target='_blank'>ATLASONC:CCNA1ID949ch13q13</a> <a href='http://wikipedia.org/wiki/CCNA1' target='_blank'>WIKI:CCNA1</a> <BR>Cyclin A2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNA2' target='_blank'>HUGO:CCNA2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1578' target='_blank'>HGNC:1578</a> <a href='http://www.ncbi.nlm.nih.gov/gene/890' target='_blank'>ENTREZ:890</a> <a href='http://www.expasy.org/uniprot/P20248' target='_blank'>UNIPROT:P20248</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNA2' target='_blank'>GENECARDS:CCNA2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87208' target='_blank'>REACTOME:87208</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:890' target='_blank'>KEGG:890</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNA2.html' target='_blank'>ATLASONC:GC_CCNA2</a> <a href='http://wikipedia.org/wiki/CCNA2' target='_blank'>WIKI:CCNA2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>degraded by the ubiquitin-proteasome system.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9736735' target='_blank'>PMID:9736735</a><BR>Degraded by APC/Cyclosome<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16123593' target='_blank'>PMID:16123593</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15558010' target='_blank'>PMID:15558010</a><BR>Ubiquitination at Lys-37, Lys-54 et Lys-68<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16123593' target='_blank'>PMID:16123593</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s627\"]) } catch (e) {}; return false;' title=\"s627 1 modifs\">CDK2</a>|Thr160_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s628\"]) } catch (e) {}; return false;' title=\"s628 1 modifs\">CyclinA*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinA*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APC&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APC/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re258(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10548110' target='_blank'>PMID:10548110</a><BR>CYCLINB phosphorylates CDH1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11598127' target='_blank'>PMID:11598127</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>,",
"c_s345": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>DP1*<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re2:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\"]); } catch (e) {}; return false;' title=\"c_s345 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8832394' target='_blank'>PMID:8832394</a><BR></p></span>",
"c_s338": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>DP1*<br>in Cytosol<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re2:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s338\"]); } catch (e) {}; return false;' title=\"c_s338 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8832394' target='_blank'>PMID:8832394</a><BR>c_re271(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s338\"]); } catch (e) {}; return false;' title=\"c_s338 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Competition between ARF and E2F1 to bind DP1.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>ARF relocalize DP1 from the cytoplasm to the nucleolus<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR></p></span>",
"c_s240": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>DP1*|pho<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re87:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s240\"]); } catch (e) {}; return false;' title=\"c_s240 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a><BR></p></span>",
"s57": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace:<a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"s624\", \"s625\"]) } catch (e) {}; return false;' title=\"c_s623 s624 s625 3 modifs\">PCAF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:PCAF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re621(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>c_re622(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>,",
"s124": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace|Ser31_pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s616\", \"s617\"]) } catch (e) {}; return false;' title=\"c_s616 s617 2 modifs\">TOPBP1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:TOPBP1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re139(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"s122": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace|Ser31_pho<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re622(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR>c_re139(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/3_5.gif'/> REF=3 <span style='color:red'>FUNC=5</span></p></span>,",
"s64": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>|pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|pho|Lys_ace:<a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"s624\", \"s625\"]) } catch (e) {}; return false;' title=\"c_s623 s624 s625 3 modifs\">PCAF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:PCAF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re87:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_4.gif'/> REF=4 <span style='color:orange'>FUNC=4</span></p></span>,",
"s119": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace|Ser364_pho<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s726\"]); } catch (e) {}; return false;' title=\"c_s726 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s726\"]); } catch (e) {}; return false;' title=\"c_s726 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re621(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s726\"]); } catch (e) {}; return false;' title=\"c_s726 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"s117": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"s115\", \"s49\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 s115 s49 4 modifs\">RB1</a>|pho|pho|pho<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:RB1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re323(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>pRB phosphorylation<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>Brg1 phosphorylation <BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420722' target='_blank'>PMID:11420722</a><BR>Brg1 (in the SWI/SNF complex) and pRB are phosphorylated, simultaneously with the complex dissociation. Phosphorylation of pRB<BR>Phosphorylation of Brg1 (SWI/SNF complex)<BR>c_re291:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/3_5.gif'/> REF=3 <span style='color:red'>FUNC=5</span></p></span>,",
"s59": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s715\"]); } catch (e) {}; return false;' title=\"c_s715 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s715\"]); } catch (e) {}; return false;' title=\"c_s715 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re64(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s715\"]); } catch (e) {}; return false;' title=\"c_s715 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p></span>,",
"s61": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re291:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR>c_re292:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR>c_re64(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p></span>,",
"s51": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"s115\", \"s49\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 s115 s49 4 modifs\">RB1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:RB1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re112(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838516' target='_blank'>PMID:15838516</a><BR>The recruitment of SWI/SNF seems to be necessary for the recrutement de HDAC1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420729' target='_blank'>PMID:11420729</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15105433' target='_blank'>PMID:15105433</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"s234": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\">DP1*</a> <a href='javascript_required.html' onclick='try { show_blog(1841); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Transcription factor Dp-1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TFDP1' target='_blank'>HUGO:TFDP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=11749' target='_blank'>HGNC:11749</a> <a href='http://www.ncbi.nlm.nih.gov/gene/7027' target='_blank'>ENTREZ:7027</a> <a href='http://www.expasy.org/uniprot/Q14186' target='_blank'>UNIPROT:Q14186</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TFDP1' target='_blank'>GENECARDS:TFDP1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=103193' target='_blank'>REACTOME:103193</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:7027' target='_blank'>KEGG:7027</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TFDP1.html' target='_blank'>ATLASONC:GC_TFDP1</a> <a href='http://wikipedia.org/wiki/TFDP1' target='_blank'>WIKI:TFDP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F6&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F6/index.html\", [\"c_s345\", \"c_s338\", \"c_s240\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\", \"c_s730\"]); } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 c_s1497 c_s737 c_s736 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 c_s730 13 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s428\", \"s260\", \"s233\"]) } catch (e) {}; return false;' title=\"s428 s260 s233 3 modifs\">p14ARF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:p14ARF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re271(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Competition between ARF and E2F1 to bind DP1.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>ARF relocalize DP1 from the cytoplasm to the nucleolus<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR>c_re268(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Cell cycle inhibition by sequestration of DP1 in the nucleolus.<BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_4.gif'/> REF=2 <span style='color:orange'>FUNC=4</span></p></span>,",
"c_s629": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>E2F1|Ser403_pho<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re317(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\"]); } catch (e) {}; return false;' title=\"c_s629 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation at the Ser-403 in S phase by the TFIIH kinase targets E2F1 for its rapid ubiquitination and degradation through the ubiquitin-proteasome pathway.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation at Ser-403 and Thr-433 by the basal TF TFHII triggers E2F1 degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re318(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\"]); } catch (e) {}; return false;' title=\"c_s629 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Degradation depends upon ubiquitination. E3: F-box protein p45Skp2<BR></p></span>",
"c_s266": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>E2F1|pho<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re98(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s266\"]); } catch (e) {}; return false;' title=\"c_s266 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>E2F1 deacetylated by pRB/HDAC<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Deacetylation by HDAC1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p></span>",
"c_s21": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>E2F1|pho|Lys_ace<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re87:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s21\"]); } catch (e) {}; return false;' title=\"c_s21 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a><BR>c_re98(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s21\"]); } catch (e) {}; return false;' title=\"c_s21 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>E2F1 deacetylated by pRB/HDAC<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Deacetylation by HDAC1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p></span>",
"c_s11": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>E2F1<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re2:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s11\"]); } catch (e) {}; return false;' title=\"c_s11 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8832394' target='_blank'>PMID:8832394</a><BR>c_re275(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s11\"]); } catch (e) {}; return false;' title=\"c_s11 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>E2F1 sequestrated by ARF in the nucleolus.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR>c_re276(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s11\"]); } catch (e) {}; return false;' title=\"c_s11 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>p14ARF induce the degradation of E2F1, E2F2 and E2F3 via the proteasome<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11274364' target='_blank'>PMID:11274364</a><BR>c_re317(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s11\"]); } catch (e) {}; return false;' title=\"c_s11 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation at the Ser-403 in S phase by the TFIIH kinase targets E2F1 for its rapid ubiquitination and degradation through the ubiquitin-proteasome pathway.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation at Ser-403 and Thr-433 by the basal TF TFHII triggers E2F1 degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR></p></span>",
"s56": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace:<a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"s624\", \"s625\"]) } catch (e) {}; return false;' title=\"c_s623 s624 s625 3 modifs\">PCAF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:PCAF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re621(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>c_re622(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>,",
"s123": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace|Ser31_pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s616\", \"s617\"]) } catch (e) {}; return false;' title=\"c_s616 s617 2 modifs\">TOPBP1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:TOPBP1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re139(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"s120": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace|Ser31_pho<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re622(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR>c_re139(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/3_5.gif'/> REF=3 <span style='color:red'>FUNC=5</span></p></span>,",
"s259": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s428\", \"s260\", \"s233\"]) } catch (e) {}; return false;' title=\"s428 s260 s233 3 modifs\">p14ARF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:E2F1:p14ARF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re275(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>E2F1 sequestrated by ARF in the nucleolus.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR>c_re273(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p></span>,",
"s63": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>|pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|pho|Lys_ace:<a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"s624\", \"s625\"]) } catch (e) {}; return false;' title=\"c_s623 s624 s625 3 modifs\">PCAF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:PCAF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re87:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_4.gif'/> REF=4 <span style='color:orange'>FUNC=4</span></p></span>,",
"s118": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace|Ser364_pho<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s726\"]); } catch (e) {}; return false;' title=\"c_s726 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s726\"]); } catch (e) {}; return false;' title=\"c_s726 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re621(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s726\"]); } catch (e) {}; return false;' title=\"c_s726 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"s116": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"s115\", \"s49\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 s115 s49 4 modifs\">RB1</a>|pho|pho|pho<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:RB1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re323(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>pRB phosphorylation<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>Brg1 phosphorylation <BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420722' target='_blank'>PMID:11420722</a><BR>Brg1 (in the SWI/SNF complex) and pRB are phosphorylated, simultaneously with the complex dissociation. Phosphorylation of pRB<BR>Phosphorylation of Brg1 (SWI/SNF complex)<BR>c_re291:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/3_5.gif'/> REF=3 <span style='color:red'>FUNC=5</span></p></span>,",
"s58": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s715\"]); } catch (e) {}; return false;' title=\"c_s715 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s715\"]); } catch (e) {}; return false;' title=\"c_s715 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re64(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s715\"]); } catch (e) {}; return false;' title=\"c_s715 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p></span>,",
"s60": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re291:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR>c_re292:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR>c_re64(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p></span>,",
"s50": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\">E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3904); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>E2F transcription factor 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=E2F1' target='_blank'>HUGO:E2F1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=3113' target='_blank'>HGNC:3113</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1869' target='_blank'>ENTREZ:1869</a> <a href='http://www.expasy.org/uniprot/Q01094' target='_blank'>UNIPROT:Q01094</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=E2F1' target='_blank'>GENECARDS:E2F1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=89561' target='_blank'>REACTOME:89561</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1869' target='_blank'>KEGG:1869</a> <a href='http://atlasgeneticsoncology.org//Genes/E2F1ID40382ch20q11.html' target='_blank'>ATLASONC:E2F1ID40382ch20q11</a> <a href='http://wikipedia.org/wiki/E2F1' target='_blank'>WIKI:E2F1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"c_s1497\", \"c_s737\", \"c_s736\", \"c_s729\", \"c_s728\", \"c_s726\", \"c_s717\", \"c_s715\", \"c_s713\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 c_s1497 c_s737 c_s736 c_s729 c_s728 c_s726 c_s717 c_s715 c_s713 c_s712 14 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"s115\", \"s49\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 s115 s49 4 modifs\">RB1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:RB1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re112(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838516' target='_blank'>PMID:15838516</a><BR>The recruitment of SWI/SNF seems to be necessary for the recrutement de HDAC1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420729' target='_blank'>PMID:11420729</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15105433' target='_blank'>PMID:15105433</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"c_s220": "<span class='bubble'></span>",
"c_s19": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s19\"]) } catch (e) {}; return false;' title=\"c_s19 1 modifs\">HDAC1</a> <a href='javascript_required.html' onclick='try { show_blog(4121); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Histone deacetylase 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=HDAC1' target='_blank'>HUGO:HDAC1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=4852' target='_blank'>HGNC:4852</a> <a href='http://www.ncbi.nlm.nih.gov/gene/3065' target='_blank'>ENTREZ:3065</a> <a href='http://www.expasy.org/uniprot/Q13547' target='_blank'>UNIPROT:Q13547</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=HDAC1' target='_blank'>GENECARDS:HDAC1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=56408' target='_blank'>REACTOME:56408</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:3065' target='_blank'>KEGG:3065</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_HDAC1.html' target='_blank'>ATLASONC:GC_HDAC1</a> <a href='http://wikipedia.org/wiki/HDAC1' target='_blank'>WIKI:HDAC1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F4&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F4/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;HEDGEHOG&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/HEDGEHOG/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>HDAC1<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re290(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15769944' target='_blank'>PMID:15769944</a><BR>c_re298(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of pRB<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR>dissociation of HDAC1 (during the G1 to S transition)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10778858' target='_blank'>PMID:10778858</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11520855' target='_blank'>PMID:11520855</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7736585' target='_blank'>PMID:7736585</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9425340' target='_blank'>PMID:9425340</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9190208' target='_blank'>PMID:9190208</a><BR>c_re31:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10964686' target='_blank'>PMID:10964686</a><BR>c_re98(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>E2F1 deacetylated by pRB/HDAC<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Deacetylation by HDAC1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR>c_re112(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s19\"]); } catch (e) {}; return false;' title=\"c_s19 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838516' target='_blank'>PMID:15838516</a><BR>The recruitment of SWI/SNF seems to be necessary for the recrutement de HDAC1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420729' target='_blank'>PMID:11420729</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15105433' target='_blank'>PMID:15105433</a><BR></p></span>",
"c_s623": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"c_s1497\", \"c_s728\"]) } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\">PCAF*</a> <a href='javascript_required.html' onclick='try { show_blog(976); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>K(lysine) acetyltransferase 2B<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=KAT2B' target='_blank'>HUGO:KAT2B</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=8638' target='_blank'>HGNC:8638</a> <a href='http://www.ncbi.nlm.nih.gov/gene/8850' target='_blank'>ENTREZ:8850</a> <a href='http://www.expasy.org/uniprot/Q92831' target='_blank'>UNIPROT:Q92831</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KAT2B' target='_blank'>GENECARDS:KAT2B</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=61366' target='_blank'>REACTOME:61366</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:8850' target='_blank'>KEGG:8850</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_KAT2B.html' target='_blank'>ATLASONC:GC_KAT2B</a> <a href='http://wikipedia.org/wiki/KAT2B' target='_blank'>WIKI:KAT2B</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>In reality, many kinds of histone acetyltransferases: p300 (EP300) + CBP (CREBBP) + PCAF + GCN5(GCN5L2), or the Tip60 complex: Tip60(HTATIP) + TRRAP + p400(EP400) + Tip48(RUVBL2) + Tip49(RUVBL1)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15121871' target='_blank'>PMID:15121871</a></p><hr><BR><b>Modification:</b><br>PCAF*<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re87:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s623\"]); } catch (e) {}; return false;' title=\"c_s623 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a><BR>c_re621(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s623\"]); } catch (e) {}; return false;' title=\"c_s623 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>c_re622(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s623\"]); } catch (e) {}; return false;' title=\"c_s623 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR>c_re64(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s623\"]); } catch (e) {}; return false;' title=\"c_s623 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p></span>",
"s624": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"c_s1497\", \"c_s728\"]) } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\">PCAF*</a> <a href='javascript_required.html' onclick='try { show_blog(976); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>K(lysine) acetyltransferase 2B<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=KAT2B' target='_blank'>HUGO:KAT2B</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=8638' target='_blank'>HGNC:8638</a> <a href='http://www.ncbi.nlm.nih.gov/gene/8850' target='_blank'>ENTREZ:8850</a> <a href='http://www.expasy.org/uniprot/Q92831' target='_blank'>UNIPROT:Q92831</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KAT2B' target='_blank'>GENECARDS:KAT2B</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=61366' target='_blank'>REACTOME:61366</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:8850' target='_blank'>KEGG:8850</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_KAT2B.html' target='_blank'>ATLASONC:GC_KAT2B</a> <a href='http://wikipedia.org/wiki/KAT2B' target='_blank'>WIKI:KAT2B</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>In reality, many kinds of histone acetyltransferases: p300 (EP300) + CBP (CREBBP) + PCAF + GCN5(GCN5L2), or the Tip60 complex: Tip60(HTATIP) + TRRAP + p400(EP400) + Tip48(RUVBL2) + Tip49(RUVBL1)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15121871' target='_blank'>PMID:15121871</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace:<a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"s624\", \"s625\"]) } catch (e) {}; return false;' title=\"c_s623 s624 s625 3 modifs\">PCAF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:PCAF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re621(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>c_re622(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>,",
"s625": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"c_s1497\", \"c_s728\"]) } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\">PCAF*</a> <a href='javascript_required.html' onclick='try { show_blog(976); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>K(lysine) acetyltransferase 2B<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=KAT2B' target='_blank'>HUGO:KAT2B</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=8638' target='_blank'>HGNC:8638</a> <a href='http://www.ncbi.nlm.nih.gov/gene/8850' target='_blank'>ENTREZ:8850</a> <a href='http://www.expasy.org/uniprot/Q92831' target='_blank'>UNIPROT:Q92831</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=KAT2B' target='_blank'>GENECARDS:KAT2B</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=61366' target='_blank'>REACTOME:61366</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:8850' target='_blank'>KEGG:8850</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_KAT2B.html' target='_blank'>ATLASONC:GC_KAT2B</a> <a href='http://wikipedia.org/wiki/KAT2B' target='_blank'>WIKI:KAT2B</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WNT_CANONICAL&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/WNT_CANONICAL/index.html\", [\"c_s623\", \"c_s1497\", \"c_s728\"]); } catch (e) {}; return false;' title=\"c_s623 c_s1497 c_s728 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>In reality, many kinds of histone acetyltransferases: p300 (EP300) + CBP (CREBBP) + PCAF + GCN5(GCN5L2), or the Tip60 complex: Tip60(HTATIP) + TRRAP + p400(EP400) + Tip48(RUVBL2) + Tip49(RUVBL1)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15121871' target='_blank'>PMID:15121871</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>|pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|pho|Lys_ace:<a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"s624\", \"s625\"]) } catch (e) {}; return false;' title=\"c_s623 s624 s625 3 modifs\">PCAF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:PCAF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re87:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_4.gif'/> REF=4 <span style='color:orange'>FUNC=4</span></p></span>,",
"c_s9": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\">RB1</a> <a href='javascript_required.html' onclick='try { show_blog(608); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Retinoblastoma 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=RB1' target='_blank'>HUGO:RB1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=9884' target='_blank'>HGNC:9884</a> <a href='http://www.ncbi.nlm.nih.gov/gene/5925' target='_blank'>ENTREZ:5925</a> <a href='http://www.expasy.org/uniprot/P06400' target='_blank'>UNIPROT:P06400</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RB1' target='_blank'>GENECARDS:RB1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=62886' target='_blank'>REACTOME:62886</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:5925' target='_blank'>KEGG:5925</a> <a href='http://atlasgeneticsoncology.org//Genes/RB1ID90.html' target='_blank'>ATLASONC:RB1ID90</a> <a href='http://wikipedia.org/wiki/RB1' target='_blank'>WIKI:RB1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Inhibition of E2F binding by phosphorylation at several of the 7 C-terminal sites or at one of the two serines 807 and 811.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a></p><hr><BR><b>Modification:</b><br>RB1|pho|pho|pho<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re291:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s9\"]); } catch (e) {}; return false;' title=\"c_s9 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR>c_re35(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s9\"]); } catch (e) {}; return false;' title=\"c_s9 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR></p></span>",
"c_s7": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\">RB1</a> <a href='javascript_required.html' onclick='try { show_blog(608); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Retinoblastoma 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=RB1' target='_blank'>HUGO:RB1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=9884' target='_blank'>HGNC:9884</a> <a href='http://www.ncbi.nlm.nih.gov/gene/5925' target='_blank'>ENTREZ:5925</a> <a href='http://www.expasy.org/uniprot/P06400' target='_blank'>UNIPROT:P06400</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RB1' target='_blank'>GENECARDS:RB1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=62886' target='_blank'>REACTOME:62886</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:5925' target='_blank'>KEGG:5925</a> <a href='http://atlasgeneticsoncology.org//Genes/RB1ID90.html' target='_blank'>ATLASONC:RB1ID90</a> <a href='http://wikipedia.org/wiki/RB1' target='_blank'>WIKI:RB1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Inhibition of E2F binding by phosphorylation at several of the 7 C-terminal sites or at one of the two serines 807 and 811.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a></p><hr><BR><b>Modification:</b><br>RB1<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re35(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s7\"]); } catch (e) {}; return false;' title=\"c_s7 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR></p></span>",
"s115": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\">RB1</a> <a href='javascript_required.html' onclick='try { show_blog(608); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Retinoblastoma 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=RB1' target='_blank'>HUGO:RB1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=9884' target='_blank'>HGNC:9884</a> <a href='http://www.ncbi.nlm.nih.gov/gene/5925' target='_blank'>ENTREZ:5925</a> <a href='http://www.expasy.org/uniprot/P06400' target='_blank'>UNIPROT:P06400</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RB1' target='_blank'>GENECARDS:RB1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=62886' target='_blank'>REACTOME:62886</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:5925' target='_blank'>KEGG:5925</a> <a href='http://atlasgeneticsoncology.org//Genes/RB1ID90.html' target='_blank'>ATLASONC:RB1ID90</a> <a href='http://wikipedia.org/wiki/RB1' target='_blank'>WIKI:RB1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Inhibition of E2F binding by phosphorylation at several of the 7 C-terminal sites or at one of the two serines 807 and 811.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"s115\", \"s49\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 s115 s49 4 modifs\">RB1</a>|pho|pho|pho<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:RB1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re323(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>pRB phosphorylation<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>Brg1 phosphorylation <BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420722' target='_blank'>PMID:11420722</a><BR>Brg1 (in the SWI/SNF complex) and pRB are phosphorylated, simultaneously with the complex dissociation. Phosphorylation of pRB<BR>Phosphorylation of Brg1 (SWI/SNF complex)<BR>c_re291:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/3_5.gif'/> REF=3 <span style='color:red'>FUNC=5</span></p></span>,",
"s49": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\">RB1</a> <a href='javascript_required.html' onclick='try { show_blog(608); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Retinoblastoma 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=RB1' target='_blank'>HUGO:RB1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=9884' target='_blank'>HGNC:9884</a> <a href='http://www.ncbi.nlm.nih.gov/gene/5925' target='_blank'>ENTREZ:5925</a> <a href='http://www.expasy.org/uniprot/P06400' target='_blank'>UNIPROT:P06400</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=RB1' target='_blank'>GENECARDS:RB1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=62886' target='_blank'>REACTOME:62886</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:5925' target='_blank'>KEGG:5925</a> <a href='http://atlasgeneticsoncology.org//Genes/RB1ID90.html' target='_blank'>ATLASONC:RB1ID90</a> <a href='http://wikipedia.org/wiki/RB1' target='_blank'>WIKI:RB1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_S_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_S_CHECKPOINT/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s9\", \"c_s7\", \"c_s717\", \"c_s712\"]); } catch (e) {}; return false;' title=\"c_s9 c_s7 c_s717 c_s712 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Inhibition of E2F binding by phosphorylation at several of the 7 C-terminal sites or at one of the two serines 807 and 811.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"s115\", \"s49\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 s115 s49 4 modifs\">RB1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:RB1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re112(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838516' target='_blank'>PMID:15838516</a><BR>The recruitment of SWI/SNF seems to be necessary for the recrutement de HDAC1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420729' target='_blank'>PMID:11420729</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15105433' target='_blank'>PMID:15105433</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"c_s631": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s631\"]) } catch (e) {}; return false;' title=\"c_s631 1 modifs\">TFIIH*</a> <a href='javascript_required.html' onclick='try { show_blog(264); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>General transcription factor IIH, polypeptide 1, 62kDa<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=GTF2H1' target='_blank'>HUGO:GTF2H1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=4655' target='_blank'>HGNC:4655</a> <a href='http://www.ncbi.nlm.nih.gov/gene/2965' target='_blank'>ENTREZ:2965</a> <a href='http://www.expasy.org/uniprot/P32780' target='_blank'>UNIPROT:P32780</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GTF2H1' target='_blank'>GENECARDS:GTF2H1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=65913' target='_blank'>REACTOME:65913</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:2965' target='_blank'>KEGG:2965</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_GTF2H1.html' target='_blank'>ATLASONC:GC_GTF2H1</a> <a href='http://wikipedia.org/wiki/GTF2H1' target='_blank'>WIKI:GTF2H1</a> <BR>General transcription factor IIH, polypeptide 2, 44kDa<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=GTF2H2' target='_blank'>HUGO:GTF2H2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=4656' target='_blank'>HGNC:4656</a> <a href='http://www.ncbi.nlm.nih.gov/gene/2966' target='_blank'>ENTREZ:2966</a> <a href='http://www.expasy.org/uniprot/Q13888' target='_blank'>UNIPROT:Q13888</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GTF2H2' target='_blank'>GENECARDS:GTF2H2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=65915' target='_blank'>REACTOME:65915</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:2966' target='_blank'>KEGG:2966</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_GTF2H2.html' target='_blank'>ATLASONC:GC_GTF2H2</a> <a href='http://wikipedia.org/wiki/GTF2H2' target='_blank'>WIKI:GTF2H2</a> <BR>General transcription factor IIH, polypeptide 2B<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=GTF2H2B' target='_blank'>HUGO:GTF2H2B</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=31393' target='_blank'>HGNC:31393</a> <a href='http://www.ncbi.nlm.nih.gov/gene/653238' target='_blank'>ENTREZ:653238</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GTF2H2B' target='_blank'>GENECARDS:GTF2H2B</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_GTF2H2B.html' target='_blank'>ATLASONC:GC_GTF2H2B</a> <a href='http://wikipedia.org/wiki/GTF2H2B' target='_blank'>WIKI:GTF2H2B</a> <BR>General transcription factor IIH, polypeptide 2C<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=GTF2H2C' target='_blank'>HUGO:GTF2H2C</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=31394' target='_blank'>HGNC:31394</a> <a href='http://www.ncbi.nlm.nih.gov/gene/728340' target='_blank'>ENTREZ:728340</a> <a href='http://www.expasy.org/uniprot/Q6P1K8' target='_blank'>UNIPROT:Q6P1K8</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GTF2H2C' target='_blank'>GENECARDS:GTF2H2C</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_GTF2H2C.html' target='_blank'>ATLASONC:GC_GTF2H2C</a> <a href='http://wikipedia.org/wiki/GTF2H2C' target='_blank'>WIKI:GTF2H2C</a> <a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=GTF2H2D' target='_blank'>HUGO:GTF2H2D</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=35418' target='_blank'>HGNC:35418</a> <a href='http://www.ncbi.nlm.nih.gov/gene/730394' target='_blank'>ENTREZ:730394</a> <a href='http://www.expasy.org/uniprot/Q6P1K8' target='_blank'>UNIPROT:Q6P1K8</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GTF2H2D' target='_blank'>GENECARDS:GTF2H2D</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_GTF2H2D.html' target='_blank'>ATLASONC:GC_GTF2H2D</a> <a href='http://wikipedia.org/wiki/GTF2H2D' target='_blank'>WIKI:GTF2H2D</a> <BR>General transcription factor IIH, polypeptide 2D<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=GTF2H2D' target='_blank'>HUGO:GTF2H2D</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=35418' target='_blank'>HGNC:35418</a> <a href='http://www.ncbi.nlm.nih.gov/gene/730394' target='_blank'>ENTREZ:730394</a> <a href='http://www.expasy.org/uniprot/Q6P1K8' target='_blank'>UNIPROT:Q6P1K8</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GTF2H2D' target='_blank'>GENECARDS:GTF2H2D</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_GTF2H2D.html' target='_blank'>ATLASONC:GC_GTF2H2D</a> <a href='http://wikipedia.org/wiki/GTF2H2D' target='_blank'>WIKI:GTF2H2D</a> <a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=GTF2H2C' target='_blank'>HUGO:GTF2H2C</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=31394' target='_blank'>HGNC:31394</a> <a href='http://www.ncbi.nlm.nih.gov/gene/728340' target='_blank'>ENTREZ:728340</a> <a href='http://www.expasy.org/uniprot/Q6P1K8' target='_blank'>UNIPROT:Q6P1K8</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GTF2H2C' target='_blank'>GENECARDS:GTF2H2C</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_GTF2H2C.html' target='_blank'>ATLASONC:GC_GTF2H2C</a> <a href='http://wikipedia.org/wiki/GTF2H2C' target='_blank'>WIKI:GTF2H2C</a> <BR>General transcription factor IIH, polypeptide 3, 34kDa<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=GTF2H3' target='_blank'>HUGO:GTF2H3</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=4657' target='_blank'>HGNC:4657</a> <a href='http://www.ncbi.nlm.nih.gov/gene/2967' target='_blank'>ENTREZ:2967</a> <a href='http://www.expasy.org/uniprot/Q13889' target='_blank'>UNIPROT:Q13889</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GTF2H3' target='_blank'>GENECARDS:GTF2H3</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=65917' target='_blank'>REACTOME:65917</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:2967' target='_blank'>KEGG:2967</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_GTF2H3.html' target='_blank'>ATLASONC:GC_GTF2H3</a> <a href='http://wikipedia.org/wiki/GTF2H3' target='_blank'>WIKI:GTF2H3</a> <BR>General transcription factor IIH, polypeptide 4, 52kDa<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=GTF2H4' target='_blank'>HUGO:GTF2H4</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=4658' target='_blank'>HGNC:4658</a> <a href='http://www.ncbi.nlm.nih.gov/gene/2968' target='_blank'>ENTREZ:2968</a> <a href='http://www.expasy.org/uniprot/Q92759' target='_blank'>UNIPROT:Q92759</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GTF2H4' target='_blank'>GENECARDS:GTF2H4</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=65919' target='_blank'>REACTOME:65919</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:2968' target='_blank'>KEGG:2968</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_GTF2H4.html' target='_blank'>ATLASONC:GC_GTF2H4</a> <a href='http://wikipedia.org/wiki/GTF2H4' target='_blank'>WIKI:GTF2H4</a> <BR>General transcription factor IIH, polypeptide 5<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=GTF2H5' target='_blank'>HUGO:GTF2H5</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=21157' target='_blank'>HGNC:21157</a> <a href='http://www.ncbi.nlm.nih.gov/gene/404672' target='_blank'>ENTREZ:404672</a> <a href='http://www.expasy.org/uniprot/Q6ZYL4' target='_blank'>UNIPROT:Q6ZYL4</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=GTF2H5' target='_blank'>GENECARDS:GTF2H5</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:404672' target='_blank'>KEGG:404672</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_GTF2H5.html' target='_blank'>ATLASONC:GC_GTF2H5</a> <a href='http://wikipedia.org/wiki/GTF2H5' target='_blank'>WIKI:GTF2H5</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s631\"]); } catch (e) {}; return false;' title=\"c_s631 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s631\"]); } catch (e) {}; return false;' title=\"c_s631 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>TFIIH*<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re317(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s631\"]); } catch (e) {}; return false;' title=\"c_s631 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation at the Ser-403 in S phase by the TFIIH kinase targets E2F1 for its rapid ubiquitination and degradation through the ubiquitin-proteasome pathway.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation at Ser-403 and Thr-433 by the basal TF TFHII triggers E2F1 degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR></p></span>",
"c_s616": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s616\", \"c_s737\"]) } catch (e) {}; return false;' title=\"c_s616 c_s737 2 modifs\">TOPBP1</a> <a href='javascript_required.html' onclick='try { show_blog(1727); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Topoisomerase (DNA) II binding protein 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TOPBP1' target='_blank'>HUGO:TOPBP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=17008' target='_blank'>HGNC:17008</a> <a href='http://www.ncbi.nlm.nih.gov/gene/11073' target='_blank'>ENTREZ:11073</a> <a href='http://www.expasy.org/uniprot/Q92547' target='_blank'>UNIPROT:Q92547</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TOPBP1' target='_blank'>GENECARDS:TOPBP1</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:11073' target='_blank'>KEGG:11073</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TOPBP1.html' target='_blank'>ATLASONC:GC_TOPBP1</a> <a href='http://wikipedia.org/wiki/TOPBP1' target='_blank'>WIKI:TOPBP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s616\", \"c_s737\"]); } catch (e) {}; return false;' title=\"c_s616 c_s737 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s616\", \"c_s737\"]); } catch (e) {}; return false;' title=\"c_s616 c_s737 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s616\", \"c_s737\"]); } catch (e) {}; return false;' title=\"c_s616 c_s737 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s616\", \"c_s737\"]); } catch (e) {}; return false;' title=\"c_s616 c_s737 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>TopBP1 contains 8 BRCT (BRCA1 carboxyl-terminal) motives.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a></p><hr><BR><b>Modification:</b><br>TOPBP1<br>in nucleus<br><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re139(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s616\"]); } catch (e) {}; return false;' title=\"c_s616 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a><BR></p></span>",
"s617": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s616\", \"c_s737\"]) } catch (e) {}; return false;' title=\"c_s616 c_s737 2 modifs\">TOPBP1</a> <a href='javascript_required.html' onclick='try { show_blog(1727); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Topoisomerase (DNA) II binding protein 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=TOPBP1' target='_blank'>HUGO:TOPBP1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=17008' target='_blank'>HGNC:17008</a> <a href='http://www.ncbi.nlm.nih.gov/gene/11073' target='_blank'>ENTREZ:11073</a> <a href='http://www.expasy.org/uniprot/Q92547' target='_blank'>UNIPROT:Q92547</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=TOPBP1' target='_blank'>GENECARDS:TOPBP1</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:11073' target='_blank'>KEGG:11073</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_TOPBP1.html' target='_blank'>ATLASONC:GC_TOPBP1</a> <a href='http://wikipedia.org/wiki/TOPBP1' target='_blank'>WIKI:TOPBP1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s616\", \"c_s737\"]); } catch (e) {}; return false;' title=\"c_s616 c_s737 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s616\", \"c_s737\"]); } catch (e) {}; return false;' title=\"c_s616 c_s737 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s616\", \"c_s737\"]); } catch (e) {}; return false;' title=\"c_s616 c_s737 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s616\", \"c_s737\"]); } catch (e) {}; return false;' title=\"c_s616 c_s737 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>TopBP1 contains 8 BRCT (BRCA1 carboxyl-terminal) motives.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace|Ser31_pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s616\", \"s617\"]) } catch (e) {}; return false;' title=\"c_s616 s617 2 modifs\">TOPBP1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:TOPBP1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re139(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"s428": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"s428\", \"c_s729\", \"c_s730\"]) } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\">p14ARF*</a> <a href='javascript_required.html' onclick='try { show_blog(3523); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDKN2A' target='_blank'>HUGO:CDKN2A</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1787' target='_blank'>HGNC:1787</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1029' target='_blank'>ENTREZ:1029</a> <a href='http://www.expasy.org/uniprot/P42771' target='_blank'>UNIPROT:P42771</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDKN2A' target='_blank'>GENECARDS:CDKN2A</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87039' target='_blank'>REACTOME:87039</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1029' target='_blank'>KEGG:1029</a> <a href='http://atlasgeneticsoncology.org//Genes/CDKN2aID146.html' target='_blank'>ATLASONC:CDKN2aID146</a> <a href='http://wikipedia.org/wiki/CDKN2A' target='_blank'>WIKI:CDKN2A</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;HIF1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/HIF1/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>p14ARF*<br>in nucleus<br>null</span>",
"s260": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"s428\", \"c_s729\", \"c_s730\"]) } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\">p14ARF*</a> <a href='javascript_required.html' onclick='try { show_blog(3523); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDKN2A' target='_blank'>HUGO:CDKN2A</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1787' target='_blank'>HGNC:1787</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1029' target='_blank'>ENTREZ:1029</a> <a href='http://www.expasy.org/uniprot/P42771' target='_blank'>UNIPROT:P42771</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDKN2A' target='_blank'>GENECARDS:CDKN2A</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87039' target='_blank'>REACTOME:87039</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1029' target='_blank'>KEGG:1029</a> <a href='http://atlasgeneticsoncology.org//Genes/CDKN2aID146.html' target='_blank'>ATLASONC:CDKN2aID146</a> <a href='http://wikipedia.org/wiki/CDKN2A' target='_blank'>WIKI:CDKN2A</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;HIF1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/HIF1/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s428\", \"s260\", \"s233\"]) } catch (e) {}; return false;' title=\"s428 s260 s233 3 modifs\">p14ARF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:E2F1:p14ARF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re275(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>E2F1 sequestrated by ARF in the nucleolus.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR>c_re273(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p></span>,",
"s233": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"s428\", \"c_s729\", \"c_s730\"]) } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\">p14ARF*</a> <a href='javascript_required.html' onclick='try { show_blog(3523); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDKN2A' target='_blank'>HUGO:CDKN2A</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1787' target='_blank'>HGNC:1787</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1029' target='_blank'>ENTREZ:1029</a> <a href='http://www.expasy.org/uniprot/P42771' target='_blank'>UNIPROT:P42771</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDKN2A' target='_blank'>GENECARDS:CDKN2A</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87039' target='_blank'>REACTOME:87039</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1029' target='_blank'>KEGG:1029</a> <a href='http://atlasgeneticsoncology.org//Genes/CDKN2aID146.html' target='_blank'>ATLASONC:CDKN2aID146</a> <a href='http://wikipedia.org/wiki/CDKN2A' target='_blank'>WIKI:CDKN2A</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;HIF1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/HIF1/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"s428\", \"c_s729\", \"c_s730\"]); } catch (e) {}; return false;' title=\"s428 c_s729 c_s730 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s428\", \"s260\", \"s233\"]) } catch (e) {}; return false;' title=\"s428 s260 s233 3 modifs\">p14ARF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:p14ARF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re271(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Competition between ARF and E2F1 to bind DP1.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>ARF relocalize DP1 from the cytoplasm to the nucleolus<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR>c_re268(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Cell cycle inhibition by sequestration of DP1 in the nucleolus.<BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_4.gif'/> REF=2 <span style='color:orange'>FUNC=4</span></p></span>,",
"c_s718": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s718\"]) } catch (e) {}; return false;' title=\"c_s718 1 modifs\">CDK2:&#8203;CyclinA*</a> <a href='javascript_required.html' onclick='try { show_blog(350); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s627\"]) } catch (e) {}; return false;' title=\"s627 1 modifs\">CDK2</a>|Thr160_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s628\"]) } catch (e) {}; return false;' title=\"s628 1 modifs\">CyclinA*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinA*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APC&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APC/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re258(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10548110' target='_blank'>PMID:10548110</a><BR>CYCLINB phosphorylates CDH1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11598127' target='_blank'>PMID:11598127</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>",
"c_s713": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s713\", \"c_s726\", \"c_s736\", \"c_s715\"]) } catch (e) {}; return false;' title=\"c_s713 c_s726 c_s736 c_s715 4 modifs\">DP1*:&#8203;E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3195); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re291:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR>c_re292:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR>c_re64(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s713\"]); } catch (e) {}; return false;' title=\"c_s713 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p></span>",
"c_s726": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s713\", \"c_s726\", \"c_s736\", \"c_s715\"]) } catch (e) {}; return false;' title=\"c_s713 c_s726 c_s736 c_s715 4 modifs\">DP1*:&#8203;E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3195); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace|Ser364_pho<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s726\"]); } catch (e) {}; return false;' title=\"c_s726 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s726\"]); } catch (e) {}; return false;' title=\"c_s726 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re621(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s726\"]); } catch (e) {}; return false;' title=\"c_s726 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>",
"c_s736": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s713\", \"c_s726\", \"c_s736\", \"c_s715\"]) } catch (e) {}; return false;' title=\"c_s713 c_s726 c_s736 c_s715 4 modifs\">DP1*:&#8203;E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3195); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace|Ser31_pho<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re622(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR>c_re139(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s736\"]); } catch (e) {}; return false;' title=\"c_s736 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/3_5.gif'/> REF=3 <span style='color:red'>FUNC=5</span></p></span>",
"c_s715": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s713\", \"c_s726\", \"c_s736\", \"c_s715\"]) } catch (e) {}; return false;' title=\"c_s713 c_s726 c_s736 c_s715 4 modifs\">DP1*:&#8203;E2F1</a> <a href='javascript_required.html' onclick='try { show_blog(3195); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s715\"]); } catch (e) {}; return false;' title=\"c_s715 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s715\"]); } catch (e) {}; return false;' title=\"c_s715 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re64(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s715\"]); } catch (e) {}; return false;' title=\"c_s715 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p></span>",
"c_s1497": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s1497\", \"c_s728\"]) } catch (e) {}; return false;' title=\"c_s1497 c_s728 2 modifs\">DP1*:&#8203;E2F1:&#8203;PCAF*</a> <a href='javascript_required.html' onclick='try { show_blog(3254); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace:<a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"s624\", \"s625\"]) } catch (e) {}; return false;' title=\"c_s623 s624 s625 3 modifs\">PCAF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:PCAF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re621(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>c_re622(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s1497\"]); } catch (e) {}; return false;' title=\"c_s1497 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>",
"c_s728": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s1497\", \"c_s728\"]) } catch (e) {}; return false;' title=\"c_s1497 c_s728 2 modifs\">DP1*:&#8203;E2F1:&#8203;PCAF*</a> <a href='javascript_required.html' onclick='try { show_blog(3254); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>|pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|pho|Lys_ace:<a href='javascript_required.html' onclick='try { show_markers([\"c_s623\", \"s624\", \"s625\"]) } catch (e) {}; return false;' title=\"c_s623 s624 s625 3 modifs\">PCAF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:PCAF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re87:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s728\"]); } catch (e) {}; return false;' title=\"c_s728 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_4.gif'/> REF=4 <span style='color:orange'>FUNC=4</span></p></span>",
"c_s712": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s712\", \"c_s717\"]) } catch (e) {}; return false;' title=\"c_s712 c_s717 2 modifs\">DP1*:&#8203;E2F1:&#8203;RB1</a> <a href='javascript_required.html' onclick='try { show_blog(1091); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"s115\", \"s49\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 s115 s49 4 modifs\">RB1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:RB1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re112(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s712\"]); } catch (e) {}; return false;' title=\"c_s712 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838516' target='_blank'>PMID:15838516</a><BR>The recruitment of SWI/SNF seems to be necessary for the recrutement de HDAC1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420729' target='_blank'>PMID:11420729</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15105433' target='_blank'>PMID:15105433</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>",
"c_s717": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s712\", \"c_s717\"]) } catch (e) {}; return false;' title=\"c_s712 c_s717 2 modifs\">DP1*:&#8203;E2F1:&#8203;RB1</a> <a href='javascript_required.html' onclick='try { show_blog(1091); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s9\", \"c_s7\", \"s115\", \"s49\"]) } catch (e) {}; return false;' title=\"c_s9 c_s7 s115 s49 4 modifs\">RB1</a>|pho|pho|pho<br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:RB1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re323(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>pRB phosphorylation<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>Brg1 phosphorylation <BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420722' target='_blank'>PMID:11420722</a><BR>Brg1 (in the SWI/SNF complex) and pRB are phosphorylated, simultaneously with the complex dissociation. Phosphorylation of pRB<BR>Phosphorylation of Brg1 (SWI/SNF complex)<BR>c_re291:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s717\"]); } catch (e) {}; return false;' title=\"c_s717 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/3_5.gif'/> REF=3 <span style='color:red'>FUNC=5</span></p></span>",
"c_s737": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s737\"]) } catch (e) {}; return false;' title=\"c_s737 1 modifs\">DP1*:&#8203;E2F1:&#8203;TOPBP1</a> <a href='javascript_required.html' onclick='try { show_blog(3196); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>|Lys_ace|Ser31_pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s616\", \"s617\"]) } catch (e) {}; return false;' title=\"c_s616 s617 2 modifs\">TOPBP1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:E2F1:TOPBP1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re139(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s737\"]); } catch (e) {}; return false;' title=\"c_s737 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>",
"c_s730": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s730\"]) } catch (e) {}; return false;' title=\"c_s730 1 modifs\">DP1*:&#8203;p14ARF*</a> <a href='javascript_required.html' onclick='try { show_blog(3879); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s345\", \"c_s338\", \"c_s240\", \"s57\", \"s124\", \"s122\", \"s64\", \"s119\", \"s117\", \"s59\", \"s61\", \"s51\", \"s234\"]) } catch (e) {}; return false;' title=\"c_s345 c_s338 c_s240 s57 s124 s122 s64 s119 s117 s59 s61 s51 s234 13 modifs\">DP1*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s428\", \"s260\", \"s233\"]) } catch (e) {}; return false;' title=\"s428 s260 s233 3 modifs\">p14ARF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:DP1*:p14ARF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re271(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Competition between ARF and E2F1 to bind DP1.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>ARF relocalize DP1 from the cytoplasm to the nucleolus<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR>c_re268(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s730\"]); } catch (e) {}; return false;' title=\"c_s730 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Cell cycle inhibition by sequestration of DP1 in the nucleolus.<BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_4.gif'/> REF=2 <span style='color:orange'>FUNC=4</span></p></span>",
"c_s729": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s729\"]) } catch (e) {}; return false;' title=\"c_s729 1 modifs\">E2F1:&#8203;p14ARF*</a> <a href='javascript_required.html' onclick='try { show_blog(1225); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\", \"c_s266\", \"c_s21\", \"c_s11\", \"s56\", \"s123\", \"s120\", \"s259\", \"s63\", \"s118\", \"s116\", \"s58\", \"s60\", \"s50\"]) } catch (e) {}; return false;' title=\"c_s629 c_s266 c_s21 c_s11 s56 s123 s120 s259 s63 s118 s116 s58 s60 s50 14 modifs\">E2F1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s428\", \"s260\", \"s233\"]) } catch (e) {}; return false;' title=\"s428 s260 s233 3 modifs\">p14ARF*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:E2F1:p14ARF*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re275(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>E2F1 sequestrated by ARF in the nucleolus.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR>c_re273(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s729\"]); } catch (e) {}; return false;' title=\"c_s729 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p></span>",
"c_re2": "<span class='bubble'>Reaction transport c_re2 <a href='javascript_required.html' onclick='try { show_blog(9672); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s338\"]) } catch (e) {}; return false;' title=\"c_s338 1 modifs\">DP1*@Cytosol</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s345\"]) } catch (e) {}; return false;' title=\"c_s345 1 modifs\">DP1*@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s11\"]) } catch (e) {}; return false;' title=\"c_s11 1 modifs\">E2F1@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re2\"]); } catch (e) {}; return false;' title=\"c_re2 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re2\"]); } catch (e) {}; return false;' title=\"c_re2 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8832394' target='_blank'>PMID:8832394</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re55": "<span class='bubble'>Reaction heterodimer_association c_re55 <a href='javascript_required.html' onclick='try { show_blog(9692); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s715\"]) } catch (e) {}; return false;' title=\"c_s715 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s623\"]) } catch (e) {}; return false;' title=\"c_s623 1 modifs\">PCAF*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s1497\"]) } catch (e) {}; return false;' title=\"c_s1497 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace:&#8203;PCAF*@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re55\"]); } catch (e) {}; return false;' title=\"c_re55 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re55\"]); } catch (e) {}; return false;' title=\"c_re55 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_4.gif'/> REF=0 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>",
"c_re60": "<span class='bubble'>Reaction heterodimer_association c_re60 <a href='javascript_required.html' onclick='try { show_blog(9694); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s11\"]) } catch (e) {}; return false;' title=\"c_s11 1 modifs\">E2F1@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s345\"]) } catch (e) {}; return false;' title=\"c_s345 1 modifs\">DP1*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s713\"]) } catch (e) {}; return false;' title=\"c_s713 1 modifs\">DP1*:&#8203;E2F1@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re60\"]); } catch (e) {}; return false;' title=\"c_re60 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re60\"]); } catch (e) {}; return false;' title=\"c_re60 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_5.gif'/> REF=0 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re64": "<span class='bubble'>Reaction state_transition c_re64 <a href='javascript_required.html' onclick='try { show_blog(9696); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s713\"]) } catch (e) {}; return false;' title=\"c_s713 1 modifs\">DP1*:&#8203;E2F1@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s715\"]) } catch (e) {}; return false;' title=\"c_s715 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s220\"]) } catch (e) {}; return false;' title=\"c_s220 1 modifs\">EP300@nucleus</a><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s221\"]) } catch (e) {}; return false;' title=\"c_s221 1 modifs\">CREBBP@nucleus</a><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s623\"]) } catch (e) {}; return false;' title=\"c_s623 1 modifs\">PCAF*@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re64\"]); } catch (e) {}; return false;' title=\"c_re64 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re64\"]); } catch (e) {}; return false;' title=\"c_re64 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_4.gif'/> REF=2 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>",
"c_re86": "<span class='bubble'>Reaction state_transition c_re86 <a href='javascript_required.html' onclick='try { show_blog(9700); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s1497\"]) } catch (e) {}; return false;' title=\"c_s1497 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace:&#8203;PCAF*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s728\"]) } catch (e) {}; return false;' title=\"c_s728 1 modifs\">DP1*|&#8203;pho:&#8203;E2F1|&#8203;pho|&#8203;Lys_ace:&#8203;PCAF*@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s718\"]) } catch (e) {}; return false;' title=\"c_s718 1 modifs\">CDK2|&#8203;Thr160_pho:&#8203;CyclinA*@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re86\"]); } catch (e) {}; return false;' title=\"c_re86 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_re86\"]); } catch (e) {}; return false;' title=\"c_re86 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re86\"]); } catch (e) {}; return false;' title=\"c_re86 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re86\"]); } catch (e) {}; return false;' title=\"c_re86 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re87": "<span class='bubble'>Reaction dissociation c_re87 <a href='javascript_required.html' onclick='try { show_blog(9702); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s728\"]) } catch (e) {}; return false;' title=\"c_s728 1 modifs\">DP1*|&#8203;pho:&#8203;E2F1|&#8203;pho|&#8203;Lys_ace:&#8203;PCAF*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s623\"]) } catch (e) {}; return false;' title=\"c_s623 1 modifs\">PCAF*@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s21\"]) } catch (e) {}; return false;' title=\"c_s21 1 modifs\">E2F1|&#8203;pho|&#8203;Lys_ace@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s240\"]) } catch (e) {}; return false;' title=\"c_s240 1 modifs\">DP1*|&#8203;pho@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re87\"]); } catch (e) {}; return false;' title=\"c_re87 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re87\"]); } catch (e) {}; return false;' title=\"c_re87 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>",
"c_re97": "<span class='bubble'>Reaction heterodimer_association c_re97 <a href='javascript_required.html' onclick='try { show_blog(9716); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s713\"]) } catch (e) {}; return false;' title=\"c_s713 1 modifs\">DP1*:&#8203;E2F1@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s7\"]) } catch (e) {}; return false;' title=\"c_s7 1 modifs\">RB1@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s712\"]) } catch (e) {}; return false;' title=\"c_s712 1 modifs\">DP1*:&#8203;E2F1:&#8203;RB1@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re97\"]); } catch (e) {}; return false;' title=\"c_re97 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re97\"]); } catch (e) {}; return false;' title=\"c_re97 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re97\"]); } catch (e) {}; return false;' title=\"c_re97 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_re97\"]); } catch (e) {}; return false;' title=\"c_re97 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_5.gif'/> REF=0 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re98": "<span class='bubble'>Reaction state_transition c_re98 <a href='javascript_required.html' onclick='try { show_blog(9718); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s21\"]) } catch (e) {}; return false;' title=\"c_s21 1 modifs\">E2F1|&#8203;pho|&#8203;Lys_ace@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s266\"]) } catch (e) {}; return false;' title=\"c_s266 1 modifs\">E2F1|&#8203;pho@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s19\"]) } catch (e) {}; return false;' title=\"c_s19 1 modifs\">HDAC1@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re98\"]); } catch (e) {}; return false;' title=\"c_re98 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re98\"]); } catch (e) {}; return false;' title=\"c_re98 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>E2F1 deacetylated by pRB/HDAC<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15126619' target='_blank'>PMID:15126619</a><BR>Deacetylation by HDAC1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re99": "<span class='bubble'>Reaction state_transition c_re99 <a href='javascript_required.html' onclick='try { show_blog(9720); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s266\"]) } catch (e) {}; return false;' title=\"c_s266 1 modifs\">E2F1|&#8203;pho@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s11\"]) } catch (e) {}; return false;' title=\"c_s11 1 modifs\">E2F1@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re99\"]); } catch (e) {}; return false;' title=\"c_re99 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re99\"]); } catch (e) {}; return false;' title=\"c_re99 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_0.gif'/> REF=0 <span style='color:black'>FUNC=0</span></p>          <BR>        \n</span>",
"c_re100": "<span class='bubble'>Reaction state_transition c_re100 <a href='javascript_required.html' onclick='try { show_blog(9722); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s240\"]) } catch (e) {}; return false;' title=\"c_s240 1 modifs\">DP1*|&#8203;pho@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s345\"]) } catch (e) {}; return false;' title=\"c_s345 1 modifs\">DP1*@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re100\"]); } catch (e) {}; return false;' title=\"c_re100 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re100\"]); } catch (e) {}; return false;' title=\"c_re100 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_0.gif'/> REF=0 <span style='color:black'>FUNC=0</span></p>          <BR>        \n</span>",
"c_re139": "<span class='bubble'>Reaction heterodimer_association c_re139 <a href='javascript_required.html' onclick='try { show_blog(9740); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s736\"]) } catch (e) {}; return false;' title=\"c_s736 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace|&#8203;Ser31_pho@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s616\"]) } catch (e) {}; return false;' title=\"c_s616 1 modifs\">TOPBP1@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s737\"]) } catch (e) {}; return false;' title=\"c_s737 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace|&#8203;Ser31_pho:&#8203;TOPBP1@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re139\"]); } catch (e) {}; return false;' title=\"c_re139 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re139\"]); } catch (e) {}; return false;' title=\"c_re139 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12697828' target='_blank'>PMID:12697828</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re271": "<span class='bubble'>Reaction heterodimer_association c_re271 <a href='javascript_required.html' onclick='try { show_blog(9910); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s338\"]) } catch (e) {}; return false;' title=\"c_s338 1 modifs\">DP1*@Cytosol</a> + <a href='javascript_required.html' onclick='try { show_markers([\"s428\"]) } catch (e) {}; return false;' title=\"s428 1 modifs\">p14ARF*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s730\"]) } catch (e) {}; return false;' title=\"c_s730 1 modifs\">DP1*:&#8203;p14ARF*@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re271\"]); } catch (e) {}; return false;' title=\"c_re271 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re271\"]); } catch (e) {}; return false;' title=\"c_re271 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re271\"]); } catch (e) {}; return false;' title=\"c_re271 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_re271\"]); } catch (e) {}; return false;' title=\"c_re271 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Competition between ARF and E2F1 to bind DP1.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>ARF relocalize DP1 from the cytoplasm to the nucleolus<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_4.gif'/> REF=2 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>",
"c_re275": "<span class='bubble'>Reaction heterodimer_association c_re275 <a href='javascript_required.html' onclick='try { show_blog(9914); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s11\"]) } catch (e) {}; return false;' title=\"c_s11 1 modifs\">E2F1@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"s428\"]) } catch (e) {}; return false;' title=\"s428 1 modifs\">p14ARF*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s729\"]) } catch (e) {}; return false;' title=\"c_s729 1 modifs\">E2F1:&#8203;p14ARF*@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re275\"]); } catch (e) {}; return false;' title=\"c_re275 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re275\"]); } catch (e) {}; return false;' title=\"c_re275 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re275\"]); } catch (e) {}; return false;' title=\"c_re275 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_re275\"]); } catch (e) {}; return false;' title=\"c_re275 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>E2F1 sequestrated by ARF in the nucleolus.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12446760' target='_blank'>PMID:12446760</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re276": "<span class='bubble'>Reaction state_transition c_re276 <a href='javascript_required.html' onclick='try { show_blog(9916); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s11\"]) } catch (e) {}; return false;' title=\"c_s11 1 modifs\">E2F1@nucleus</a> &rarr; degraded<BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"s428\"]) } catch (e) {}; return false;' title=\"s428 1 modifs\">p14ARF*@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re276\"]); } catch (e) {}; return false;' title=\"c_re276 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re276\"]); } catch (e) {}; return false;' title=\"c_re276 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re276\"]); } catch (e) {}; return false;' title=\"c_re276 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_re276\"]); } catch (e) {}; return false;' title=\"c_re276 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>p14ARF induce the degradation of E2F1, E2F2 and E2F3 via the proteasome<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11274364' target='_blank'>PMID:11274364</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re291": "<span class='bubble'>Reaction dissociation c_re291 <a href='javascript_required.html' onclick='try { show_blog(9938); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s717\"]) } catch (e) {}; return false;' title=\"c_s717 1 modifs\">DP1*:&#8203;E2F1:&#8203;RB1|&#8203;pho|&#8203;pho|&#8203;pho@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s9\"]) } catch (e) {}; return false;' title=\"c_s9 1 modifs\">RB1|&#8203;pho|&#8203;pho|&#8203;pho@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s713\"]) } catch (e) {}; return false;' title=\"c_s713 1 modifs\">DP1*:&#8203;E2F1@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re291\"]); } catch (e) {}; return false;' title=\"c_re291 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re291\"]); } catch (e) {}; return false;' title=\"c_re291 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re291\"]); } catch (e) {}; return false;' title=\"c_re291 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_re291\"]); } catch (e) {}; return false;' title=\"c_re291 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8380224' target='_blank'>PMID:8380224</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>; <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10773440' target='_blank'>PMID:10773440</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re292": "<span class='bubble'>Reaction state_transition c_re292 <a href='javascript_required.html' onclick='try { show_blog(9940); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s715\"]) } catch (e) {}; return false;' title=\"c_s715 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s713\"]) } catch (e) {}; return false;' title=\"c_s713 1 modifs\">DP1*:&#8203;E2F1@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s19\"]) } catch (e) {}; return false;' title=\"c_s19 1 modifs\">HDAC1@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re292\"]); } catch (e) {}; return false;' title=\"c_re292 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re292\"]); } catch (e) {}; return false;' title=\"c_re292 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10753885' target='_blank'>PMID:10753885</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re317": "<span class='bubble'>Reaction state_transition c_re317 <a href='javascript_required.html' onclick='try { show_blog(9954); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s11\"]) } catch (e) {}; return false;' title=\"c_s11 1 modifs\">E2F1@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s629\"]) } catch (e) {}; return false;' title=\"c_s629 1 modifs\">E2F1|&#8203;Ser403_pho@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s631\"]) } catch (e) {}; return false;' title=\"c_s631 1 modifs\">TFIIH*@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re317\"]); } catch (e) {}; return false;' title=\"c_re317 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re317\"]); } catch (e) {}; return false;' title=\"c_re317 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Phosphorylation at the Ser-403 in S phase by the TFIIH kinase targets E2F1 for its rapid ubiquitination and degradation through the ubiquitin-proteasome pathway.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation at Ser-403 and Thr-433 by the basal TF TFHII triggers E2F1 degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re318": "<span class='bubble'>Reaction state_transition c_re318 <a href='javascript_required.html' onclick='try { show_blog(9956); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s629\"]) } catch (e) {}; return false;' title=\"c_s629 1 modifs\">E2F1|&#8203;Ser403_pho@nucleus</a> &rarr; degraded<BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re318\"]); } catch (e) {}; return false;' title=\"c_re318 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re318\"]); } catch (e) {}; return false;' title=\"c_re318 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Degradation depends upon ubiquitination. E3: F-box protein p45Skp2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_0.gif'/> REF=0 <span style='color:black'>FUNC=0</span></p>          <BR>        \n</span>",
"c_re621": "<span class='bubble'>Reaction dissociation c_re621 <a href='javascript_required.html' onclick='try { show_blog(9982); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s1497\"]) } catch (e) {}; return false;' title=\"c_s1497 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace:&#8203;PCAF*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s623\"]) } catch (e) {}; return false;' title=\"c_s623 1 modifs\">PCAF*@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s726\"]) } catch (e) {}; return false;' title=\"c_s726 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace|&#8203;Ser364_pho@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s207\"]) } catch (e) {}; return false;' title=\"c_s207 1 modifs\">CHEK2@nucleus</a><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s377\"]) } catch (e) {}; return false;' title=\"c_s377 1 modifs\">CHEK2|&#8203;Thr68_pho@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re621\"]); } catch (e) {}; return false;' title=\"c_re621 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re621\"]); } catch (e) {}; return false;' title=\"c_re621 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re621\"]); } catch (e) {}; return false;' title=\"c_re621 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_re621\"]); } catch (e) {}; return false;' title=\"c_re621 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Protein stabilized by phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>",
"c_re622": "<span class='bubble'>Reaction dissociation c_re622 <a href='javascript_required.html' onclick='try { show_blog(9984); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s1497\"]) } catch (e) {}; return false;' title=\"c_s1497 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace:&#8203;PCAF*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s736\"]) } catch (e) {}; return false;' title=\"c_s736 1 modifs\">DP1*:&#8203;E2F1|&#8203;Lys_ace|&#8203;Ser31_pho@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s623\"]) } catch (e) {}; return false;' title=\"c_s623 1 modifs\">PCAF*@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s378\"]) } catch (e) {}; return false;' title=\"c_s378 1 modifs\">ATR@nucleus</a><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s390\"]) } catch (e) {}; return false;' title=\"c_s390 1 modifs\">ATM|&#8203;Ser 1981_pho@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re622\"]); } catch (e) {}; return false;' title=\"c_re622 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;E2F1&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/E2F1/index.html\", [\"c_re622\"]); } catch (e) {}; return false;' title=\"c_re622 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re622\"]); } catch (e) {}; return false;' title=\"c_re622 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_ENTRY&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APOPTOSIS_ENTRY/index.html\", [\"c_re622\"]); } catch (e) {}; return false;' title=\"c_re622 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Upon DNA damage, E2F is stabilized by ATM phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15838517' target='_blank'>PMID:15838517</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15140942' target='_blank'>PMID:15140942</a><BR>14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15494392' target='_blank'>PMID:15494392</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_4.gif'/> REF=2 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>"}