{"s1522": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s748\", \"c_s746\"]) } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\">CDK1</a> <a href='javascript_required.html' onclick='try { show_blog(654); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK1' target='_blank'>HUGO:CDK1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1722' target='_blank'>HGNC:1722</a> <a href='http://www.ncbi.nlm.nih.gov/gene/983' target='_blank'>ENTREZ:983</a> <a href='http://www.expasy.org/uniprot/P06493' target='_blank'>UNIPROT:P06493</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK1' target='_blank'>GENECARDS:CDK1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=86981' target='_blank'>REACTOME:86981</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:983' target='_blank'>KEGG:983</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK1.html' target='_blank'>ATLASONC:GC_CDK1</a> <a href='http://wikipedia.org/wiki/CDK1' target='_blank'>WIKI:CDK1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CASPASES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/CASPASES/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;MOMP_REGULATION&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/MOMP_REGULATION/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_CC_PHASE/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;M_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/M_CC_PHASE/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s1522\", \"s184\"]) } catch (e) {}; return false;' title=\"s1522 s184 2 modifs\">CDK1</a>|Thr161_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s186\", \"s185\"]) } catch (e) {}; return false;' title=\"s186 s185 2 modifs\">CyclinB*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK1:CyclinB*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APC&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APC/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CDC25&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CDC25/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P21CIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P21CIP/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WEE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/WEE/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re216(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re195(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>phosphorylation and inactivation of Wee1 kinase<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8515817' target='_blank'>PMID:8515817</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15070733' target='_blank'>PMID:15070733</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7681363' target='_blank'>PMID:7681363</a> (yeast)<BR>Cyclin B phosphorylates Myt1 in vitro<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9268380' target='_blank'>PMID:9268380</a><BR>c_re255:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840442' target='_blank'>PMID:15840442</a><BR>c_re258(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10548110' target='_blank'>PMID:10548110</a><BR>CYCLINB phosphorylates CDH1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11598127' target='_blank'>PMID:11598127</a><BR>c_re328:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15798220' target='_blank'>PMID:15798220</a><BR>c_re330(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Inactivated by phosphorylation by CHEK1 and CHEK2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12478465' target='_blank'>PMID:12478465</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a><BR>Phosphorylation by CYCLINB-CDC2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11313986' target='_blank'>PMID:11313986</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>,",
"s184": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s748\", \"c_s746\"]) } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\">CDK1</a> <a href='javascript_required.html' onclick='try { show_blog(654); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK1' target='_blank'>HUGO:CDK1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1722' target='_blank'>HGNC:1722</a> <a href='http://www.ncbi.nlm.nih.gov/gene/983' target='_blank'>ENTREZ:983</a> <a href='http://www.expasy.org/uniprot/P06493' target='_blank'>UNIPROT:P06493</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK1' target='_blank'>GENECARDS:CDK1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=86981' target='_blank'>REACTOME:86981</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:983' target='_blank'>KEGG:983</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK1.html' target='_blank'>ATLASONC:GC_CDK1</a> <a href='http://wikipedia.org/wiki/CDK1' target='_blank'>WIKI:CDK1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CASPASES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/CASPASES/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;MOMP_REGULATION&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/MOMP_REGULATION/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_CC_PHASE/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;M_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/M_CC_PHASE/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G2_M_CHECKPOINT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G2_M_CHECKPOINT/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s1522\", \"s184\"]) } catch (e) {}; return false;' title=\"s1522 s184 2 modifs\">CDK1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s186\", \"s185\"]) } catch (e) {}; return false;' title=\"s186 s185 2 modifs\">CyclinB*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK1:CyclinB*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re219(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>dephosphorylation of CDC2 induce its activation<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8348613' target='_blank'>PMID:8348613</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a><BR>c_re230:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11063929' target='_blank'>PMID:11063929</a><BR>c_re233(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Dephosphorylation of CDC2 induces its activation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8348613' target='_blank'>PMID:8348613</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=1828290' target='_blank'>PMID:1828290</a><BR>c_re216(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re232(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a><BR>WEE1 allows CDC2 to stay in an inactive state after its translocation in late G2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8348613' target='_blank'>PMID:8348613</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9001210' target='_blank'>PMID:9001210</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15037762' target='_blank'>PMID:15037762</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>,",
"s215": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]) } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\">CDK2</a> <a href='javascript_required.html' onclick='try { show_blog(3919); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK2' target='_blank'>HUGO:CDK2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1771' target='_blank'>HGNC:1771</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1017' target='_blank'>ENTREZ:1017</a> <a href='http://www.expasy.org/uniprot/P24941' target='_blank'>UNIPROT:P24941</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK2' target='_blank'>GENECARDS:CDK2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87018' target='_blank'>REACTOME:87018</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1017' target='_blank'>KEGG:1017</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK2.html' target='_blank'>ATLASONC:GC_CDK2</a> <a href='http://wikipedia.org/wiki/CDK2' target='_blank'>WIKI:CDK2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>|Thr160_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s214\", \"s213\"]) } catch (e) {}; return false;' title=\"s214 s213 2 modifs\">CyclinE*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinE*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re147(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR>c_re169(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of p27 by cyclin E/CDK2 at Thr-187 results in targeting p27 for its degradation by proteolysis<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re248(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Cyclin E phosphorylation by CDK2 at Thr-380.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8861947' target='_blank'>PMID:8861947</a><BR>Autophosphorylation of the complex CYCLINE/CDK2 at Thr-380 and Thr-62. Phosphorylation at Thr-380 also by GSK-3B. Two other sites of regulation: Ser-372 et Ser-384<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16131838' target='_blank'>PMID:16131838</a><BR>c_re289:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re323(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>pRB phosphorylation<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>Brg1 phosphorylation <BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420722' target='_blank'>PMID:11420722</a><BR>Brg1 (in the SWI/SNF complex) and pRB are phosphorylated, simultaneously with the complex dissociation. Phosphorylation of pRB<BR>Phosphorylation of Brg1 (SWI/SNF complex)<BR>c_re327:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12836612' target='_blank'>PMID:12836612</a><BR>c_re1275:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR>c_re1276(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>p130 binds to and inhibits CYCLINE-CDK2, independantly of its phosphorylation state.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>,",
"s212": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]) } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\">CDK2</a> <a href='javascript_required.html' onclick='try { show_blog(3919); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK2' target='_blank'>HUGO:CDK2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1771' target='_blank'>HGNC:1771</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1017' target='_blank'>ENTREZ:1017</a> <a href='http://www.expasy.org/uniprot/P24941' target='_blank'>UNIPROT:P24941</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK2' target='_blank'>GENECARDS:CDK2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87018' target='_blank'>REACTOME:87018</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1017' target='_blank'>KEGG:1017</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK2.html' target='_blank'>ATLASONC:GC_CDK2</a> <a href='http://wikipedia.org/wiki/CDK2' target='_blank'>WIKI:CDK2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s214\", \"s213\"]) } catch (e) {}; return false;' title=\"s214 s213 2 modifs\">CyclinE*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinE*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re306:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re147(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR>c_re170(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Complex CYCLINE-CDK2 inhibited by its interaction with CKI.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p></span>,",
"s126": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]) } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\">CDK2</a> <a href='javascript_required.html' onclick='try { show_blog(3919); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK2' target='_blank'>HUGO:CDK2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1771' target='_blank'>HGNC:1771</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1017' target='_blank'>ENTREZ:1017</a> <a href='http://www.expasy.org/uniprot/P24941' target='_blank'>UNIPROT:P24941</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK2' target='_blank'>GENECARDS:CDK2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87018' target='_blank'>REACTOME:87018</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1017' target='_blank'>KEGG:1017</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK2.html' target='_blank'>ATLASONC:GC_CDK2</a> <a href='http://wikipedia.org/wiki/CDK2' target='_blank'>WIKI:CDK2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s127\", \"s628\"]) } catch (e) {}; return false;' title=\"s127 s628 2 modifs\">CyclinA*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinA*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P21CIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P21CIP/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re171(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Complex CYCLINA-CDK2 inhibited by its interaction with CKI<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR>c_re326:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12836612' target='_blank'>PMID:12836612</a><BR>c_re1272:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15798220' target='_blank'>PMID:15798220</a><BR>c_re1273:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR>c_re1274(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>p130 binds to and inhibits CYCLINA-CDK2, independantly of its phosphorylation state.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p></span>,",
"s627": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]) } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\">CDK2</a> <a href='javascript_required.html' onclick='try { show_blog(3919); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK2' target='_blank'>HUGO:CDK2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1771' target='_blank'>HGNC:1771</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1017' target='_blank'>ENTREZ:1017</a> <a href='http://www.expasy.org/uniprot/P24941' target='_blank'>UNIPROT:P24941</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK2' target='_blank'>GENECARDS:CDK2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87018' target='_blank'>REACTOME:87018</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1017' target='_blank'>KEGG:1017</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK2.html' target='_blank'>ATLASONC:GC_CDK2</a> <a href='http://wikipedia.org/wiki/CDK2' target='_blank'>WIKI:CDK2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s723\", \"c_s721\", \"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 c_s719 c_s718 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>|Thr160_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s127\", \"s628\"]) } catch (e) {}; return false;' title=\"s127 s628 2 modifs\">CyclinA*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinA*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APC&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APC/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re258(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10548110' target='_blank'>PMID:10548110</a><BR>CYCLINB phosphorylates CDH1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11598127' target='_blank'>PMID:11598127</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>,",
"s256": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s725\"]) } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\">CDK4</a> <a href='javascript_required.html' onclick='try { show_blog(4010); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 4<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK4' target='_blank'>HUGO:CDK4</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1773' target='_blank'>HGNC:1773</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1019' target='_blank'>ENTREZ:1019</a> <a href='http://www.expasy.org/uniprot/P11802' target='_blank'>UNIPROT:P11802</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK4' target='_blank'>GENECARDS:CDK4</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68329' target='_blank'>REACTOME:68329</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1019' target='_blank'>KEGG:1019</a> <a href='http://atlasgeneticsoncology.org//Genes/CDK4ID238ch12q14.html' target='_blank'>ATLASONC:CDK4ID238ch12q14</a> <a href='http://wikipedia.org/wiki/CDK4' target='_blank'>WIKI:CDK4</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s751\", \"c_s725\"]); } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s751\", \"c_s725\"]); } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s725\"]); } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLIND&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLIND/index.html\", [\"c_s751\", \"c_s725\"]); } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>The native protein is first correctly folded by HSP90 and CDC37 before being able to bind to the D-type cyclins.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10498883' target='_blank'>PMID:10498883</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s256\", \"s253\"]) } catch (e) {}; return false;' title=\"s256 s253 2 modifs\">CDK4</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK4:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re180(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>The complex CYCLIND-CDK stability increases when bound to a Cip/Kip family member.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"s253": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s725\"]) } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\">CDK4</a> <a href='javascript_required.html' onclick='try { show_blog(4010); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 4<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK4' target='_blank'>HUGO:CDK4</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1773' target='_blank'>HGNC:1773</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1019' target='_blank'>ENTREZ:1019</a> <a href='http://www.expasy.org/uniprot/P11802' target='_blank'>UNIPROT:P11802</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK4' target='_blank'>GENECARDS:CDK4</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68329' target='_blank'>REACTOME:68329</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1019' target='_blank'>KEGG:1019</a> <a href='http://atlasgeneticsoncology.org//Genes/CDK4ID238ch12q14.html' target='_blank'>ATLASONC:CDK4ID238ch12q14</a> <a href='http://wikipedia.org/wiki/CDK4' target='_blank'>WIKI:CDK4</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s751\", \"c_s725\"]); } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s751\", \"c_s725\"]); } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s725\"]); } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLIND&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLIND/index.html\", [\"c_s751\", \"c_s725\"]); } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>The native protein is first correctly folded by HSP90 and CDC37 before being able to bind to the D-type cyclins.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10498883' target='_blank'>PMID:10498883</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s256\", \"s253\"]) } catch (e) {}; return false;' title=\"s256 s253 2 modifs\">CDK4</a>|Thr172_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK4:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re92:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re298(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of pRB<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR>dissociation of HDAC1 (during the G1 to S transition)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10778858' target='_blank'>PMID:10778858</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11520855' target='_blank'>PMID:11520855</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7736585' target='_blank'>PMID:7736585</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9425340' target='_blank'>PMID:9425340</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9190208' target='_blank'>PMID:9190208</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>,",
"s247": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s750\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\">CDK6</a> <a href='javascript_required.html' onclick='try { show_blog(4005); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 6<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK6' target='_blank'>HUGO:CDK6</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1777' target='_blank'>HGNC:1777</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1021' target='_blank'>ENTREZ:1021</a> <a href='http://www.expasy.org/uniprot/Q00534' target='_blank'>UNIPROT:Q00534</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK6' target='_blank'>GENECARDS:CDK6</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68335' target='_blank'>REACTOME:68335</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1021' target='_blank'>KEGG:1021</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK6.html' target='_blank'>ATLASONC:GC_CDK6</a> <a href='http://wikipedia.org/wiki/CDK6' target='_blank'>WIKI:CDK6</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLIND&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLIND/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Like CDK4, CDK6 has first to be folded by HSP90 and CDC37 before being able to bind D-type cyclins.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10498883' target='_blank'>PMID:10498883</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s247\", \"s250\"]) } catch (e) {}; return false;' title=\"s247 s250 2 modifs\">CDK6</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK6:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re181(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>The complex CYCLIND-CDK stability increases when bound to a Cip/Kip family member.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p></span>,",
"s250": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s750\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\">CDK6</a> <a href='javascript_required.html' onclick='try { show_blog(4005); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 6<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK6' target='_blank'>HUGO:CDK6</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1777' target='_blank'>HGNC:1777</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1021' target='_blank'>ENTREZ:1021</a> <a href='http://www.expasy.org/uniprot/Q00534' target='_blank'>UNIPROT:Q00534</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK6' target='_blank'>GENECARDS:CDK6</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68335' target='_blank'>REACTOME:68335</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1021' target='_blank'>KEGG:1021</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK6.html' target='_blank'>ATLASONC:GC_CDK6</a> <a href='http://wikipedia.org/wiki/CDK6' target='_blank'>WIKI:CDK6</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLIND&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLIND/index.html\", [\"c_s750\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Like CDK4, CDK6 has first to be folded by HSP90 and CDC37 before being able to bind D-type cyclins.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10498883' target='_blank'>PMID:10498883</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s247\", \"s250\"]) } catch (e) {}; return false;' title=\"s247 s250 2 modifs\">CDK6</a>|Thr_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK6:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re92:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re298(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of pRB<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR>dissociation of HDAC1 (during the G1 to S transition)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10778858' target='_blank'>PMID:10778858</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11520855' target='_blank'>PMID:11520855</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7736585' target='_blank'>PMID:7736585</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9425340' target='_blank'>PMID:9425340</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9190208' target='_blank'>PMID:9190208</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>,",
"c_s402": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"c_s752\", \"c_s749\"]) } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\">CDK7</a> <a href='javascript_required.html' onclick='try { show_blog(1085); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 7<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK7' target='_blank'>HUGO:CDK7</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1778' target='_blank'>HGNC:1778</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1022' target='_blank'>ENTREZ:1022</a> <a href='http://www.expasy.org/uniprot/P50613' target='_blank'>UNIPROT:P50613</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK7' target='_blank'>GENECARDS:CDK7</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87028' target='_blank'>REACTOME:87028</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1022' target='_blank'>KEGG:1022</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK7.html' target='_blank'>ATLASONC:GC_CDK7</a> <a href='http://wikipedia.org/wiki/CDK7' target='_blank'>WIKI:CDK7</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;NER&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/NER/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>CDK7<br>in nucleus<br></span>",
"s203": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"c_s752\", \"c_s749\"]) } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\">CDK7</a> <a href='javascript_required.html' onclick='try { show_blog(1085); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 7<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK7' target='_blank'>HUGO:CDK7</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1778' target='_blank'>HGNC:1778</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1022' target='_blank'>ENTREZ:1022</a> <a href='http://www.expasy.org/uniprot/P50613' target='_blank'>UNIPROT:P50613</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK7' target='_blank'>GENECARDS:CDK7</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87028' target='_blank'>REACTOME:87028</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1022' target='_blank'>KEGG:1022</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK7.html' target='_blank'>ATLASONC:GC_CDK7</a> <a href='http://wikipedia.org/wiki/CDK7' target='_blank'>WIKI:CDK7</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;NER&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/NER/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"s203\", \"s209\"]) } catch (e) {}; return false;' title=\"c_s402 s203 s209 3 modifs\">CDK7</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"s204\", \"s210\"]) } catch (e) {}; return false;' title=\"c_s401 s204 s210 3 modifs\">CyclinH*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"s205\", \"s211\"]) } catch (e) {}; return false;' title=\"c_s403 s205 s211 3 modifs\">MNAT1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK7:CyclinH*:MNAT1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re245(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK7 activation by its phosphorylation at Thr-170<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11355576' target='_blank'>PMID:11355576</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_5.gif'/> REF=0 <span style='color:red'>FUNC=5</span></p></span>,",
"s209": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"c_s752\", \"c_s749\"]) } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\">CDK7</a> <a href='javascript_required.html' onclick='try { show_blog(1085); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase 7<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDK7' target='_blank'>HUGO:CDK7</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1778' target='_blank'>HGNC:1778</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1022' target='_blank'>ENTREZ:1022</a> <a href='http://www.expasy.org/uniprot/P50613' target='_blank'>UNIPROT:P50613</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDK7' target='_blank'>GENECARDS:CDK7</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87028' target='_blank'>REACTOME:87028</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1022' target='_blank'>KEGG:1022</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CDK7.html' target='_blank'>ATLASONC:GC_CDK7</a> <a href='http://wikipedia.org/wiki/CDK7' target='_blank'>WIKI:CDK7</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;NER&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/NER/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s402\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s402 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"s203\", \"s209\"]) } catch (e) {}; return false;' title=\"c_s402 s203 s209 3 modifs\">CDK7</a>|Thr170_pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"s204\", \"s210\"]) } catch (e) {}; return false;' title=\"c_s401 s204 s210 3 modifs\">CyclinH*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"s205\", \"s211\"]) } catch (e) {}; return false;' title=\"c_s403 s205 s211 3 modifs\">MNAT1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK7:CyclinH*:MNAT1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re245(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK7 activation by its phosphorylation at Thr-170<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11355576' target='_blank'>PMID:11355576</a><BR>c_re147(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re216(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p></span>,",
"s127": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s719\", \"c_s718\"]) } catch (e) {}; return false;' title=\"c_s719 c_s718 2 modifs\">CyclinA*</a> <a href='javascript_required.html' onclick='try { show_blog(1818); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin A1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNA1' target='_blank'>HUGO:CCNA1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1577' target='_blank'>HGNC:1577</a> <a href='http://www.ncbi.nlm.nih.gov/gene/8900' target='_blank'>ENTREZ:8900</a> <a href='http://www.expasy.org/uniprot/P78396' target='_blank'>UNIPROT:P78396</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNA1' target='_blank'>GENECARDS:CCNA1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87205' target='_blank'>REACTOME:87205</a> <a href='http://atlasgeneticsoncology.org//Genes/CCNA1ID949ch13q13.html' target='_blank'>ATLASONC:CCNA1ID949ch13q13</a> <a href='http://wikipedia.org/wiki/CCNA1' target='_blank'>WIKI:CCNA1</a> <BR>Cyclin A2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNA2' target='_blank'>HUGO:CCNA2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1578' target='_blank'>HGNC:1578</a> <a href='http://www.ncbi.nlm.nih.gov/gene/890' target='_blank'>ENTREZ:890</a> <a href='http://www.expasy.org/uniprot/P20248' target='_blank'>UNIPROT:P20248</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNA2' target='_blank'>GENECARDS:CCNA2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87208' target='_blank'>REACTOME:87208</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:890' target='_blank'>KEGG:890</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNA2.html' target='_blank'>ATLASONC:GC_CCNA2</a> <a href='http://wikipedia.org/wiki/CCNA2' target='_blank'>WIKI:CCNA2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s719 c_s718 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s719 c_s718 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>degraded by the ubiquitin-proteasome system.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9736735' target='_blank'>PMID:9736735</a><BR>Degraded by APC/Cyclosome<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16123593' target='_blank'>PMID:16123593</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15558010' target='_blank'>PMID:15558010</a><BR>Ubiquitination at Lys-37, Lys-54 et Lys-68<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16123593' target='_blank'>PMID:16123593</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s127\", \"s628\"]) } catch (e) {}; return false;' title=\"s127 s628 2 modifs\">CyclinA*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinA*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P21CIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P21CIP/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re171(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Complex CYCLINA-CDK2 inhibited by its interaction with CKI<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR>c_re326:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12836612' target='_blank'>PMID:12836612</a><BR>c_re1272:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15798220' target='_blank'>PMID:15798220</a><BR>c_re1273:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR>c_re1274(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>p130 binds to and inhibits CYCLINA-CDK2, independantly of its phosphorylation state.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p></span>,",
"s628": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s719\", \"c_s718\"]) } catch (e) {}; return false;' title=\"c_s719 c_s718 2 modifs\">CyclinA*</a> <a href='javascript_required.html' onclick='try { show_blog(1818); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin A1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNA1' target='_blank'>HUGO:CCNA1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1577' target='_blank'>HGNC:1577</a> <a href='http://www.ncbi.nlm.nih.gov/gene/8900' target='_blank'>ENTREZ:8900</a> <a href='http://www.expasy.org/uniprot/P78396' target='_blank'>UNIPROT:P78396</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNA1' target='_blank'>GENECARDS:CCNA1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87205' target='_blank'>REACTOME:87205</a> <a href='http://atlasgeneticsoncology.org//Genes/CCNA1ID949ch13q13.html' target='_blank'>ATLASONC:CCNA1ID949ch13q13</a> <a href='http://wikipedia.org/wiki/CCNA1' target='_blank'>WIKI:CCNA1</a> <BR>Cyclin A2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNA2' target='_blank'>HUGO:CCNA2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1578' target='_blank'>HGNC:1578</a> <a href='http://www.ncbi.nlm.nih.gov/gene/890' target='_blank'>ENTREZ:890</a> <a href='http://www.expasy.org/uniprot/P20248' target='_blank'>UNIPROT:P20248</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNA2' target='_blank'>GENECARDS:CCNA2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87208' target='_blank'>REACTOME:87208</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:890' target='_blank'>KEGG:890</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNA2.html' target='_blank'>ATLASONC:GC_CCNA2</a> <a href='http://wikipedia.org/wiki/CCNA2' target='_blank'>WIKI:CCNA2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s719 c_s718 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s719\", \"c_s718\"]); } catch (e) {}; return false;' title=\"c_s719 c_s718 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>degraded by the ubiquitin-proteasome system.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9736735' target='_blank'>PMID:9736735</a><BR>Degraded by APC/Cyclosome<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16123593' target='_blank'>PMID:16123593</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15558010' target='_blank'>PMID:15558010</a><BR>Ubiquitination at Lys-37, Lys-54 et Lys-68<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16123593' target='_blank'>PMID:16123593</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>|Thr160_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s127\", \"s628\"]) } catch (e) {}; return false;' title=\"s127 s628 2 modifs\">CyclinA*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinA*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APC&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APC/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re258(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10548110' target='_blank'>PMID:10548110</a><BR>CYCLINB phosphorylates CDH1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11598127' target='_blank'>PMID:11598127</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>,",
"s186": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s748\", \"c_s746\"]) } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\">CyclinB*</a> <a href='javascript_required.html' onclick='try { show_blog(1820); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin B1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNB1' target='_blank'>HUGO:CCNB1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1579' target='_blank'>HGNC:1579</a> <a href='http://www.ncbi.nlm.nih.gov/gene/891' target='_blank'>ENTREZ:891</a> <a href='http://www.expasy.org/uniprot/P14635' target='_blank'>UNIPROT:P14635</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNB1' target='_blank'>GENECARDS:CCNB1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87210' target='_blank'>REACTOME:87210</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:891' target='_blank'>KEGG:891</a> <a href='http://atlasgeneticsoncology.org//Genes/CCNB1ID951ch5q13.html' target='_blank'>ATLASONC:CCNB1ID951ch5q13</a> <a href='http://wikipedia.org/wiki/CCNB1' target='_blank'>WIKI:CCNB1</a> <BR>Cyclin B2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNB2' target='_blank'>HUGO:CCNB2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1580' target='_blank'>HGNC:1580</a> <a href='http://www.ncbi.nlm.nih.gov/gene/9133' target='_blank'>ENTREZ:9133</a> <a href='http://www.expasy.org/uniprot/O95067' target='_blank'>UNIPROT:O95067</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNB2' target='_blank'>GENECARDS:CCNB2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87214' target='_blank'>REACTOME:87214</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:9133' target='_blank'>KEGG:9133</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNB2.html' target='_blank'>ATLASONC:GC_CCNB2</a> <a href='http://wikipedia.org/wiki/CCNB2' target='_blank'>WIKI:CCNB2</a> <BR>Cyclin B3<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNB3' target='_blank'>HUGO:CCNB3</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=18709' target='_blank'>HGNC:18709</a> <a href='http://www.ncbi.nlm.nih.gov/gene/85417' target='_blank'>ENTREZ:85417</a> <a href='http://www.expasy.org/uniprot/Q8WWL7' target='_blank'>UNIPROT:Q8WWL7</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNB3' target='_blank'>GENECARDS:CCNB3</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNB3.html' target='_blank'>ATLASONC:GC_CCNB3</a> <a href='http://wikipedia.org/wiki/CCNB3' target='_blank'>WIKI:CCNB3</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;HEDGEHOG&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/HEDGEHOG/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Degraded by the system of ubiquitin-proteasome Anaphase Promoting Complex / Cyclosome: APC/C(CDC20)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16123593' target='_blank'>PMID:16123593</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s1522\", \"s184\"]) } catch (e) {}; return false;' title=\"s1522 s184 2 modifs\">CDK1</a>|Thr161_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s186\", \"s185\"]) } catch (e) {}; return false;' title=\"s186 s185 2 modifs\">CyclinB*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK1:CyclinB*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APC&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APC/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CDC25&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CDC25/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P21CIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P21CIP/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WEE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/WEE/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re216(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re195(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>phosphorylation and inactivation of Wee1 kinase<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8515817' target='_blank'>PMID:8515817</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15070733' target='_blank'>PMID:15070733</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7681363' target='_blank'>PMID:7681363</a> (yeast)<BR>Cyclin B phosphorylates Myt1 in vitro<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9268380' target='_blank'>PMID:9268380</a><BR>c_re255:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840442' target='_blank'>PMID:15840442</a><BR>c_re258(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10548110' target='_blank'>PMID:10548110</a><BR>CYCLINB phosphorylates CDH1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11598127' target='_blank'>PMID:11598127</a><BR>c_re328:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15798220' target='_blank'>PMID:15798220</a><BR>c_re330(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Inactivated by phosphorylation by CHEK1 and CHEK2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12478465' target='_blank'>PMID:12478465</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a><BR>Phosphorylation by CYCLINB-CDC2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11313986' target='_blank'>PMID:11313986</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>,",
"s185": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s748\", \"c_s746\"]) } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\">CyclinB*</a> <a href='javascript_required.html' onclick='try { show_blog(1820); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin B1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNB1' target='_blank'>HUGO:CCNB1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1579' target='_blank'>HGNC:1579</a> <a href='http://www.ncbi.nlm.nih.gov/gene/891' target='_blank'>ENTREZ:891</a> <a href='http://www.expasy.org/uniprot/P14635' target='_blank'>UNIPROT:P14635</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNB1' target='_blank'>GENECARDS:CCNB1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87210' target='_blank'>REACTOME:87210</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:891' target='_blank'>KEGG:891</a> <a href='http://atlasgeneticsoncology.org//Genes/CCNB1ID951ch5q13.html' target='_blank'>ATLASONC:CCNB1ID951ch5q13</a> <a href='http://wikipedia.org/wiki/CCNB1' target='_blank'>WIKI:CCNB1</a> <BR>Cyclin B2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNB2' target='_blank'>HUGO:CCNB2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1580' target='_blank'>HGNC:1580</a> <a href='http://www.ncbi.nlm.nih.gov/gene/9133' target='_blank'>ENTREZ:9133</a> <a href='http://www.expasy.org/uniprot/O95067' target='_blank'>UNIPROT:O95067</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNB2' target='_blank'>GENECARDS:CCNB2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87214' target='_blank'>REACTOME:87214</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:9133' target='_blank'>KEGG:9133</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNB2.html' target='_blank'>ATLASONC:GC_CCNB2</a> <a href='http://wikipedia.org/wiki/CCNB2' target='_blank'>WIKI:CCNB2</a> <BR>Cyclin B3<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNB3' target='_blank'>HUGO:CCNB3</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=18709' target='_blank'>HGNC:18709</a> <a href='http://www.ncbi.nlm.nih.gov/gene/85417' target='_blank'>ENTREZ:85417</a> <a href='http://www.expasy.org/uniprot/Q8WWL7' target='_blank'>UNIPROT:Q8WWL7</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNB3' target='_blank'>GENECARDS:CCNB3</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNB3.html' target='_blank'>ATLASONC:GC_CCNB3</a> <a href='http://wikipedia.org/wiki/CCNB3' target='_blank'>WIKI:CCNB3</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;HEDGEHOG&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/HEDGEHOG/index.html\", [\"c_s748\", \"c_s746\"]); } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>Degraded by the system of ubiquitin-proteasome Anaphase Promoting Complex / Cyclosome: APC/C(CDC20)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16123593' target='_blank'>PMID:16123593</a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s1522\", \"s184\"]) } catch (e) {}; return false;' title=\"s1522 s184 2 modifs\">CDK1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s186\", \"s185\"]) } catch (e) {}; return false;' title=\"s186 s185 2 modifs\">CyclinB*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK1:CyclinB*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re219(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>dephosphorylation of CDC2 induce its activation<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8348613' target='_blank'>PMID:8348613</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a><BR>c_re230:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11063929' target='_blank'>PMID:11063929</a><BR>c_re233(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Dephosphorylation of CDC2 induces its activation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8348613' target='_blank'>PMID:8348613</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=1828290' target='_blank'>PMID:1828290</a><BR>c_re216(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re232(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a><BR>WEE1 allows CDC2 to stay in an inactive state after its translocation in late G2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8348613' target='_blank'>PMID:8348613</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9001210' target='_blank'>PMID:9001210</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15037762' target='_blank'>PMID:15037762</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>,",
"s255": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\">CyclinD*</a> <a href='javascript_required.html' onclick='try { show_blog(1764); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin D1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND1' target='_blank'>HUGO:CCND1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1582' target='_blank'>HGNC:1582</a> <a href='http://www.ncbi.nlm.nih.gov/gene/595' target='_blank'>ENTREZ:595</a> <a href='http://www.expasy.org/uniprot/P24385' target='_blank'>UNIPROT:P24385</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND1' target='_blank'>GENECARDS:CCND1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68327' target='_blank'>REACTOME:68327</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:595' target='_blank'>KEGG:595</a> <a href='http://atlasgeneticsoncology.org//Genes/BCL1.html' target='_blank'>ATLASONC:BCL1</a> <a href='http://wikipedia.org/wiki/CCND1' target='_blank'>WIKI:CCND1</a> <BR>Cyclin D2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND2' target='_blank'>HUGO:CCND2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1583' target='_blank'>HGNC:1583</a> <a href='http://www.ncbi.nlm.nih.gov/gene/894' target='_blank'>ENTREZ:894</a> <a href='http://www.expasy.org/uniprot/P30279' target='_blank'>UNIPROT:P30279</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND2' target='_blank'>GENECARDS:CCND2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68339' target='_blank'>REACTOME:68339</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:894' target='_blank'>KEGG:894</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCND2.html' target='_blank'>ATLASONC:GC_CCND2</a> <a href='http://wikipedia.org/wiki/CCND2' target='_blank'>WIKI:CCND2</a> <BR>Cyclin D3<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND3' target='_blank'>HUGO:CCND3</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1585' target='_blank'>HGNC:1585</a> <a href='http://www.ncbi.nlm.nih.gov/gene/896' target='_blank'>ENTREZ:896</a> <a href='http://www.expasy.org/uniprot/P30281' target='_blank'>UNIPROT:P30281</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND3' target='_blank'>GENECARDS:CCND3</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68332' target='_blank'>REACTOME:68332</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCND3.html' target='_blank'>ATLASONC:GC_CCND3</a> <a href='http://wikipedia.org/wiki/CCND3' target='_blank'>WIKI:CCND3</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLIND&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLIND/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s256\", \"s253\"]) } catch (e) {}; return false;' title=\"s256 s253 2 modifs\">CDK4</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK4:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re180(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>The complex CYCLIND-CDK stability increases when bound to a Cip/Kip family member.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"s246": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\">CyclinD*</a> <a href='javascript_required.html' onclick='try { show_blog(1764); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin D1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND1' target='_blank'>HUGO:CCND1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1582' target='_blank'>HGNC:1582</a> <a href='http://www.ncbi.nlm.nih.gov/gene/595' target='_blank'>ENTREZ:595</a> <a href='http://www.expasy.org/uniprot/P24385' target='_blank'>UNIPROT:P24385</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND1' target='_blank'>GENECARDS:CCND1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68327' target='_blank'>REACTOME:68327</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:595' target='_blank'>KEGG:595</a> <a href='http://atlasgeneticsoncology.org//Genes/BCL1.html' target='_blank'>ATLASONC:BCL1</a> <a href='http://wikipedia.org/wiki/CCND1' target='_blank'>WIKI:CCND1</a> <BR>Cyclin D2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND2' target='_blank'>HUGO:CCND2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1583' target='_blank'>HGNC:1583</a> <a href='http://www.ncbi.nlm.nih.gov/gene/894' target='_blank'>ENTREZ:894</a> <a href='http://www.expasy.org/uniprot/P30279' target='_blank'>UNIPROT:P30279</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND2' target='_blank'>GENECARDS:CCND2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68339' target='_blank'>REACTOME:68339</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:894' target='_blank'>KEGG:894</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCND2.html' target='_blank'>ATLASONC:GC_CCND2</a> <a href='http://wikipedia.org/wiki/CCND2' target='_blank'>WIKI:CCND2</a> <BR>Cyclin D3<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND3' target='_blank'>HUGO:CCND3</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1585' target='_blank'>HGNC:1585</a> <a href='http://www.ncbi.nlm.nih.gov/gene/896' target='_blank'>ENTREZ:896</a> <a href='http://www.expasy.org/uniprot/P30281' target='_blank'>UNIPROT:P30281</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND3' target='_blank'>GENECARDS:CCND3</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68332' target='_blank'>REACTOME:68332</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCND3.html' target='_blank'>ATLASONC:GC_CCND3</a> <a href='http://wikipedia.org/wiki/CCND3' target='_blank'>WIKI:CCND3</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLIND&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLIND/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s247\", \"s250\"]) } catch (e) {}; return false;' title=\"s247 s250 2 modifs\">CDK6</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK6:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re181(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>The complex CYCLIND-CDK stability increases when bound to a Cip/Kip family member.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p></span>,",
"s252": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\">CyclinD*</a> <a href='javascript_required.html' onclick='try { show_blog(1764); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin D1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND1' target='_blank'>HUGO:CCND1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1582' target='_blank'>HGNC:1582</a> <a href='http://www.ncbi.nlm.nih.gov/gene/595' target='_blank'>ENTREZ:595</a> <a href='http://www.expasy.org/uniprot/P24385' target='_blank'>UNIPROT:P24385</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND1' target='_blank'>GENECARDS:CCND1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68327' target='_blank'>REACTOME:68327</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:595' target='_blank'>KEGG:595</a> <a href='http://atlasgeneticsoncology.org//Genes/BCL1.html' target='_blank'>ATLASONC:BCL1</a> <a href='http://wikipedia.org/wiki/CCND1' target='_blank'>WIKI:CCND1</a> <BR>Cyclin D2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND2' target='_blank'>HUGO:CCND2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1583' target='_blank'>HGNC:1583</a> <a href='http://www.ncbi.nlm.nih.gov/gene/894' target='_blank'>ENTREZ:894</a> <a href='http://www.expasy.org/uniprot/P30279' target='_blank'>UNIPROT:P30279</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND2' target='_blank'>GENECARDS:CCND2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68339' target='_blank'>REACTOME:68339</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:894' target='_blank'>KEGG:894</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCND2.html' target='_blank'>ATLASONC:GC_CCND2</a> <a href='http://wikipedia.org/wiki/CCND2' target='_blank'>WIKI:CCND2</a> <BR>Cyclin D3<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND3' target='_blank'>HUGO:CCND3</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1585' target='_blank'>HGNC:1585</a> <a href='http://www.ncbi.nlm.nih.gov/gene/896' target='_blank'>ENTREZ:896</a> <a href='http://www.expasy.org/uniprot/P30281' target='_blank'>UNIPROT:P30281</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND3' target='_blank'>GENECARDS:CCND3</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68332' target='_blank'>REACTOME:68332</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCND3.html' target='_blank'>ATLASONC:GC_CCND3</a> <a href='http://wikipedia.org/wiki/CCND3' target='_blank'>WIKI:CCND3</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLIND&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLIND/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s256\", \"s253\"]) } catch (e) {}; return false;' title=\"s256 s253 2 modifs\">CDK4</a>|Thr172_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK4:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re92:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re298(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of pRB<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR>dissociation of HDAC1 (during the G1 to S transition)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10778858' target='_blank'>PMID:10778858</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11520855' target='_blank'>PMID:11520855</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7736585' target='_blank'>PMID:7736585</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9425340' target='_blank'>PMID:9425340</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9190208' target='_blank'>PMID:9190208</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>,",
"s249": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\">CyclinD*</a> <a href='javascript_required.html' onclick='try { show_blog(1764); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin D1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND1' target='_blank'>HUGO:CCND1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1582' target='_blank'>HGNC:1582</a> <a href='http://www.ncbi.nlm.nih.gov/gene/595' target='_blank'>ENTREZ:595</a> <a href='http://www.expasy.org/uniprot/P24385' target='_blank'>UNIPROT:P24385</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND1' target='_blank'>GENECARDS:CCND1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68327' target='_blank'>REACTOME:68327</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:595' target='_blank'>KEGG:595</a> <a href='http://atlasgeneticsoncology.org//Genes/BCL1.html' target='_blank'>ATLASONC:BCL1</a> <a href='http://wikipedia.org/wiki/CCND1' target='_blank'>WIKI:CCND1</a> <BR>Cyclin D2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND2' target='_blank'>HUGO:CCND2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1583' target='_blank'>HGNC:1583</a> <a href='http://www.ncbi.nlm.nih.gov/gene/894' target='_blank'>ENTREZ:894</a> <a href='http://www.expasy.org/uniprot/P30279' target='_blank'>UNIPROT:P30279</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND2' target='_blank'>GENECARDS:CCND2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68339' target='_blank'>REACTOME:68339</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:894' target='_blank'>KEGG:894</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCND2.html' target='_blank'>ATLASONC:GC_CCND2</a> <a href='http://wikipedia.org/wiki/CCND2' target='_blank'>WIKI:CCND2</a> <BR>Cyclin D3<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCND3' target='_blank'>HUGO:CCND3</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1585' target='_blank'>HGNC:1585</a> <a href='http://www.ncbi.nlm.nih.gov/gene/896' target='_blank'>ENTREZ:896</a> <a href='http://www.expasy.org/uniprot/P30281' target='_blank'>UNIPROT:P30281</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCND3' target='_blank'>GENECARDS:CCND3</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=68332' target='_blank'>REACTOME:68332</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCND3.html' target='_blank'>ATLASONC:GC_CCND3</a> <a href='http://wikipedia.org/wiki/CCND3' target='_blank'>WIKI:CCND3</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLIND&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLIND/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s247\", \"s250\"]) } catch (e) {}; return false;' title=\"s247 s250 2 modifs\">CDK6</a>|Thr_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK6:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re92:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re298(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of pRB<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR>dissociation of HDAC1 (during the G1 to S transition)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10778858' target='_blank'>PMID:10778858</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11520855' target='_blank'>PMID:11520855</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7736585' target='_blank'>PMID:7736585</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9425340' target='_blank'>PMID:9425340</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9190208' target='_blank'>PMID:9190208</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>,",
"s214": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s723\", \"c_s721\"]) } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\">CyclinE*</a> <a href='javascript_required.html' onclick='try { show_blog(1040); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin E1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNE1' target='_blank'>HUGO:CCNE1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1589' target='_blank'>HGNC:1589</a> <a href='http://www.ncbi.nlm.nih.gov/gene/898' target='_blank'>ENTREZ:898</a> <a href='http://www.expasy.org/uniprot/P24864' target='_blank'>UNIPROT:P24864</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNE1' target='_blank'>GENECARDS:CCNE1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87225' target='_blank'>REACTOME:87225</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:898' target='_blank'>KEGG:898</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNE1.html' target='_blank'>ATLASONC:GC_CCNE1</a> <a href='http://wikipedia.org/wiki/CCNE1' target='_blank'>WIKI:CCNE1</a> <BR>Cyclin E2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNE2' target='_blank'>HUGO:CCNE2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1590' target='_blank'>HGNC:1590</a> <a href='http://www.ncbi.nlm.nih.gov/gene/9134' target='_blank'>ENTREZ:9134</a> <a href='http://www.expasy.org/uniprot/O96020' target='_blank'>UNIPROT:O96020</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNE2' target='_blank'>GENECARDS:CCNE2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87228' target='_blank'>REACTOME:87228</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:9134' target='_blank'>KEGG:9134</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNE2.html' target='_blank'>ATLASONC:GC_CCNE2</a> <a href='http://wikipedia.org/wiki/CCNE2' target='_blank'>WIKI:CCNE2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>|Thr160_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s214\", \"s213\"]) } catch (e) {}; return false;' title=\"s214 s213 2 modifs\">CyclinE*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinE*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re147(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR>c_re169(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of p27 by cyclin E/CDK2 at Thr-187 results in targeting p27 for its degradation by proteolysis<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re248(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Cyclin E phosphorylation by CDK2 at Thr-380.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8861947' target='_blank'>PMID:8861947</a><BR>Autophosphorylation of the complex CYCLINE/CDK2 at Thr-380 and Thr-62. Phosphorylation at Thr-380 also by GSK-3B. Two other sites of regulation: Ser-372 et Ser-384<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16131838' target='_blank'>PMID:16131838</a><BR>c_re289:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re323(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>pRB phosphorylation<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>Brg1 phosphorylation <BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420722' target='_blank'>PMID:11420722</a><BR>Brg1 (in the SWI/SNF complex) and pRB are phosphorylated, simultaneously with the complex dissociation. Phosphorylation of pRB<BR>Phosphorylation of Brg1 (SWI/SNF complex)<BR>c_re327:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12836612' target='_blank'>PMID:12836612</a><BR>c_re1275:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR>c_re1276(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>p130 binds to and inhibits CYCLINE-CDK2, independantly of its phosphorylation state.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>,",
"s213": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s723\", \"c_s721\"]) } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\">CyclinE*</a> <a href='javascript_required.html' onclick='try { show_blog(1040); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin E1<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNE1' target='_blank'>HUGO:CCNE1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1589' target='_blank'>HGNC:1589</a> <a href='http://www.ncbi.nlm.nih.gov/gene/898' target='_blank'>ENTREZ:898</a> <a href='http://www.expasy.org/uniprot/P24864' target='_blank'>UNIPROT:P24864</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNE1' target='_blank'>GENECARDS:CCNE1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87225' target='_blank'>REACTOME:87225</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:898' target='_blank'>KEGG:898</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNE1.html' target='_blank'>ATLASONC:GC_CCNE1</a> <a href='http://wikipedia.org/wiki/CCNE1' target='_blank'>WIKI:CCNE1</a> <BR>Cyclin E2<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNE2' target='_blank'>HUGO:CCNE2</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1590' target='_blank'>HGNC:1590</a> <a href='http://www.ncbi.nlm.nih.gov/gene/9134' target='_blank'>ENTREZ:9134</a> <a href='http://www.expasy.org/uniprot/O96020' target='_blank'>UNIPROT:O96020</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNE2' target='_blank'>GENECARDS:CCNE2</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=87228' target='_blank'>REACTOME:87228</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:9134' target='_blank'>KEGG:9134</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNE2.html' target='_blank'>ATLASONC:GC_CCNE2</a> <a href='http://wikipedia.org/wiki/CCNE2' target='_blank'>WIKI:CCNE2</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s723\", \"c_s721\"]); } catch (e) {}; return false;' title=\"c_s723 c_s721 2 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s214\", \"s213\"]) } catch (e) {}; return false;' title=\"s214 s213 2 modifs\">CyclinE*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinE*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re306:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re147(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR>c_re170(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Complex CYCLINE-CDK2 inhibited by its interaction with CKI.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p></span>,",
"c_s401": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"c_s752\", \"c_s749\"]) } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\">CyclinH*</a> <a href='javascript_required.html' onclick='try { show_blog(1086); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin H<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNH' target='_blank'>HUGO:CCNH</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1594' target='_blank'>HGNC:1594</a> <a href='http://www.ncbi.nlm.nih.gov/gene/902' target='_blank'>ENTREZ:902</a> <a href='http://www.expasy.org/uniprot/P51946' target='_blank'>UNIPROT:P51946</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNH' target='_blank'>GENECARDS:CCNH</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=88594' target='_blank'>REACTOME:88594</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:902' target='_blank'>KEGG:902</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNH.html' target='_blank'>ATLASONC:GC_CCNH</a> <a href='http://wikipedia.org/wiki/CCNH' target='_blank'>WIKI:CCNH</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>CyclinH*<br>in nucleus<br></span>",
"s204": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"c_s752\", \"c_s749\"]) } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\">CyclinH*</a> <a href='javascript_required.html' onclick='try { show_blog(1086); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin H<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNH' target='_blank'>HUGO:CCNH</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1594' target='_blank'>HGNC:1594</a> <a href='http://www.ncbi.nlm.nih.gov/gene/902' target='_blank'>ENTREZ:902</a> <a href='http://www.expasy.org/uniprot/P51946' target='_blank'>UNIPROT:P51946</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNH' target='_blank'>GENECARDS:CCNH</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=88594' target='_blank'>REACTOME:88594</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:902' target='_blank'>KEGG:902</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNH.html' target='_blank'>ATLASONC:GC_CCNH</a> <a href='http://wikipedia.org/wiki/CCNH' target='_blank'>WIKI:CCNH</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"s203\", \"s209\"]) } catch (e) {}; return false;' title=\"c_s402 s203 s209 3 modifs\">CDK7</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"s204\", \"s210\"]) } catch (e) {}; return false;' title=\"c_s401 s204 s210 3 modifs\">CyclinH*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"s205\", \"s211\"]) } catch (e) {}; return false;' title=\"c_s403 s205 s211 3 modifs\">MNAT1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK7:CyclinH*:MNAT1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re245(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK7 activation by its phosphorylation at Thr-170<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11355576' target='_blank'>PMID:11355576</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_5.gif'/> REF=0 <span style='color:red'>FUNC=5</span></p></span>,",
"s210": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"c_s752\", \"c_s749\"]) } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\">CyclinH*</a> <a href='javascript_required.html' onclick='try { show_blog(1086); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin H<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CCNH' target='_blank'>HUGO:CCNH</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1594' target='_blank'>HGNC:1594</a> <a href='http://www.ncbi.nlm.nih.gov/gene/902' target='_blank'>ENTREZ:902</a> <a href='http://www.expasy.org/uniprot/P51946' target='_blank'>UNIPROT:P51946</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CCNH' target='_blank'>GENECARDS:CCNH</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=88594' target='_blank'>REACTOME:88594</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:902' target='_blank'>KEGG:902</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_CCNH.html' target='_blank'>ATLASONC:GC_CCNH</a> <a href='http://wikipedia.org/wiki/CCNH' target='_blank'>WIKI:CCNH</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s401\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s401 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"s203\", \"s209\"]) } catch (e) {}; return false;' title=\"c_s402 s203 s209 3 modifs\">CDK7</a>|Thr170_pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"s204\", \"s210\"]) } catch (e) {}; return false;' title=\"c_s401 s204 s210 3 modifs\">CyclinH*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"s205\", \"s211\"]) } catch (e) {}; return false;' title=\"c_s403 s205 s211 3 modifs\">MNAT1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK7:CyclinH*:MNAT1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re245(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK7 activation by its phosphorylation at Thr-170<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11355576' target='_blank'>PMID:11355576</a><BR>c_re147(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re216(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p></span>,",
"c_s403": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"c_s752\", \"c_s749\"]) } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\">MNAT1</a> <a href='javascript_required.html' onclick='try { show_blog(1092); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=MNAT1' target='_blank'>HUGO:MNAT1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=7181' target='_blank'>HGNC:7181</a> <a href='http://www.ncbi.nlm.nih.gov/gene/4331' target='_blank'>ENTREZ:4331</a> <a href='http://www.expasy.org/uniprot/P51948' target='_blank'>UNIPROT:P51948</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MNAT1' target='_blank'>GENECARDS:MNAT1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=69677' target='_blank'>REACTOME:69677</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:4331' target='_blank'>KEGG:4331</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_MNAT1.html' target='_blank'>ATLASONC:GC_MNAT1</a> <a href='http://wikipedia.org/wiki/MNAT1' target='_blank'>WIKI:MNAT1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;NER&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/NER/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br>MNAT1<br>in nucleus<br></span>",
"s205": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"c_s752\", \"c_s749\"]) } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\">MNAT1</a> <a href='javascript_required.html' onclick='try { show_blog(1092); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=MNAT1' target='_blank'>HUGO:MNAT1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=7181' target='_blank'>HGNC:7181</a> <a href='http://www.ncbi.nlm.nih.gov/gene/4331' target='_blank'>ENTREZ:4331</a> <a href='http://www.expasy.org/uniprot/P51948' target='_blank'>UNIPROT:P51948</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MNAT1' target='_blank'>GENECARDS:MNAT1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=69677' target='_blank'>REACTOME:69677</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:4331' target='_blank'>KEGG:4331</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_MNAT1.html' target='_blank'>ATLASONC:GC_MNAT1</a> <a href='http://wikipedia.org/wiki/MNAT1' target='_blank'>WIKI:MNAT1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;NER&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/NER/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"s203\", \"s209\"]) } catch (e) {}; return false;' title=\"c_s402 s203 s209 3 modifs\">CDK7</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"s204\", \"s210\"]) } catch (e) {}; return false;' title=\"c_s401 s204 s210 3 modifs\">CyclinH*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"s205\", \"s211\"]) } catch (e) {}; return false;' title=\"c_s403 s205 s211 3 modifs\">MNAT1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK7:CyclinH*:MNAT1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re245(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK7 activation by its phosphorylation at Thr-170<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11355576' target='_blank'>PMID:11355576</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_5.gif'/> REF=0 <span style='color:red'>FUNC=5</span></p></span>,",
"s211": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"c_s752\", \"c_s749\"]) } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\">MNAT1</a> <a href='javascript_required.html' onclick='try { show_blog(1092); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=MNAT1' target='_blank'>HUGO:MNAT1</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=7181' target='_blank'>HGNC:7181</a> <a href='http://www.ncbi.nlm.nih.gov/gene/4331' target='_blank'>ENTREZ:4331</a> <a href='http://www.expasy.org/uniprot/P51948' target='_blank'>UNIPROT:P51948</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=MNAT1' target='_blank'>GENECARDS:MNAT1</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=69677' target='_blank'>REACTOME:69677</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:4331' target='_blank'>KEGG:4331</a> <a href='http://atlasgeneticsoncology.org//Genes/GC_MNAT1.html' target='_blank'>ATLASONC:GC_MNAT1</a> <a href='http://wikipedia.org/wiki/MNAT1' target='_blank'>WIKI:MNAT1</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;G1_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/G1_CC_PHASE/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;S_CC_PHASE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/S_CC_PHASE/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;DNA repair&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;NER&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../dnarepair/NER/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s403\", \"c_s752\", \"c_s749\"]); } catch (e) {}; return false;' title=\"c_s403 c_s752 c_s749 3 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"s203\", \"s209\"]) } catch (e) {}; return false;' title=\"c_s402 s203 s209 3 modifs\">CDK7</a>|Thr170_pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"s204\", \"s210\"]) } catch (e) {}; return false;' title=\"c_s401 s204 s210 3 modifs\">CyclinH*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"s205\", \"s211\"]) } catch (e) {}; return false;' title=\"c_s403 s205 s211 3 modifs\">MNAT1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK7:CyclinH*:MNAT1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re245(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK7 activation by its phosphorylation at Thr-170<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11355576' target='_blank'>PMID:11355576</a><BR>c_re147(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re216(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p></span>,",
"s654": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\">p27KIP1*</a> <a href='javascript_required.html' onclick='try { show_blog(4001); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase inhibitor 1B (p27, Kip1)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDKN1B' target='_blank'>HUGO:CDKN1B</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1785' target='_blank'>HGNC:1785</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1027' target='_blank'>ENTREZ:1027</a> <a href='http://www.expasy.org/uniprot/P46527' target='_blank'>UNIPROT:P46527</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDKN1B' target='_blank'>GENECARDS:CDKN1B</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=198633' target='_blank'>REACTOME:198633</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1027' target='_blank'>KEGG:1027</a> <a href='http://atlasgeneticsoncology.org//Genes/CDKN1BID116.html' target='_blank'>ATLASONC:CDKN1BID116</a> <a href='http://wikipedia.org/wiki/CDKN1B' target='_blank'>WIKI:CDKN1B</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s256\", \"s253\"]) } catch (e) {}; return false;' title=\"s256 s253 2 modifs\">CDK4</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK4:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re180(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>The complex CYCLIND-CDK stability increases when bound to a Cip/Kip family member.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>,",
"s651": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\">p27KIP1*</a> <a href='javascript_required.html' onclick='try { show_blog(4001); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase inhibitor 1B (p27, Kip1)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDKN1B' target='_blank'>HUGO:CDKN1B</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1785' target='_blank'>HGNC:1785</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1027' target='_blank'>ENTREZ:1027</a> <a href='http://www.expasy.org/uniprot/P46527' target='_blank'>UNIPROT:P46527</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDKN1B' target='_blank'>GENECARDS:CDKN1B</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=198633' target='_blank'>REACTOME:198633</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1027' target='_blank'>KEGG:1027</a> <a href='http://atlasgeneticsoncology.org//Genes/CDKN1BID116.html' target='_blank'>ATLASONC:CDKN1BID116</a> <a href='http://wikipedia.org/wiki/CDKN1B' target='_blank'>WIKI:CDKN1B</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s247\", \"s250\"]) } catch (e) {}; return false;' title=\"s247 s250 2 modifs\">CDK6</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK6:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re181(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>The complex CYCLIND-CDK stability increases when bound to a Cip/Kip family member.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p></span>,",
"s653": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\">p27KIP1*</a> <a href='javascript_required.html' onclick='try { show_blog(4001); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase inhibitor 1B (p27, Kip1)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDKN1B' target='_blank'>HUGO:CDKN1B</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1785' target='_blank'>HGNC:1785</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1027' target='_blank'>ENTREZ:1027</a> <a href='http://www.expasy.org/uniprot/P46527' target='_blank'>UNIPROT:P46527</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDKN1B' target='_blank'>GENECARDS:CDKN1B</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=198633' target='_blank'>REACTOME:198633</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1027' target='_blank'>KEGG:1027</a> <a href='http://atlasgeneticsoncology.org//Genes/CDKN1BID116.html' target='_blank'>ATLASONC:CDKN1BID116</a> <a href='http://wikipedia.org/wiki/CDKN1B' target='_blank'>WIKI:CDKN1B</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s256\", \"s253\"]) } catch (e) {}; return false;' title=\"s256 s253 2 modifs\">CDK4</a>|Thr172_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK4:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re92:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re298(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of pRB<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR>dissociation of HDAC1 (during the G1 to S transition)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10778858' target='_blank'>PMID:10778858</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11520855' target='_blank'>PMID:11520855</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7736585' target='_blank'>PMID:7736585</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9425340' target='_blank'>PMID:9425340</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9190208' target='_blank'>PMID:9190208</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>,",
"s652": "<span class='bubble'><b><big>Protein<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\">p27KIP1*</a> <a href='javascript_required.html' onclick='try { show_blog(4001); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><p class=\"bubble-cyan\"><b>Identifiers</b><BR>Cyclin-dependent kinase inhibitor 1B (p27, Kip1)<BR><a href='http://www.genenames.org/cgi-bin/quick_search.pl?.cgifields=type&amp;type=equals&amp;num=50&amp;submit=Submit&amp;search=CDKN1B' target='_blank'>HUGO:CDKN1B</a> <a href='http://www.genenames.org/data/hgnc_data.php?hgnc_id=1785' target='_blank'>HGNC:1785</a> <a href='http://www.ncbi.nlm.nih.gov/gene/1027' target='_blank'>ENTREZ:1027</a> <a href='http://www.expasy.org/uniprot/P46527' target='_blank'>UNIPROT:P46527</a> <a href='http://www.genecards.org/cgi-bin/carddisp.pl?gc_id=CDKN1B' target='_blank'>GENECARDS:CDKN1B</a> <a href='http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&amp;ID=198633' target='_blank'>REACTOME:198633</a> <a href='http://www.genome.jp/dbget-bin/www_bget?hsa:1027' target='_blank'>KEGG:1027</a> <a href='http://atlasgeneticsoncology.org//Genes/CDKN1BID116.html' target='_blank'>ATLASONC:CDKN1BID116</a> <a href='http://wikipedia.org/wiki/CDKN1B' target='_blank'>WIKI:CDKN1B</a></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;EMT&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;EMT_REGULATORS&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../emtcellmotility/EMT_REGULATORS/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Apoptosis&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APOPTOSIS_GENES&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../apoptosis/APOPTOSIS_GENES/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Survival&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/master/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;PI3K_AKT_MTOR&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../survival/PI3K_AKT_MTOR/index.html\", [\"c_s751\", \"c_s750\", \"c_s725\", \"c_s724\"]); } catch (e) {}; return false;' title=\"c_s751 c_s750 c_s725 c_s724 4 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a></p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s247\", \"s250\"]) } catch (e) {}; return false;' title=\"s247 s250 2 modifs\">CDK6</a>|Thr_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK6:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re92:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re298(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of pRB<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR>dissociation of HDAC1 (during the G1 to S transition)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10778858' target='_blank'>PMID:10778858</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11520855' target='_blank'>PMID:11520855</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7736585' target='_blank'>PMID:7736585</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9425340' target='_blank'>PMID:9425340</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9190208' target='_blank'>PMID:9190208</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>,",
"c_s748": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s748\", \"c_s746\"]) } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\">CDK1:&#8203;CyclinB*</a> <a href='javascript_required.html' onclick='try { show_blog(23584); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s1522\", \"s184\"]) } catch (e) {}; return false;' title=\"s1522 s184 2 modifs\">CDK1</a>|Thr161_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s186\", \"s185\"]) } catch (e) {}; return false;' title=\"s186 s185 2 modifs\">CyclinB*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK1:CyclinB*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APC&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APC/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CDC25&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CDC25/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P21CIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P21CIP/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;WEE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/WEE/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re216(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re195(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>phosphorylation and inactivation of Wee1 kinase<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8515817' target='_blank'>PMID:8515817</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15070733' target='_blank'>PMID:15070733</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7681363' target='_blank'>PMID:7681363</a> (yeast)<BR>Cyclin B phosphorylates Myt1 in vitro<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9268380' target='_blank'>PMID:9268380</a><BR>c_re255:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840442' target='_blank'>PMID:15840442</a><BR>c_re258(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10548110' target='_blank'>PMID:10548110</a><BR>CYCLINB phosphorylates CDH1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11598127' target='_blank'>PMID:11598127</a><BR>c_re328:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15798220' target='_blank'>PMID:15798220</a><BR>c_re330(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s748\"]); } catch (e) {}; return false;' title=\"c_s748 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Inactivated by phosphorylation by CHEK1 and CHEK2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12478465' target='_blank'>PMID:12478465</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a><BR>Phosphorylation by CYCLINB-CDC2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11313986' target='_blank'>PMID:11313986</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>",
"c_s746": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s748\", \"c_s746\"]) } catch (e) {}; return false;' title=\"c_s748 c_s746 2 modifs\">CDK1:&#8203;CyclinB*</a> <a href='javascript_required.html' onclick='try { show_blog(23584); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s1522\", \"s184\"]) } catch (e) {}; return false;' title=\"s1522 s184 2 modifs\">CDK1</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s186\", \"s185\"]) } catch (e) {}; return false;' title=\"s186 s185 2 modifs\">CyclinB*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK1:CyclinB*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re219(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>dephosphorylation of CDC2 induce its activation<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8348613' target='_blank'>PMID:8348613</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a><BR>c_re230:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11063929' target='_blank'>PMID:11063929</a><BR>c_re233(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Dephosphorylation of CDC2 induces its activation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8348613' target='_blank'>PMID:8348613</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=1828290' target='_blank'>PMID:1828290</a><BR>c_re216(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re232(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s746\"]); } catch (e) {}; return false;' title=\"c_s746 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDC2 phosphorylation at Tyr15 by WEE1, only when CDC2 is bound to a cyclin.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a><BR>WEE1 allows CDC2 to stay in an inactive state after its translocation in late G2<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10373560' target='_blank'>PMID:10373560</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8348613' target='_blank'>PMID:8348613</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9001210' target='_blank'>PMID:9001210</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15037762' target='_blank'>PMID:15037762</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>",
"c_s719": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s719\", \"c_s718\"]) } catch (e) {}; return false;' title=\"c_s719 c_s718 2 modifs\">CDK2:&#8203;CyclinA*</a> <a href='javascript_required.html' onclick='try { show_blog(350); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s127\", \"s628\"]) } catch (e) {}; return false;' title=\"s127 s628 2 modifs\">CyclinA*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinA*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P21CIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P21CIP/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re171(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Complex CYCLINA-CDK2 inhibited by its interaction with CKI<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR>c_re326:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12836612' target='_blank'>PMID:12836612</a><BR>c_re1272:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15798220' target='_blank'>PMID:15798220</a><BR>c_re1273:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR>c_re1274(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s719\"]); } catch (e) {}; return false;' title=\"c_s719 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>p130 binds to and inhibits CYCLINA-CDK2, independantly of its phosphorylation state.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p></span>",
"c_s718": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s719\", \"c_s718\"]) } catch (e) {}; return false;' title=\"c_s719 c_s718 2 modifs\">CDK2:&#8203;CyclinA*</a> <a href='javascript_required.html' onclick='try { show_blog(350); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>|Thr160_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s127\", \"s628\"]) } catch (e) {}; return false;' title=\"s127 s628 2 modifs\">CyclinA*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinA*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;APC&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/APC/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR>c_re86(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of E2F1 leads to the end of transcription stimulation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15840440' target='_blank'>PMID:15840440</a><BR>Phosphorylation of DP-1 induce the diminution of the binding of E2F to the DNA (leading to the end of its activation).<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15133492' target='_blank'>PMID:15133492</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9556498' target='_blank'>PMID:9556498</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15123636' target='_blank'>PMID:15123636</a><BR>Phosphorylation of both DP-1 and E2F1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16135794' target='_blank'>PMID:16135794</a><BR>Phosphorylation of E2F-1, 2, 3a and 3b by cyclin A/CDK2 induce E2F degradation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11980909' target='_blank'>PMID:11980909</a><BR>Phosphorylation of E2F1 on Ser-375 increases its binding affinity for pRb.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16213134' target='_blank'>PMID:16213134</a><BR>c_re258(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s718\"]); } catch (e) {}; return false;' title=\"c_s718 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10548110' target='_blank'>PMID:10548110</a><BR>CYCLINB phosphorylates CDH1<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11598127' target='_blank'>PMID:11598127</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>",
"c_s721": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s721\", \"c_s723\"]) } catch (e) {}; return false;' title=\"c_s721 c_s723 2 modifs\">CDK2:&#8203;CyclinE*</a> <a href='javascript_required.html' onclick='try { show_blog(2822); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s214\", \"s213\"]) } catch (e) {}; return false;' title=\"s214 s213 2 modifs\">CyclinE*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinE*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re306:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re147(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR>c_re170(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s721\"]); } catch (e) {}; return false;' title=\"c_s721 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Complex CYCLINE-CDK2 inhibited by its interaction with CKI.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/2_5.gif'/> REF=2 <span style='color:red'>FUNC=5</span></p></span>",
"c_s723": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s721\", \"c_s723\"]) } catch (e) {}; return false;' title=\"c_s721 c_s723 2 modifs\">CDK2:&#8203;CyclinE*</a> <a href='javascript_required.html' onclick='try { show_blog(2822); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s215\", \"s212\", \"s126\", \"s627\"]) } catch (e) {}; return false;' title=\"s215 s212 s126 s627 4 modifs\">CDK2</a>|Thr160_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s214\", \"s213\"]) } catch (e) {}; return false;' title=\"s214 s213 2 modifs\">CyclinE*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK2:CyclinE*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re147(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR>c_re169(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of p27 by cyclin E/CDK2 at Thr-187 results in targeting p27 for its degradation by proteolysis<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re248(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Cyclin E phosphorylation by CDK2 at Thr-380.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=8861947' target='_blank'>PMID:8861947</a><BR>Autophosphorylation of the complex CYCLINE/CDK2 at Thr-380 and Thr-62. Phosphorylation at Thr-380 also by GSK-3B. Two other sites of regulation: Ser-372 et Ser-384<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16131838' target='_blank'>PMID:16131838</a><BR>c_re289:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re323(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>pRB phosphorylation<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>Brg1 phosphorylation <BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11420722' target='_blank'>PMID:11420722</a><BR>Brg1 (in the SWI/SNF complex) and pRB are phosphorylated, simultaneously with the complex dissociation. Phosphorylation of pRB<BR>Phosphorylation of Brg1 (SWI/SNF complex)<BR>c_re327:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12836612' target='_blank'>PMID:12836612</a><BR>c_re1275:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR>c_re1276(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s723\"]); } catch (e) {}; return false;' title=\"c_s723 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>p130 binds to and inhibits CYCLINE-CDK2, independantly of its phosphorylation state.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=15456871' target='_blank'>PMID:15456871</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11237530' target='_blank'>PMID:11237530</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>",
"c_s751": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s725\"]) } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\">CDK4:&#8203;CyclinD*:&#8203;p27KIP1*</a> <a href='javascript_required.html' onclick='try { show_blog(957); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s256\", \"s253\"]) } catch (e) {}; return false;' title=\"s256 s253 2 modifs\">CDK4</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK4:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re180(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>The complex CYCLIND-CDK stability increases when bound to a Cip/Kip family member.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s751\"]); } catch (e) {}; return false;' title=\"c_s751 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_5.gif'/> REF=1 <span style='color:red'>FUNC=5</span></p></span>",
"c_s725": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\", \"c_s725\"]) } catch (e) {}; return false;' title=\"c_s751 c_s725 2 modifs\">CDK4:&#8203;CyclinD*:&#8203;p27KIP1*</a> <a href='javascript_required.html' onclick='try { show_blog(957); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s256\", \"s253\"]) } catch (e) {}; return false;' title=\"s256 s253 2 modifs\">CDK4</a>|Thr172_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK4:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re92:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re298(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s725\"]); } catch (e) {}; return false;' title=\"c_s725 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of pRB<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR>dissociation of HDAC1 (during the G1 to S transition)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10778858' target='_blank'>PMID:10778858</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11520855' target='_blank'>PMID:11520855</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7736585' target='_blank'>PMID:7736585</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9425340' target='_blank'>PMID:9425340</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9190208' target='_blank'>PMID:9190208</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_5.gif'/> REF=5 <span style='color:red'>FUNC=5</span></p></span>",
"c_s750": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s750\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\">CDK6:&#8203;CyclinD*:&#8203;p27KIP1*</a> <a href='javascript_required.html' onclick='try { show_blog(2707); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s247\", \"s250\"]) } catch (e) {}; return false;' title=\"s247 s250 2 modifs\">CDK6</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK6:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re181(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>The complex CYCLIND-CDK stability increases when bound to a Cip/Kip family member.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10385618' target='_blank'>PMID:10385618</a><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s750\"]); } catch (e) {}; return false;' title=\"c_s750 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p></span>",
"c_s724": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s750\", \"c_s724\"]) } catch (e) {}; return false;' title=\"c_s750 c_s724 2 modifs\">CDK6:&#8203;CyclinD*:&#8203;p27KIP1*</a> <a href='javascript_required.html' onclick='try { show_blog(2707); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"s247\", \"s250\"]) } catch (e) {}; return false;' title=\"s247 s250 2 modifs\">CDK6</a>|Thr_pho:<a href='javascript_required.html' onclick='try { show_markers([\"s255\", \"s246\", \"s252\", \"s249\"]) } catch (e) {}; return false;' title=\"s255 s246 s252 s249 4 modifs\">CyclinD*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"s654\", \"s651\", \"s653\", \"s652\"]) } catch (e) {}; return false;' title=\"s654 s651 s653 s652 4 modifs\">p27KIP1*</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK6:CyclinD*:p27KIP1*<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;RB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/RB/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re92:(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>) <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12006580' target='_blank'>PMID:12006580</a><BR>c_re298(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s724\"]); } catch (e) {}; return false;' title=\"c_s724 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>Phosphorylation of pRB<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9315635' target='_blank'>PMID:9315635</a><BR>dissociation of HDAC1 (during the G1 to S transition)<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=10778858' target='_blank'>PMID:10778858</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11520855' target='_blank'>PMID:11520855</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7736585' target='_blank'>PMID:7736585</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9425340' target='_blank'>PMID:9425340</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=9190208' target='_blank'>PMID:9190208</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/5_4.gif'/> REF=5 <span style='color:orange'>FUNC=4</span></p></span>",
"c_s749": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s749\", \"c_s752\"]) } catch (e) {}; return false;' title=\"c_s749 c_s752 2 modifs\">CDK7:&#8203;CyclinH*:&#8203;MNAT1</a> <a href='javascript_required.html' onclick='try { show_blog(620); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"s203\", \"s209\"]) } catch (e) {}; return false;' title=\"c_s402 s203 s209 3 modifs\">CDK7</a>|Thr170_pho:<a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"s204\", \"s210\"]) } catch (e) {}; return false;' title=\"c_s401 s204 s210 3 modifs\">CyclinH*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"s205\", \"s211\"]) } catch (e) {}; return false;' title=\"c_s403 s205 s211 3 modifs\">MNAT1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK7:CyclinH*:MNAT1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re245(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK7 activation by its phosphorylation at Thr-170<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11355576' target='_blank'>PMID:11355576</a><BR>c_re147(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR>c_re174(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re175(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR>c_re216(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR>c_re310(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s749\"]); } catch (e) {}; return false;' title=\"c_s749 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/4_5.gif'/> REF=4 <span style='color:red'>FUNC=5</span></p></span>",
"c_s752": "<span class='bubble'><b><big>Complex<br><a href='javascript_required.html' onclick='try { show_markers([\"c_s749\", \"c_s752\"]) } catch (e) {}; return false;' title=\"c_s749 c_s752 2 modifs\">CDK7:&#8203;CyclinH*:&#8203;MNAT1</a> <a href='javascript_required.html' onclick='try { show_blog(620); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a></big></b><BR><p><hr><BR><b>Modification:</b><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s402\", \"s203\", \"s209\"]) } catch (e) {}; return false;' title=\"c_s402 s203 s209 3 modifs\">CDK7</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s401\", \"s204\", \"s210\"]) } catch (e) {}; return false;' title=\"c_s401 s204 s210 3 modifs\">CyclinH*</a>:<a href='javascript_required.html' onclick='try { show_markers([\"c_s403\", \"s205\", \"s211\"]) } catch (e) {}; return false;' title=\"c_s403 s205 s211 3 modifs\">MNAT1</a><br>in nucleus<br><p class=\"bubble-cyan\"><b>Identifiers</b><BR>NAME:CDK7:CyclinH*:MNAT1<BR></p><p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>c_re245(&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_s752\"]); } catch (e) {}; return false;' title=\"c_s752 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>):<BR>CDK7 activation by its phosphorylation at Thr-170<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11355576' target='_blank'>PMID:11355576</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_5.gif'/> REF=0 <span style='color:red'>FUNC=5</span></p></span>",
"c_re147": "<span class='bubble'>Reaction state_transition c_re147 <a href='javascript_required.html' onclick='try { show_blog(9746); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s721\"]) } catch (e) {}; return false;' title=\"c_s721 1 modifs\">CDK2:&#8203;CyclinE*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s723\"]) } catch (e) {}; return false;' title=\"c_s723 1 modifs\">CDK2|&#8203;Thr160_pho:&#8203;CyclinE*@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s749\"]) } catch (e) {}; return false;' title=\"c_s749 1 modifs\">CDK7|&#8203;Thr170_pho:&#8203;CyclinH*:&#8203;MNAT1@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re147\"]); } catch (e) {}; return false;' title=\"c_re147 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINE&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINE/index.html\", [\"c_re147\"]); } catch (e) {}; return false;' title=\"c_re147 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re147\"]); } catch (e) {}; return false;' title=\"c_re147 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_re147\"]); } catch (e) {}; return false;' title=\"c_re147 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7629134' target='_blank'>PMID:7629134</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>",
"c_re148": "<span class='bubble'>Reaction heterodimer_association c_re148 <a href='javascript_required.html' onclick='try { show_blog(9748); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s401\"]) } catch (e) {}; return false;' title=\"c_s401 1 modifs\">CyclinH*@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s402\"]) } catch (e) {}; return false;' title=\"c_s402 1 modifs\">CDK7@nucleus</a> + <a href='javascript_required.html' onclick='try { show_markers([\"c_s403\"]) } catch (e) {}; return false;' title=\"c_s403 1 modifs\">MNAT1@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s752\"]) } catch (e) {}; return false;' title=\"c_s752 1 modifs\">CDK7:&#8203;CyclinH*:&#8203;MNAT1@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re148\"]); } catch (e) {}; return false;' title=\"c_re148 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_re148\"]); } catch (e) {}; return false;' title=\"c_re148 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_5.gif'/> REF=0 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re174": "<span class='bubble'>Reaction state_transition c_re174 <a href='javascript_required.html' onclick='try { show_blog(9776); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s750\"]) } catch (e) {}; return false;' title=\"c_s750 1 modifs\">CDK6:&#8203;CyclinD*:&#8203;p27KIP1*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s724\"]) } catch (e) {}; return false;' title=\"c_s724 1 modifs\">CDK6|&#8203;Thr_pho:&#8203;CyclinD*:&#8203;p27KIP1*@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s749\"]) } catch (e) {}; return false;' title=\"c_s749 1 modifs\">CDK7|&#8203;Thr170_pho:&#8203;CyclinH*:&#8203;MNAT1@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re174\"]); } catch (e) {}; return false;' title=\"c_re174 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_re174\"]); } catch (e) {}; return false;' title=\"c_re174 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re174\"]); } catch (e) {}; return false;' title=\"c_re174 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_re174\"]); } catch (e) {}; return false;' title=\"c_re174 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>",
"c_re175": "<span class='bubble'>Reaction state_transition c_re175 <a href='javascript_required.html' onclick='try { show_blog(9778); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s751\"]) } catch (e) {}; return false;' title=\"c_s751 1 modifs\">CDK4:&#8203;CyclinD*:&#8203;p27KIP1*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s725\"]) } catch (e) {}; return false;' title=\"c_s725 1 modifs\">CDK4|&#8203;Thr172_pho:&#8203;CyclinD*:&#8203;p27KIP1*@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s749\"]) } catch (e) {}; return false;' title=\"c_s749 1 modifs\">CDK7|&#8203;Thr170_pho:&#8203;CyclinH*:&#8203;MNAT1@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re175\"]); } catch (e) {}; return false;' title=\"c_re175 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_re175\"]); } catch (e) {}; return false;' title=\"c_re175 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re175\"]); } catch (e) {}; return false;' title=\"c_re175 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;P27KIP&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/P27KIP/index.html\", [\"c_re175\"]); } catch (e) {}; return false;' title=\"c_re175 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=16782892' target='_blank'>PMID:16782892</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>",
"c_re216": "<span class='bubble'>Reaction state_transition c_re216 <a href='javascript_required.html' onclick='try { show_blog(9818); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s746\"]) } catch (e) {}; return false;' title=\"c_s746 1 modifs\">CDK1:&#8203;CyclinB*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s748\"]) } catch (e) {}; return false;' title=\"c_s748 1 modifs\">CDK1|&#8203;Thr161_pho:&#8203;CyclinB*@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s749\"]) } catch (e) {}; return false;' title=\"c_s749 1 modifs\">CDK7|&#8203;Thr170_pho:&#8203;CyclinH*:&#8203;MNAT1@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re216\"]); } catch (e) {}; return false;' title=\"c_re216 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_re216\"]); } catch (e) {}; return false;' title=\"c_re216 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re216\"]); } catch (e) {}; return false;' title=\"c_re216 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINB&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINB/index.html\", [\"c_re216\"]); } catch (e) {}; return false;' title=\"c_re216 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>CDK activity stimulated by its CAK-complex phosphorylation.<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12459251' target='_blank'>PMID:12459251</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=12814430' target='_blank'>PMID:12814430</a>, <a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=7799941' target='_blank'>PMID:7799941</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>",
"c_re245": "<span class='bubble'>Reaction state_transition c_re245 <a href='javascript_required.html' onclick='try { show_blog(9872); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s752\"]) } catch (e) {}; return false;' title=\"c_s752 1 modifs\">CDK7:&#8203;CyclinH*:&#8203;MNAT1@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s749\"]) } catch (e) {}; return false;' title=\"c_s749 1 modifs\">CDK7|&#8203;Thr170_pho:&#8203;CyclinH*:&#8203;MNAT1@nucleus</a><BR><br><b>No reaction regulators</b><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re245\"]); } catch (e) {}; return false;' title=\"c_re245 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_re245\"]); } catch (e) {}; return false;' title=\"c_re245 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>CDK7 activation by its phosphorylation at Thr-170<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11355576' target='_blank'>PMID:11355576</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/0_5.gif'/> REF=0 <span style='color:red'>FUNC=5</span></p>          <BR>        \n</span>",
"c_re310": "<span class='bubble'>Reaction state_transition c_re310 <a href='javascript_required.html' onclick='try { show_blog(9952); } catch (e) {}; return false;' title=\"go to blog\"><img border='0' width='16' height='16' src=\"../../../map_icons/misc/blog.png\" alt='blog'></a><BR><br><a href='javascript_required.html' onclick='try { show_markers([\"c_s719\"]) } catch (e) {}; return false;' title=\"c_s719 1 modifs\">CDK2:&#8203;CyclinA*@nucleus</a> &rarr; <a href='javascript_required.html' onclick='try { show_markers([\"c_s718\"]) } catch (e) {}; return false;' title=\"c_s718 1 modifs\">CDK2|&#8203;Thr160_pho:&#8203;CyclinA*@nucleus</a><BR><br><b>Reaction regulators:</b><BR><dl><dt>Catalysis</dt><dd><ol><li><a href='javascript_required.html' onclick='try { show_markers([\"c_s749\"]) } catch (e) {}; return false;' title=\"c_s749 1 modifs\">CDK7|&#8203;Thr170_pho:&#8203;CyclinH*:&#8203;MNAT1@nucleus</a></ol></dd></dl><BR>          <BR>            <p class=\"bubble-LightGreen\"><b>Maps_Modules</b><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re310\"]); } catch (e) {}; return false;' title=\"c_re310 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINA&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINA/index.html\", [\"c_re310\"]); } catch (e) {}; return false;' title=\"c_re310 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR>&nbsp;Cell cycle&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/master/index.html\", [\"c_re310\"]); } catch (e) {}; return false;' title=\"c_re310 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a>&nbsp;/&nbsp;CYCLINH&nbsp;<a href='javascript_required.html' onclick='try { nv_perform(\"nv_open_module\", window, \"../../cellcycle/CYCLINH/index.html\", [\"c_re310\"]); } catch (e) {}; return false;' title=\"c_re310 1 modifs\"><img border='0' src=\"../../../map_icons/map.png\" alt='map' /></a><BR></p><p class=\"bubble-LightGoldenRodYellow\"><b>References</b><BR>CDK activity activated by its phosphorylation by CAK-complex<BR><a href='http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&amp;amp;Cmd=ShowDetailView&amp;amp;TermToSearch=11959850' target='_blank'>PMID:11959850</a><BR></p><p class=\"bubble-Khaki\"><b>Confidence</b><BR><img width='100' height='22' border='0' src='../../../map_icons/confidence/1_4.gif'/> REF=1 <span style='color:orange'>FUNC=4</span></p>          <BR>        \n</span>"}