RIPK1_at_Cytoplasm RIPK1_at_Cytoplasm TNFRSF1A_at_Cytoplasm TNFRSF1A_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS TRAF2_at_Cytoplasm TRAF2_at_Cytoplasm 21474067 pubmed TRAF2 TRAF2 BAF250 BAF250 21267694 pubmed NFAT NFAT NFAT NFAT FOS_pho_at_Nucleus FOS_pho_at_Nucleus ATF2_pho_at_Nucleus ATF2_pho_at_Nucleus JUN_pho_at_Nucleus JUN_pho_at_Nucleus DUSP1 DUSP1 p53 p53 15061133 pubmed p53 p53 ACTIVATION CDTYPE:CATALYSIS TRADD TRADD 9216996 pubmed DUSP1_at_Nucleus DUSP1_at_Nucleus DUSP1_at_Nucleus DUSP1_at_Nucleus PKD PKD JNK JNK p38 p38 JNK__at_Nucleus JNK__at_Nucleus p38__at_Nucleus p38__at_Nucleus RAS__pho_at_Plasma_Membrane RAS__pho_at_Plasma_Membrane SOS__at_Plasma_Membrane SOS__at_Plasma_Membrane SOS__at_Plasma_Membrane SOS__at_Plasma_Membrane SOS__at_Plasma_Membrane SOS__at_Plasma_Membrane 23296977 pubmed RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane GRB2_at_Plasma_Membrane GRB2_at_Plasma_Membrane ERK__pho_pho_at_Cytoplasm ERK__pho_pho_at_Cytoplasm SOS__at_Cytoplasm SOS__at_Cytoplasm CNB CNB LEF_TCF__at_Nucleus LEF_TCF__at_Nucleus MAP3K5_pho_at_Cytoplasm MAP3K5_pho_at_Cytoplasm SOS__at_Plasma_Membrane SOS__at_Plasma_Membrane MYCBP2 HGNC _beta__Catenin__at_Nucleus _beta__Catenin__at_Nucleus IRS2 IRS2 TRADD_at_Cytoplasm TRADD_at_Cytoplasm 10756197 pubmed TRAF2_at_Cytoplasm TRAF2_at_Cytoplasm _beta__Arrestin2 _beta__Arrestin2 15584861 pubmed MAP3K4_pho_at_Cytoplasm MAP3K4_pho_at_Cytoplasm 10094050 pubmed MAPK3 HGNC FOXA2 FOXA2 TRADD_at_Cytoplasm TRADD_at_Cytoplasm TRADD_at_Cytoplasm TRADD_at_Cytoplasm TRAF2_at_Cytoplasm TRAF2_at_Cytoplasm TAK1__pho_at_Cytoplasm TAK1__pho_at_Cytoplasm RIPK1_at_Cytoplasm RIPK1_at_Cytoplasm GADD45__at_Cytoplasm GADD45__at_Cytoplasm TRAF2_at_Cytoplasm TRAF2_at_Cytoplasm 15367661 pubmed MAPK1 HGNC 17127310 pubmed GLI1_SUFU GLI1_SUFU SUFU_at_Cytoplasm SUFU_at_Cytoplasm GLI1_at_Cytoplasm GLI1_at_Cytoplasm 15808505 pubmed PP2A_A__at_Cytoplasm PP2A_A__at_Cytoplasm CARD8 HGNC GRB2_at_Plasma_Membrane GRB2_at_Plasma_Membrane CSNK2B HGNC PP2A_C__at_Cytoplasm PP2A_C__at_Cytoplasm HH_Ligand HH_Ligand PP2A_B55_alpha___at_Cytoplasm PP2A_B55_alpha___at_Cytoplasm SIL__SUFU SIL__SUFU SIL SIL 11108711 pubmed p70_beta p70_beta RAS_activation RAS_activation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. RAS RAS SIL__at_Cytoplasm SIL__at_Cytoplasm SUFU_at_Cytoplasm SUFU_at_Cytoplasm HIPK1 HGNC MAP3K5_at_Cytoplasm MAP3K5_at_Cytoplasm 20056399 pubmed ACTIVATION CDTYPE:CATALYSIS HDAC1 HDAC1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS SH3RF1 HGNC CRIPTO_1 CRIPTO_1 CYCS HGNC GSK3_beta GSK3_beta PI3K_AKT_MTOR_pathway PI3K_AKT_MTOR_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. AKT__T308_pho_T450_pho_at_Cytoplasm AKT__T308_pho_T450_pho_at_Cytoplasm PRAS40__S183_pho_T246_pho_S212_pho_S221_pho_at_Membrane_Lysosome PRAS40__S183_pho_T246_pho_S212_pho_S221_pho_at_Membrane_Lysosome AKT__T308_pho_T450_pho_S473_pho_active_at_Cytoplasm AKT__T308_pho_T450_pho_S473_pho_active_at_Cytoplasm PI3_4_5_P3_at_Cytoplasm PI3_4_5_P3_at_Cytoplasm p70_alpha p70_alpha PI3_4_5_P3_at_Cytoplasm PI3_4_5_P3_at_Cytoplasm TAB__at_Plasma_Membrane TAB__at_Plasma_Membrane TRAF2_at_Plasma_Membrane TRAF2_at_Plasma_Membrane NFKB1_p50 NFKB1_p50 ATF2 ATF2 JUN JUN id_14_3_3__at_Membrane_Lysosome id_14_3_3__at_Membrane_Lysosome FOS FOS JUN_pho_at_Nucleus JUN_pho_at_Nucleus id_14_3_3 id_14_3_3 JUN_pho_hm2_at_Nucleus JUN_pho_hm2_at_Nucleus id_14_3_3__PRAS40 id_14_3_3__PRAS40 FZD1 HGNC ZNF354A HGNC PPP2R1A HGNC 19966784 pubmed 16396903 pubmed RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Membrane_Lysosome RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome DEPTOR_at_Membrane_Lysosome DEPTOR_at_Membrane_Lysosome 19049965 pubmed ACTIVATION CDTYPE:CATALYSIS PRAS40__S183_pho_T246_pho_S212_pho_S221_pho_at_Membrane_Lysosome PRAS40__S183_pho_T246_pho_S212_pho_S221_pho_at_Membrane_Lysosome ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION 22304967 pubmed CAST HGNC APC1 APC1 INHIBITION CDTYPE:INHIBITION PRAS40 PRAS40 MLST8_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome BCL2L11 BCL2L11 PRAS40__S183_emp_T246_emp_at_Membrane_Lysosome PRAS40__S183_emp_T246_emp_at_Membrane_Lysosome PRAS40__S183_emp_T246_emp_at_Membrane_Lysosome PRAS40__S183_emp_T246_emp_at_Membrane_Lysosome ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS TFAM HGNC CCNY HGNC 21169405 pubmed MLST8_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Membrane_Lysosome RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome PIAS1 PIAS1 PTCH1 PTCH1 ACTIVATION CDTYPE:CATALYSIS HIP1 HIP1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS DKK3 DKK3 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 18539112 pubmed ACTIVATION CDTYPE:CATALYSIS FIP200 FIP200 RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Membrane_Lysosome RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Membrane_Lysosome Unknown_kinase Unknown_kinase This is a CellDesigner UNKNOWN entity. SRC HGNC FZD7 FZD7 PRR__at_Endosome PRR__at_Endosome PRR__at_Cytoplasm PRR__at_Cytoplasm PRR__at_Endosome PRR__at_Endosome PRR__at_Cytoplasm PRR__at_Cytoplasm PRR__at_Cytoplasm PRR__at_Cytoplasm PRR__at_Cytoplasm PRR__at_Cytoplasm CDTYPE:PHYSICAL_STIMULATION PRR__at_Cytoplasm PRR__at_Cytoplasm 20068088 pubmed MLST8_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome PRR__at_Cytoplasm PRR__at_Cytoplasm RPTOR_at_Membrane_Lysosome RPTOR_at_Membrane_Lysosome PRAS40__at_Membrane_Lysosome PRAS40__at_Membrane_Lysosome RPTOR_S696_pho_T706_pho_S863_pho_S877_pho_at_Membrane_Lysosome RPTOR_S696_pho_T706_pho_S863_pho_S877_pho_at_Membrane_Lysosome ANAPC11 HGNC JNK_pathway JNK_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. RSPO3_at_Endosome RSPO3_at_Endosome PRR__at_Endosome PRR__at_Endosome PRAS40__at_Membrane_Lysosome PRAS40__at_Membrane_Lysosome MLST8_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome BAX HGNC RPTOR_at_Membrane_Lysosome RPTOR_at_Membrane_Lysosome 19289794 pubmed TCFL5 HGNC MLST8 MLST8 GAS5 HGNC GAS6 HGNC GAS7 HGNC GAS8 HGNC GAS1 HGNC GAS2 HGNC GRK4 HGNC GRK5 HGNC GRK6 HGNC GRK7 HGNC MIR378 HGNC ER_alpha ER_alpha 17255949 pubmed MEK MEK DUSP5 DUSP5 GRK1 HGNC DUSP1 DUSP1 SYN4__at_Cytoplasm SYN4__at_Cytoplasm CTHRC1_at_Cytoplasm CTHRC1_at_Cytoplasm CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm WNT__at_Cytoplasm WNT__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm WNT5A HGNC PAR6__at_Cytoplasm PAR6__at_Cytoplasm RACK1__at_Cytoplasm RACK1__at_Cytoplasm VANGL__at_Cytoplasm VANGL__at_Cytoplasm Unknown Unknown This is a CellDesigner UNKNOWN entity. DEPTOR DEPTOR 18570873 pubmed WNT3 WNT3 RSPO3_at_Cytoplasm RSPO3_at_Cytoplasm PRR PRR 16396959 pubmed 12408816 pubmed PPP3PR2 HGNC _CK2 _CK2 TUCAN TUCAN UBE2G1 HGNC FZD1 FZD1 TSC2 HGNC UBE2G2 HGNC MIR23B MIR23B FZD7 FZD7 FZD7 FZD7 APC2__CK1_epsilon___CTHRC1_DAAM1_DVL__FZD__GSK3__PAR6__RACK1__RHOA_ROR2_RSPO3_SYN4__VANGL__WGEF__WNT___beta__Arrestin2 APC2__CK1_epsilon___CTHRC1_DAAM1_DVL__FZD__GSK3__PAR6__RACK1__RHOA_ROR2_RSPO3_SYN4__VANGL__WGEF__WNT___beta__Arrestin2 rFZD7_at_Nucleus rFZD7_at_Nucleus arMIR23B_at_Nucleus arMIR23B_at_Nucleus FZD7_MIR23B FZD7_MIR23B DVL__pho_pho_pho_at_Cytoplasm DVL__pho_pho_pho_at_Cytoplasm MIR23B MIR23B arMIR374A_at_Nucleus arMIR374A_at_Nucleus RAD51 HGNC NEDD4 NEDD4 GSK3 GSK3 MIR374A_WIF1 MIR374A_WIF1 rWIF1_at_Nucleus rWIF1_at_Nucleus p400 p400 MIR374A MIR374A WNT5A WNT5A JUNB JUNB MIR374A_WNT5A MIR374A_WNT5A MIR374A MIR374A arMIR374A_at_Nucleus arMIR374A_at_Nucleus Cell_death Cell_death This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. rWNT5A_at_Nucleus rWNT5A_at_Nucleus Growth_arrest Growth_arrest This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. WIF1 WIF1 JUND JUND WIF1 WIF1 DNA_repair DNA_repair This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. MORF4L1 HGNC RSPO3_at_Endosome RSPO3_at_Endosome RSPO3_at_Endosome RSPO3_at_Endosome Proliferation Proliferation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. RSPO3_at_Endosome RSPO3_at_Endosome PP2A_B PP2A_B RSPO3_at_Endosome RSPO3_at_Endosome EREG HGNC 12958364 pubmed BAK1 BAK1 TGFB1 HGNC FOXF1 FOXF1 WNT5A WNT5A rFZD8_at_Nucleus rFZD8_at_Nucleus UBE2E1 HGNC arMIR375_at_Nucleus arMIR375_at_Nucleus FZD8_MIR375 FZD8_MIR375 _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome UBE2D1 HGNC FZD8 FZD8 DVL__pho_emp_emp_at_Endosome DVL__pho_emp_emp_at_Endosome UBE2D2 HGNC FZD8 FZD8 PAR6__at_Endosome PAR6__at_Endosome UBE2D3 HGNC MIR375 MIR375 RSPO3_at_Endosome RSPO3_at_Endosome ACTIVATION CDTYPE:CATALYSIS MIR375 MIR375 AXIN2 AXIN2 ACTIVATION CDTYPE:CATALYSIS AXIN2 AXIN2 POSH POSH JUN JUN POSH POSH POSH__RAC1 POSH__RAC1 RAC1_at_Cytoplasm RAC1_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS POSH__at_Cytoplasm POSH__at_Cytoplasm CTNNB1 HGNC AKT1S1 HGNC MIR378 MIR378 PKA_C__at_Cytoplasm PKA_C__at_Cytoplasm 20347994 pubmed PKA_R__at_Cytoplasm PKA_R__at_Cytoplasm _PKA _PKA CK2_beta___at_Cytoplasm CK2_beta___at_Cytoplasm TCF4_at_Nucleus TCF4_at_Nucleus gWRE__at_Nucleus gWRE__at_Nucleus Kindlin2__TCF4_WRE___beta__Catenin Kindlin2__TCF4_WRE___beta__Catenin FZD__at_Endosome FZD__at_Endosome TCF4_WRE TCF4_WRE ROR2_at_Endosome ROR2_at_Endosome gWRE__at_Nucleus gWRE__at_Nucleus 15169778 pubmed Kindlin2__at_Nucleus Kindlin2__at_Nucleus UBE2E2 HGNC CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRR__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRR__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 _beta__Catenin__at_Nucleus _beta__Catenin__at_Nucleus TCF4_at_Nucleus TCF4_at_Nucleus Kindlin2__at_Cytoplasm Kindlin2__at_Cytoplasm PRR__at_Endosome PRR__at_Endosome RACK1__at_Endosome RACK1__at_Endosome CK2_alpha___at_Cytoplasm CK2_alpha___at_Cytoplasm CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome CK2_alpha____at_Cytoplasm CK2_alpha____at_Cytoplasm SYN4__at_Endosome SYN4__at_Endosome VANGL__at_Endosome VANGL__at_Endosome WNT__at_Endosome WNT__at_Endosome CTHRC1_at_Endosome CTHRC1_at_Endosome TNKS1_2 TNKS1_2 15781316 pubmed ACTIVATION CDTYPE:CATALYSIS WNT2B WNT2B ACTIVATION CDTYPE:CATALYSIS MSI1 MSI1 Notch_pathway Notch_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 17910481 pubmed BMP_pathway BMP_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. WNT_canonical_pathway WNT_canonical_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Sonic_hedgehog_pathway Sonic_hedgehog_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ACTIVATION CDTYPE:CATALYSIS AXIN2 AXIN2 DKK3 DKK3 H2AFX HGNC CDTYPE:TRIGGER E2F1 E2F1 Cell_cycle_pathway Cell_cycle_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS DKK3 DKK3 MP1 MP1 PAX6 PAX6 TNFRSF1B HGNC CyclinE CyclinE UBE2L6 HGNC UBE2L3 HGNC UBE2L4 HGNC ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION 0643644 pubmed ACTIVATION CDTYPE:CATALYSIS RSPO3_at_Cytoplasm RSPO3_at_Cytoplasm DVL DVL DVL1 DVL1 DVL1 DVL1 SIRT1_2 SIRT1_2 ACTIVATION CDTYPE:CATALYSIS DVL1_SIRT1_2 DVL1_SIRT1_2 _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm SIRT1_2__at_Nucleus SIRT1_2__at_Nucleus SYN4__at_Cytoplasm SYN4__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS DVL1_at_Nucleus DVL1_at_Nucleus CTHRC1_at_Cytoplasm CTHRC1_at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm Transcription_of_WNT_target_genes Transcription_of_WNT_target_genes This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. WNT2B WNT2B PAR6__at_Cytoplasm PAR6__at_Cytoplasm CCND3 HGNC WNT2B WNT2B ROR2_S864_pho_pho_pho_at_Cytoplasm ROR2_S864_pho_pho_pho_at_Cytoplasm CCND2 HGNC RACK1__at_Cytoplasm RACK1__at_Cytoplasm CCND1 HGNC ACTIVATION CDTYPE:CATALYSIS VANGL__pho_pho_pho_pho_at_Cytoplasm VANGL__pho_pho_pho_pho_at_Cytoplasm APC2__at_Cytoplasm APC2__at_Cytoplasm 10753867 pubmed 21602792 pubmed MIR31 HGNC ATG13 ATG13 arMIR31_at_Nucleus arMIR31_at_Nucleus 18249169 pubmed rFZD3_at_Nucleus rFZD3_at_Nucleus ACTIVATION CDTYPE:CATALYSIS FZD3_MIR31 FZD3_MIR31 CDTYPE:PHYSICAL_STIMULATION CDTYPE:BOOLEAN_LOGIC_GATE_AND CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm LRP5_6 LRP5_6 WNT__at_Cytoplasm WNT__at_Cytoplasm PI3_4_5_P3_at_Cytoplasm PI3_4_5_P3_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS TIAM1_at_Cytoplasm TIAM1_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS GDP_RAC1 GDP_RAC1 INHIBITION CDTYPE:INHIBITION rFZD4_at_Nucleus rFZD4_at_Nucleus ACTIVATION CDTYPE:CATALYSIS Actin_polymerization Actin_polymerization This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. RAC1_at_Cytoplasm RAC1_at_Cytoplasm FZD4_MIR493 FZD4_MIR493 FZD__at_Cytoplasm FZD__at_Cytoplasm GDP_at_Cytoplasm GDP_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS arMIR493_at_Nucleus arMIR493_at_Nucleus GDP_at_Cytoplasm GDP_at_Cytoplasm MIR493 MIR493 GTP_at_Cytoplasm GTP_at_Cytoplasm Cell_migration Cell_migration This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. MIR493 MIR493 GTP_at_Cytoplasm GTP_at_Cytoplasm IRS2 HGNC FZD4 FZD4 GSK3A HGNC Centrosome_positioning Centrosome_positioning This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. GTP_at_Cytoplasm GTP_at_Cytoplasm FZD4 FZD4 Angiogenesis Angiogenesis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 17680028 pubmed UBE2J1 HGNC UBE2J2 HGNC MAP2K4 HGNC ATP6VOC HGNC NFE2L1 HGNC INHIBITION CDTYPE:UNKNOWN_INHIBITION INHIBITION CDTYPE:UNKNOWN_INHIBITION FZD1 FZD1 MIR204 MIR204 ACTIVATION CDTYPE:CATALYSIS RHOA RHOA ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS FZD3 FZD3 WGEF WGEF ACTIVATION CDTYPE:CATALYSIS FZD3 FZD3 DAAM1 DAAM1 MIR31 MIR31 ACTIVATION CDTYPE:CATALYSIS MIR31 MIR31 12459251 pubmed ACTIVATION CDTYPE:CATALYSIS MIR204 MIR204 INHIBITION CDTYPE:INHIBITION FZD1_MIR204 FZD1_MIR204 arMIR204_at_Nucleus arMIR204_at_Nucleus 11124803 pubmed rFZD1_at_Nucleus rFZD1_at_Nucleus PPP1R14C HGNC PPP1R14B HGNC MIR96 MIR96 PPP1R14D HGNC FOXO1 FOXO1 SUFU_at_Cytoplasm SUFU_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS MAPKAP1 HGNC PPP1R14A HGNC RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane KIF3B_at_Cytoplasm KIF3B_at_Cytoplasm RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane ACTIVATION CDTYPE:CATALYSIS RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane ACTIVATION CDTYPE:CATALYSIS RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane GLI2_185__at_Cytoplasm GLI2_185__at_Cytoplasm ULK3_at_Cytoplasm ULK3_at_Cytoplasm PAX6 PAX6 MDM2 HGNC KIF3A_KIF3B KIF3A_KIF3B GLI2_185__SUFU_ULK3 GLI2_185__SUFU_ULK3 KIF3B_at_Clathrin_coated_vesicle KIF3B_at_Clathrin_coated_vesicle RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane GPCR__pho_at_Plasma_Membrane GPCR__pho_at_Plasma_Membrane KIF3B_at_Primary_Cilium KIF3B_at_Primary_Cilium COPS7B HGNC KIF3A_KIF3B KIF3A_KIF3B KIF3B_at_Primary_Cilium KIF3B_at_Primary_Cilium COPS7A HGNC PPP1R13B HGNC HH_Ligand_at_Cytoplasm HH_Ligand_at_Cytoplasm PTCH__at_Cytoplasm PTCH__at_Cytoplasm 11001584 pubmed 15755874 pubmed TGFBR2_at_Cytoplasm TGFBR2_at_Cytoplasm GPCR__at_Early_Endosomes GPCR__at_Early_Endosomes IL1R1_at_Cytoplasm IL1R1_at_Cytoplasm TGFBR1_at_Cytoplasm TGFBR1_at_Cytoplasm TNFRSF1B_at_Cytoplasm TNFRSF1B_at_Cytoplasm MYCN HGNC HH_Ligand_PTCH HH_Ligand_PTCH RTK__at_Late_Endosomes RTK__at_Late_Endosomes GPCR__at_Early_Endosomes GPCR__at_Early_Endosomes RTK__at_Late_Endosomes RTK__at_Late_Endosomes SIX1 HGNC PRKD2 HGNC PRKD1 HGNC PPP1R12A HGNC 12050670 pubmed PPP1R12C HGNC PRKD3 HGNC PPP1R12B HGNC PKA_C PKA_C PP2A_C PP2A_C 21738214 pubmed DDB2 DDB2 TULP3_at_Primary_Cilium TULP3_at_Primary_Cilium PP2A_C PP2A_C SEF__at_Cytoplasm SEF__at_Cytoplasm WDR19_at_Primary_Cilium WDR19_at_Primary_Cilium _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm ERK__pho_pho_hm2_at_Cytoplasm ERK__pho_pho_hm2_at_Cytoplasm MEK__pho_pho_at_Cytoplasm MEK__pho_pho_at_Cytoplasm DYN1 DYN1 TNFRSF1B_at_Cytoplasm TNFRSF1B_at_Cytoplasm RAB23 RAB23 TNFRSF1B_at_Cytoplasm TNFRSF1B_at_Cytoplasm IFT122_at_Primary_Cilium IFT122_at_Primary_Cilium TNFRSF1A_at_Cytoplasm TNFRSF1A_at_Cytoplasm IFT140_at_Primary_Cilium IFT140_at_Primary_Cilium TNFRSF1A_at_Cytoplasm TNFRSF1A_at_Cytoplasm HH_Ligand_at_Primary_Cilium HH_Ligand_at_Primary_Cilium GAS1_at_Primary_Cilium GAS1_at_Primary_Cilium TXN HGNC CDO__at_Primary_Cilium CDO__at_Primary_Cilium PERP HGNC MSI1 MSI1 DKK3 DKK3 Pontin Pontin 18953287 pubmed ACTIVATION CDTYPE:CATALYSIS IFT122_at_Cytoplasm IFT122_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS IFT140_at_Cytoplasm IFT140_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS WDR19_at_Cytoplasm WDR19_at_Cytoplasm TULP3_at_Cytoplasm TULP3_at_Cytoplasm WDR19_at_Cytoplasm WDR19_at_Cytoplasm IFT122_at_Cytoplasm IFT122_at_Cytoplasm IFT140_at_Cytoplasm IFT140_at_Cytoplasm TULP3 TULP3 10514377 pubmed XFZ3 XFZ3 WNT1_3 WNT1_3 ULK3 ULK3 TBX2 HGNC GTP_G_alpha__sub_i_endsub GTP_G_alpha__sub_i_endsub G_alpha__sub_i_endsub___at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm G_gamma__sub_i_endsub___at_Cytoplasm G_gamma__sub_i_endsub___at_Cytoplasm G_beta__sub_i_endsub___at_Cytoplasm G_beta__sub_i_endsub___at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm GDP GDP GTP GTP GDP_at_Cytoplasm GDP_at_Cytoplasm 19190345 pubmed GDP_G_alpha__sub_i_endsub___G_beta__sub_i_endsub___G_gamma__sub_i_endsub___SMO GDP_G_alpha__sub_i_endsub___G_beta__sub_i_endsub___G_gamma__sub_i_endsub___SMO G_gamma__sub_i_endsub___at_Cytoplasm G_gamma__sub_i_endsub___at_Cytoplasm ITGA9 HGNC 17143292 pubmed G_beta__sub_i_endsub___at_Cytoplasm G_beta__sub_i_endsub___at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm HH_Ligand_at_Primary_Cilium HH_Ligand_at_Primary_Cilium BOC_at_Primary_Cilium BOC_at_Primary_Cilium KIF7 KIF7 BOC_HH_Ligand BOC_HH_Ligand GAS1_HH_Ligand GAS1_HH_Ligand CDO__HH_Ligand CDO__HH_Ligand HH_Ligand_at_Primary_Cilium HH_Ligand_at_Primary_Cilium CAIN_sub_TRUNC_endsub CAIN_sub_TRUNC_endsub PPP1R16A HGNC PPP1R16B HGNC 16328026 pubmed 14627704 pubmed CDK8 HGNC UBE2Q1 HGNC AXIN2 HGNC GNB HGNC UBE2Q2 HGNC PPP1R15A HGNC PPP1R15B HGNC GRK__at_Cytoplasm GRK__at_Cytoplasm GRK__G_beta__sub_i_endsub___G_gamma__sub_i_endsub GRK__G_beta__sub_i_endsub___G_gamma__sub_i_endsub G_gamma__sub_i_endsub___at_Cytoplasm G_gamma__sub_i_endsub___at_Cytoplasm G_beta__sub_i_endsub___at_Cytoplasm G_beta__sub_i_endsub___at_Cytoplasm CDKN2A HGNC G_beta__sub_i_endsub___at_Cytoplasm G_beta__sub_i_endsub___at_Cytoplasm UBE2R2 HGNC GTP_at_Cytoplasm GTP_at_Cytoplasm G_beta__sub_i_endsub___G_gamma__sub_i_endsub G_beta__sub_i_endsub___G_gamma__sub_i_endsub G_gamma__sub_i_endsub___at_Cytoplasm G_gamma__sub_i_endsub___at_Cytoplasm GTP_at_Cytoplasm GTP_at_Cytoplasm RAS__pho_at_Cytoplasm RAS__pho_at_Cytoplasm RAS__pho_at_Cytoplasm RAS__pho_at_Cytoplasm TNFRSF1B_at_Cytoplasm TNFRSF1B_at_Cytoplasm TAK1__pho_at_Cytoplasm TAK1__pho_at_Cytoplasm MAP3K2_3__pho_at_Cytoplasm MAP3K2_3__pho_at_Cytoplasm RTK__at_Cytoplasm RTK__at_Cytoplasm 21829496 pubmed RTK__at_Cytoplasm RTK__at_Cytoplasm SOS__at_Cytoplasm SOS__at_Cytoplasm GRB2_at_Cytoplasm GRB2_at_Cytoplasm DYN1 DYN1 GRB2_at_Cytoplasm GRB2_at_Cytoplasm SOS2 HGNC SOS1 HGNC CASPASE3 HGNC PLA2G4A HGNC _PIP3_AKT _PIP3_AKT _PIP3_AKT _PIP3_AKT _IFT_A_complex _IFT_A_complex _IFT_A_TULP3 _IFT_A_TULP3 16510874 pubmed GRB2_at_Plasma_Membrane GRB2_at_Plasma_Membrane RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane SOS__at_Cytoplasm SOS__at_Cytoplasm RTK__at_Cytoplasm RTK__at_Cytoplasm MST1 HGNC FOS FOS BCL2 BCL2 TNFRSF1A_at_Cytoplasm TNFRSF1A_at_Cytoplasm Ca2__at_Plasma_Membrane Ca2__at_Plasma_Membrane RASGRP1_at_Plasma_Membrane RASGRP1_at_Plasma_Membrane DAG_at_Plasma_Membrane DAG_at_Plasma_Membrane 11447289 pubmed _IFT_A_TULP3 _IFT_A_TULP3 _PP2A _PP2A 17158541 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CDTYPE:MODULATION EGR1 EGR1 FZD4 HGNC DUSP1 DUSP1 MMP13 MMP13 GADD45 GADD45 CTNNB1 HGNC CHUK HGNC 18636226 pubmed ACTIVATION CDTYPE:CATALYSIS SNAI1 HGNC IL1R2 HGNC FZD3 FZD3 NFKB1 HGNC BAD HGNC CUL3 HGNC 12734397 pubmed FTX HGNC ACTG1 HGNC TGFBR1_at_Plasma_Membrane TGFBR1_at_Plasma_Membrane IL1R1_at_Plasma_Membrane IL1R1_at_Plasma_Membrane DAG_at_Golgi_Apparatus DAG_at_Golgi_Apparatus TNFRSF1A_at_Plasma_Membrane TNFRSF1A_at_Plasma_Membrane TNFRSF1A_at_Plasma_Membrane TNFRSF1A_at_Plasma_Membrane IL1R1_at_Plasma_Membrane IL1R1_at_Plasma_Membrane IL1R1_at_Plasma_Membrane IL1R1_at_Plasma_Membrane ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS PDPK1 PDPK1 ACTIVATION CDTYPE:CATALYSIS Ca2__at_Golgi_Apparatus Ca2__at_Golgi_Apparatus RASGRP1_at_Golgi_Apparatus RASGRP1_at_Golgi_Apparatus 22037766 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS AXIN1 HGNC LRP6 HGNC E2F1 HGNC ACTIVATION CDTYPE:CATALYSIS SOS__at_Late_Endosomes SOS__at_Late_Endosomes GRB2_at_Late_Endosomes GRB2_at_Late_Endosomes RTK__at_Late_Endosomes RTK__at_Late_Endosomes RAS__pho_at_Late_Endosomes RAS__pho_at_Late_Endosomes RAF1_pho_at_Golgi_Apparatus RAF1_pho_at_Golgi_Apparatus RPTOR RPTOR RAS__pho_at_Golgi_Apparatus RAS__pho_at_Golgi_Apparatus DAG_at_Golgi_Apparatus DAG_at_Golgi_Apparatus TRRAP HGNC TCF20 HGNC TCF21 HGNC GPC6 GPC6 TCF23 HGNC TCF24 HGNC MLST8 MLST8 CDTYPE:PHYSICAL_STIMULATION TCF25 HGNC PRAS40 PRAS40 CDTYPE:BOOLEAN_LOGIC_GATE_AND RAS__pho_at_Late_Endosomes RAS__pho_at_Late_Endosomes IL2 HGNC TCF19 HGNC CDTYPE:PHYSICAL_STIMULATION S100A7 HGNC 21209912 pubmed LAMTOR2_at_Late_Endosomes LAMTOR2_at_Late_Endosomes MP1__at_Late_Endosomes MP1__at_Late_Endosomes MIR17_3P MIR17_3P ACTA1 HGNC LAMTOR2_at_Late_Endosomes LAMTOR2_at_Late_Endosomes RAS__pho_at_Late_Endosomes RAS__pho_at_Late_Endosomes MEK__at_Cytoplasm MEK__at_Cytoplasm MP1__at_Late_Endosomes MP1__at_Late_Endosomes RAS__pho_at_Plasma_Membrane RAS__pho_at_Plasma_Membrane RAS__pho_at_Plasma_Membrane RAS__pho_at_Plasma_Membrane MDM2 MDM2 WNT2B HGNC CDTYPE:BOOLEAN_LOGIC_GATE_OR MOD:01148 MOD GRB2_at_Plasma_Membrane GRB2_at_Plasma_Membrane SOS__at_Plasma_Membrane SOS__at_Plasma_Membrane RTK__at_Plasma_Membrane RTK__at_Plasma_Membrane KSR1_at_Plasma_Membrane KSR1_at_Plasma_Membrane WIF1 WIF1 BRAF_pho_at_Plasma_Membrane BRAF_pho_at_Plasma_Membrane MEK__pho_pho_at_Plasma_Membrane MEK__pho_pho_at_Plasma_Membrane ERK__pho_pho_at_Plasma_Membrane ERK__pho_pho_at_Plasma_Membrane PP2B_B PP2B_B 18466115 pubmed ACTIVATION CDTYPE:CATALYSIS RSPO3 RSPO3 MAP3K5_pho_at_Cytoplasm MAP3K5_pho_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS TRAF2_at_Cytoplasm TRAF2_at_Cytoplasm RAS__pho_at_Plasma_Membrane RAS__pho_at_Plasma_Membrane GPCR__pho_at_Plasma_Membrane GPCR__pho_at_Plasma_Membrane _Repressor_complex _Repressor_complex Caspase9__hm2_active_at_Cytoplasm Caspase9__hm2_active_at_Cytoplasm MAP3K2 HGNC HSPA1A HGNC _Repressor_complex _Repressor_complex GTP_RAC1 GTP_RAC1 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS HSPA1B HGNC _Tip60 _Tip60 _Clas_IA_PI3K _Clas_IA_PI3K _MLL2 _MLL2 _Gi_beta_gamma_dimer_PI3K _Gi_beta_gamma_dimer_PI3K ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CK2_beta___at_Nucleus CK2_beta___at_Nucleus MAP3K3 HGNC _CK2 _CK2 IKK IKK _Repressor_complex _Repressor_complex TUCAN__at_Cytoplasm TUCAN__at_Cytoplasm AKT1 AKT1 CK2 CK2 _Caspase_activating_complex _Caspase_activating_complex _Class_IB_PI3K _Class_IB_PI3K Gene_under_control_of_br__P300_mediated_transcription Gene_under_control_of_br__P300_mediated_transcription AKT1_T450_emp_S473_emp_S129_pho_at_Cytoplasm AKT1_T450_emp_S473_emp_S129_pho_at_Cytoplasm _Smo_Gi_protein _Smo_Gi_protein 10648629 pubmed TSC2_at_Endosome_Membrane TSC2_at_Endosome_Membrane TSC1_at_Endosome_Membrane TSC1_at_Endosome_Membrane FOXC2 FOXC2 MAP2K4 MAP2K4 _SWI_SNF _SWI_SNF PTEN PTEN _APC_C_CDC20 _APC_C_CDC20 STAT3 STAT3 estrogen estrogen 19556239 pubmed CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION FES HGNC CDTYPE:PHYSICAL_STIMULATION MLST8 HGNC CSN3 CSN3 ACTIVATION CDTYPE:CATALYSIS RHEB RHEB RHEB RHEB AKT1_HSP90 AKT1_HSP90 HSP90__at_Cytoplasm HSP90__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS DMAP1 DMAP1 ESR1 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS GDP_at_Cytoplasm GDP_at_Cytoplasm RAC1_at_Cytoplasm RAC1_at_Cytoplasm 20538596 pubmed PREX PREX PI3_4_5_P3 PI3_4_5_P3 PI3_4_5_P3_at_Cytoplasm PI3_4_5_P3_at_Cytoplasm 11777939 pubmed PI3_4_5_P3_PREX PI3_4_5_P3_PREX EMT EMT This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ACTIVATION CDTYPE:CATALYSIS PREX__at_Cytoplasm PREX__at_Cytoplasm DSC1 HGNC 16571352 pubmed TSC1 TSC1 TSC2 TSC2 TSC1 TSC1 TSC2 TSC2 TCF15 HGNC TCF12 HGNC CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS 17052211 pubmed TSC1_TSC2 TSC1_TSC2 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS SHIP2 SHIP2 ACTIVATION CDTYPE:CATALYSIS 15520176 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS TSC2_at_Cytoplasm TSC2_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS TSC1_at_Cytoplasm TSC1_at_Cytoplasm PTCH__at_Cytoplasm PTCH__at_Cytoplasm Caspase9 Caspase9 TUCAN TUCAN RGS3 HGNC DRAL DRAL TSC1_at_Endosome_Membrane TSC1_at_Endosome_Membrane PP2_C PP2_C DRAL__at_Cytoplasm DRAL__at_Cytoplasm TSC2_at_Cytoplasm TSC2_at_Cytoplasm HERC1_at_Cytoplasm HERC1_at_Cytoplasm HERC1_TSC2 HERC1_TSC2 HERC1 HERC1 CK1_gamma CK1_gamma 20060931 pubmed NKD1 HGNC 20885820 pubmed ACTIVATION CDTYPE:CATALYSIS CDTYPE:TRIGGER WNT3 WNT3 21179058 pubmed HIP1 HIP1 19549984 pubmed MAPKAP1_at_Lipid_Raft MAPKAP1_at_Lipid_Raft ACTIVATION CDTYPE:CATALYSIS 18379348 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 20946121 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS SIX1 HGNC 12684003 pubmed INHIBITION CDTYPE:INHIBITION DKK3 HGNC HCFC2 HGNC 21727895 pubmed MIR372 MIR372 PLK1 PLK1 NFAT1 NFAT1 19878745 pubmed PTEN PTEN PTEN PTEN PTEN PTEN PTEN PTEN ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS IQGAP1 HGNC WDR19 HGNC ACTIVATION CDTYPE:CATALYSIS GATAD2A HGNC PP2A_C__at_Cytoplasm PP2A_C__at_Cytoplasm PP2A_B55_alpha___at_Cytoplasm PP2A_B55_alpha___at_Cytoplasm PROTOR__at_Lipid_Raft PROTOR__at_Lipid_Raft RICTOR_at_Lipid_Raft RICTOR_at_Lipid_Raft MLST8_at_Lipid_Raft MLST8_at_Lipid_Raft PP2A_A__at_Cytoplasm PP2A_A__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS 20093472 pubmed ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION PTEN PTEN ROCK1 HGNC ROCK2 HGNC SPRY2 SPRY2 HECTH9 HECTH9 INHIBITION CDTYPE:UNKNOWN_INHIBITION JUN HGNC 22761862 pubmed 16393692 pubmed JAG2 HGNC 20562908 pubmed 10931041 pubmed 12011974 pubmed 21736902 pubmed 19151919 pubmed GLI1 GLI1 BCL6 BCL6 RASGRP1 HGNC RASA4 HGNC Kindlin2 Kindlin2 PKA_C__at_Cytoplasm PKA_C__at_Cytoplasm _PKA _PKA PKA_R__at_Cytoplasm PKA_R__at_Cytoplasm APC__beta__Catenin APC__beta__Catenin _Mi_2_NuRD _Mi_2_NuRD JUN HGNC p120 p120 AXIN2 HGNC AXIN1 HGNC phosphorylated _CK2_APC _CK2_APC CK2_beta___at_Cytoplasm CK2_beta___at_Cytoplasm 19082481 pubmed 11226259 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS G_alpha__sub_i_endsub G_alpha__sub_i_endsub 18006823 pubmed PDGFRA HGNC HECTD1 HGNC PDGFRB HGNC GNA12 HGNC TNFRSF1A TNFRSF1A PLK4 HGNC 16547521 pubmed PLK3 HGNC ACTIVATION CDTYPE:CATALYSIS PLK2 HGNC ACTIVATION CDTYPE:CATALYSIS PLK1 HGNC ACTIVATION CDTYPE:CATALYSIS CDK2 HGNC HDAC1 HGNC HDAC2 HGNC TGFBR1 TGFBR1 21118996 pubmed 16604063 pubmed HTID1_50_48_kDa_isoform HTID1_50_48_kDa_isoform GADD45 GADD45 11154281 pubmed 21234400 pubmed 16547505 pubmed MSK MSK 15567848 pubmed GLI1 HGNC PIM1 HGNC MAX HGNC GADD45 GADD45 ATG13 HGNC 19574535 pubmed MEK__SEF MEK__SEF p14INK4A p14INK4A ERK__MEK__SEF ERK__MEK__SEF MYC MYC ERK__MEK__SEF ERK__MEK__SEF MST1 MST1 ERK__MEK__SEF ERK__MEK__SEF MST1 MST1 CSN8 CSN8 GRB2_SOS GRB2_SOS GAB1_GRB2 GAB1_GRB2 SMAD3_at_Nucleus SMAD3_at_Nucleus 15720724 pubmed SMAD4 SMAD4 Ca2__DAG_RAF1_RAS__RASGRP1 Ca2__DAG_RAF1_RAS__RASGRP1 ATM ATM LAMTOR2_at_Late_Endosomes LAMTOR2_at_Late_Endosomes Ca2__DAG_RAS__RASGRP1 Ca2__DAG_RAS__RASGRP1 11331587 pubmed 17535800 pubmed Ca2__DAG_RASGRP1 Ca2__DAG_RASGRP1 MDM2 MDM2 TAB__TGFBR1_TGFBR2 TAB__TGFBR1_TGFBR2 p14INK4A p14INK4A LONP1 HGNC E2F1 HGNC ACTIVATION CDTYPE:CATALYSIS MIR204 HGNC ANAPC2 HGNC ERK__GSK3_beta___RSK ERK__GSK3_beta___RSK SMAD4_at_Nucleus SMAD4_at_Nucleus ERK__GRB2_LAMTOR2_MEK__MP1__RAF1_RAS__RTK__SOS ERK__GRB2_LAMTOR2_MEK__MP1__RAF1_RAS__RTK__SOS SMAD4_at_Nucleus SMAD4_at_Nucleus ERK__GPCR__GRK__MEK__RAF1__beta__Arrestin2 ERK__GPCR__GRK__MEK__RAF1__beta__Arrestin2 DUSP6_ERK DUSP6_ERK LEF_TCF___beta__Catenin LEF_TCF___beta__Catenin HOMER3 HGNC SMAD2_at_Nucleus SMAD2_at_Nucleus Apoptosis Apoptosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. GAB1_GRB2 GAB1_GRB2 SMAD2 SMAD2 LAMTOR2_MEK__MP1 LAMTOR2_MEK__MP1 SMAD3 SMAD3 LAMTOR2_MP1 LAMTOR2_MP1 CTBP1 HGNC GRB2_LAMTOR2_MEK__MP1__RAF1_RAS__RTK__SOS GRB2_LAMTOR2_MEK__MP1__RAF1_RAS__RTK__SOS GRB2_LAMTOR2_MEK__MP1__RAS__RTK__SOS GRB2_LAMTOR2_MEK__MP1__RAS__RTK__SOS Proliferation Proliferation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. module_CK1 module_CK1 Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr AKT AKT CTBP2 HGNC AKT AKT p110 p110 PKD1 PKD1 PKD1 PKD1 p110 p110 WNT1 WNT1 MAP3K5 HGNC 17426148 pubmed ACTIVATION CDTYPE:CATALYSIS p70_alpha p70_alpha p70_alpha p70_alpha DAG_at_Plasma_Membrane DAG_at_Plasma_Membrane PKC__at_Plasma_Membrane PKC__at_Plasma_Membrane Ca2__at_Plasma_Membrane Ca2__at_Plasma_Membrane FOXO3 FOXO3 PKC PKC FOXO3 FOXO3 ACTIVATION CDTYPE:CATALYSIS CSNK2A1 HGNC GTP GTP CSNK2A3 HGNC MAP3K1_TNFRSF1B_TRAF2 MAP3K1_TNFRSF1B_TRAF2 MAP3K5_TNFRSF1B_TRAF2 MAP3K5_TNFRSF1B_TRAF2 GRB2_MAP3K2_3__RAS__RTK__SOS GRB2_MAP3K2_3__RAS__RTK__SOS GRB2_MAP3K1_RAS__RTK__SOS GRB2_MAP3K1_RAS__RTK__SOS MAP3K1_RIPK1_TNFRSF1A_TRADD_TRAF2 MAP3K1_RIPK1_TNFRSF1A_TRADD_TRAF2 SOX9 SOX9 RIPK1_TAK1__TNFRSF1A_TRADD_TRAF2 RIPK1_TAK1__TNFRSF1A_TRADD_TRAF2 TAK1__TNFRSF1B_TRAF2 TAK1__TNFRSF1B_TRAF2 MAP3K2_3__TNFRSF1B_TRAF2 MAP3K2_3__TNFRSF1B_TRAF2 MAP3K5_RIPK1_TNFRSF1A_TRADD_TRAF2 MAP3K5_RIPK1_TNFRSF1A_TRADD_TRAF2 ACTIVATION CDTYPE:CATALYSIS MAP3K2_3__RIPK1_TNFRSF1A_TRADD_TRAF2 MAP3K2_3__RIPK1_TNFRSF1A_TRADD_TRAF2 USP8 USP8 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 22421157 pubmed _AP_1 _AP_1 _AP_1 _AP_1 _AP_1 _AP_1 ACTIVATION CDTYPE:CATALYSIS FOXM1 FOXM1 WNT3 WNT3 DUSP1_JNK DUSP1_JNK MDM2 MDM2 DUSP1_p38 DUSP1_p38 p21CIP1 p21CIP1 PMAIP1 PMAIP1 PERP PERP DUSP5_ERK DUSP5_ERK Forskolin Forskolin Growth_arrest Growth_arrest This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 9367342 pubmed LRP6 LRP6 SMAD2_SMAD4 SMAD2_SMAD4 GPCR__GRK GPCR__GRK DDB2 DDB2 Ca2 Ca2 SMAD3_SMAD4 SMAD3_SMAD4 18815277 pubmed 18414028 pubmed 19720745 pubmed ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ERK__KSR1_MEK ERK__KSR1_MEK PPP1CC HGNC ERK__KSR1_MEK ERK__KSR1_MEK PPP1CB HGNC GADD45__MAP3K4 GADD45__MAP3K4 PPP1CA HGNC TAB__TAK1__TGFBR1_TGFBR2 TAB__TAK1__TGFBR1_TGFBR2 KSR1_MEK KSR1_MEK KSR1_CTER__MEK KSR1_CTER__MEK IMP__KSR1_MEK IMP__KSR1_MEK SNAI1 SNAI1 MAP3K5_TXN MAP3K5_TXN IL1R1_IRAK1_MYD88_TAK1__TRAF6 IL1R1_IRAK1_MYD88_TAK1__TRAF6 GRB2_MAP3K10_11__RAC1_RTK__SOS GRB2_MAP3K10_11__RAC1_RTK__SOS _beta__Catenin _beta__Catenin MYC HGNC RTK__SRC RTK__SRC DAG_RASGRP1 DAG_RASGRP1 Ca2__DAG_PKC Ca2__DAG_PKC ACTIVATION CDTYPE:CATALYSIS CTHRC1 HGNC ACTIVATION CDTYPE:CATALYSIS CDKN2A HGNC SOS SOS GRB2 GRB2 SPRY1 SPRY1 MIR493 MIR493 GAB1 GAB1 module_MAPK module_MAPK Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr MEK___beta__Arrestin2 MEK___beta__Arrestin2 SPRY1 SPRY1 BANF1 HGNC GRB2_RAC1_RTK__SOS GRB2_RAC1_RTK__SOS BRAF_GRB2_RAS__RTK__SOS BRAF_GRB2_RAS__RTK__SOS BRAF_ERK__GRB2_KSR1_MEK__RAS__RTK__SOS BRAF_ERK__GRB2_KSR1_MEK__RAS__RTK__SOS GRB2_RAS__RTK__SOS GRB2_RAS__RTK__SOS GRB2_RAF1_RAS__RTK__SOS GRB2_RAF1_RAS__RTK__SOS 15856024 pubmed FZD1 HGNC glycosylated PLCG1_RTK__SRC PLCG1_RTK__SRC ERK__MEK___beta__Arrestin2 ERK__MEK___beta__Arrestin2 ERK__MEK___beta__Arrestin2 ERK__MEK___beta__Arrestin2 GRB2_RTK__SOS GRB2_RTK__SOS Ca2__DAG_RASGRP1 Ca2__DAG_RASGRP1 FRS2 FRS2 FRS2 FRS2 FRS2 FRS2 AES HGNC LRP5_6 LRP5_6 module_HEDGEHOG module_HEDGEHOG Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr MIR23B HGNC STAT1 STAT1 HAT1 HGNC BCL2_at_Mitochondria BCL2_at_Mitochondria STAT1 STAT1 GSK3_beta GSK3_beta p21CIP1 p21CIP1 BCL2 HGNC p21CIP1 p21CIP1 BAD_at_Mitochondria BAD_at_Mitochondria BAD_BCL2 BAD_BCL2 GAB1_pho_at_Cytoplasm GAB1_pho_at_Cytoplasm JUND HGNC GRB2_at_Cytoplasm GRB2_at_Cytoplasm 21172654 pubmed 9932450 pubmed 16227978 pubmed GAB1_at_Cytoplasm GAB1_at_Cytoplasm GRB2_at_Cytoplasm GRB2_at_Cytoplasm RAF1 RAF1 SPRY2 SPRY2 SPRY2 SPRY2 SUFU SUFU CDH1 HGNC _alpha__Importin _alpha__Importin 21069266 pubmed PR65_A PR65_A 19996099 pubmed ATF2 ATF2 PtdIns_4_5__P2 PtdIns_4_5__P2 19114553 pubmed 11715018 pubmed FZD3 HGNC 19818708 pubmed GNB4 HGNC SIRT1 HGNC GNB2 HGNC GNB3 HGNC RAC1 RAC1 GNB1 HGNC MIR18A HGNC SIRT2 HGNC AXIN1 AXIN1 CREB3 HGNC CREB5 HGNC SGK1 SGK1 KREMEN1 HGNC KREMEN2 HGNC p85 p85 IL1R1_IRAK1_MYD88 IL1R1_IRAK1_MYD88 BRAF_GRB2_KSR1_MEK__RAS__RTK__SOS BRAF_GRB2_KSR1_MEK__RAS__RTK__SOS BRAF_GRB2_KSR1_NTER__RAS__RTK__SOS BRAF_GRB2_KSR1_NTER__RAS__RTK__SOS GPCR__GRK GPCR__GRK GPCR__GRK___beta__Arrestin2 GPCR__GRK___beta__Arrestin2 KLF4 KLF4 21767405 pubmed 15265686 pubmed DPY30 DPY30 20215527 pubmed RAC1 HGNC PRKCA PRKCA MYD88 HGNC 12845332 pubmed WNT1 WNT1 TLE1 HGNC CyclinE__at_Nucleus CyclinE__at_Nucleus CDK2_at_Nucleus CDK2_at_Nucleus CDK2_CyclinE CDK2_CyclinE TUBA8 HGNC CDK2_CyclinE__p27KIP1 CDK2_CyclinE__p27KIP1 CyclinE__at_Nucleus CyclinE__at_Nucleus APC HGNC Caspase8 Caspase8 p27KIP1__pho_at_Nucleus p27KIP1__pho_at_Nucleus DLG DLG EIF4E2 HGNC CDK2_at_Nucleus CDK2_at_Nucleus EIF4E3 HGNC KSR1 HGNC 17646672 pubmed p27KIP1 p27KIP1 KIS KIS G1_phase G1_phase This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CyclinE CyclinE CDK2 CDK2 CAMK2 CAMK2 G0_phase G0_phase This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. DYRK1B DYRK1B Unknown_kinase Unknown_kinase This is a CellDesigner UNKNOWN entity. MYD88 MYD88 20008297 pubmed 21152425 pubmed FAM123B HGNC 19244117 pubmed 20628572 pubmed Ca2 Ca2 IKK_beta IKK_beta CSN5 CSN5 GADD45B HGNC GADD45A HGNC DUSP1 HGNC HOMER3 HOMER3 GADD45G HGNC NFATC2 HGNC NFATC1 HGNC MMP9 HGNC 20543981 pubmed RSK RSK 15766528 pubmed SFRP1 HGNC IKK_beta IKK_beta 15834423 pubmed FZD6 FZD6 DUSP1 DUSP1 CUL4 CUL4 CK1_epsilon CK1_epsilon IL1R1 IL1R1 PTEN PTEN 12844354 pubmed HAUSP HAUSP DAXX_at_Nucleus DAXX_at_Nucleus RAD51 RAD51 Chromosome_integrity_and_DSB_repair Chromosome_integrity_and_DSB_repair This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. E2F1 E2F1 RAD51 RAD51 UBE2B HGNC UBE2A HGNC IP3 IP3 ACTIVATION CDTYPE:CATALYSIS PTCH PTCH EAF6 EAF6 p27KIP1 p27KIP1 p27KIP1 p27KIP1 p27KIP1 p27KIP1 DAXX_at_Nucleus DAXX_at_Nucleus 19321440 pubmed 21498506 pubmed GATA GATA CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm AXIN__at_Cytoplasm AXIN__at_Cytoplasm 11431469 pubmed RICTOR HGNC _beta__Catenin _beta__Catenin APC_at_Cytoplasm APC_at_Cytoplasm PP2A_B__at_Nucleus PP2A_B__at_Nucleus PP2A_C__at_Nucleus PP2A_C__at_Nucleus MIR372 MIR372 HSP70 HSP70 AKT AKT PP2A_A__at_Nucleus PP2A_A__at_Nucleus ACTIVATION CDTYPE:CATALYSIS 15766563 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 19934277 pubmed HES1 HES1 FOXQ1 HGNC PKA PKA BAX BAX DKK1 DKK1 RAD51 RAD51 MTOR MTOR 21670566 pubmed CDH2 HGNC ROR2_S864_pho_pho_pho_at_Endosome ROR2_S864_pho_pho_pho_at_Endosome RACK1__at_Endosome RACK1__at_Endosome VANGL__pho_pho_pho_pho_at_Endosome VANGL__pho_pho_pho_pho_at_Endosome PAR6__at_Endosome PAR6__at_Endosome 20008353 pubmed 22745173 pubmed Actin Actin MIR375 HGNC KLF4 KLF4 19334287 pubmed DDIT3 HGNC 15340381 pubmed CTHRC1_at_Endosome CTHRC1_at_Endosome GSK3__at_Endosome GSK3__at_Endosome _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome SYN4__at_Endosome SYN4__at_Endosome CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome WNT__at_Endosome WNT__at_Endosome APC2__at_Endosome APC2__at_Endosome FZD__at_Endosome FZD__at_Endosome 19597330 pubmed 15208637 pubmed DAG DAG CREB CREB DVL__at_Cytoplasm DVL__at_Cytoplasm 19597341 pubmed MAPKAP1 MAPKAP1 DACT1_at_Cytoplasm DACT1_at_Cytoplasm FOXC2 HGNC ACTIVATION CDTYPE:CATALYSIS 21796133 pubmed 19597351 pubmed ACTIVATION CDTYPE:CATALYSIS p38 p38 VANGL__at_Cytoplasm VANGL__at_Cytoplasm DACT1_VANGL DACT1_VANGL DACT1_at_Cytoplasm DACT1_at_Cytoplasm DACT1 DACT1 WNT3 HGNC YWHAB YWHAB DACT1_YWHAB DACT1_YWHAB DACT1_S237_pho_S827_pho_at_Cytoplasm DACT1_S237_pho_S827_pho_at_Cytoplasm DACT1_DVL DACT1_DVL GLI2_185__SUFU_ULK3 GLI2_185__SUFU_ULK3 20711444 pubmed GLI3_190 GLI3_190 SDC4 HGNC TIAM1 HGNC SUFU_at_Cytoplasm SUFU_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ULK3_at_Cytoplasm ULK3_at_Cytoplasm S100A7 S100A7 PAR6__at_Cytoplasm PAR6__at_Cytoplasm MAP2K3 HGNC RACK1__at_Cytoplasm RACK1__at_Cytoplasm PIK3CA HGNC DACT1 DACT1 JAG2 HGNC PRICKLE1 PRICKLE1 PAR6 PAR6 ULK3_at_Cytoplasm ULK3_at_Cytoplasm GLI3_190__SUFU_ULK3 GLI3_190__SUFU_ULK3 GLI3_190__SUFU_ULK3 GLI3_190__SUFU_ULK3 PIK3CG HGNC SUFU_at_Cytoplasm SUFU_at_Cytoplasm PIK3CD HGNC SUFU_at_Cytoplasm SUFU_at_Cytoplasm ULK3_at_Cytoplasm ULK3_at_Cytoplasm PIK3CB HGNC IKBKB HGNC GLI3_190__SUFU_ULK3 GLI3_190__SUFU_ULK3 id_5T4 id_5T4 SUFU_at_Cytoplasm SUFU_at_Cytoplasm ULK3_at_Cytoplasm ULK3_at_Cytoplasm MIR29B1 HGNC SMURF1_at_Cytoplasm SMURF1_at_Cytoplasm MIR29B2 HGNC 17461779 pubmed CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRICKLE1_PRR__RACK1__ROR2_SMURF1_SYN4__VANGL__WNT___beta__Arrestin2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRICKLE1_PRR__RACK1__ROR2_SMURF1_SYN4__VANGL__WNT___beta__Arrestin2 p15INK4B p15INK4B CCN2 CCN2 CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm 19436832 pubmed TCF7L1 HGNC HDAC3 HDAC3 RB1CC1 HGNC TCF7L2 HGNC 12738796 pubmed 16455648 pubmed CUL1 HGNC CDO CDO SUFU_at_Cytoplasm SUFU_at_Cytoplasm ULK3_at_Cytoplasm ULK3_at_Cytoplasm GLI2_185__S789_pho_S805_pho_S817_pho_S847_pho_at_Cytoplasm GLI2_185__S789_pho_S805_pho_S817_pho_S847_pho_at_Cytoplasm GLI2_185__SUFU_ULK3 GLI2_185__SUFU_ULK3 ULK3_at_Cytoplasm ULK3_at_Cytoplasm GLI2_185__SUFU_ULK3 GLI2_185__SUFU_ULK3 SUFU_at_Cytoplasm SUFU_at_Cytoplasm PCBD2 HGNC GLI3_83_sub_TRUNC_endsub GLI3_83_sub_TRUNC_endsub ULK3_at_Cytoplasm ULK3_at_Cytoplasm KIF7_at_Cytoplasm KIF7_at_Cytoplasm SUFU_at_Cytoplasm SUFU_at_Cytoplasm GLI3_190__S849_emp_at_Cytoplasm GLI3_190__S849_emp_at_Cytoplasm WNT1 HGNC CyclinB CyclinB 17928811 pubmed TCF4 TCF4 GLI2_185 GLI2_185 module_splits module_splits Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr SPRY1 SPRY1 ULK3 ULK3 SNAI1 SNAI1 FZD1 HGNC ULK3 ULK3 FZD4 HGNC FZD5 HGNC TCF7 HGNC FZD2 HGNC FZD3 HGNC FZD8 HGNC FZD9 HGNC TCF3 HGNC FZD6 HGNC TCF4 HGNC FZD7 HGNC BRD7 HGNC AES HGNC PPP1C PPP1C PTH1R HGNC PTH26 HGNC GLI3_190__SUFU_ULK3 GLI3_190__SUFU_ULK3 DYNC2H1 DYNC2H1 GLI3_190__S849_emp_at_Cytoplasm GLI3_190__S849_emp_at_Cytoplasm PKA__at_Primary_Cilium PKA__at_Primary_Cilium H H PKA PKA PKA PKA AKAP AKAP 12681518 pubmed PDK1 HGNC acetylated SUFU SUFU AKAP__at_Primary_Cilium AKAP__at_Primary_Cilium AKAP__PKA AKAP__PKA GLI3_190 GLI3_190 19286674 pubmed GATA6 HGNC GATA5 HGNC 20229235 pubmed ACTIVATION CDTYPE:CATALYSIS PAR6 PAR6 DVL2_NKD1 DVL2_NKD1 LRP5_6__at_Cytoplasm LRP5_6__at_Cytoplasm GLI3_190__KIF7_SUFU_ULK3 GLI3_190__KIF7_SUFU_ULK3 NKD1_at_Cytoplasm NKD1_at_Cytoplasm GLI2_185__KIF7_SUFU_ULK3 GLI2_185__KIF7_SUFU_ULK3 _beta__Catenin__at_Cytoplasm _beta__Catenin__at_Cytoplasm NKD1__beta__Catenin NKD1__beta__Catenin NKD1_at_Cytoplasm NKD1_at_Cytoplasm LRP5_6__WNT LRP5_6__WNT KIF3A_at_Primary_Cilium KIF3A_at_Primary_Cilium SMO SMO _beta__Catenin _beta__Catenin DVL2 DVL2 _beta__Arrestin2 _beta__Arrestin2 NKD1 NKD1 WNT WNT GLI2_185__KIF7_SUFU_ULK3 GLI2_185__KIF7_SUFU_ULK3 SIX3 SIX3 DVL2_at_Cytoplasm DVL2_at_Cytoplasm MIR17HG HGNC GATA3 HGNC 20537194 pubmed GATA4 HGNC GATA1 HGNC GATA2 HGNC MYCN HGNC DACT1 DACT1 WNT1 WNT1 _beta__Catenin _beta__Catenin _beta__Catenin _beta__Catenin TEAD1 HGNC DACT1 DACT1 GLI3 HGNC ACTIVATION CDTYPE:CATALYSIS YWHAB YWHAB 21233202 pubmed 16243507 pubmed Forskolin Forskolin KIF7_at_Cytoplasm KIF7_at_Cytoplasm Clathrin_mediated_endocytosis Clathrin_mediated_endocytosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. AP2_sigma___at_Cytoplasm AP2_sigma___at_Cytoplasm ULK3 ULK3 ULK3_at_Cytoplasm ULK3_at_Cytoplasm RPS6KB2 HGNC KIF7 KIF7 AP2_beta__at_Cytoplasm AP2_beta__at_Cytoplasm AP2_mu___at_Cytoplasm AP2_mu___at_Cytoplasm AP2_alpha__at_Cytoplasm AP2_alpha__at_Cytoplasm TEAD4 HGNC 19020754 pubmed GLI3_190__KIF7_SUFU_ULK3 GLI3_190__KIF7_SUFU_ULK3 GLI2_185__at_Cytoplasm GLI2_185__at_Cytoplasm SUFU_at_Cytoplasm SUFU_at_Cytoplasm GLI2_185 GLI2_185 GLI3_190 GLI3_190 GATADB HGNC 20679392 pubmed 23343194 pubmed ACTB HGNC 18199536 pubmed BCL9 BCL9 FOXA2 FOXA2 SUFU SUFU NFATC1 HGNC NFATC2 HGNC ULK3_at_Cytoplasm ULK3_at_Cytoplasm SUFU_at_Cytoplasm SUFU_at_Cytoplasm GLI2_185__S385_pho_S1011_pho_at_Cytoplasm GLI2_185__S385_pho_S1011_pho_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS FZD3 FZD3 ACTIVATION CDTYPE:CATALYSIS 18813803 pubmed 18381890 pubmed 15688063 pubmed RNF7 HGNC GLI2_185__SUFU_ULK3 GLI2_185__SUFU_ULK3 CSKN2B HGNC TUBA3E HGNC TUBA3C HGNC TUBA3D HGNC Caspase9 Caspase9 19996169 pubmed 12944472 pubmed WNT1 HGNC WNT3 HGNC TUBA4A HGNC ACTIVATION CDTYPE:CATALYSIS DAB1 HGNC 19398556 pubmed MMP1 MMP1 TGFB1 TGFB1 MIR34C MIR34C TUBA1C HGNC DAB2 HGNC TUBA1B HGNC TUBA1A HGNC GPC3 GPC3 CDKN1B HGNC DYRK DYRK SPRY1 HGNC p15INK4B p15INK4B MIR204 MIR204 18588945 pubmed RPS6KB1 HGNC CDC20 CDC20 TRAIL TRAIL HAUSP HAUSP NDUFA6 HGNC p300 p300 PTCH2 HGNC SGK1 HGNC PTCH1 HGNC 17318175 pubmed BCL2 BCL2 GLI2_78_sub_TRUNC_endsub GLI2_78_sub_TRUNC_endsub RPS6KA2 HGNC 20851997 pubmed PKC PKC MIR29B*2 HGNC MIR29B*1 HGNC M7GTP M7GTP p21CIP1 p21CIP1 19339977 pubmed Ca2 Ca2 19615955 pubmed APC HGNC CDKN2D HGNC 19244247 pubmed F2 HGNC ACTIVATION CDTYPE:CATALYSIS WNT5A WNT5A TXN TXN Tubulin__alpha Tubulin__alpha PLA2G4A PLA2G4A PR55_alpha PR55_alpha PCAF PCAF DVL1 DVL1 PKA_R PKA_R 10385121 pubmed DACT1 HGNC 21490931 pubmed KRM KRM KIF7 HGNC TCF4 TCF4 22094462 pubmed SNAI1 HGNC JUNB HGNC TRAF2 HGNC IL17RD HGNC MCL1 HGNC PARP PARP DVL1 DVL1 PtdIns_4_5__P2 PtdIns_4_5__P2 FGF2 FGF2 16651270 pubmed IRAK1 IRAK1 LEF1 HGNC ECM_proteins ECM_proteins 17052453 pubmed ULK1 ULK1 18775330 pubmed 17306568 pubmed BCL2L1 HGNC PIAS1 HGNC DVL__pho_emp_emp_at_Cytoplasm DVL__pho_emp_emp_at_Cytoplasm Adenylyl_cyclase Adenylyl_cyclase LRP6 LRP6 CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm Caspase8_sub_TRUNC_endsub Caspase8_sub_TRUNC_endsub ACTIVATION CDTYPE:CATALYSIS RAC1_at_Endosome RAC1_at_Endosome _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm UBE2B HGNC UBE2A HGNC FZD__at_Endosome FZD__at_Endosome FOXO3_pho_pho_pho_at_Nucleus FOXO3_pho_pho_pho_at_Nucleus FOXO3 FOXO3 UBE2H HGNC UBE2I HGNC id_14_3_3 id_14_3_3 UBE2C HGNC id_14_3_3__FOXO3 id_14_3_3__FOXO3 id_14_3_3 id_14_3_3 id_14_3_3__FOXO3 id_14_3_3__FOXO3 UBE2O HGNC id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm id_14_3_3__at_Nucleus id_14_3_3__at_Nucleus CCND1 HGNC 17329932 pubmed FOXO3_pho_pho_pho_at_Nucleus FOXO3_pho_pho_pho_at_Nucleus CCND2 HGNC UBE2K HGNC 21383238 pubmed UBE2M HGNC IL1R2 IL1R2 UBE2N HGNC UBE2Z HGNC VANGL__at_Cytoplasm VANGL__at_Cytoplasm SYN4__at_Cytoplasm SYN4__at_Cytoplasm CTHRC1_at_Cytoplasm CTHRC1_at_Cytoplasm WNT__at_Cytoplasm WNT__at_Cytoplasm STIL HGNC ROR2_at_Cytoplasm ROR2_at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm CCND3 HGNC UBE2S HGNC PLCG1 PLCG1 SIX3 HGNC SMURF1_at_Cytoplasm SMURF1_at_Cytoplasm PAR6__at_Cytoplasm PAR6__at_Cytoplasm PRICKLE1_pho_ubi_at_Cytoplasm PRICKLE1_pho_ubi_at_Cytoplasm RACK1__at_Cytoplasm RACK1__at_Cytoplasm 22088220 pubmed ACTIVATION CDTYPE:UNKNOWN_CATALYSIS FOXO3_pho_pho_pho_at_Cytoplasm FOXO3_pho_pho_pho_at_Cytoplasm BBC3 BBC3 BBC3 BBC3 FASL FASL FASL FASL TRAIL TRAIL TRAIL TRAIL PTEN PTEN PTEN PTEN AMER1 AMER1 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS 22699938 pubmed HUWE1 HGNC WNT__at_Endosome WNT__at_Endosome ROR2_at_Endosome ROR2_at_Endosome CTHRC1_at_Endosome CTHRC1_at_Endosome CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome SYN4__at_Endosome SYN4__at_Endosome RACK1__at_Endosome RACK1__at_Endosome VANGL__at_Endosome VANGL__at_Endosome ARC ARC PAR6__at_Endosome PAR6__at_Endosome 20976471 pubmed CTHRC1_at_Endosome CTHRC1_at_Endosome CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome WNT__at_Endosome WNT__at_Endosome ROR2_at_Endosome ROR2_at_Endosome PPP2R2A HGNC RACK1__at_Endosome RACK1__at_Endosome VANGL__at_Endosome VANGL__at_Endosome _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome SYN4__at_Endosome SYN4__at_Endosome p110 p110 SOS SOS AXIN2 AXIN2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRR__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRR__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 PAR6__at_Endosome PAR6__at_Endosome promoter_binding_site promoter_binding_site RPS6KA4 HGNC RPS6KA5 HGNC BCL2L11 BCL2L11 BCL2L11 BCL2L11 SGK1 SGK1 CASP9 HGNC gpromoter_region_at_Nucleus gpromoter_region_at_Nucleus gpromoter_region_at_Nucleus gpromoter_region_at_Nucleus FOXO3_pho_at_Nucleus FOXO3_pho_at_Nucleus FZD__at_Endosome FZD__at_Endosome gpromoter_region_at_Nucleus gpromoter_region_at_Nucleus DVL DVL DVL__pho_emp_emp_at_Cytoplasm DVL__pho_emp_emp_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS PI3_4_5_P3 PI3_4_5_P3 DVL__pho_emp_emp_at_Cytoplasm DVL__pho_emp_emp_at_Cytoplasm DVL__pho_emp_emp_at_Cytoplasm DVL__pho_emp_emp_at_Cytoplasm FZD8 HGNC DVL__pho_emp_emp_at_Cytoplasm DVL__pho_emp_emp_at_Cytoplasm PRICKLE1_pho_at_Cytoplasm PRICKLE1_pho_at_Cytoplasm PAR6__at_Cytoplasm PAR6__at_Cytoplasm 19575820 pubmed TNKS1 TNKS1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS TULP3 HGNC Calpastatin Calpastatin CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRR__RAC1_RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRR__RAC1_RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 14612448 pubmed DVL__pho_emp_emp_at_Endosome DVL__pho_emp_emp_at_Endosome ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS VANGL__at_Endosome VANGL__at_Endosome RACK1__at_Endosome RACK1__at_Endosome ACTIVATION CDTYPE:CATALYSIS PAR6__at_Endosome PAR6__at_Endosome ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 12839624 pubmed 15388793 pubmed ROR2_at_Endosome ROR2_at_Endosome WNT__at_Endosome WNT__at_Endosome FZD__at_Endosome FZD__at_Endosome 8655584 pubmed CDTYPE:PHYSICAL_STIMULATION CTHRC1_at_Endosome CTHRC1_at_Endosome SYN4__at_Endosome SYN4__at_Endosome DVL__pho_emp_emp_at_Cytoplasm DVL__pho_emp_emp_at_Cytoplasm VANGL__emp_emp_emp_emp_at_Cytoplasm VANGL__emp_emp_emp_emp_at_Cytoplasm ROR2_S864_emp_emp_emp_at_Cytoplasm ROR2_S864_emp_emp_emp_at_Cytoplasm 10837139 pubmed NUMB NUMB 19440234 pubmed GLI1 GLI1 SUFU SUFU TCF4 HGNC E3 E3 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:CATALYSIS E2 E2 ITCH_at_Cytoplasm ITCH_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS 12107820 pubmed ACTIVATION CDTYPE:UNKNOWN_CATALYSIS YEATS4 HGNC NUMB_at_Cytoplasm NUMB_at_Cytoplasm GLI1 GLI1 SUFU_at_Cytoplasm SUFU_at_Cytoplasm NUMB NUMB ITCH ITCH GLI1 GLI1 ITCH_NUMB ITCH_NUMB ULK3_at_Cytoplasm ULK3_at_Cytoplasm SUFU_at_Cytoplasm SUFU_at_Cytoplasm IMP IMP MAP3K1 HGNC EB1 EB1 ACTIVATION CDTYPE:CATALYSIS GLI3_190 GLI3_190 ULK3_at_Cytoplasm ULK3_at_Cytoplasm SUFU_at_Cytoplasm SUFU_at_Cytoplasm PTCH__at_Primary_Cilium PTCH__at_Primary_Cilium CyclinB__PTCH CyclinB__PTCH CyclinB__at_Primary_Cilium CyclinB__at_Primary_Cilium CyclinB CyclinB CyclinB CyclinB G2_M_phase_arrest G2_M_phase_arrest This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. TLE6 HGNC Proliferation Proliferation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. TLE4 HGNC TLE3 HGNC TLE1 HGNC TLE2 HGNC GPC3_at_Endosome GPC3_at_Endosome GPC3_HH_Ligand GPC3_HH_Ligand ACTIVATION CDTYPE:CATALYSIS GPC3_at_Primary_Cilium GPC3_at_Primary_Cilium HH_Ligand_at_Primary_Cilium HH_Ligand_at_Primary_Cilium 15187187 pubmed Caspase3_sub_TRUNC_endsub Caspase3_sub_TRUNC_endsub ULK3_at_Cytoplasm ULK3_at_Cytoplasm RCAN RCAN HH_Ligand_at_Endosome HH_Ligand_at_Endosome ATP6V0D1 HGNC RGS19 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS GLI2_185 GLI2_185 ACTIVATION CDTYPE:CATALYSIS GLI2_185 GLI2_185 ACTIVATION CDTYPE:CATALYSIS GLI3_190 GLI3_190 ITGA3 HGNC GPC3 GPC3 HHIP1_at_Primary_Cilium HHIP1_at_Primary_Cilium GPC3_HH_Ligand GPC3_HH_Ligand HHIP1 HHIP1 ATP6V0D2 HGNC GLI3_190 GLI3_190 HH_Ligand_HHIP1 HH_Ligand_HHIP1 20370576 pubmed HH_Ligand_at_Primary_Cilium HH_Ligand_at_Primary_Cilium FASLG HGNC FOS HGNC AOS1__UBA2 AOS1__UBA2 KIF7_at_Primary_Cilium KIF7_at_Primary_Cilium ULK3_at_Primary_Cilium ULK3_at_Primary_Cilium UBC9 UBC9 MIR374A MIR374A PIAS1 PIAS1 UBA2_at_Primary_Cilium UBA2_at_Primary_Cilium AOS1__at_Primary_Cilium AOS1__at_Primary_Cilium FOXO1 FOXO1 GLI2_185__at_Primary_Cilium GLI2_185__at_Primary_Cilium SUFU_at_Primary_Cilium SUFU_at_Primary_Cilium MED13 MED13 GLI2_185 GLI2_185 DYRK DYRK MAP3K10 MAP3K10 PTCH__at_Primary_Cilium PTCH__at_Primary_Cilium HH_Ligand_at_Primary_Cilium HH_Ligand_at_Primary_Cilium GLI3_190__S849_emp_at_Primary_Cilium GLI3_190__S849_emp_at_Primary_Cilium SUFU_at_Primary_Cilium SUFU_at_Primary_Cilium KIF7_at_Primary_Cilium KIF7_at_Primary_Cilium MINK1 MINK1 DYRK DYRK MLL2 MLL2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRR__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRR__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 ULK3_at_Primary_Cilium ULK3_at_Primary_Cilium DVL__pho_emp_emp_at_Endosome DVL__pho_emp_emp_at_Endosome 18372248 pubmed FZD__at_Cytoplasm FZD__at_Cytoplasm ROR2_at_Cytoplasm ROR2_at_Cytoplasm 22898821 pubmed ARRB1 HGNC DVL__pho_pho_pho_at_Endosome DVL__pho_pho_pho_at_Endosome ARRB2 HGNC RSPO3 RSPO3 RSPO3_at_Endosome RSPO3_at_Endosome GLI2_185__S792_pho_S808_pho_S820_pho_S850_pho_S801_pho_S813_pho_S844_pho_pho_S385_pho_S1011_pho_at_Cytoplasm GLI2_185__S792_pho_S808_pho_S820_pho_S850_pho_S801_pho_S813_pho_S844_pho_pho_S385_pho_S1011_pho_at_Cytoplasm GLI2_185__SUFU_ULK3 GLI2_185__SUFU_ULK3 HDAC2 HGNC HDAC1 HGNC 23306204 pubmed FZD4 FZD4 FOXO3 FOXO3 11313945 pubmed H2AFZ HGNC 21614932 pubmed HDAC5 HGNC HDAC6 HGNC HDAC3 HGNC HDAC4 HGNC HDAC7 HGNC GLI2_185__S792_pho_S808_pho_S820_pho_S850_pho_S801_pho_S813_pho_S844_pho_pho_ubi_ubi_S385_pho_S1011_pho_at_Cytoplasm GLI2_185__S792_pho_S808_pho_S820_pho_S850_pho_S801_pho_S813_pho_S844_pho_pho_ubi_ubi_S385_pho_S1011_pho_at_Cytoplasm FOXM1 FOXM1 HDAC8 HGNC GLI2_185 GLI2_185 GLI2_185__SUFU_ULK3 GLI2_185__SUFU_ULK3 UBE2D1 HGNC GLI2_185__S789_pho_S805_pho_S817_pho_S847_pho_S792_pho_S808_pho_S820_pho_S850_pho_S801_pho_S813_pho_S844_pho_pho_at_Cytoplasm GLI2_185__S789_pho_S805_pho_S817_pho_S847_pho_S792_pho_S808_pho_S820_pho_S850_pho_S801_pho_S813_pho_S844_pho_pho_at_Cytoplasm UBE2D2 HGNC GLI2_185__S789_pho_S805_pho_S817_pho_S847_pho_S792_pho_S808_pho_S820_pho_S850_pho_S801_pho_S813_pho_S844_pho_pho_ubi_ubi_at_Cytoplasm GLI2_185__S789_pho_S805_pho_S817_pho_S847_pho_S792_pho_S808_pho_S820_pho_S850_pho_S801_pho_S813_pho_S844_pho_pho_ubi_ubi_at_Cytoplasm UBE2D3 HGNC GLI2_185 GLI2_185 PAX9 PAX9 17244647 pubmed 18974774 pubmed SKAR SKAR PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm AMER1__CK1_gamma___PtdIns AMER1__CK1_gamma___PtdIns AMER1__at_Vaceolae AMER1__at_Vaceolae CK1_gamma___at_Cytoplasm CK1_gamma___at_Cytoplasm AMER1__at_Cytoplasm AMER1__at_Cytoplasm HBEGF HGNC MAP3K10 HGNC MAP3K11 HGNC 20194509 pubmed 23308069 pubmed CUL1_RBX1_SKP1__beta_TRCP CUL1_RBX1_SKP1__beta_TRCP 15901767 pubmed 19641503 pubmed ARC HGNC 19641508 pubmed 15371335 pubmed GLI3 HGNC EP400 HGNC ATP6V0C_D ATP6V0C_D MIR23B HGNC TACE TACE H H ATP6V0C_D ATP6V0C_D 16878133 pubmed H H Reptin Reptin TGFBR2 HGNC MED13 HGNC CDK4_6 CDK4_6 DUSP6 HGNC GATAD2A_B__at_Nucleus GATAD2A_B__at_Nucleus HDAC1_2__at_Nucleus HDAC1_2__at_Nucleus RBBP4_7__at_Nucleus RBBP4_7__at_Nucleus MBD2_3__at_Nucleus MBD2_3__at_Nucleus _CK2 _CK2 CHD3_4__at_Nucleus CHD3_4__at_Nucleus MTA1_2_3__at_Nucleus MTA1_2_3__at_Nucleus MSH6 HGNC ACTIVATION CDTYPE:CATALYSIS ATP6V0C_D ATP6V0C_D ACTIVATION CDTYPE:CATALYSIS 10862767 pubmed ACTIVATION CDTYPE:CATALYSIS PPP2R5A HGNC 11554450 pubmed BID BID MTOR_S2481_pho_at_Lipid_Raft MTOR_S2481_pho_at_Lipid_Raft MTOR_S2481_pho_at_Lipid_Raft MTOR_S2481_pho_at_Lipid_Raft MTOR_S2481_pho_at_Lipid_Raft MTOR_S2481_pho_at_Lipid_Raft TGF_beta TGF_beta CRIPTO_1 CRIPTO_1 AMER1__at_Cytoplasm AMER1__at_Cytoplasm RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Cytoplasm RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Cytoplasm MLST8_at_Cytoplasm MLST8_at_Cytoplasm TLE1 HGNC MTOR_S2481_pho_at_Lipid_Raft MTOR_S2481_pho_at_Lipid_Raft 12851486 pubmed AKT1 HGNC 12063245 pubmed HES1 HES1 16446366 pubmed AMER1 AMER1 AMER1__PtdIns AMER1__PtdIns E1 E1 JUN_promoter_region JUN_promoter_region MIR20A MIR20A gpromoter_region gpromoter_region WNT3 HGNC HECW2 HGNC HECW1 HGNC IL1R2 IL1R2 MAPK_pathway MAPK_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 18931698 pubmed NF__kappa_B_pathway NF__kappa_B_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CDC34 CDC34 19055941 pubmed ACTIVATION CDTYPE:CATALYSIS gpromoter_region gpromoter_region IL1R2 IL1R2 JNK_pathway JNK_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. JUN_S63_pho_S73_pho JUN_S63_pho_S73_pho JUN JUN JUN JUN 9779982 pubmed JUN JUN MSIN3 MSIN3 FU FU 19055944 pubmed MIR27A HGNC ACTIVATION CDTYPE:CATALYSIS GLI1_MSIN3__SAP18_SUFU_promoter_region GLI1_MSIN3__SAP18_SUFU_promoter_region gpromoter_region gpromoter_region GLI1_pho_pho GLI1_pho_pho SAP18 SAP18 SUFU SUFU G_beta G_beta MIR92A1 MIR92A1 SNAI1 SNAI1 SUFU SUFU SUFU SUFU GNAI1 HGNC SAP18 SAP18 GNAI2 HGNC MSIN3 MSIN3 PPP3CA HGNC PPP3CC HGNC 10999941 pubmed PPP3CB HGNC 21157483 pubmed _AP2_complex _AP2_complex _Fzl_GPCR _Fzl_GPCR HIP1 HIP1 MYCN MYCN _LRP6_phosph_G_protein _LRP6_phosph_G_protein GLI2_185 GLI2_185 _G_alpha_s _G_alpha_s HIP1 HIP1 _G_protein_LRP6 _G_protein_LRP6 _G_protein_LRP6 _G_protein_LRP6 _GPCR _GPCR MYCN MYCN _GPCR _GPCR SNAI1 SNAI1 ACTL6A HGNC HDAC1 HDAC1 GPS2 HGNC GPS1 HGNC CUL3 CUL3 REN REN _GPCR _GPCR 17444818 pubmed 15526030 pubmed id_14_3_3__GLI2_185 id_14_3_3__GLI2_185 id_14_3_3 id_14_3_3 GLI2_185__pho_unk_S956_pho_active GLI2_185__pho_unk_S956_pho_active GAB1 GAB1 HDAC1 HDAC1 HAT HAT CUL3_REN CUL3_REN FOXP3 FOXP3 id_14_3_3 id_14_3_3 id_14_3_3__GLI3_190 id_14_3_3__GLI3_190 GLI1 GLI1 GLI3_190__unk_pho_active GLI3_190__unk_pho_active 20460648 pubmed 12050133 pubmed GLI1 GLI1 GLI3_190 GLI3_190 GLI3_190 GLI3_190 GLI2_185 GLI2_185 GLI2_185 GLI2_185 GLI1_S640_pho GLI1_S640_pho id_14_3_3 id_14_3_3 id_14_3_3__GLI1 id_14_3_3__GLI1 id_14_3_3 id_14_3_3 PKA PKA MYCN HGNC 18285450 pubmed ACTIVATION CDTYPE:CATALYSIS CUL1_at_Cytoplasm CUL1_at_Cytoplasm SKP1_at_Cytoplasm SKP1_at_Cytoplasm RBX1_at_Cytoplasm RBX1_at_Cytoplasm 16740475 pubmed _beta_TRCP__at_Cytoplasm _beta_TRCP__at_Cytoplasm PtdIns PtdIns YWHAB_at_Cytoplasm YWHAB_at_Cytoplasm PDPK1 HGNC RIPK4 HGNC 11516665 pubmed INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS NRON NRON ACTIVATION CDTYPE:CATALYSIS PPP1R2 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS B56_alpha B56_alpha ACTIVATION CDTYPE:CATALYSIS MAP3K7 HGNC ACTIVATION CDTYPE:CATALYSIS PTCH1 PTCH1 STAT3 HGNC PPP1R7 HGNC PPP1R8 HGNC p21CIP1 p21CIP1 ACTIVATION CDTYPE:CATALYSIS 19143635 pubmed INHIBITION CDTYPE:INHIBITION GLI3 HGNC ACTIVATION CDTYPE:CATALYSIS MIR31 HGNC G_beta__sub_i_endsub G_beta__sub_i_endsub LEF_TCF__at_Nucleus LEF_TCF__at_Nucleus _beta__Catenin__ace_at_Nucleus _beta__Catenin__ace_at_Nucleus PYGO__at_Nucleus PYGO__at_Nucleus BCL9_at_Nucleus BCL9_at_Nucleus KLF4_at_Nucleus KLF4_at_Nucleus PTCH2 HGNC PTCH1 HGNC 19218564 pubmed 16402909 pubmed GLI2 HGNC 19619488 pubmed Chromatin_remodeling Chromatin_remodeling This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. INHIBITION CDTYPE:INHIBITION CTBP__at_Nucleus CTBP__at_Nucleus gWRE__at_Nucleus gWRE__at_Nucleus BCL9_CTBP__KLF4_LEF_TCF__PYGO__WRE___beta__Catenin BCL9_CTBP__KLF4_LEF_TCF__PYGO__WRE___beta__Catenin ACTIVATION CDTYPE:CATALYSIS TBX2 TBX2 STAT1 STAT1 TMEM198 TMEM198 GNAI3 HGNC PAX9 HGNC BTRC HGNC TP53 HGNC CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS Cytochrome_C Cytochrome_C 19685005 pubmed 17693255 pubmed 16611981 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 20145151 pubmed 15140942 pubmed 15314020 pubmed DKK3 HGNC 18299389 pubmed JUN JUN PINK1 HGNC CDKN1B HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS YL1 YL1 PP2A_A PP2A_A RIPK1 RIPK1 DKK1 DKK1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 19029934 pubmed ACTIVATION CDTYPE:CATALYSIS KLF4 KLF4 17430994 pubmed ACTIVATION CDTYPE:CATALYSIS KLF4 KLF4 ACTIVATION CDTYPE:CATALYSIS KLF8 KLF8 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 21908588 pubmed FBXW11 HGNC ACTIVATION CDTYPE:CATALYSIS PRKCA PRKCA ACTIVATION CDTYPE:CATALYSIS PIP5KI_beta PIP5KI_beta PDPK1 PDPK1 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS 15649893 pubmed id_14_3_3 id_14_3_3 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS TDGF1 HGNC TGFBR2 TGFBR2 20514436 pubmed BCL9_at_Nucleus BCL9_at_Nucleus SKP SKP 21316585 pubmed KLF8_at_Nucleus KLF8_at_Nucleus p300__at_Nucleus p300__at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus BCL9_KLF8_PYGO___beta__Catenin__p300 BCL9_KLF8_PYGO___beta__Catenin__p300 ACTIVATION CDTYPE:CATALYSIS 19893571 pubmed PI3_4_5_P3_at_Lipid_Raft PI3_4_5_P3_at_Lipid_Raft PYGO__at_Nucleus PYGO__at_Nucleus AKT1_T308_pho_T450_pho_S473_pho_active_at_Lipid_Raft AKT1_T308_pho_T450_pho_S473_pho_active_at_Lipid_Raft PRKCA PRKCA MTOR_at_Cytoplasm MTOR_at_Cytoplasm MAPKAP1_at_Cytoplasm MAPKAP1_at_Cytoplasm id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm MLST8_at_Cytoplasm MLST8_at_Cytoplasm PROTOR__at_Cytoplasm PROTOR__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS RICTOR_at_Cytoplasm RICTOR_at_Cytoplasm 18460397 pubmed 10581160 pubmed CTBP__p300 CTBP__p300 APC__beta__Catenin APC__beta__Catenin MIR373 HGNC 20699474 pubmed CASR CASR GLI2_78_sub_TRUNC_endsub GLI2_78_sub_TRUNC_endsub PROTOR__at_Cytoplasm PROTOR__at_Cytoplasm GLI3_83_sub_TRUNC_endsub GLI3_83_sub_TRUNC_endsub RICTOR_T1135_pho_at_Cytoplasm RICTOR_T1135_pho_at_Cytoplasm MLST8_at_Cytoplasm MLST8_at_Cytoplasm PRR5 HGNC INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS CDK1 HGNC MTOR_at_Cytoplasm MTOR_at_Cytoplasm MAPKAP1_at_Cytoplasm MAPKAP1_at_Cytoplasm IKK_beta IKK_beta SYN4 SYN4 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CDTYPE:MODULATION _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS 20457807 pubmed ACTIVATION CDTYPE:CATALYSIS p300__at_Nucleus p300__at_Nucleus CTBP__at_Nucleus CTBP__at_Nucleus CTBP__at_Nucleus CTBP__at_Nucleus _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome CDK8 CDK8 _beta__Catenin__K345_ace_ace_at_Cytoplasm _beta__Catenin__K345_ace_ace_at_Cytoplasm APC_T1487_pho_at_Cytoplasm APC_T1487_pho_at_Cytoplasm APC__beta__Catenin APC__beta__Catenin CTBP__HDAC1_2__LEF_TCF__WRE CTBP__HDAC1_2__LEF_TCF__WRE gWRE__at_Nucleus gWRE__at_Nucleus LEF_TCF__at_Nucleus LEF_TCF__at_Nucleus SIX1 SIX1 HDAC1_2__at_Nucleus HDAC1_2__at_Nucleus TSC1 TSC1 ACTIVATION CDTYPE:CATALYSIS TSC1 TSC1 FBW5 FBW5 ACTIVATION CDTYPE:CATALYSIS id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm TSC2_S981_pho_S1130_pho_T1462_pho_S1132_pho_S939_pho_S1088_pho_S1086_pho_at_Endosome_Membrane TSC2_S981_pho_S1130_pho_T1462_pho_S1132_pho_S939_pho_S1088_pho_S1086_pho_at_Endosome_Membrane id_14_3_3__TSC2 id_14_3_3__TSC2 ACTIVATION CDTYPE:CATALYSIS CDK1 CDK1 21195116 pubmed CTBP__KLF8 CTBP__KLF8 CTBP__at_Nucleus CTBP__at_Nucleus 12782630 pubmed KLF8_K67_unk_at_Nucleus KLF8_K67_unk_at_Nucleus id_14_3_3__TSC2 id_14_3_3__TSC2 INHIBITION CDTYPE:INHIBITION E_Cadherin E_Cadherin E_Cadherin E_Cadherin MMP9 MMP9 INHIBITION CDTYPE:INHIBITION MMP9 MMP9 PRKAR1A HGNC BCL9_at_Nucleus BCL9_at_Nucleus PRKAR1B HGNC id_14_3_3__at_Endosome_Membrane id_14_3_3__at_Endosome_Membrane FOS HGNC 20338997 pubmed 14664696 pubmed 16371461 pubmed TSC2_S981_pho_S1130_pho_T1462_pho_S1132_pho_S939_pho_S1088_pho_S1086_pho_at_Endosome_Membrane TSC2_S981_pho_S1130_pho_T1462_pho_S1132_pho_S939_pho_S1088_pho_S1086_pho_at_Endosome_Membrane TSC2_S981_pho_S1130_pho_T1462_pho_S1132_pho_S939_pho_S1088_pho_S1086_pho_at_Cytoplasm TSC2_S981_pho_S1130_pho_T1462_pho_S1132_pho_S939_pho_S1088_pho_S1086_pho_at_Cytoplasm TSC2 TSC2 ACTIVATION CDTYPE:CATALYSIS NARF HGNC PYGO__at_Nucleus PYGO__at_Nucleus ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS KLF8_K67_ace_K93_ace_K95_ace_at_Nucleus KLF8_K67_ace_K93_ace_K95_ace_at_Nucleus gWRE__at_Nucleus gWRE__at_Nucleus ACTIVATION CDTYPE:CATALYSIS _beta__Catenin__K345_ace_ace_at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus p300__at_Nucleus p300__at_Nucleus Differentiation Differentiation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. GLI3_190__S849_pho_S907_pho_S865_pho_S877_pho_S1006_pho_S980_pho_at_Cytoplasm GLI3_190__S849_pho_S907_pho_S865_pho_S877_pho_S1006_pho_S980_pho_at_Cytoplasm Genes_under_control_of__br_CBP_mediated_transcription Genes_under_control_of__br_CBP_mediated_transcription LEF_TCF__at_Nucleus LEF_TCF__at_Nucleus BCL9_KLF8_LEF_TCF__PYGO__WRE___beta__Catenin__p300 BCL9_KLF8_LEF_TCF__PYGO__WRE___beta__Catenin__p300 ACTIVATION CDTYPE:CATALYSIS CALM2 HGNC CALM3 HGNC CDC34 HGNC Stem_cell_progenitor_cell_maintenance_and_proliferation Stem_cell_progenitor_cell_maintenance_and_proliferation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CALM1 HGNC FOXQ1 HGNC RBX1_at_Cytoplasm RBX1_at_Cytoplasm CUL1_at_Cytoplasm CUL1_at_Cytoplasm SKP1_at_Cytoplasm SKP1_at_Cytoplasm PHLPP PHLPP ACTIVATION CDTYPE:CATALYSIS PHLPP PHLPP E1 E1 E2 E2 ACTIVATION CDTYPE:CATALYSIS SMAD1 SMAD1 ACTIVATION CDTYPE:CATALYSIS CDTYPE:BOOLEAN_LOGIC_GATE_AND p300__at_Nucleus p300__at_Nucleus KLF8_K67_ace_K93_ace_K95_ace_at_Nucleus KLF8_K67_ace_K93_ace_K95_ace_at_Nucleus CyclinD CyclinD 18423201 pubmed CyclinD CyclinD BCL9_KLF8_PYGO___beta__Catenin__p300 BCL9_KLF8_PYGO___beta__Catenin__p300 ACTIVATION CDTYPE:CATALYSIS 19072724 pubmed BCL9_at_Nucleus BCL9_at_Nucleus PYGO__at_Nucleus PYGO__at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus PHLPP PHLPP PHLPP PHLPP _beta_TRCP__at_Cytoplasm _beta_TRCP__at_Cytoplasm CDTYPE:BOOLEAN_LOGIC_GATE_AND PHLPP PHLPP ACTIVATION CDTYPE:CATALYSIS 8545107 pubmed AXIN1 AXIN1 EIF3M HGNC 16697215 pubmed AXIN1 AXIN1 CDTYPE:BOOLEAN_LOGIC_GATE_OR ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS IQGAP IQGAP EIF3F HGNC EIF3E HGNC EIF3H HGNC PRKAR2B HGNC PIAS1 PIAS1 EIF3G HGNC EIF3J HGNC KLF8_at_Nucleus KLF8_at_Nucleus EIF3I HGNC PRKAR2A HGNC CTBP__at_Nucleus CTBP__at_Nucleus EIF3L HGNC EIF3K HGNC CTBP__KLF8 CTBP__KLF8 PTEN PTEN EIF3A HGNC EIF3B HGNC CCNC HGNC EIF3C HGNC EIF3D HGNC GAB1_Y977_pho_Y989_pho_at_Lipid_Raft GAB1_Y977_pho_Y989_pho_at_Lipid_Raft ACTIVATION CDTYPE:CATALYSIS PKC PKC ACTIVATION CDTYPE:CATALYSIS GAB1 GAB1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 15173823 pubmed DVL__G_beta___G_gamma____beta__Arrestin2 DVL__G_beta___G_gamma____beta__Arrestin2 TRADD HGNC G_beta___at_Endosome G_beta___at_Endosome PAM PAM GSK3__at_Endosome GSK3__at_Endosome CK1_alpha___at_Endosome CK1_alpha___at_Endosome G_alpha_o__at_Endosome G_alpha_o__at_Endosome AXIN__at_Endosome AXIN__at_Endosome FZD__at_Endosome FZD__at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome _Signalosome _Signalosome APC_at_Cytoplasm APC_at_Cytoplasm WNT__at_Endosome WNT__at_Endosome CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm AMER1__at_Endosome AMER1__at_Endosome GSK3__at_Cytoplasm GSK3__at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_at_Cytoplasm DVL__pho_S139_emp_S142_emp_at_Cytoplasm DVL__pho_S139_emp_S142_emp_at_Cytoplasm APC_at_Cytoplasm APC_at_Cytoplasm MARK2 MARK2 _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2 _beta__Arrestin2 19352404 pubmed 12000790 pubmed DVL__pho_S139_pho_S142_pho_pho_at_Endosome DVL__pho_S139_pho_S142_pho_pho_at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_T1530_pho_S1533_pho_at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_T1530_pho_S1533_pho_at_Endosome 15121840 pubmed WNT2B WNT2B AMER1__at_Endosome AMER1__at_Endosome WNT__at_Endosome WNT__at_Endosome GNAS HGNC _Signalosome _Signalosome FZD__at_Endosome FZD__at_Endosome GSK3__at_Cytoplasm GSK3__at_Cytoplasm LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_T1530_pho_S1533_pho_at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_T1530_pho_S1533_pho_at_Endosome _beta__Catenin__S45_pho_at_Cytoplasm _beta__Catenin__S45_pho_at_Cytoplasm G_gamma___at_Endosome G_gamma___at_Endosome APC_at_Cytoplasm APC_at_Cytoplasm _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_gamma___at_Endosome CK1_gamma___at_Endosome _beta__Arrestin2__at_Vaceolae _beta__Arrestin2__at_Vaceolae GSK3__at_Cytoplasm GSK3__at_Cytoplasm _beta__Catenin__at_Cytoplasm _beta__Catenin__at_Cytoplasm 14567915 pubmed CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm MDM2 HGNC FZD1 FZD1 AMER1__at_Endosome AMER1__at_Endosome WNT__at_Endosome WNT__at_Endosome BCL9 BCL9 LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_T1530_pho_S1533_pho_at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_T1530_pho_S1533_pho_at_Endosome CK1_gamma___at_Endosome CK1_gamma___at_Endosome ATP6V0C_D ATP6V0C_D CK1_gamma___at_Endosome CK1_gamma___at_Endosome CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm NARF NARF GSK3__at_Cytoplasm GSK3__at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm 10582334 pubmed APC_S1505_pho_S1501_pho_at_Cytoplasm APC_S1505_pho_S1501_pho_at_Cytoplasm FZD__at_Endosome FZD__at_Endosome TGFBR1 HGNC _Signalosome _Signalosome WNT__at_Endosome WNT__at_Endosome AMER1__at_Endosome AMER1__at_Endosome CK2_alpha___at_Cytoplasm CK2_alpha___at_Cytoplasm G_beta___at_Vaceolae G_beta___at_Vaceolae CK2_alpha__CK2_alpha___CK2_beta CK2_alpha__CK2_alpha___CK2_beta CK2_beta___at_Cytoplasm CK2_beta___at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm G_gamma___at_Vaceolae G_gamma___at_Vaceolae APC_S1505_pho_at_Cytoplasm APC_S1505_pho_at_Cytoplasm GLI1 GLI1 KIF3A HGNC FOXO3 FOXO3 GSK3__at_Cytoplasm GSK3__at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm APC_at_Cytoplasm APC_at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm SFRP1 HGNC LRP5_6 LRP5_6 CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm ITCH ITCH ARRB2 HGNC ARRB1 HGNC _beta__Catenin__S45_pho_T41_pho_S37_pho_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_at_Cytoplasm ENOS ENOS ENOS ENOS Prosurvival Prosurvival This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. NO_production NO_production This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 20587515 pubmed Caspase9 Caspase9 Caspase9 Caspase9 ANAPC4 HGNC 19147008 pubmed _beta__Catenin _beta__Catenin 19356152 pubmed LRP6 HGNC Caspase9__sub_TRUNC_endsub Caspase9__sub_TRUNC_endsub Cytochrome_C__at_Cytoplasm Cytochrome_C__at_Cytoplasm APAF1_at_Cytoplasm APAF1_at_Cytoplasm dATP_ATP_at_Cytoplasm dATP_ATP_at_Cytoplasm RTK__pho_pho_hm2_at_Lipid_Raft RTK__pho_pho_hm2_at_Lipid_Raft RTK__pho_pho_hm2_at_Endosome RTK__pho_pho_hm2_at_Endosome 15071497 pubmed GF_RTK GF_RTK 19584721 pubmed HES1 HGNC GF_at_Lipid_Raft GF_at_Lipid_Raft RTK__pho_pho_hm2_at_Lipid_Raft RTK__pho_pho_hm2_at_Lipid_Raft PI3_4_5_P3_at_Lipid_Raft PI3_4_5_P3_at_Lipid_Raft GAB1_GF_GRB2_PI3_4_5_P3_RAS__RTK__SOS__p110__p85 GAB1_GF_GRB2_PI3_4_5_P3_RAS__RTK__SOS__p110__p85 GF_at_Lipid_Raft GF_at_Lipid_Raft RAS RAS p85__at_Lipid_Raft p85__at_Lipid_Raft GRB2_at_Lipid_Raft GRB2_at_Lipid_Raft ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS p110__at_Lipid_Raft p110__at_Lipid_Raft VANGL VANGL Calmodulin__at_Cytoplasm Calmodulin__at_Cytoplasm FOXL1 FOXL1 Calmodulin__at_Cytoplasm Calmodulin__at_Cytoplasm MYC HGNC 10021362 pubmed NFAT2 NFAT2 9585406 pubmed RTK__pho_pho_hm2_at_Lipid_Raft RTK__pho_pho_hm2_at_Lipid_Raft RTK__pho_pho_hm2_at_Endosome RTK__pho_pho_hm2_at_Endosome id_14_3_3__PRAS40 id_14_3_3__PRAS40 id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm SOS__at_Lipid_Raft SOS__at_Lipid_Raft RAS__at_Lipid_Raft RAS__at_Lipid_Raft Ubiquitination Ubiquitination This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. LEF_TCF LEF_TCF PRAS40__S183_pho_T246_pho_S212_pho_S221_pho_at_Cytoplasm PRAS40__S183_pho_T246_pho_S212_pho_S221_pho_at_Cytoplasm GSK3_alpha GSK3_alpha Calpain Calpain Calmodulin Calmodulin 15708980 pubmed Ca2__at_Cytoplasm Ca2__at_Cytoplasm Ca2__Calmodulin Ca2__Calmodulin 20307497 pubmed 12114545 pubmed NFAT5 HGNC GPCR GPCR ESR2 HGNC ESR1 HGNC MIR29B__PTEN MIR29B__PTEN 19623618 pubmed arMIR29B arMIR29B 22020335 pubmed 16636147 pubmed PTEN PTEN GSK3_alpha GSK3_alpha BCL2L11 BCL2L11 _beta__Arrestin__at_Cytoplasm _beta__Arrestin__at_Cytoplasm STAT3_pathway STAT3_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PTEN_pho_pho_pho_pho_active_at_Cytoplasm PTEN_pho_pho_pho_pho_active_at_Cytoplasm PLK1 HGNC PTEN__beta__Arrestin PTEN__beta__Arrestin ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS PLK4 HGNC PLK2 HGNC ACTIVATION CDTYPE:CATALYSIS PLK3 HGNC SKI SKI MIR29B MIR29B JUN_S63_pho_S73_pho JUN_S63_pho_S73_pho HDAC3 HDAC3 PP2B_C PP2B_C SMO SMO PTEN PTEN MIR378 MIR378 MIR29B MIR29B Microtubules Microtubules This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Cell_contraction Cell_contraction This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PIN1 HGNC RHOA_ROCK RHOA_ROCK RHOA_at_Cytoplasm RHOA_at_Cytoplasm rPTEN rPTEN ROCK__at_Cytoplasm ROCK__at_Cytoplasm TAB2 HGNC TAB1 HGNC ROCK ROCK TAB3 HGNC 11395409 pubmed 18036779 pubmed RPS6KA1 HGNC 15747065 pubmed BAK1_MIR29B BAK1_MIR29B DAAM1_at_Cytoplasm DAAM1_at_Cytoplasm arMIR29B arMIR29B arMIR29B arMIR29B rBBC3 rBBC3 CDK4 HGNC HRK_MIR29B HRK_MIR29B rHRK rHRK CDK6 HGNC arMIR29B arMIR29B BBC3_MIR29B BBC3_MIR29B 18193162 pubmed SYN4__at_Cytoplasm SYN4__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm VANGL__pho_pho_pho_pho_at_Cytoplasm VANGL__pho_pho_pho_pho_at_Cytoplasm RACK1__at_Cytoplasm RACK1__at_Cytoplasm rBAK1 rBAK1 ROR2_S864_pho_pho_pho_at_Cytoplasm ROR2_S864_pho_pho_pho_at_Cytoplasm MIR17_92 MIR17_92 PAR6__at_Cytoplasm PAR6__at_Cytoplasm RSPO3_at_Cytoplasm RSPO3_at_Cytoplasm WGEF__at_Cytoplasm WGEF__at_Cytoplasm CTHRC1_at_Cytoplasm CTHRC1_at_Cytoplasm 21177869 pubmed MIR17_5P MIR17_5P 18497536 pubmed 18347071 pubmed ACTIVATION CDTYPE:CATALYSIS rBCL2L11 rBCL2L11 arMIR29B arMIR29B BAK1 BAK1 APC2__at_Cytoplasm APC2__at_Cytoplasm BCL2L11_MIR29B BCL2L11_MIR29B GSK3__at_Cytoplasm GSK3__at_Cytoplasm HRK HRK BBC3 BBC3 MIR17 HGNC BMF BMF 15518237 pubmed PLCG1 HGNC RHOA_at_Cytoplasm RHOA_at_Cytoplasm 14551205 pubmed APC2__CK1_epsilon___CTHRC1_DAAM1_DVL__FZD__GSK3__PAR6__RACK1__ROR2_RSPO3_SYN4__VANGL__WGEF__WNT___beta__Arrestin2 APC2__CK1_epsilon___CTHRC1_DAAM1_DVL__FZD__GSK3__PAR6__RACK1__ROR2_RSPO3_SYN4__VANGL__WGEF__WNT___beta__Arrestin2 WGEF__at_Cytoplasm WGEF__at_Cytoplasm DAAM1_at_Cytoplasm DAAM1_at_Cytoplasm arMIR29B arMIR29B CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm DVL__pho_pho_pho_at_Cytoplasm DVL__pho_pho_pho_at_Cytoplasm BMF_MIR29B BMF_MIR29B FZD__at_Cytoplasm FZD__at_Cytoplasm rBMF rBMF WNT__at_Cytoplasm WNT__at_Cytoplasm FOXF1 HGNC CyclinC CyclinC Mediator Mediator MTA3 HGNC MED12 MED12 MTA2 HGNC CDK8 CDK8 MTA1 HGNC CBP__CDK8_Core_promoter__CyclinC__GLI3_190__MED12_MED13_Mediator__promoter_region CBP__CDK8_Core_promoter__CyclinC__GLI3_190__MED12_MED13_Mediator__promoter_region MED13 MED13 Mediator Mediator gCore_promoter gCore_promoter CDK4 HGNC gCore_promoter gCore_promoter CDK8_Core_promoter__CyclinC__MED12_MED13_Mediator CDK8_Core_promoter__CyclinC__MED12_MED13_Mediator FOXO1 HGNC SMAD4 HGNC MEF2B HGNC MEF2A HGNC MEF2D HGNC MEF2C HGNC arMIR378 arMIR378 rSUFU rSUFU MIR378_SUFU MIR378_SUFU arMIR378 arMIR378 rFUS rFUS FUS_MIR378 FUS_MIR378 PRKCA HGNC 11585828 pubmed DAG DAG PABPC1 HGNC MIR34A HGNC 19387550 pubmed GLI2_185 GLI2_185 KCASH3 KCASH3 22659456 pubmed MIR34B HGNC PABPC3 HGNC MIR34C HGNC CUL3_KCASH3 CUL3_KCASH3 CDKN2B HGNC CUL3 CUL3 CUL3 CUL3 KCASH3 KCASH3 KCASH2 KCASH2 _beta__Catenin _beta__Catenin CUL3_KCASH2 CUL3_KCASH2 MAPK_pathway MAPK_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 16880536 pubmed TAOK1 HGNC HDAC3 HDAC3 MSI1 HGNC SKI SKI CBP CBP KSR1 KSR1 CBP CBP 19641496 pubmed GLI3_190 GLI3_190 gpromoter_region gpromoter_region MED13 MED13 MED12 MED12 CUL4A HGNC GNB5 HGNC CDK8 CDK8 CUL4B HGNC GNB4 HGNC CyclinC CyclinC GNB3 HGNC GNB2 HGNC GNB1 HGNC 17060945 pubmed TAOK2 HGNC TAOK3 HGNC RGS3 RGS3 18359851 pubmed CSNK2A3 HGNC 20028971 pubmed CSNK2A2 HGNC CTBP CTBP DVL2 HGNC ACTIVATION CDTYPE:CATALYSIS CK1_delta CK1_delta ACTIVATION CDTYPE:CATALYSIS LEF_TCF LEF_TCF ACTIVATION CDTYPE:CATALYSIS TLE1 TLE1 BAX HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 21034673 pubmed 22274711 pubmed NDUFA6 NDUFA6 CTBP CTBP APC_at_Nucleus APC_at_Nucleus APC_CTBP APC_CTBP ARC HGNC ACTIVATION CDTYPE:CATALYSIS KAT2B HGNC GLI3_190__S849_pho_S868_pho_S907_pho_S873_pho_S852_pho_S865_pho_S877_pho_S903_pho_S860_pho_S880_pho_S910_pho_S1006_pho_S980_pho_at_Cytoplasm GLI3_190__S849_pho_S868_pho_S907_pho_S873_pho_S852_pho_S865_pho_S877_pho_S903_pho_S860_pho_S880_pho_S910_pho_S1006_pho_S980_pho_at_Cytoplasm CDC16 HGNC APC_at_Nucleus APC_at_Nucleus APC_CTBP__HDAC1_2 APC_CTBP__HDAC1_2 HDAC1_2__at_Nucleus HDAC1_2__at_Nucleus ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS KLF8 HGNC ACTIVATION CDTYPE:CATALYSIS EGFR EGFR FZD4 FZD4 DKK1 HGNC CDTYPE:MODULATION HDAC1_2__at_Nucleus HDAC1_2__at_Nucleus APC_CTBP__HDAC1_2 APC_CTBP__HDAC1_2 ACTIVATION CDTYPE:CATALYSIS CTBP__hm2_at_Nucleus CTBP__hm2_at_Nucleus CTBP__hm2_at_Nucleus CTBP__hm2_at_Nucleus CTBP__hm2_at_Nucleus CTBP__hm2_at_Nucleus APC_T1487_pho_at_Nucleus APC_T1487_pho_at_Nucleus 19449449 pubmed 15707890 pubmed FUS1 HGNC APC_T1487_pho_at_Nucleus APC_T1487_pho_at_Nucleus HHIP HGNC WRE WRE 21983832 pubmed 20081366 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS MI34 MI34 ACTIVATION CDTYPE:CATALYSIS PYGO__at_Nucleus PYGO__at_Nucleus 18218901 pubmed BCL9_at_Nucleus BCL9_at_Nucleus LEF_TCF__at_Nucleus LEF_TCF__at_Nucleus ACTIVATION CDTYPE:CATALYSIS _beta__Catenin__K345_ace_ace_at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus p300__at_Nucleus p300__at_Nucleus ACTIVATION CDTYPE:CATALYSIS gWRE__at_Nucleus gWRE__at_Nucleus CTBP__hm2_at_Nucleus CTBP__hm2_at_Nucleus CDTYPE:BOOLEAN_LOGIC_GATE_AND HDAC1_2__at_Nucleus HDAC1_2__at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus APC_T1487_pho_at_Nucleus APC_T1487_pho_at_Nucleus ACTIVATION CDTYPE:CATALYSIS ARC ARC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS TLE1 TLE1 PI3K_Akt_MTOR_pathway PI3K_Akt_MTOR_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PHLPP1 HGNC PHLPP2 HGNC 17113272 pubmed ACTIVATION CDTYPE:CATALYSIS S100A9 S100A9 S100A9 S100A9 ACTIVATION CDTYPE:CATALYSIS S100A7 S100A7 S100A7 S100A7 GLI1_pho_pho GLI1_pho_pho LEF_TCF LEF_TCF INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS GLI3_190__S849_pho_S868_pho_S907_pho_S873_pho_S852_pho_S865_pho_S877_pho_S903_pho_S860_pho_S880_pho_S910_pho_S1006_pho_S980_pho_ubi_ubi_ubi_ubi_at_Cytoplasm GLI3_190__S849_pho_S868_pho_S907_pho_S873_pho_S852_pho_S865_pho_S877_pho_S903_pho_S860_pho_S880_pho_S910_pho_S1006_pho_S980_pho_ubi_ubi_ubi_ubi_at_Cytoplasm JUN_S63_pho_S73_pho JUN_S63_pho_S73_pho CSNK1E HGNC gpromoter_region gpromoter_region CSNK1D HGNC 14652070 pubmed CDTYPE:TRIGGER ACTIVATION CDTYPE:CATALYSIS Autophagy Autophagy This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ULK1 ULK1 ULK1 ULK1 Transcription_regulation Transcription_regulation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ARC ARC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CDTYPE:MODULATION WNT11 WNT11 ACTIVATION CDTYPE:CATALYSIS PAX9 PAX9 PAX9 PAX9 2550447 pubmed 10788511 pubmed MIR34C HGNC 2126816 pubmed LEF_TCF___beta__Catenin__promoter_region LEF_TCF___beta__Catenin__promoter_region _beta__Catenin _beta__Catenin GLI3 GLI3 gpromoter_region gpromoter_region ACTIVATION CDTYPE:CATALYSIS MMP11 MMP11 ACTIVATION CDTYPE:CATALYSIS GLI3 GLI3 WNT11 WNT11 MMP11 MMP11 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 21330129 pubmed ACTIVATION CDTYPE:CATALYSIS 10454566 pubmed PRR PRR _beta__Catenin _beta__Catenin GLI3_83_sub_TRUNC_endsub____beta__Catenin GLI3_83_sub_TRUNC_endsub____beta__Catenin _beta__Catenin _beta__Catenin LEF_TCF LEF_TCF 16714285 pubmed SUFU SUFU MIR378 MIR378 GLI3_83_sub_TRUNC_endsub GLI3_83_sub_TRUNC_endsub AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm SMO_at_Cytoplasm SMO_at_Cytoplasm THBS1 HGNC GTP_G_alpha__sub_i_endsub___G_beta__sub_i_endsub___G_gamma__sub_i_endsub___HH_Ligand_PTCH__SMO GTP_G_alpha__sub_i_endsub___G_beta__sub_i_endsub___G_gamma__sub_i_endsub___HH_Ligand_PTCH__SMO 17035233 pubmed AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm MRGBP HGNC AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm MIR31 MIR31 id_14_3_3__BAD_BCL2_XL id_14_3_3__BAD_BCL2_XL BAD_S112_emp_S136_emp_at_Mitochondria BAD_S112_emp_S136_emp_at_Mitochondria CBL HGNC id_14_3_3 id_14_3_3 BAD_S112_pho_S136_pho_at_Mitochondria BAD_S112_pho_S136_pho_at_Mitochondria BAD_BCL2_XL BAD_BCL2_XL BCL2_XL__at_Mitochondria BCL2_XL__at_Mitochondria GLI3_190 GLI3_190 RUNX2 HGNC HH_Ligand_at_Cytoplasm HH_Ligand_at_Cytoplasm YWHAB HGNC PTCH__at_Cytoplasm PTCH__at_Cytoplasm SMO SMO SMO_at_Cytoplasm SMO_at_Cytoplasm GRK GRK ACTIVATION CDTYPE:CATALYSIS SMO SMO _beta__Arrestin2 _beta__Arrestin2 15611338 pubmed FOXP3 HGNC MIR214 HGNC BAD_BCL2_XL BAD_BCL2_XL BCL2_XL__at_Mitochondria BCL2_XL__at_Mitochondria GTP GTP RSPO1 HGNC Apoptosis Apoptosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. KPC2 KPC2 IRS2 HGNC 21965663 pubmed GLI2_185 GLI2_185 id_14_3_3__BAD id_14_3_3__BAD SUFU SUFU id_14_3_3__BAD id_14_3_3__BAD CK1 CK1 BAD_S112_pho_S136_pho_S155_pho_at_Mitochondria BAD_S112_pho_S136_pho_S155_pho_at_Mitochondria GSK3_beta GSK3_beta id_14_3_3__at_Mitochondria id_14_3_3__at_Mitochondria PKA PKA Cell_cycle_pathway Cell_cycle_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PIK3CB HGNC APC APC PIK3CG HGNC AKAP17A HGNC APC APC ADRBK1 HGNC APC APC ADRBK2 HGNC DNA_replication DNA_replication This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. BAD_S112_pho_S136_pho_S155_pho_at_Mitochondria BAD_S112_pho_S136_pho_S155_pho_at_Mitochondria BCL2_XL__at_Mitochondria BCL2_XL__at_Mitochondria id_14_3_3__at_Mitochondria id_14_3_3__at_Mitochondria BAD_S112_pho_S136_pho_S155_pho_at_Cytoplasm BAD_S112_pho_S136_pho_S155_pho_at_Cytoplasm BCL2_XL BCL2_XL id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm CRM1 CRM1 CAIN CAIN _alpha__Importin _alpha__Importin APC APC High_cell_density High_cell_density This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. APC__beta__Catenin APC__beta__Catenin APC_S2034_pho_at_Nucleus APC_S2034_pho_at_Nucleus _beta__Catenin__at_Nucleus _beta__Catenin__at_Nucleus APC__beta__Catenin APC__beta__Catenin HH_Ligand_PTCH HH_Ligand_PTCH APC_at_Nucleus APC_at_Nucleus FUS HGNC _beta__Catenin__at_Nucleus _beta__Catenin__at_Nucleus RICTOR RICTOR FZD4 HGNC BAD_S112_pho_S136_pho_at_Mitochondria BAD_S112_pho_S136_pho_at_Mitochondria BCL2_XL__at_Mitochondria BCL2_XL__at_Mitochondria 18235236 pubmed id_14_3_3__at_Mitochondria id_14_3_3__at_Mitochondria id_14_3_3__BAD_BCL2_XL id_14_3_3__BAD_BCL2_XL APC_at_Cytoplasm APC_at_Cytoplasm B56_alpha B56_alpha APC_B56_alpha APC_B56_alpha APC_S2034_pho_at_Cytoplasm APC_S2034_pho_at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm _beta__Catenin__at_Cytoplasm _beta__Catenin__at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm APC__beta__Catenin APC__beta__Catenin APC_S1505_pho_S1501_pho_S1504_pho_at_Cytoplasm APC_S1505_pho_S1501_pho_S1504_pho_at_Cytoplasm IL1R2 HGNC _beta__Catenin__at_Cytoplasm _beta__Catenin__at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm CTHRC1 CTHRC1 _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS B56_alpha___at_Cytoplasm B56_alpha___at_Cytoplasm APC_at_Nucleus APC_at_Nucleus Kindlin2__at_Nucleus Kindlin2__at_Nucleus APC_B56_alpha APC_B56_alpha APC_S1505_pho_S1501_pho_S1504_pho_S1507_pho_at_Cytoplasm APC_S1505_pho_S1501_pho_S1504_pho_S1507_pho_at_Cytoplasm PHF10 HGNC Kindlin2___beta__Catenin Kindlin2___beta__Catenin APC_B56_alpha APC_B56_alpha B56_alpha___at_Nucleus B56_alpha___at_Nucleus APC_S2034_pho_at_Nucleus APC_S2034_pho_at_Nucleus B56_alpha B56_alpha _beta__Catenin__at_Cytoplasm _beta__Catenin__at_Cytoplasm APC_B56_alpha APC_B56_alpha Kindlin2___beta__Catenin Kindlin2___beta__Catenin B56_alpha___at_Nucleus B56_alpha___at_Nucleus _beta__Catenin__at_Nucleus _beta__Catenin__at_Nucleus APC_at_Cytoplasm APC_at_Cytoplasm APC_at_Cytoplasm APC_at_Cytoplasm APC_S1505_pho_S1501_pho_S1504_pho_S1507_pho_S1503_pho_S1510_pho_at_Cytoplasm APC_S1505_pho_S1501_pho_S1504_pho_S1507_pho_S1503_pho_S1510_pho_at_Cytoplasm _beta__Catenin _beta__Catenin Kindlin2 Kindlin2 ITGA9 ITGA9 MAP2K7 HGNC MIR372 HGNC 11023813 pubmed _beta__Arrestin2__at_Clathrin_coated_vesicle _beta__Arrestin2__at_Clathrin_coated_vesicle ITCH HGNC SMO_pho_active_at_Clathrin_coated_vesicle SMO_pho_active_at_Clathrin_coated_vesicle KIF3A_at_Primary_Cilium KIF3A_at_Primary_Cilium KIF3A_KIF3B_SMO__beta__Arrestin2 KIF3A_KIF3B_SMO__beta__Arrestin2 p38 p38 SMO_pho_active_at_Primary_Cilium SMO_pho_active_at_Primary_Cilium Immune_system Immune_system This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. KIF3A_at_Cytoplasm KIF3A_at_Cytoplasm KIF3A_KIF3B_SMO__beta__Arrestin2 KIF3A_KIF3B_SMO__beta__Arrestin2 Degradation_complex_WNT_canoncical_pathway Degradation_complex_WNT_canoncical_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. _beta__Arrestin2__at_Primary_Cilium _beta__Arrestin2__at_Primary_Cilium AXIN__S80_pho_S82_pho_S222_pho_S473_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_at_Cytoplasm 11973335 pubmed APC_S2034_pho_at_Cytoplasm APC_S2034_pho_at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm B56_alpha___at_Cytoplasm B56_alpha___at_Cytoplasm KIF3A_at_Clathrin_coated_vesicle KIF3A_at_Clathrin_coated_vesicle BER_DNA_Repair BER_DNA_Repair This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. MLST8_at_Lipid_Raft MLST8_at_Lipid_Raft DEPTOR_at_Lipid_Raft DEPTOR_at_Lipid_Raft MDM2 MDM2 MDM2 MDM2 AP2_beta AP2_beta MDM2 MDM2 USP34 USP34 MDM2 MDM2 KIF3A KIF3A CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm 19849719 pubmed CK2_alpha____at_Nucleus CK2_alpha____at_Nucleus GSK3__at_Cytoplasm GSK3__at_Cytoplasm TNFRSF1A HGNC APC_at_Cytoplasm APC_at_Cytoplasm 21414921 pubmed CK2_alpha___at_Nucleus CK2_alpha___at_Nucleus AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm FOXL1 HGNC CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm TLE__ubi_at_Nucleus TLE__ubi_at_Nucleus APC_at_Cytoplasm APC_at_Cytoplasm 14603322 pubmed HRK HRK ERE ERE AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_emp_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_emp_S621_pho_at_Cytoplasm GSK3_beta GSK3_beta Ligand Ligand PHLPP PHLPP SHIP2 SHIP2 PI3_4_P2 PI3_4_P2 RICTOR_at_Lipid_Raft RICTOR_at_Lipid_Raft PROTOR__at_Lipid_Raft PROTOR__at_Lipid_Raft MAPKAP1_at_Lipid_Raft MAPKAP1_at_Lipid_Raft 15084260 pubmed CK1_alpha___at_Endosome CK1_alpha___at_Endosome GSK3__at_Endosome GSK3__at_Endosome FOXO3 FOXO3 CK1_gamma___at_Endosome CK1_gamma___at_Endosome SGK1 SGK1 AXIN__at_Endosome AXIN__at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome FZD__at_Endosome FZD__at_Endosome ATP ATP LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_at_Endosome p27KIP1__S10_pho_T187_pho_T157_pho_at_Cytoplasm p27KIP1__S10_pho_T187_pho_T157_pho_at_Cytoplasm G_alpha_o__at_Endosome G_alpha_o__at_Endosome FOXO3 FOXO3 G_alpha__sub_s_endsub G_alpha__sub_s_endsub LRP6 LRP6 CDK4_6__at_Cytoplasm CDK4_6__at_Cytoplasm p120__at_Endosome p120__at_Endosome TULP3 TULP3 CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome CyclinD CyclinD CDK4_6 CDK4_6 CyclinD__at_Cytoplasm CyclinD__at_Cytoplasm CDK4_6__CyclinD__p27KIP1 CDK4_6__CyclinD__p27KIP1 _Signalosome _Signalosome p27KIP1 p27KIP1 AXIN__at_Endosome AXIN__at_Endosome p27KIP1 p27KIP1 GSK3__at_Endosome GSK3__at_Endosome FOXO3_T32_pho_S253_pho_S315_pho_at_Nucleus FOXO3_T32_pho_S253_pho_S315_pho_at_Nucleus DVL1 HGNC CK1_alpha___at_Endosome CK1_alpha___at_Endosome id_14_3_3__at_Nucleus id_14_3_3__at_Nucleus MAP2K7 MAP2K7 E_Cadherin__at_Endosome E_Cadherin__at_Endosome id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm p120__at_Endosome p120__at_Endosome CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome FZD__at_Endosome FZD__at_Endosome FOXO3_T32_pho_S253_pho_S315_pho_at_Cytoplasm FOXO3_T32_pho_S253_pho_S315_pho_at_Cytoplasm 20516082 pubmed E_Cadherin__at_Endosome E_Cadherin__at_Endosome DTL HGNC SMARCC1 HGNC TNKS2 HGNC DVL__pho_S139_pho_S142_pho_at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome id_14_3_3__FOXO3 id_14_3_3__FOXO3 AKT1 AKT1 FOXO3 FOXO3 CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome DNAJA3 HGNC LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_at_Endosome E_Cadherin__at_Endosome E_Cadherin__at_Endosome p120__at_Endosome p120__at_Endosome WNT__at_Endosome WNT__at_Endosome _Signalosome _Signalosome FOXO1 HGNC LGR5 LGR5 CDH1 HGNC DDIT3 DDIT3 DRAL DRAL TNPO1 TNPO1 G_beta___at_Endosome G_beta___at_Endosome p27KIP1 p27KIP1 CK1_gamma___at_Endosome CK1_gamma___at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome FZD__at_Endosome FZD__at_Endosome WNT__at_Endosome WNT__at_Endosome _Signalosome _Signalosome RSK2 RSK2 WNT__at_Endosome WNT__at_Endosome CSNK1D HGNC AMER1__at_Endosome AMER1__at_Endosome id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm G_gamma___at_Endosome G_gamma___at_Endosome p27KIP1__S10_pho_T187_pho_T157_pho_at_Cytoplasm p27KIP1__S10_pho_T187_pho_T157_pho_at_Cytoplasm DUSP1 DUSP1 _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome AMER1__at_Endosome AMER1__at_Endosome id_14_3_3__p27KIP1 id_14_3_3__p27KIP1 BAF180 BAF180 18744248 pubmed RSPO1_4 RSPO1_4 FOXP3 HGNC AXIN2 HGNC 17291450 pubmed 16965538 pubmed IRS2 HGNC AXIN1 HGNC BRAP HGNC 11449277 pubmed 19900451 pubmed p27KIP1 p27KIP1 ACTIVATION CDTYPE:CATALYSIS G_gamma___at_Endosome G_gamma___at_Endosome _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome ANAPC1 HGNC RSK1 RSK1 ACTIVATION CDTYPE:CATALYSIS G_beta___at_Endosome G_beta___at_Endosome arMIR20A arMIR20A TNF__alpha TNF__alpha arMIR17_5P arMIR17_5P rCyclinD rCyclinD CyclinD__MIR20A CyclinD__MIR20A rCyclinD rCyclinD arMIR20A arMIR20A CyclinD__MIR17_5P CyclinD__MIR17_5P rSTAT3 rSTAT3 _Destruction_complex_PP2A _Destruction_complex_PP2A _Destruction_complex_PP2A _Destruction_complex_PP2A _COP9_signalosome _COP9_signalosome _CRL _CRL _V_ATPase _V_ATPase DVL2 DVL2 _PP2A_PR55_alpha _PP2A_PR55_alpha _CSN_CRL_Destruction_complex _CSN_CRL_Destruction_complex _Signalosome _Signalosome E_Cadherin__at_Endosome E_Cadherin__at_Endosome NFAT1_2 NFAT1_2 MIR19A_TNF__alpha MIR19A_TNF__alpha BCL9_CBP__DVL__JUN_LEF_TCF__PYGO__WRE___beta__Catenin BCL9_CBP__DVL__JUN_LEF_TCF__PYGO__WRE___beta__Catenin arMIR17_3P arMIR17_3P STAT3 STAT3 MIR17_5P__STAT3 MIR17_5P__STAT3 rSTAT3 rSTAT3 TSP1 TSP1 EPC1 HGNC CTGF CTGF MIR17_3P__TSP1 MIR17_3P__TSP1 rTSP1 rTSP1 p120__at_Endosome p120__at_Endosome LRP5_6__T1479_pho_at_Endosome LRP5_6__T1479_pho_at_Endosome CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome FZD__at_Endosome FZD__at_Endosome CK1_gamma___at_Endosome CK1_gamma___at_Endosome G_beta___at_Endosome G_beta___at_Endosome G_gamma___at_Endosome G_gamma___at_Endosome CABIN1 HGNC _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome SEC24B SEC24B AMER1__at_Endosome AMER1__at_Endosome 15082531 pubmed JUN_pho_pho_at_Nucleus JUN_pho_pho_at_Nucleus APC_BCL9_CTBP__DVL__HDAC1_2__JUN_LEF_TCF__PYGO__WRE___beta__Catenin__p300 APC_BCL9_CTBP__DVL__HDAC1_2__JUN_LEF_TCF__PYGO__WRE___beta__Catenin__p300 BCL9_DVL__JUN_LEF_TCF__PYGO__WRE___beta__Catenin__p300 BCL9_DVL__JUN_LEF_TCF__PYGO__WRE___beta__Catenin__p300 MIR20A_STAT3 MIR20A_STAT3 UBE2I HGNC DVL__at_Nucleus DVL__at_Nucleus arMIR17_5P arMIR17_5P PAX6 HGNC DVL__at_Nucleus DVL__at_Nucleus JUN_pho_pho_at_Nucleus JUN_pho_pho_at_Nucleus UBE21 HGNC mRNA_generic mRNA_generic IDAX__at_Cytoplasm IDAX__at_Cytoplasm DVL__at_Cytoplasm DVL__at_Cytoplasm 20351293 pubmed 19797085 pubmed MTOR MTOR Mediator Mediator MLST8_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome RPTOR_at_Membrane_Lysosome RPTOR_at_Membrane_Lysosome _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex APC APC _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex TNF__alpha TNF__alpha _Destruction_complex_PP1 _Destruction_complex_PP1 BRD7 BRD7 module_WNT_NON_CANONICAL module_WNT_NON_CANONICAL Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr _Destruction_complex _Destruction_complex FZD7 FZD7 _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex _E3_ligase_complex _E3_ligase_complex _CSN_CRL_Destruction_complex _CSN_CRL_Destruction_complex 20399103 pubmed PRAS40__at_Membrane_Lysosome PRAS40__at_Membrane_Lysosome CK2_beta___at_Cytoplasm CK2_beta___at_Cytoplasm GSK3_beta GSK3_beta _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex _Destruction_complex GLI2 GLI2 _Destruction_complex _Destruction_complex 22017973 pubmed Calmodulin Calmodulin 19424782 pubmed CDTYPE:PHYSICAL_STIMULATION IPO7 HGNC 19568798 pubmed IPO5 HGNC IPO4 HGNC IPO9 HGNC IPO8 HGNC AKAP5 HGNC AKAP6 HGNC AKAP7 HGNC AKAP8 HGNC TNF HGNC AKAP9 HGNC DYRK1B DYRK1B ACTIVATION CDTYPE:CATALYSIS GATAD2A_B GATAD2A_B MAPK1 HGNC 22399895 pubmed AKAP4 HGNC AKAP3 HGNC AKAP2 HGNC AKAP1 HGNC LEF1 LEF1 rFUS rFUS rSUFU rSUFU MIR378_SUFU MIR378_SUFU Sonic_hedgehog_pathway Sonic_hedgehog_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. arMIR378 arMIR378 _GLI3R_DNA_binding_site _GLI3R_DNA_binding_site _JUN_gene _JUN_gene _GLI1_JUN_DNA_binding_site _GLI1_JUN_DNA_binding_site _GLI1_DNA_binding_site _GLI1_DNA_binding_site IL1R1 HGNC RSPO3 HGNC RSPO2 HGNC KLF4 HGNC RSPO1 HGNC UBE2B UBE2B RSPO4 HGNC TRAF6 TRAF6 MIR375 HGNC arMIR19A arMIR19A rTNF__alpha rTNF__alpha arMIR18A arMIR18A rER_alpha rER_alpha ER_alpha___MIR18A ER_alpha___MIR18A ER_alpha ER_alpha arMIR378 arMIR378 FUS_MIR378 FUS_MIR378 SUFU SUFU FUS FUS FZD8 FZD8 PROTOR PROTOR BRAF BRAF NLK HGNC PPID HGNC RAD51 RAD51 WNT1 HGNC WNT2 HGNC WNT6 HGNC 19576224 pubmed WNT3 HGNC WNT4 HGNC 16158046 pubmed FASL FASL FOXE1 FOXE1 ACTIVATION CDTYPE:CATALYSIS NRON HGNC ACTIVATION CDTYPE:CATALYSIS RPS6KA3 HGNC RPS6KA4 HGNC RPS6KA1 HGNC RPS6KA2 HGNC 17218260 pubmed 17218261 pubmed 17721078 pubmed 17218262 pubmed ACTIVATION CDTYPE:CATALYSIS LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_at_Endosome G_alpha_o__at_Endosome G_alpha_o__at_Endosome RAD6B RAD6B 15852005 pubmed WNT__at_Endosome WNT__at_Endosome AMER1__at_Endosome AMER1__at_Endosome E_Cadherin__at_Endosome E_Cadherin__at_Endosome RPS6KA6 HGNC _Signalosome _Signalosome RPS6KA5 HGNC G_beta___at_Endosome G_beta___at_Endosome CK1_gamma___at_Endosome CK1_gamma___at_Endosome _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome G_gamma___at_Endosome G_gamma___at_Endosome 17218252 pubmed 9390557 pubmed ACTIVATION CDTYPE:CATALYSIS FZD__at_Endosome FZD__at_Endosome ACTIVATION CDTYPE:CATALYSIS CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome p120__at_Endosome p120__at_Endosome CK1_gamma___at_Endosome CK1_gamma___at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_T1530_pho_S1533_pho_at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_T1530_pho_S1533_pho_at_Endosome RBX1 HGNC CK1_alpha___at_Endosome CK1_alpha___at_Endosome GSK3__at_Endosome GSK3__at_Endosome ACTIVATION CDTYPE:CATALYSIS AXIN__at_Endosome AXIN__at_Endosome G_alpha_o__at_Endosome G_alpha_o__at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome SMURF1 HGNC AKAP14 HGNC AKAP10 HGNC AKAP12 HGNC 21376121 pubmed PRKACA HGNC PRKACB HGNC 21112773 pubmed 12479806 pubmed APC11 APC11 ROCK ROCK WRE WRE SPRY2 HGNC MYCN MYCN MIR92A1 MIR92A1 gpromoter_region gpromoter_region MYCN_promoter_region MYCN_promoter_region MIR18A MIR18A H H MIR20A MIR20A MIR19B1 MIR19B1 MIR19A MIR19A MYCN MYCN Death_receptor4 Death_receptor4 MIR17_3P MIR17_3P E2F1 E2F1 Angiogenesis Angiogenesis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. arMIR17_5P arMIR17_5P rBCL2L11 rBCL2L11 BCL2L11_MIR17_5P BCL2L11_MIR17_5P E2F1_MIR17_3P E2F1_MIR17_3P arMIR17_3P arMIR17_3P rE2F1 rE2F1 APC8 APC8 SIX3 SIX3 PKD1 HGNC RBBP5 RBBP5 IQGAP1 HGNC IQGAP2 HGNC IQGAP3 HGNC 6321473 pubmed DMAP1 HGNC p110 p110 WNT11 HGNC ACTIVATION CDTYPE:CATALYSIS UBE3B HGNC ACTIVATION CDTYPE:CATALYSIS UBE3A HGNC EIF4G2 HGNC EIF4G3 HGNC JBN JBN EIF4G1 HGNC ANAPC5 HGNC 20508033 pubmed HRAS HRAS Core_promoter Core_promoter SAP18 SAP18 ACTIVATION CDTYPE:CATALYSIS USP7 HGNC Y14 Y14 UBE3C HGNC UBE3D HGNC SPOP HGNC ADCY10 HGNC NFAT1_2 NFAT1_2 18550634 pubmed HDAC HDAC 15576399 pubmed SMARCB1 HGNC 11003839 pubmed CyclinD CyclinD IFT140 IFT140 DVL1 HGNC _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome G_gamma___at_Endosome G_gamma___at_Endosome G_beta___at_Endosome G_beta___at_Endosome CK1_gamma___at_Endosome CK1_gamma___at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_T1530_pho_S1533_pho_at_Endosome LRP5_6__T1479_pho_S1490_pho_T1493_pho_S1496_pho_T1530_pho_S1533_pho_at_Endosome CK1_alpha___at_Endosome CK1_alpha___at_Endosome GSK3__at_Endosome GSK3__at_Endosome AXIN__at_Endosome AXIN__at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome DVL__pho_S139_pho_S142_pho_at_Endosome G_alpha__sub_12_endsub G_alpha__sub_12_endsub G_alpha_o__at_Endosome G_alpha_o__at_Endosome ACTIVATION CDTYPE:CATALYSIS SFRP1 SFRP1 PTHR PTHR 18566586 pubmed MNK MNK 11136230 pubmed 21237163 pubmed FZD__at_Endosome FZD__at_Endosome E_Cadherin__pho_at_Endosome E_Cadherin__pho_at_Endosome _Signalosome _Signalosome CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome p120__S268_pho_S269_pho_at_Endosome p120__S268_pho_S269_pho_at_Endosome _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome G_gamma___at_Endosome G_gamma___at_Endosome WNT__at_Endosome WNT__at_Endosome AMER1__at_Endosome AMER1__at_Endosome G_beta___at_Endosome G_beta___at_Endosome 19027299 pubmed 18481918 pubmed INHIBITION CDTYPE:INHIBITION 19459846 pubmed AP2S1 HGNC 19032343 pubmed 20956384 pubmed INHIBITION CDTYPE:INHIBITION BCL9_at_Nucleus BCL9_at_Nucleus PYGO__at_Nucleus PYGO__at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus RSPO3 HGNC 20832730 pubmed BCL9_at_Nucleus BCL9_at_Nucleus FGFR1 HGNC FGFR2 HGNC FGFR3 HGNC p300__at_Nucleus p300__at_Nucleus FGFR4 HGNC DVL__at_Nucleus DVL__at_Nucleus JUN_pho_pho_at_Nucleus JUN_pho_pho_at_Nucleus BCL9_DVL__JUN_PYGO___beta__Catenin__p300 BCL9_DVL__JUN_PYGO___beta__Catenin__p300 CDC26 HGNC WNT3 HGNC MIR375 MIR375 ACTIVATION CDTYPE:CATALYSIS EIF4E HGNC CASP9 HGNC DVL__at_Nucleus DVL__at_Nucleus JUN_pho_pho_at_Nucleus JUN_pho_pho_at_Nucleus _beta__Catenin__ace_ace_at_Nucleus _beta__Catenin__ace_ace_at_Nucleus CBP__S92_pho_at_Nucleus CBP__S92_pho_at_Nucleus PYGO__at_Nucleus PYGO__at_Nucleus DVL__at_Nucleus DVL__at_Nucleus JUN_pho_pho_at_Nucleus JUN_pho_pho_at_Nucleus BCL9_CBP__DVL__JUN_PYGO___beta__Catenin BCL9_CBP__DVL__JUN_PYGO___beta__Catenin MAPKAP1_at_Lipid_Raft MAPKAP1_at_Lipid_Raft PROTOR__at_Lipid_Raft PROTOR__at_Lipid_Raft NFATC4 HGNC MLST8_at_Lipid_Raft MLST8_at_Lipid_Raft RICTOR_T1135_pho_at_Lipid_Raft RICTOR_T1135_pho_at_Lipid_Raft MAPKAP1_at_Lipid_Raft MAPKAP1_at_Lipid_Raft PROTOR__at_Lipid_Raft PROTOR__at_Lipid_Raft CAPNS1 HGNC NFATC1 HGNC CAPNS2 HGNC NFATC3 HGNC NFATC2 HGNC CRIPTO_1 CRIPTO_1 PI3K_AKT_MTOR_pathway PI3K_AKT_MTOR_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CRIPTO_1 CRIPTO_1 19225151 pubmed DAB2 DAB2 ACTA1 HGNC MLST8_at_Lipid_Raft MLST8_at_Lipid_Raft id_14_3_3__at_Lipid_Raft id_14_3_3__at_Lipid_Raft IRS2 IRS2 RICTOR_T1135_pho_at_Lipid_Raft RICTOR_T1135_pho_at_Lipid_Raft IRS2 IRS2 SKAR__at_Cytoplasm SKAR__at_Cytoplasm p70_alpha___T389_pho_T229_pho_at_Cytoplasm p70_alpha___T389_pho_T229_pho_at_Cytoplasm SRM160__at_Cytoplasm SRM160__at_Cytoplasm DEK_at_Cytoplasm DEK_at_Cytoplasm SGK1 SGK1 SGK1 SGK1 PTEN PTEN SGK1 SGK1 APC6 APC6 20925119 pubmed RHEB RHEB JUN JUN 16998587 pubmed JUN_pho_pho_at_Nucleus JUN_pho_pho_at_Nucleus DVL__at_Nucleus DVL__at_Nucleus DVL__JUN DVL__JUN LRP6 LRP6 DVL DVL PABP1__at_Cytoplasm PABP1__at_Cytoplasm mRNA_translation mRNA_translation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. SRM160__at_Cytoplasm SRM160__at_Cytoplasm RPS6_S235_pho_S236_pho_S240_pho_S244_pho_S247_pho_at_Cytoplasm RPS6_S235_pho_S236_pho_S240_pho_S244_pho_S247_pho_at_Cytoplasm WNT1 WNT1 EIF4G EIF4G EIF4G__at_Cytoplasm EIF4G__at_Cytoplasm PABP1 PABP1 DEK_at_Cytoplasm DEK_at_Cytoplasm SKAR SKAR arMIR372_at_Nucleus arMIR372_at_Nucleus 17496910 pubmed MIR373 MIR373 MIR372 MIR372 MIR373 MIR373 MIR372 MIR372 10995457 pubmed 11923280 pubmed TBX2 HGNC 16039586 pubmed DEK_REF__RNPS1_SKAR__SRM160__Y14__p70_alpha DEK_REF__RNPS1_SKAR__SRM160__Y14__p70_alpha EIF4E__at_Cytoplasm EIF4E__at_Cytoplasm EIF3__at_Cytoplasm EIF3__at_Cytoplasm rmRNA_generic__at_Cytoplasm rmRNA_generic__at_Cytoplasm M7GTP__at_Cytoplasm M7GTP__at_Cytoplasm PIP2 PIP2 CSNK1E HGNC EIF4B_S422_pho_at_Cytoplasm EIF4B_S422_pho_at_Cytoplasm IRS2 IRS2 DVL DVL 17496916 pubmed DKK1_MIR372 DKK1_MIR372 rDKK1_at_Nucleus rDKK1_at_Nucleus arMIR373_at_Nucleus arMIR373_at_Nucleus DKK1_MIR373 DKK1_MIR373 rDKK1_at_Nucleus rDKK1_at_Nucleus NFAT__at_Nucleus NFAT__at_Nucleus NFAT3 NFAT3 ING3 ING3 Ca2__Calmodulin Ca2__Calmodulin FOXA FOXA APAF1 HGNC FOXA__at_Nucleus FOXA__at_Nucleus ERE_ER_alpha___FOXA__NFAT__estrogen ERE_ER_alpha___FOXA__NFAT__estrogen MLST8_at_Cytoplasm MLST8_at_Cytoplasm 16169192 pubmed RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Cytoplasm RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Cytoplasm MTOR_S1261_pho_S2481_pho_at_Cytoplasm MTOR_S1261_pho_S2481_pho_at_Cytoplasm PIK3CB HGNC PIK3CA HGNC TCF4 TCF4 15967165 pubmed TCF4 TCF4 Ca2__at_Nucleus Ca2__at_Nucleus RAD6B RAD6B Calmodulin__at_Nucleus Calmodulin__at_Nucleus SOX9 SOX9 RAD6B RAD6B HDAC1 HGNC NFAT2 NFAT2 12941693 pubmed PIAS1 PIAS1 APC12__at_Nucleus APC12__at_Nucleus E1 E1 APC13__at_Nucleus APC13__at_Nucleus UBC9 UBC9 APC10__at_Nucleus APC10__at_Nucleus NFAT1 NFAT1 APC11__at_Nucleus APC11__at_Nucleus NFAT1 NFAT1 12615961 pubmed EIF4E__at_Cytoplasm EIF4E__at_Cytoplasm EIF3__at_Cytoplasm EIF3__at_Cytoplasm rmRNA_generic__at_Cytoplasm rmRNA_generic__at_Cytoplasm M7GTP__at_Cytoplasm M7GTP__at_Cytoplasm MYC MYC p70_alpha___T389_pho_at_Cytoplasm p70_alpha___T389_pho_at_Cytoplasm AXIN2 AXIN2 RSK RSK APC5__at_Nucleus APC5__at_Nucleus NFAT3 NFAT3 CDC20_at_Nucleus CDC20_at_Nucleus AXIN2 AXIN2 UBCH10 UBCH10 19751731 pubmed RNF146 RNF146 DAXX_HDAC2_PML DAXX_HDAC2_PML 19424602 pubmed PML_at_Nucleus PML_at_Nucleus FOXC2 FOXC2 HDAC2_at_Nucleus HDAC2_at_Nucleus BCL9 BCL9 11500365 pubmed BCL9 BCL9 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS p70_alpha p70_alpha EIF4A1 HGNC PRR__at_Endosome PRR__at_Endosome EIF4A3 HGNC YWHAZ HGNC EIF4A2 HGNC GAS1 GAS1 17053147 pubmed Actin_cytoskeletal Actin_cytoskeletal HDAC2_at_Nucleus HDAC2_at_Nucleus DAXX_at_Nucleus DAXX_at_Nucleus PML_unk_unk_at_Nucleus PML_unk_unk_at_Nucleus Cell_cycle_pathway Cell_cycle_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. YWHAE HGNC G2_M_phase G2_M_phase This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PARP PARP TGFBR3 HGNC IL2 IL2 IL2 IL2 18039929 pubmed YWHAH HGNC YWHAG HGNC APC_at_Endosome APC_at_Endosome RPS6 RPS6 10786854 pubmed APC_Microtubules APC_Microtubules PCNA HGNC APC_at_Cytoplasm APC_at_Cytoplasm PDPK1 PDPK1 Microtubules Microtubules This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. H H DDB2 HGNC TGFBR1 HGNC EIF4B EIF4B TGFBR2 HGNC YWHAQ HGNC PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm AMER1__at_Cytoplasm AMER1__at_Cytoplasm Menin Menin AMER1__at_Cytoplasm AMER1__at_Cytoplasm MYCN MYCN PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm EIF4B EIF4B id_4E_BP id_4E_BP PML_unk_unk_at_Nucleus PML_unk_unk_at_Nucleus PML_at_Nucleus PML_at_Nucleus RBBP5 HGNC YWHAB HGNC DAXX_HDAC2_NFAT2__PML DAXX_HDAC2_NFAT2__PML NFAT2__K702_unk_K914_unk_at_Nucleus NFAT2__K702_unk_K914_unk_at_Nucleus DAXX_at_Nucleus DAXX_at_Nucleus RPS6 RPS6 RSK RSK GPC6 GPC6 CDK4 CDK4 CNA__at_Nucleus CNA__at_Nucleus KLF4 HGNC GPC6 GPC6 HDAC__NFAT1 HDAC__NFAT1 NFAT1__at_Nucleus NFAT1__at_Nucleus HDAC__at_Nucleus HDAC__at_Nucleus CDK4 CDK4 NFAT1 NFAT1 HDAC HDAC RPS6 RPS6 CK1 CK1 EIF4A__PDCD4 EIF4A__PDCD4 EIF4A EIF4A EIF4A__PDCD4 EIF4A__PDCD4 21327159 pubmed EIF4A__at_Cytoplasm EIF4A__at_Cytoplasm 12453415 pubmed PDCD4_S67_pho_at_Cytoplasm PDCD4_S67_pho_at_Cytoplasm EIF4A__at_Cytoplasm EIF4A__at_Cytoplasm ACTG1 HGNC 11094066 pubmed 20107231 pubmed 15327769 pubmed SNAI1 SNAI1 PDCD4 PDCD4 PABP1 PABP1 PDCD4_at_Cytoplasm PDCD4_at_Cytoplasm TAB1 HGNC M7GTP__at_Cytoplasm M7GTP__at_Cytoplasm rmRNA_generic__at_Cytoplasm rmRNA_generic__at_Cytoplasm PYGO1 HGNC EIF3__at_Cytoplasm EIF3__at_Cytoplasm EIF4E__at_Cytoplasm EIF4E__at_Cytoplasm 22730322 pubmed PAX9 PAX9 PtdIns_4__P PtdIns_4__P MIR373 HGNC PLCB4 HGNC 18700987 pubmed PLCB2 HGNC PLCB3 HGNC PDCD4 PDCD4 TRADD TRADD PLCB1 HGNC PRR__at_Endosome PRR__at_Endosome Microtubules_at_Cytoplasm Microtubules_at_Cytoplasm This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 21536646 pubmed 20947020 pubmed 20360384 pubmed p19INK4D p19INK4D MBD2_3 MBD2_3 ITGA3 ITGA3 EIF4A__at_Cytoplasm EIF4A__at_Cytoplasm RPS6 HGNC AKA13 HGNC CK2 CK2 PAX6 HGNC FOXE1 HGNC 16007074 pubmed ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS FZD3 HGNC ATF2 HGNC 21303971 pubmed CSN7 CSN7 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 16099633 pubmed H2AFX H2AFX PPP3R1 HGNC PPP3R2 HGNC AMER1__at_Cytoplasm AMER1__at_Cytoplasm 12435627 pubmed ER_alpha ER_alpha PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm CyclinY CyclinY AMER1__at_Cytoplasm AMER1__at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm DKK3 DKK3 AMER1__at_Cytoplasm AMER1__at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm AMER1__at_Cytoplasm AMER1__at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm AMER1__at_Cytoplasm AMER1__at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm MAP3K1 MAP3K1 AKAP AKAP 21640127 pubmed 14976311 pubmed AMER1__at_Cytoplasm AMER1__at_Cytoplasm KLHL6 HGNC PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm KLHL5 HGNC AMER1__at_Cytoplasm AMER1__at_Cytoplasm KLHL4 HGNC PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm KLHL3 HGNC AMER1__at_Cytoplasm AMER1__at_Cytoplasm KLHL2 HGNC PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm KLHL1 HGNC AMER1__at_Cytoplasm AMER1__at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm AMER1__at_Cytoplasm AMER1__at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm RPTOR RPTOR 14555646 pubmed 15199124 pubmed KLHL9 HGNC KLHL8 HGNC KLHL7 HGNC DVL DVL PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm AMER1__at_Cytoplasm AMER1__at_Cytoplasm Cell_migration Cell_migration This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. AMER1__at_Cytoplasm AMER1__at_Cytoplasm SRRM1 HGNC CyclinY__at_Cytoplasm CyclinY__at_Cytoplasm Cell_cell_adhesions Cell_cell_adhesions This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PFTK__at_Cytoplasm PFTK__at_Cytoplasm FUS FUS PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm PtdIns_4_5__P2_at_Cytoplasm KLF4 KLF4 AMER1__at_Cytoplasm AMER1__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS AMER2 HGNC SIN3A HGNC ROR2 HGNC WNT_non_canonical_pathway WNT_non_canonical_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. id_5T4__LRP5_6 id_5T4__LRP5_6 id_5T4__at_Cytoplasm id_5T4__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS DVL__IDAX DVL__IDAX IDAX IDAX LRP5_6__at_Cytoplasm LRP5_6__at_Cytoplasm id_5T4 id_5T4 CyclinY__PFTK CyclinY__PFTK MLL2 HGNC GLI1 HGNC GDP GDP AXIN1 AXIN1 MST1 MST1 14681224 pubmed MIR375 MIR375 GNG4 HGNC GNG5 HGNC GNG2 HGNC PINK1 PINK1 GNG3 HGNC GNG8 HGNC GNG7 HGNC p14INK4A p14INK4A SMURF1 SMURF1 PPP2R5E HGNC PPP2R5D HGNC PPP2R5C HGNC PPP2R5B HGNC 18855897 pubmed PPP2R5A HGNC INHIBITION CDTYPE:INHIBITION BBC3 BBC3 FGF2 HGNC MIR34A MIR34A ACTIVATION CDTYPE:CATALYSIS PI3_4_5_P3_at_Lipid_Raft PI3_4_5_P3_at_Lipid_Raft HECTD1 HECTD1 AKT1 AKT1 11035045 pubmed HSP90 HSP90 BCOR HGNC MED12 HGNC ACTIVATION CDTYPE:CATALYSIS BID HGNC MTOR MTOR AKT1 AKT1 AKT1_T308_pho_T450_pho_S473_emp_active_at_Lipid_Raft AKT1_T308_pho_T450_pho_S473_emp_active_at_Lipid_Raft FOXA2 HGNC DCAF4 HGNC DCAF5 HGNC PIRH2 PIRH2 DCAF8 HGNC DCAF7 HGNC DCAF6 HGNC PPP3CB_sub_trunc_endsub PPP3CB_sub_trunc_endsub GTP GTP 16464865 pubmed MEK1_2 MEK1_2 ACTIVATION CDTYPE:CATALYSIS 20223821 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION EIF4B EIF4B ACTIVATION CDTYPE:CATALYSIS CHD3_4 CHD3_4 ACTIVATION CDTYPE:CATALYSIS GAB1 GAB1 ACTIVATION CDTYPE:CATALYSIS PI3_4_5_P3_at_Endosome PI3_4_5_P3_at_Endosome LEF_TCF__at_Nucleus LEF_TCF__at_Nucleus p110__at_Endosome p110__at_Endosome HIPK2_at_Nucleus HIPK2_at_Nucleus CTBP__at_Nucleus CTBP__at_Nucleus GAB1_at_Endosome GAB1_at_Endosome ACTIVATION CDTYPE:CATALYSIS GAB1_GF_GRB2_PI3_4_5_P3_RAS__RTK__SOS__p110__p85 GAB1_GF_GRB2_PI3_4_5_P3_RAS__RTK__SOS__p110__p85 ASK1 ASK1 GRB2_at_Endosome GRB2_at_Endosome p85__at_Endosome p85__at_Endosome 21718540 pubmed TAK1__T184_pho_T178_pho_T187_pho_S192_pho_active_at_Nucleus TAK1__T184_pho_T178_pho_T187_pho_S192_pho_active_at_Nucleus GF_at_Endosome GF_at_Endosome TAB TAB E3 E3 GRB2_at_Cytoplasm GRB2_at_Cytoplasm SOS__at_Cytoplasm SOS__at_Cytoplasm RASA4 HGNC RASA3 HGNC SOLH HGNC gWRE__at_Nucleus gWRE__at_Nucleus FRK FRK TLE__at_Nucleus TLE__at_Nucleus PTEN PTEN RAS__at_Endosome RAS__at_Endosome GRB2_SOS GRB2_SOS SOS__at_Endosome SOS__at_Endosome Apoptosis Apoptosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. _beta__Catenin__at_Nucleus _beta__Catenin__at_Nucleus CTBP__HIPK2_LEF_TCF___beta__Catenin CTBP__HIPK2_LEF_TCF___beta__Catenin RASA2 HGNC RASA1 HGNC CEBPB HGNC ACTIVATION CDTYPE:CATALYSIS NEDD4 NEDD4 REF REF PTEN PTEN 20579883 pubmed _beta__Catenin _beta__Catenin 20530697 pubmed PPP3R2 HGNC PPP3R1 HGNC HDAC1_2__at_Nucleus HDAC1_2__at_Nucleus LEF_TCF__pho_at_Nucleus LEF_TCF__pho_at_Nucleus LEF_TCF LEF_TCF BAF47 BAF47 Metastasis Metastasis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PIK3R5 HGNC ACTIVATION CDTYPE:CATALYSIS MRGBP MRGBP ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS APC7__at_Nucleus APC7__at_Nucleus APC8__at_Nucleus APC8__at_Nucleus ACTIVATION CDTYPE:CATALYSIS APC4__at_Nucleus APC4__at_Nucleus APC6__at_Nucleus APC6__at_Nucleus CTNNA1 HGNC 15793569 pubmed MIR34B HGNC CTNNA3 HGNC CTNNA2 HGNC APC2__at_Nucleus APC2__at_Nucleus APC3__at_Nucleus APC3__at_Nucleus 20107328 pubmed APC1__at_Nucleus APC1__at_Nucleus AXIN2 AXIN2 CK2_beta CK2_beta FOS FOS CK1_delta CK1_delta JUN JUN AP_1_ARRE_binding_sites AP_1_ARRE_binding_sites 20448436 pubmed rAXIN2_at_Nucleus rAXIN2_at_Nucleus arMIR34A_at_Nucleus arMIR34A_at_Nucleus BBC3 HGNC GATA__at_Nucleus GATA__at_Nucleus PPP2R2B HGNC AXIN2 AXIN2 gGATA_binding_site__at_Nucleus gGATA_binding_site__at_Nucleus RTK RTK PPP2R2C HGNC NFAT__at_Nucleus NFAT__at_Nucleus FGF2 FGF2 AXIN2_MIR34A AXIN2_MIR34A LRP6 LRP6 PPP2R2A HGNC AXIN2 AXIN2 GATA_binding_site__GATA__NFAT GATA_binding_site__GATA__NFAT PPP2R2D HGNC 16680151 pubmed TLE__at_Nucleus TLE__at_Nucleus MAPK3 HGNC MAPK4 HGNC MAPK1 HGNC MAPK6 HGNC 18057099 pubmed gNF__kappa_B_at_Nucleus gNF__kappa_B_at_Nucleus MAPK_pathway MAPK_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CCNE1 HGNC SIX3_at_Nucleus SIX3_at_Nucleus CCNE2 HGNC GF_at_Lipid_Raft GF_at_Lipid_Raft SIX3_TLE SIX3_TLE p38 p38 GF_at_Endosome GF_at_Endosome SIX3 SIX3 SIX3 SIX3 PPP2R3A HGNC SIX3 SIX3 PPP2R3B HGNC PPP2R3C HGNC MLST8_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome 21447091 pubmed ER_alpha ER_alpha 17283082 pubmed MLST8_MTOR_RPTOR MLST8_MTOR_RPTOR CK2_alpha___at_Cytoplasm CK2_alpha___at_Cytoplasm PIK3CG HGNC 21228116 pubmed PIK3CD HGNC AKT1 AKT1 AKT1 AKT1 _beta__Catenin _beta__Catenin ER_alpha___at_Nucleus ER_alpha___at_Nucleus _beta__Catenin _beta__Catenin RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Membrane_Lysosome RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Membrane_Lysosome CK2_beta___at_Cytoplasm CK2_beta___at_Cytoplasm AES AES GF_RTK__p110__p85 GF_RTK__p110__p85 GLI3 GLI3 PtdIns_4_5__P2 PtdIns_4_5__P2 TLE__at_Nucleus TLE__at_Nucleus estrogen_at_Nucleus estrogen_at_Nucleus Transcription Transcription This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PI3_4_5_P3 PI3_4_5_P3 AES_TLE AES_TLE gERE_at_Nucleus gERE_at_Nucleus estrogen estrogen RAS_activation RAS_activation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. AES_at_Nucleus AES_at_Nucleus RAS RAS ERE ERE RAS__p110__p85 RAS__p110__p85 estrogen estrogen MIR34B MIR34B CUL3_Spop CUL3_Spop EIF4E__at_Cytoplasm EIF4E__at_Cytoplasm FGF2_at_Cytoplasm FGF2_at_Cytoplasm MAPKAPK MAPKAPK CUL3 CUL3 id_4E_BP__at_Cytoplasm id_4E_BP__at_Cytoplasm FGF2_RTK FGF2_RTK SPOP SPOP CAPN11 HGNC ANAPC10 HGNC CAPN12 HGNC GLI3_190 GLI3_190 LRP6 LRP6 CAPN10 HGNC CAPN13 HGNC CAPN14 HGNC rmRNA_generic__at_Cytoplasm rmRNA_generic__at_Cytoplasm M7GTP__at_Cytoplasm M7GTP__at_Cytoplasm p70_alpha___at_Cytoplasm p70_alpha___at_Cytoplasm id_14_3_3 id_14_3_3 PDPK1 PDPK1 PDPK1_S241_pho_active_at_Lipid_Raft PDPK1_S241_pho_active_at_Lipid_Raft EIF3__at_Cytoplasm EIF3__at_Cytoplasm DVL DVL HIPK1 HIPK1 MEF2__at_Nucleus MEF2__at_Nucleus gpromoter_binding_site__at_Nucleus gpromoter_binding_site__at_Nucleus p110__at_Lipid_Raft p110__at_Lipid_Raft HIPK2 HIPK2 NFAT__at_Nucleus NFAT__at_Nucleus p85__at_Lipid_Raft p85__at_Lipid_Raft HIPK1_at_Nucleus HIPK1_at_Nucleus MEF2__NFAT__promoter_binding_site MEF2__NFAT__promoter_binding_site 15117942 pubmed BCL2L11 HGNC RAS__at_Lipid_Raft RAS__at_Lipid_Raft DVL__at_Nucleus DVL__at_Nucleus promoter_binding_site promoter_binding_site PHLPP PHLPP p85__at_Lipid_Raft p85__at_Lipid_Raft DVL__HIPK1 DVL__HIPK1 MEF2 MEF2 GATA GATA ACTIVATION CDTYPE:CATALYSIS PI3_4_5_P3_at_Lipid_Raft PI3_4_5_P3_at_Lipid_Raft p53_pathway p53_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. GATA_binding_site GATA_binding_site ACTIVATION CDTYPE:CATALYSIS p110__at_Lipid_Raft p110__at_Lipid_Raft NF__kappa_B NF__kappa_B ACTIVATION CDTYPE:CATALYSIS PTEN PTEN CTBP CTBP NFAT NFAT ZEB1 HGNC NOTCH1 HGNC NOTCH3 HGNC NOTCH2 HGNC ACTIVATION CDTYPE:CATALYSIS TNFSF10 HGNC HDAC2 HGNC ACTIVATION CDTYPE:CATALYSIS EGFR HGNC UBA5 HGNC UBA3 HGNC ACTIVATION CDTYPE:CATALYSIS UBA2 HGNC 10671551 pubmed UBA7 HGNC SIX3 HGNC UBA6 HGNC 10702316 pubmed ACTIVATION CDTYPE:CATALYSIS UBA1 HGNC CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS NFAT3 NFAT3 ACTIVATION CDTYPE:CATALYSIS MIR34A HGNC CDTYPE:BOOLEAN_LOGIC_GATE_OR ACTIVATION CDTYPE:CATALYSIS 15944709 pubmed NOTCH4 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS SMO HGNC ACTIVATION CDTYPE:CATALYSIS NKX2_2 NKX2_2 22203675 pubmed 20146692 pubmed PRKACA HGNC PRKACB HGNC ACTIVATION CDTYPE:CATALYSIS JUN JUN PBRM1 HGNC PRKACG HGNC PHLPP PHLPP 22787431 pubmed BBC3 HGNC ACTIVATION CDTYPE:CATALYSIS 11796223 pubmed Thrombin Thrombin CBL CBL LEF1 HGNC 21505104 pubmed 17804805 pubmed WNT11 WNT11 PARP9 HGNC PARP6 HGNC PARP8 HGNC COPS5 HGNC CBP CBP GADD45 GADD45 PARP3 HGNC PARP4 HGNC CUL1 CUL1 PARP1 HGNC PARP2 HGNC 22100263 pubmed 21266584 pubmed INHIBITION CDTYPE:INHIBITION 11030334 pubmed GCFC2 HGNC CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS RELA RELA ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ERN1 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS DUSP1 HGNC RUVBL1 HGNC 10978313 pubmed MIR18A MIR18A 19592253 pubmed DAAM1 HGNC ATROGIN_1 ATROGIN_1 16169709 pubmed 19608982 pubmed PMAIP1 HGNC 9859994 pubmed CDC23 HGNC CDC27 HGNC 9228084 pubmed DKK1 HGNC MOD:00696 MOD MOD:00693 MOD Pro_HB_EGF Pro_HB_EGF PIP5KIC HGNC INHIBITION CDTYPE:INHIBITION INHIBITION CDTYPE:INHIBITION 21734722 pubmed INHIBITION CDTYPE:INHIBITION CXXC4 HGNC 19216069 pubmed ASH2L ASH2L PTCH PTCH HH_Ligand HH_Ligand 11782431 pubmed MEN1 HGNC 18511290 pubmed _beta__Arrestin__at_Cytoplasm _beta__Arrestin__at_Cytoplasm G_alpha__sub_13q_endsub___at_Cytoplasm G_alpha__sub_13q_endsub___at_Cytoplasm Apoptosis Apoptosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. WNT_canonical_pathway WNT_canonical_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PRKAA1 HGNC PRKAA2 HGNC PLC__beta PLC__beta WNT__at_Cytoplasm WNT__at_Cytoplasm GTP_at_Cytoplasm GTP_at_Cytoplasm RSPO1_4__at_Cytoplasm RSPO1_4__at_Cytoplasm LGR5_at_Cytoplasm LGR5_at_Cytoplasm TNPO1 HGNC PLC__beta___at_Cytoplasm PLC__beta___at_Cytoplasm GNAI3 HGNC GNAI1 HGNC GNAI2 HGNC 16909212 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 12223464 pubmed ACTIVATION CDTYPE:CATALYSIS MMP1 HGNC Ca2 Ca2 CAMK2__at_Cytoplasm CAMK2__at_Cytoplasm IP3 IP3 PI4_5_P2 PI4_5_P2 19091303 pubmed IP3R IP3R DAG DAG IP3_IP3R IP3_IP3R IP3_at_Endoplasmic_Reticulum IP3_at_Endoplasmic_Reticulum IP3R__at_Endoplasmic_Reticulum IP3R__at_Endoplasmic_Reticulum 19359428 pubmed ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:CATALYSIS Ca2 Ca2 PDCD4 PDCD4 IP3R IP3R FOXO3 HGNC RAB23 RAB23 PI3K_AKT_MTOR_pathway PI3K_AKT_MTOR_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. AKT1 AKT1 CAMK2 CAMK2 G_alpha__sub_13q_endsub___PLC__beta____beta__Arrestin G_alpha__sub_13q_endsub___PLC__beta____beta__Arrestin TRAIL TRAIL APC4 APC4 CAMK2__Ca2__Calmodulin CAMK2__Ca2__Calmodulin Ca2__at_Cytoplasm Ca2__at_Cytoplasm CRIPTO_1 CRIPTO_1 GLI2 GLI2 GLI2 GLI2 PAX6 PAX6 FOXE1 FOXE1 MMP11 MMP11 MIR493 HGNC PAX6 PAX6 20843316 pubmed 18097445 pubmed gpromoter_region gpromoter_region SIX1 SIX1 SIX1 SIX1 11940578 pubmed GLI1 GLI1 ACTIVATION CDTYPE:CATALYSIS GLI1 GLI1 NOS2 NOS2 PMAIP1 PMAIP1 HDAC11 HGNC HDAC10 HGNC SMAD3 SMAD3 GLI2_185__pho_active GLI2_185__pho_active Cell_survival Cell_survival This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. NKX2_2 NKX2_2 NKX2_2 NKX2_2 BCL2 BCL2 _beta__Catenin _beta__Catenin BCL2 BCL2 IGFBP6 IGFBP6 ULK1 HGNC IGFBP6 IGFBP6 CDK4 CDK4 TBX2 TBX2 RPTOR HGNC APC_S1505_pho_S1501_ubi_S1504_pho_S1507_pho_S1503_pho_S1510_ubi_at_Cytoplasm APC_S1505_pho_S1501_ubi_S1504_pho_S1507_pho_S1503_pho_S1510_ubi_at_Cytoplasm NFAT__at_Nucleus NFAT__at_Nucleus _beta__Catenin _beta__Catenin CNA__at_Nucleus CNA__at_Nucleus DAB2 DAB2 AXIN__CK1_alpha___GSK3 AXIN__CK1_alpha___GSK3 CNB__at_Nucleus CNB__at_Nucleus MEK1 MEK1 ERK2 ERK2 FAF__at_Cytoplasm FAF__at_Cytoplasm FAF__at_Cytoplasm FAF__at_Cytoplasm 19104148 pubmed GPC6 HGNC 21102635 pubmed G_alpha_o__at_Cytoplasm G_alpha_o__at_Cytoplasm CNA__at_Nucleus CNA__at_Nucleus CNB__at_Nucleus CNB__at_Nucleus 11689703 pubmed 17925383 pubmed 11940581 pubmed 16537363 pubmed CNB__at_Nucleus CNB__at_Nucleus 17925382 pubmed 15489953 pubmed GNA13 HGNC TRAF2_at_Plasma_Membrane TRAF2_at_Plasma_Membrane TNFRSF1A_at_Plasma_Membrane TNFRSF1A_at_Plasma_Membrane JUND JUND TRADD_at_Plasma_Membrane TRADD_at_Plasma_Membrane Homo sapiens TRADD HGNC TRADD_at_Plasma_Membrane TRADD_at_Plasma_Membrane TRAF2 TRAF2 TNFRSF1A TNFRSF1A HNF4A HGNC BMF HGNC 22558232 pubmed SIL SIL HNF1B HGNC HNF1A HGNC MIR31 MIR31 18698484 pubmed SEC24B HGNC FOXA2 HGNC FOXO4 HGNC FBXO32 HGNC ITPR1 HGNC ITPR2 HGNC ITPR3 HGNC SMARCA4 HGNC APC_AXIN APC_AXIN AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm CTGF HGNC 16488589 pubmed MIR17_92 MIR17_92 DKK3 HGNC 15657420 pubmed FOXO3 HGNC NF__kappa_B NF__kappa_B 21386996 pubmed HTID1_40_kDA_isoform HTID1_40_kDA_isoform MAP3K4 HGNC SMAD4 SMAD4 gpromoter_region gpromoter_region GLI3_83_sub_TRUNC_endsub GLI3_83_sub_TRUNC_endsub Death_receptor4 Death_receptor4 HDAC3 HGNC Death_receptor4 Death_receptor4 E2 E2 E1 E1 GLI3_83_sub_TRUNC_endsub GLI3_83_sub_TRUNC_endsub promoter_region promoter_region 21411632 pubmed FOXC2 HGNC CRM1__GLI1 CRM1__GLI1 GLI1 GLI1 CRM1 CRM1 CRM1__GLI1 CRM1__GLI1 GLI1 GLI1 DYRK1A DYRK1A CRM1 CRM1 GLI1 GLI1 Apoptosis Apoptosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. GNA15 HGNC Trail_pathway Trail_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. GNA12 HGNC GNA11 HGNC GNA14 HGNC GNA13 HGNC NEDD8 NEDD8 HAT HAT PML PML MAP3K5 MAP3K5 11980723 pubmed GAS41 GAS41 ACTIVATION CDTYPE:CATALYSIS JUN JUN PKA PKA SFRP1 SFRP1 20595387 pubmed ACTIVATION CDTYPE:CATALYSIS gpromoter_region gpromoter_region RGS19 RGS19 GLI1 GLI1 GLI1_pho_pho GLI1_pho_pho CRM1__at_Cytoplasm CRM1__at_Cytoplasm GLI1_at_Cytoplasm GLI1_at_Cytoplasm CRM1 CRM1 GLI1 GLI1 _Calcineurin_NFAT_ERK2_MEK1 _Calcineurin_NFAT_ERK2_MEK1 _Calcineurin_NFAT_ERK2_MEK1 _Calcineurin_NFAT_ERK2_MEK1 _Calcineurin _Calcineurin FOXL1 FOXL1 _Calcineurin__br_NFAT _Calcineurin__br_NFAT MIR29B2 HGNC MIR29B1 HGNC _beta_TRCP__at_Cytoplasm _beta_TRCP__at_Cytoplasm SKP__at_Cytoplasm SKP__at_Cytoplasm RBX1_at_Cytoplasm RBX1_at_Cytoplasm ERK ERK CUL1_at_Cytoplasm CUL1_at_Cytoplasm PRR__at_Vaceolae PRR__at_Vaceolae WNT__at_Vaceolae WNT__at_Vaceolae AMER1__at_Vaceolae AMER1__at_Vaceolae DNAJA3 HGNC _beta__Arrestin2__at_Vaceolae _beta__Arrestin2__at_Vaceolae G_gamma___at_Vaceolae G_gamma___at_Vaceolae SFRP1 SFRP1 GLI2_185__promoter_region GLI2_185__promoter_region AXIN__at_Endosome AXIN__at_Endosome AXIN__CK1_alpha___GSK3__G_alpha_o___beta__Arrestin2 AXIN__CK1_alpha___GSK3__G_alpha_o___beta__Arrestin2 _NFAT_NF_kB _NFAT_NF_kB WNT_canonical_pathway WNT_canonical_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. NFAT__at_Nucleus NFAT__at_Nucleus gAP_1_ARRE_binding_sites__at_Nucleus gAP_1_ARRE_binding_sites__at_Nucleus GLI2 HGNC FOXF1 FOXF1 NFAT__at_Nucleus NFAT__at_Nucleus FOXL1 FOXL1 G_alpha_o__at_Endosome G_alpha_o__at_Endosome 22045851 pubmed JUN_at_Nucleus JUN_at_Nucleus gpromoter_region gpromoter_region CK1_alpha___at_Endosome CK1_alpha___at_Endosome FOS_at_Nucleus FOS_at_Nucleus FOXF1 FOXF1 GSK3__at_Endosome GSK3__at_Endosome MEK1__at_Nucleus MEK1__at_Nucleus ERK2__at_Nucleus ERK2__at_Nucleus _NFAT_AP_1 _NFAT_AP_1 NFAT__pho_at_Nucleus NFAT__pho_at_Nucleus CK1_gamma___at_Vaceolae CK1_gamma___at_Vaceolae G_beta___at_Vaceolae G_beta___at_Vaceolae GDP GDP CyclinC CyclinC p120__at_Vaceolae p120__at_Vaceolae CK1_epsilon___at_Vaceolae CK1_epsilon___at_Vaceolae FZD__at_Vaceolae FZD__at_Vaceolae DVL__pho_S139_pho_S142_pho_at_Vaceolae DVL__pho_S139_pho_S142_pho_at_Vaceolae CK1_epsilon___at_Vaceolae CK1_epsilon___at_Vaceolae p120__at_Vaceolae p120__at_Vaceolae E_Cadherin__at_Vaceolae E_Cadherin__at_Vaceolae AMER1__CK1_epsilon___CK1_gamma___DVL__E_Cadherin__FZD__G_beta___G_gamma___LRP5_6__PRR__WNT___beta__Arrestin2__p120 AMER1__CK1_epsilon___CK1_gamma___DVL__E_Cadherin__FZD__G_beta___G_gamma___LRP5_6__PRR__WNT___beta__Arrestin2__p120 EMT EMT This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 18627596 pubmed FOXA2 FOXA2 FOXA2 FOXA2 CNA__at_Nucleus CNA__at_Nucleus Proliferation Proliferation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ACTIVATION CDTYPE:CATALYSIS CNB__at_Nucleus CNB__at_Nucleus FOXC2 FOXC2 FOXC2 FOXC2 NFAT__at_Nucleus NFAT__at_Nucleus FOXP3 FOXP3 ERK2__at_Nucleus ERK2__at_Nucleus FOXP3 FOXP3 MEK1__at_Nucleus MEK1__at_Nucleus FOXQ1 FOXQ1 FOXQ1 FOXQ1 MED12 MED12 Renin_angiotensin_system Renin_angiotensin_system This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. RUNX2 RUNX2 PKD__at_Cytoplasm PKD__at_Cytoplasm Cancer_progression_ER_neg Cancer_progression_ER_neg This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. USP15_at_Cytoplasm USP15_at_Cytoplasm RUNX2 RUNX2 DVL DVL CK2_alpha___at_Cytoplasm CK2_alpha___at_Cytoplasm CK2_alpha____at_Cytoplasm CK2_alpha____at_Cytoplasm FOXM1 FOXM1 PI3_4_5_P3 PI3_4_5_P3 FOXE1 FOXE1 FOXM1 FOXM1 Notch_pathway Notch_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. FOXE1 FOXE1 JAG2 JAG2 JAG2 JAG2 SRM160 SRM160 KIF7 KIF7 CSN5__at_Cytoplasm CSN5__at_Cytoplasm CSN6__at_Cytoplasm CSN6__at_Cytoplasm CSN7__at_Cytoplasm CSN7__at_Cytoplasm 19136967 pubmed CSN8__at_Cytoplasm CSN8__at_Cytoplasm 21406690 pubmed CyclinD CyclinD CyclinD CyclinD NEDD8_at_Cytoplasm NEDD8_at_Cytoplasm TBX2 TBX2 RAD6__at_Cytoplasm RAD6__at_Cytoplasm TBX2 TBX2 CSN2__at_Cytoplasm CSN2__at_Cytoplasm CSN1__at_Cytoplasm CSN1__at_Cytoplasm CSN4__at_Cytoplasm CSN4__at_Cytoplasm 21359530 pubmed CSN3__at_Cytoplasm CSN3__at_Cytoplasm GLI3_190__promoter_region GLI3_190__promoter_region GLI3_190 GLI3_190 PTCH1 PTCH1 PTCH1 PTCH1 NFAT__at_Cytoplasm NFAT__at_Cytoplasm CSE1L CSE1L TNPO1 TNPO1 Calmodulin__at_Cytoplasm Calmodulin__at_Cytoplasm Ca2__at_Cytoplasm Ca2__at_Cytoplasm PPP3CB_at_Cytoplasm PPP3CB_at_Cytoplasm PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm 16511445 pubmed RUVBL2 HGNC CK1_epsilon CK1_epsilon GSK3 GSK3 IQGAP IQGAP TNPO1_at_Cytoplasm TNPO1_at_Cytoplasm rNRON_at_Cytoplasm rNRON_at_Cytoplasm E1 E1 LRRK2 LRRK2 LRRK2_at_Cytoplasm LRRK2_at_Cytoplasm CSE1L_Ca2__Calmodulin__KPNB1_LRRK2_NFAT__NRON_PPP3CB_PPP3R__TNPO1_Tubulin__alpha CSE1L_Ca2__Calmodulin__KPNB1_LRRK2_NFAT__NRON_PPP3CB_PPP3R__TNPO1_Tubulin__alpha Caspase9__sub_TRUNC_endsub Caspase9__sub_TRUNC_endsub PPP3CB_sub_trunc_endsub___at_Cytoplasm PPP3CB_sub_trunc_endsub___at_Cytoplasm PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CSE1L_at_Cytoplasm CSE1L_at_Cytoplasm 12655147 pubmed ACTIVATION CDTYPE:CATALYSIS Tubulin__alpha___at_Cytoplasm Tubulin__alpha___at_Cytoplasm KPNB1_at_Cytoplasm KPNB1_at_Cytoplasm GSK3_beta GSK3_beta Calmodulin__at_Cytoplasm Calmodulin__at_Cytoplasm Ca2__at_Cytoplasm Ca2__at_Cytoplasm PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm rNRON_at_Cytoplasm rNRON_at_Cytoplasm LRRK2_at_Cytoplasm LRRK2_at_Cytoplasm CSE1L_at_Cytoplasm CSE1L_at_Cytoplasm TNPO1_at_Cytoplasm TNPO1_at_Cytoplasm KPNB1_at_Cytoplasm KPNB1_at_Cytoplasm Tubulin__alpha___at_Cytoplasm Tubulin__alpha___at_Cytoplasm IQGAP1 IQGAP1 ACTIVATION CDTYPE:CATALYSIS DACT1 DACT1 RACK1 RACK1 S100A7 HGNC RUNX2 RUNX2 GPC5 HGNC GPC4 HGNC GPC3 HGNC MYCN MYCN GPC2 HGNC GPC1 HGNC 15337521 pubmed NFAT__at_Cytoplasm NFAT__at_Cytoplasm USP15 HGNC 22807036 pubmed STAT1 HGNC 20558317 pubmed 12792650 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 17848687 pubmed ACTIVATION CDTYPE:CATALYSIS CAPN3 HGNC CAPN2 HGNC CAPN5 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CAPN1 HGNC ACTIVATION CDTYPE:CATALYSIS CDTYPE:MODULATION ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 12529437 pubmed CAPN6 HGNC CAPN7 HGNC CAPN8 HGNC FZD7 HGNC CAPN9 HGNC ACTIVATION CDTYPE:CATALYSIS MAP3K1_pho_at_Cytoplasm MAP3K1_pho_at_Cytoplasm MAP3K1_pho_at_Cytoplasm MAP3K1_pho_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS TRAF2_at_Cytoplasm TRAF2_at_Cytoplasm TRADD_at_Cytoplasm TRADD_at_Cytoplasm FOXO1 HGNC 21078818 pubmed ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:UNKNOWN_INHIBITION DYRK1B HGNC ACTIVATION CDTYPE:CATALYSIS 15240885 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS RAS__pho_at_Plasma_Membrane RAS__pho_at_Plasma_Membrane SOS__at_Plasma_Membrane SOS__at_Plasma_Membrane CDTYPE:TRIGGER CDTYPE:PHYSICAL_STIMULATION ERN1_at_Plasma_Membrane ERN1_at_Plasma_Membrane MEK__pho_pho_at_Plasma_Membrane MEK__pho_pho_at_Plasma_Membrane 19366350 pubmed GRB2_at_Plasma_Membrane GRB2_at_Plasma_Membrane 10721693 pubmed CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS KSR1_at_Cytoplasm KSR1_at_Cytoplasm MEK__at_Cytoplasm MEK__at_Cytoplasm 19561074 pubmed KSR1_at_Plasma_Membrane KSR1_at_Plasma_Membrane CDTYPE:BOOLEAN_LOGIC_GATE_AND BCL9 HGNC CDTYPE:BOOLEAN_LOGIC_GATE_AND MAP3K1 MAP3K1 20562099 pubmed 17533367 pubmed CDTYPE:TRIGGER CDTYPE:PHYSICAL_STIMULATION IGFBP6 IGFBP6 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION APC_sub_TRUNC_endsub APC_sub_TRUNC_endsub DEK HGNC TDGF1 HGNC G_alpha__sub_s_endsub___at_Cytoplasm G_alpha__sub_s_endsub___at_Cytoplasm 19815709 pubmed 19000719 pubmed LRP6_at_Cytoplasm LRP6_at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm G_alpha__sub_s_endsub___at_Cytoplasm G_alpha__sub_s_endsub___at_Cytoplasm G_alpha__sub_s_endsub___at_Cytoplasm G_alpha__sub_s_endsub___at_Cytoplasm TIAM1 TIAM1 Adenylyl_cyclase Adenylyl_cyclase _beta__Catenin _beta__Catenin 12713446 pubmed WNT_canonical_pathway WNT_canonical_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. _alpha__Catenin__at_Cytoplasm _alpha__Catenin__at_Cytoplasm TNFSF10 HGNC cytoskeleton_at_Cytoplasm cytoskeleton_at_Cytoplasm This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 18562292 pubmed p53 p53 HIPK2 HIPK2 WNT_canonical_pathway_nucleus WNT_canonical_pathway_nucleus This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 18559511 pubmed AXIN AXIN AXIN__HIPK2_p53 AXIN__HIPK2_p53 18519670 pubmed GRB2 GRB2 p53__at_Nucleus p53__at_Nucleus 21486225 pubmed BAD BAD E_Cadherin__at_Cytoplasm E_Cadherin__at_Cytoplasm p120__at_Cytoplasm p120__at_Cytoplasm _alpha__Catenin__at_Cytoplasm _alpha__Catenin__at_Cytoplasm MIR204 HGNC PPP3CB_sub_trunc_endsub___at_Cytoplasm PPP3CB_sub_trunc_endsub___at_Cytoplasm Cytoskeleton_at_Cytoplasm Cytoskeleton_at_Cytoplasm This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. _beta__Catenin__Y142_pho_at_Cytoplasm _beta__Catenin__Y142_pho_at_Cytoplasm E_Cadherin__at_Cytoplasm E_Cadherin__at_Cytoplasm p120__at_Cytoplasm p120__at_Cytoplasm MCL1 MCL1 MAP2K2 HGNC NFAT__PPP3CB_sub_trunc_endsub___PPP3R NFAT__PPP3CB_sub_trunc_endsub___PPP3R MAP2K1 HGNC PIP5K1A HGNC PPP3CB_sub_trunc_endsub___at_Cytoplasm PPP3CB_sub_trunc_endsub___at_Cytoplasm PIP5K1B HGNC NFAT__PPP3CB_sub_trunc_endsub___PPP3R NFAT__PPP3CB_sub_trunc_endsub___PPP3R PIP5K1C HGNC WDR19 WDR19 NFAT__pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_at_Cytoplasm NFAT__pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_at_Cytoplasm PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm FOXO1_pho_emp_pho_at_Cytoplasm FOXO1_pho_emp_pho_at_Cytoplasm PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm NFAT__at_Nucleus NFAT__at_Nucleus NFAT NFAT Cytoskeleton_at_Cytoplasm Cytoskeleton_at_Cytoplasm This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. USP34 HGNC p120__at_Cytoplasm p120__at_Cytoplasm PPP3CB_sub_trunc_endsub___at_Nucleus PPP3CB_sub_trunc_endsub___at_Nucleus _alpha__Catenin__at_Cytoplasm _alpha__Catenin__at_Cytoplasm PPP3R__at_Nucleus PPP3R__at_Nucleus _beta__Catenin__at_Cytoplasm _beta__Catenin__at_Cytoplasm E_Cadherin__at_Cytoplasm E_Cadherin__at_Cytoplasm 16413481 pubmed MAP3K4 MAP3K4 PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm PPP3CB_at_Cytoplasm PPP3CB_at_Cytoplasm 12867079 pubmed NFAT__at_Cytoplasm NFAT__at_Cytoplasm PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm PPP3CB_sub_trunc_endsub___at_Cytoplasm PPP3CB_sub_trunc_endsub___at_Cytoplasm NFAT__at_Nucleus NFAT__at_Nucleus Ca2__at_Cytoplasm Ca2__at_Cytoplasm ERK ERK NFAT__pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_at_Cytoplasm NFAT__pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_at_Cytoplasm ARID1A HGNC MAPK_pathway MAPK_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CTNNB1 HGNC Calmodulin__at_Cytoplasm Calmodulin__at_Cytoplasm UBCH10 UBCH10 RTK__at_Cytoplasm RTK__at_Cytoplasm 21416054 pubmed PPP3CB_at_Nucleus PPP3CB_at_Nucleus PPP3R__at_Nucleus PPP3R__at_Nucleus Calmodulin__at_Nucleus Calmodulin__at_Nucleus Ca2__at_Nucleus Ca2__at_Nucleus AXIN1_at_Nucleus AXIN1_at_Nucleus DVL2 HGNC MYC_S62_pho_T58_pho_at_Nucleus MYC_S62_pho_T58_pho_at_Nucleus DVL3 HGNC NFAT__at_Cytoplasm NFAT__at_Cytoplasm GSK3__at_Nucleus GSK3__at_Nucleus PTEN PTEN PIN1_at_Nucleus PIN1_at_Nucleus BAF BAF G_beta___at_Cytoplasm G_beta___at_Cytoplasm 18979497 pubmed HBEGF HGNC F2R HGNC GLI2 HGNC 12747838 pubmed DVL1 HGNC PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm PPP3CB_at_Cytoplasm PPP3CB_at_Cytoplasm MIR493 HGNC Ca2__at_Cytoplasm Ca2__at_Cytoplasm PIN1_at_Nucleus PIN1_at_Nucleus Calmodulin__at_Cytoplasm Calmodulin__at_Cytoplasm GSK3__at_Nucleus GSK3__at_Nucleus GTP_at_Cytoplasm GTP_at_Cytoplasm KPNB1 KPNB1 Tubulin__alpha Tubulin__alpha LRP6_at_Cytoplasm LRP6_at_Cytoplasm NRON NRON CCN2__LRP6 CCN2__LRP6 CCN2 CCN2 IQGAP__at_Cytoplasm IQGAP__at_Cytoplasm WNT WNT MYC_S62_pho_at_Nucleus MYC_S62_pho_at_Nucleus NFAT__at_Cytoplasm NFAT__at_Cytoplasm GSK3__at_Nucleus GSK3__at_Nucleus WNT__at_Cytoplasm WNT__at_Cytoplasm KCASH2 KCASH2 KIF3B KIF3B PPP3CB_at_Cytoplasm PPP3CB_at_Cytoplasm AXIN1_at_Nucleus AXIN1_at_Nucleus PIN1_at_Nucleus PIN1_at_Nucleus AOS1 AOS1 ING3 HGNC Tubulin__alpha___at_Cytoplasm Tubulin__alpha___at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm Ca2__at_Cytoplasm Ca2__at_Cytoplasm 18997815 pubmed Calmodulin__at_Cytoplasm Calmodulin__at_Cytoplasm PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm FZD__GTP_G_alpha___G_beta___G_gamma___WNT FZD__GTP_G_alpha___G_beta___G_gamma___WNT LRP6_S1544_pho_T1548_pho_at_Cytoplasm LRP6_S1544_pho_T1548_pho_at_Cytoplasm NFAT__at_Cytoplasm NFAT__at_Cytoplasm AXIN1 AXIN1 ACTIVATION CDTYPE:CATALYSIS GSK3 GSK3 GSK3 GSK3 17613518 pubmed 18497258 pubmed G_alpha__sub_s_endsub___at_Cytoplasm G_alpha__sub_s_endsub___at_Cytoplasm KPNB1_at_Cytoplasm KPNB1_at_Cytoplasm cAMP cAMP PPP3CB_sub_trunc_endsub___at_Cytoplasm PPP3CB_sub_trunc_endsub___at_Cytoplasm PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm GPC6 GPC6 HIPK1 HIPK1 GTP_at_Cytoplasm GTP_at_Cytoplasm IDAX IDAX KPNB1_at_Nucleus KPNB1_at_Nucleus CCN2__at_Cytoplasm CCN2__at_Cytoplasm Tubulin__alpha___at_Nucleus Tubulin__alpha___at_Nucleus PP2A_B__at_Nucleus PP2A_B__at_Nucleus PP2_C__at_Nucleus PP2_C__at_Nucleus KPNB1_at_Cytoplasm KPNB1_at_Cytoplasm PP2A_A__at_Nucleus PP2A_A__at_Nucleus Tubulin__alpha___at_Cytoplasm Tubulin__alpha___at_Cytoplasm 21709260 pubmed PIN1 PIN1 G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm KPNB1 KPNB1 G_beta___at_Cytoplasm G_beta___at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS LRP6_at_Cytoplasm LRP6_at_Cytoplasm HIPK2_at_Nucleus HIPK2_at_Nucleus Tubulin__alpha___at_Nucleus Tubulin__alpha___at_Nucleus G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm KPNB1_NFAT__PPP3CB_sub_trunc_endsub___PPP3R__Tubulin__alpha KPNB1_NFAT__PPP3CB_sub_trunc_endsub___PPP3R__Tubulin__alpha GTP_at_Cytoplasm GTP_at_Cytoplasm KPNB1_at_Nucleus KPNB1_at_Nucleus ACTIVATION CDTYPE:CATALYSIS MIR27A MIR27A PTH_at_Cytoplasm PTH_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS G_alpha__sub_s_endsub___at_Cytoplasm G_alpha__sub_s_endsub___at_Cytoplasm WNT2B WNT2B 21506126 pubmed KCTD6 HGNC Cell_cycle_pathway Cell_cycle_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Apoptosis Apoptosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. DYRK DYRK p53__S46_pho_at_Nucleus p53__S46_pho_at_Nucleus ATP ATP NFAT__pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_at_Cytoplasm NFAT__pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_at_Cytoplasm MYC MYC rNRON_at_Cytoplasm rNRON_at_Cytoplasm p53_target_genes p53_target_genes This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CK1_epsilon___DYRK__GSK3__IQGAP__NFAT__NRON CK1_epsilon___DYRK__GSK3__IQGAP__NFAT__NRON AXIN__HIPK2_p53 AXIN__HIPK2_p53 DYRK__at_Cytoplasm DYRK__at_Cytoplasm AXIN__at_Nucleus AXIN__at_Nucleus GSK3__at_Cytoplasm GSK3__at_Cytoplasm HIPK2_at_Nucleus HIPK2_at_Nucleus CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm AXIN__at_Nucleus AXIN__at_Nucleus HB_EGF__at_Cytoplasm HB_EGF__at_Cytoplasm HER2__at_Cytoplasm HER2__at_Cytoplasm LRP6 LRP6 MYC HGNC EGFR_HB_EGF__HER2 EGFR_HB_EGF__HER2 EGFR_at_Cytoplasm EGFR_at_Cytoplasm HER2 HER2 19809516 pubmed 21087212 pubmed EGFR EGFR PKC PKC Pro_HB_EGF Pro_HB_EGF HB_EGF HB_EGF G_beta___at_Endosome G_beta___at_Endosome GDP_G_alpha__sub_s_endsub___G_beta___G_gamma GDP_G_alpha__sub_s_endsub___G_beta___G_gamma PRR__at_Endosome PRR__at_Endosome GDP_at_Cytoplasm GDP_at_Cytoplasm 9829964 pubmed G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm G_gamma___at_Endosome G_gamma___at_Endosome _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome _beta__Catenin__at_Nucleus _beta__Catenin__at_Nucleus JBN__at_Nucleus JBN__at_Nucleus 18820483 pubmed JBN__at_Cilium JBN__at_Cilium JBN___beta__Catenin JBN___beta__Catenin JBN___beta__Catenin JBN___beta__Catenin _beta__Catenin__at_Cilium _beta__Catenin__at_Cilium _beta__Catenin__at_Cytoplasm _beta__Catenin__at_Cytoplasm PIK3CD HGNC PIK3CB HGNC CDKN2D HGNC PIK3CA HGNC DYNC2H1 DYNC2H1 G_alpha__sub_13q_endsub___at_Cytoplasm G_alpha__sub_13q_endsub___at_Cytoplasm PHLPP1 HGNC G_beta___at_Cytoplasm G_beta___at_Cytoplasm PHLPP2 HGNC PIK3CG HGNC PAR1__at_Cytoplasm PAR1__at_Cytoplasm HECTH9 HECTH9 MYC MYC MYC MYC p101__p110_beta__gamma p101__p110_beta__gamma p101__at_Cytoplasm p101__at_Cytoplasm AXIN2 AXIN2 Adenylyl_cyclase Adenylyl_cyclase DVL__Iversin DVL__Iversin DVL__Iversin DVL__Iversin Iversin__at_Cilium Iversin__at_Cilium DVL__at_Cilium DVL__at_Cilium JBN JBN KIF3A_at_Cytoplasm KIF3A_at_Cytoplasm SKI HGNC 17884187 pubmed JBN__at_Cytoplasm JBN__at_Cytoplasm JBN___beta__Catenin JBN___beta__Catenin AXIN1_at_Nucleus AXIN1_at_Nucleus ACTB HGNC G_gamma___at_Endoplasmic_Reticulum G_gamma___at_Endoplasmic_Reticulum 20930545 pubmed G_beta___at_Endoplasmic_Reticulum G_beta___at_Endoplasmic_Reticulum G_gamma G_gamma G_beta___G_gamma___IP3R G_beta___G_gamma___IP3R MYC_S62_emp_T58_pho_at_Nucleus MYC_S62_emp_T58_pho_at_Nucleus IP3R__at_Endoplasmic_Reticulum IP3R__at_Endoplasmic_Reticulum CK2_alpha CK2_alpha MAPK_pathway MAPK_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. BCL2 BCL2 G_beta___G_gamma___p101__p110_beta__gamma G_beta___G_gamma___p101__p110_beta__gamma 20506250 pubmed TACE TACE TACE TACE GTP_at_Cytoplasm GTP_at_Cytoplasm 15375164 pubmed 15239952 pubmed BAF57 BAF57 20083225 pubmed RTK RTK KIF3B HGNC G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm p110_beta__gamma___at_Cytoplasm p110_beta__gamma___at_Cytoplasm 18477453 pubmed G_beta___at_Cytoplasm G_beta___at_Cytoplasm p101__at_Cytoplasm p101__at_Cytoplasm p110_beta__gamma___at_Cytoplasm p110_beta__gamma___at_Cytoplasm 11929833 pubmed 9812896 pubmed CUL3_DVL__KLHL__RBX1 CUL3_DVL__KLHL__RBX1 DVL__at_Cytoplasm DVL__at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm Iversin Iversin APC_at_Cytoplasm APC_at_Cytoplasm NEDL1 NEDL1 AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm BCL6 BCL6 GSK3__at_Cytoplasm GSK3__at_Cytoplasm PR55_alpha___at_Cytoplasm PR55_alpha___at_Cytoplasm PP2A_C__at_Cytoplasm PP2A_C__at_Cytoplasm FOS FOS CK1_epsilon___E_Cadherin__LRP5_6__p120 CK1_epsilon___E_Cadherin__LRP5_6__p120 PR65_A__at_Cytoplasm PR65_A__at_Cytoplasm GPC6 HGNC E_Cadherin__at_Vaceolae E_Cadherin__at_Vaceolae LRP5_6__at_Vaceolae LRP5_6__at_Vaceolae PRICKLE1 HGNC MMP9 MMP9 MIR378 MIR378 DVL__at_Cytoplasm DVL__at_Cytoplasm Iversin__at_Cytoplasm Iversin__at_Cytoplasm KLHL__at_Cytoplasm KLHL__at_Cytoplasm APC_at_Cytoplasm APC_at_Cytoplasm PRR__at_Endosome PRR__at_Endosome PPP1C__at_Cytoplasm PPP1C__at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm RHOA RHOA 16263762 pubmed GSK3__at_Cytoplasm GSK3__at_Cytoplasm PPP1R__at_Cytoplasm PPP1R__at_Cytoplasm RBX1_at_Cytoplasm RBX1_at_Cytoplasm KLHL__at_Cytoplasm KLHL__at_Cytoplasm CUL3_at_Cytoplasm CUL3_at_Cytoplasm CUL3_KLHL__RBX1 CUL3_KLHL__RBX1 CUL3_at_Cytoplasm CUL3_at_Cytoplasm RBX1_at_Cytoplasm RBX1_at_Cytoplasm AXIN__at_Endosome AXIN__at_Endosome G_alpha_o__at_Endosome G_alpha_o__at_Endosome PTHR PTHR PTH PTH CK1_alpha___at_Endosome CK1_alpha___at_Endosome GSK3__at_Endosome GSK3__at_Endosome HSP90 HSP90 22682247 pubmed FOXO3_at_Nucleus FOXO3_at_Nucleus p27KIP1 p27KIP1 p27KIP1 p27KIP1 FOXO4 FOXO4 p19INK4D p19INK4D GSK3__at_Cytoplasm GSK3__at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm APC_at_Cytoplasm APC_at_Cytoplasm WNT2B HGNC AKT AKT PPP3R PPP3R GDP_at_Cytoplasm GDP_at_Cytoplasm RPS6 RPS6 CSN1 CSN1 _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm CDK14 HGNC FOXL1 HGNC Genes_under_control_of__br_CBP_mediated_transcription Genes_under_control_of__br_CBP_mediated_transcription SMAD2 SMAD2 18936100 pubmed APC7 APC7 FOS FOS PAR1 PAR1 15087129 pubmed TAB__at_Cytoplasm TAB__at_Cytoplasm TAK1__pho_at_Cytoplasm TAK1__pho_at_Cytoplasm MIR34B HGNC TGFBR2_at_Plasma_Membrane TGFBR2_at_Plasma_Membrane TAK1__pho_at_Cytoplasm TAK1__pho_at_Cytoplasm DEK DEK 20647036 pubmed TCF4 HGNC DEPTOR HGNC dATP_ATP dATP_ATP IRAK1_at_Cytoplasm IRAK1_at_Cytoplasm 18802401 pubmed TRAF6_at_Cytoplasm TRAF6_at_Cytoplasm MYD88_at_Cytoplasm MYD88_at_Cytoplasm GRB2_at_Plasma_Membrane GRB2_at_Plasma_Membrane TAB2 HGNC UHMK1 HGNC GNG10 HGNC GNG11 HGNC BAF60A BAF60A GNG12 HGNC MYD88_at_Plasma_Membrane MYD88_at_Plasma_Membrane IRAK1_at_Plasma_Membrane IRAK1_at_Plasma_Membrane MYD88 MYD88 IL1R1 IL1R1 IL1R1_MYD88 IL1R1_MYD88 MYD88_at_Plasma_Membrane MYD88_at_Plasma_Membrane GRB2_at_Cytoplasm GRB2_at_Cytoplasm SEF SEF MIR182 MIR182 CDK2 CDK2 TGFBR1_TGFBR2 TGFBR1_TGFBR2 AXIN2 HGNC TGFBR2_at_Plasma_Membrane TGFBR2_at_Plasma_Membrane GNG13 HGNC 17115028 pubmed TRAF6_at_Plasma_Membrane TRAF6_at_Plasma_Membrane MYD88_at_Plasma_Membrane MYD88_at_Plasma_Membrane IRAK1_at_Plasma_Membrane IRAK1_at_Plasma_Membrane TAK1 TAK1 TGFBR1_at_Plasma_Membrane TGFBR1_at_Plasma_Membrane PRR__at_Endosome PRR__at_Endosome PRR__at_Endosome PRR__at_Endosome PRR__at_Endosome PRR__at_Endosome ACTIVATION CDTYPE:CATALYSIS CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 20580290 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 20143239 pubmed IGFBP6 HGNC SKP1 HGNC TRAF6 TRAF6 SKP2 HGNC TRADD TRADD 20713713 pubmed RIPK1 RIPK1 ACTIVATION CDTYPE:CATALYSIS CDTYPE:BOOLEAN_LOGIC_GATE_AND CDON HGNC TRAF2_at_Plasma_Membrane TRAF2_at_Plasma_Membrane TRADD_at_Plasma_Membrane TRADD_at_Plasma_Membrane TNFRSF1A_TRADD_TRAF2 TNFRSF1A_TRADD_TRAF2 PRR__at_Endosome PRR__at_Endosome RIPK1_TNFRSF1A_TRADD_TRAF2 RIPK1_TNFRSF1A_TRADD_TRAF2 TNFRSF1A_TRADD TNFRSF1A_TRADD 15036616 pubmed DUSP5 HGNC 19565474 pubmed RBX1 RBX1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 20081843 pubmed ACTIVATION CDTYPE:CATALYSIS TNFRSF1B_at_Plasma_Membrane TNFRSF1B_at_Plasma_Membrane TNFRSF1B_TRAF2 TNFRSF1B_TRAF2 TNFRSF1B TNFRSF1B ERN1 ERN1 ACTIVATION CDTYPE:CATALYSIS RIPK1_at_Plasma_Membrane RIPK1_at_Plasma_Membrane ACTIVATION CDTYPE:CATALYSIS ATM HGNC ADAM17 HGNC IRAK1 IRAK1 TRAF2_at_Plasma_Membrane TRAF2_at_Plasma_Membrane SHOC2 HGNC XIAP HGNC ERN1_TRAF2 ERN1_TRAF2 RAS RAS ROS ROS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS E2 E2 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ULK ULK E2F1 E2F1 Pi Pi MEK1 MEK1 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS TIPARP HGNC ACTIVATION CDTYPE:CATALYSIS MEF2 MEF2 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:CATALYSIS FAF FAF H2AFX_at_Nucleus H2AFX_at_Nucleus PPP3CB_sub_trunc_endsub___at_Nucleus PPP3CB_sub_trunc_endsub___at_Nucleus Actin__at_Nucleus Actin__at_Nucleus FOXO1_PPP3CB_sub_trunc_endsub___PPP3R FOXO1_PPP3CB_sub_trunc_endsub___PPP3R FOXO1 FOXO1 FOXO1 FOXO1 PI3K_Akt_MTOR_pathway PI3K_Akt_MTOR_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. MIR34C MIR34C BAD BAD BAD BAD MTOR_S2448_pho_at_Membrane_Lysosome MTOR_S2448_pho_at_Membrane_Lysosome Pontin__at_Nucleus Pontin__at_Nucleus H2B__at_Nucleus H2B__at_Nucleus BAF53A__at_Nucleus BAF53A__at_Nucleus Ca2 Ca2 RAC1 RAC1 GAS41__at_Nucleus GAS41__at_Nucleus MTOR_S2448_pho_at_Cytoplasm MTOR_S2448_pho_at_Cytoplasm DMAP1_at_Nucleus DMAP1_at_Nucleus RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome H2AFZ_at_Nucleus H2AFZ_at_Nucleus RAC1_at_Cytoplasm RAC1_at_Cytoplasm INVS HGNC YL1__at_Nucleus YL1__at_Nucleus PRAS40__at_Membrane_Lysosome PRAS40__at_Membrane_Lysosome MLST8_at_Membrane_Lysosome MLST8_at_Membrane_Lysosome MTOR_S2448_emp_at_Membrane_Lysosome MTOR_S2448_emp_at_Membrane_Lysosome LEF_TCF__at_Nucleus LEF_TCF__at_Nucleus MTOR_S1261_pho_S2448_emp_at_Membrane_Lysosome MTOR_S1261_pho_S2448_emp_at_Membrane_Lysosome RPTOR_at_Membrane_Lysosome RPTOR_at_Membrane_Lysosome MIR34B MIR34B ACTIVATION CDTYPE:UNKNOWN_CATALYSIS FOXM1 HGNC MIR34A MIR34A MIR34C MIR34C MIR34B MIR34B TLE__ubi_at_Nucleus TLE__ubi_at_Nucleus FOXO1_PPP3CB_sub_trunc_endsub___PPP3R FOXO1_PPP3CB_sub_trunc_endsub___PPP3R HDAC1_2__at_Nucleus HDAC1_2__at_Nucleus ACTIVATION CDTYPE:UNKNOWN_CATALYSIS MIR34A MIR34A PPP3R__at_Nucleus PPP3R__at_Nucleus Wnt_canonical_signaling Wnt_canonical_signaling This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. FOXO1_pho_emp_pho_at_Nucleus FOXO1_pho_emp_pho_at_Nucleus CRM1 CRM1 PREX2 HGNC ACTIVATION CDTYPE:CATALYSIS Gene_under_control_of_br__P300_mediated_transcription Gene_under_control_of_br__P300_mediated_transcription PREX1 HGNC gWRE__at_Nucleus gWRE__at_Nucleus ING3_at_Nucleus ING3_at_Nucleus EAF6__at_Nucleus EAF6__at_Nucleus 16288288 pubmed BRD8_at_Nucleus BRD8_at_Nucleus MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome p400__at_Nucleus p400__at_Nucleus MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome 16288286 pubmed TRRAP_at_Nucleus TRRAP_at_Nucleus MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome RNA RNA MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome MRG15__at_Nucleus MRG15__at_Nucleus MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome EPC1_at_Nucleus EPC1_at_Nucleus AP2A2 HGNC AP2A1 HGNC 15574420 pubmed 10217147 pubmed MRGBP_at_Nucleus MRGBP_at_Nucleus ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS TLE TLE XIAP XIAP ACTIVATION CDTYPE:CATALYSIS TLE1 TLE1 11972058 pubmed PYGO__at_Nucleus PYGO__at_Nucleus BCL9_at_Nucleus BCL9_at_Nucleus p70_beta p70_beta gWRE__at_Nucleus gWRE__at_Nucleus p70_beta p70_beta HDAC1_2__at_Nucleus HDAC1_2__at_Nucleus p70_beta p70_beta ACTIVATION CDTYPE:CATALYSIS 12829230 pubmed HDAC1_2__TLE HDAC1_2__TLE MI34__WNT3 MI34__WNT3 NEDD8 HGNC MI34__WNT1 MI34__WNT1 arMI34__at_Nucleus arMI34__at_Nucleus LEF1_MI34 LEF1_MI34 arMI34__at_Nucleus arMI34__at_Nucleus MI34___beta__Catenin MI34___beta__Catenin arMI34__at_Nucleus arMI34__at_Nucleus ACTIVATION CDTYPE:CATALYSIS WNT1 WNT1 LEF1 LEF1 WNT3 WNT3 UBE2B HGNC PYGO PYGO BCL9 BCL9 BCL9 BCL9 PYGO__at_Nucleus PYGO__at_Nucleus BCL9_PYGO___beta__Catenin BCL9_PYGO___beta__Catenin TSP1 TSP1 BCL9_at_Nucleus BCL9_at_Nucleus LEF_TCF__at_Nucleus LEF_TCF__at_Nucleus MLST8_at_Cytoplasm MLST8_at_Cytoplasm arMI34__at_Nucleus arMI34__at_Nucleus RPTOR_at_Cytoplasm RPTOR_at_Cytoplasm p53 p53 PRAS40__at_Cytoplasm PRAS40__at_Cytoplasm FRK FRK r_beta__Catenin__at_Nucleus r_beta__Catenin__at_Nucleus rLRP6_at_Nucleus rLRP6_at_Nucleus rWNT3_at_Nucleus rWNT3_at_Nucleus FOXF1 HGNC rWNT1_at_Nucleus rWNT1_at_Nucleus arMI34__at_Nucleus arMI34__at_Nucleus LRP6_MI34 LRP6_MI34 ACTIVATION CDTYPE:CATALYSIS ULK1 HGNC rLEF1_at_Nucleus rLEF1_at_Nucleus SKP1_at_Cytoplasm SKP1_at_Cytoplasm RBX1_at_Cytoplasm RBX1_at_Cytoplasm FBW7__at_Cytoplasm FBW7__at_Cytoplasm MTOR MTOR p27KIP1 p27KIP1 CUL1_FBW7__RBX1_SKP1 CUL1_FBW7__RBX1_SKP1 CUL1_at_Cytoplasm CUL1_at_Cytoplasm 16525676 pubmed PP2B_B__at_Cytoplasm PP2B_B__at_Cytoplasm BCL9 BCL9 PP2B_C__at_Cytoplasm PP2B_C__at_Cytoplasm INHIBITION CDTYPE:UNKNOWN_INHIBITION ACTIVATION CDTYPE:UNKNOWN_CATALYSIS Caspase3__at_Cytoplasm Caspase3__at_Cytoplasm Caspase3__p21CIP1 Caspase3__p21CIP1 p21CIP1__T145_pho_at_Cytoplasm p21CIP1__T145_pho_at_Cytoplasm p21CIP1 p21CIP1 TAB1 TAB1 Caspase3 Caspase3 p21CIP1 p21CIP1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS PINK1 PINK1 TPBG HGNC ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS Caspase8 Caspase8 20348948 pubmed ACTIVATION CDTYPE:CATALYSIS p21CIP1 p21CIP1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CK1 CK1 RASGRP1_at_Plasma_Membrane RASGRP1_at_Plasma_Membrane TAK1__pho_active_at_Cytoplasm TAK1__pho_active_at_Cytoplasm APAF1_at_Cytoplasm APAF1_at_Cytoplasm DAG_at_Plasma_Membrane DAG_at_Plasma_Membrane MIR372 HGNC dATP_ATP dATP_ATP CBL CBL H2B H2B UBC4 UBC4 PAM__TSC2 PAM__TSC2 E3__TSC2 E3__TSC2 PAM__at_Cytoplasm PAM__at_Cytoplasm TSC2_at_Cytoplasm TSC2_at_Cytoplasm 12040186 pubmed TSC2_at_Cytoplasm TSC2_at_Cytoplasm E3__at_Cytoplasm E3__at_Cytoplasm H H INHIBITION CDTYPE:INHIBITION ALYREF HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 14741051 pubmed TAB1_at_Cytoplasm TAB1_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS MYCN MYCN ROR2_TAB1_TAB2_TAK1 ROR2_TAB1_TAB2_TAK1 WNT_canonical_pathway WNT_canonical_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 11208056 pubmed ACTIVATION CDTYPE:CATALYSIS TAB2_at_Cytoplasm TAB2_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ROR2_pho_at_Cytoplasm ROR2_pho_at_Cytoplasm WNT3_at_Cytoplasm WNT3_at_Cytoplasm INHIBITION CDTYPE:INHIBITION INHIBITION CDTYPE:INHIBITION TDGF1 HGNC WNT3 WNT3 FHL2 HGNC FBW5__at_Cytoplasm FBW5__at_Cytoplasm DCAF__at_Cytoplasm DCAF__at_Cytoplasm ACTIVATION CDTYPE:UNKNOWN_CATALYSIS CUL4__DCAF__FBW5__RBX1_TSC2 CUL4__DCAF__FBW5__RBX1_TSC2 CUL4__at_Cytoplasm CUL4__at_Cytoplasm CDK4_6__CyclinD__p27KIP1 CDK4_6__CyclinD__p27KIP1 RBX1_at_Cytoplasm RBX1_at_Cytoplasm TSC2_at_Cytoplasm TSC2_at_Cytoplasm p27KIP1__S10_pho_T187_pho_T157_pho_at_Nucleus p27KIP1__S10_pho_T187_pho_T157_pho_at_Nucleus CyclinD__at_Nucleus CyclinD__at_Nucleus CDK4_6__at_Nucleus CDK4_6__at_Nucleus PLCG1_at_Plasma_Membrane PLCG1_at_Plasma_Membrane ACTIVATION CDTYPE:UNKNOWN_CATALYSIS SRC_at_Plasma_Membrane SRC_at_Plasma_Membrane ACTIVATION CDTYPE:CATALYSIS WNT5A HGNC 17374729 pubmed Calpain Calpain 21472142 pubmed INHIBITION CDTYPE:INHIBITION 20439735 pubmed CDTYPE:BOOLEAN_LOGIC_GATE_AND CK2_alpha____at_Cytoplasm CK2_alpha____at_Cytoplasm Caspase3_sub_TRUNC_endsub Caspase3_sub_TRUNC_endsub CK2_alpha___at_Cytoplasm CK2_alpha___at_Cytoplasm NFAT1 NFAT1 APC_at_Cytoplasm APC_at_Cytoplasm NFAT NFAT PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm _beta__Catenin _beta__Catenin _beta__Catenin _beta__Catenin AKT AKT PPP3CB_ubi_ubi_ubi_at_Cytoplasm PPP3CB_ubi_ubi_ubi_at_Cytoplasm MTA1_2_3 MTA1_2_3 DVL__LRP5_6__WNT DVL__LRP5_6__WNT LRP5_6__at_Cytoplasm LRP5_6__at_Cytoplasm 21262972 pubmed WNT__at_Cytoplasm WNT__at_Cytoplasm _beta__Catenin _beta__Catenin WNT__at_Cytoplasm WNT__at_Cytoplasm DVL DVL DVL__pho_pho_pho_at_Cytoplasm DVL__pho_pho_pho_at_Cytoplasm Y14__at_Cytoplasm Y14__at_Cytoplasm 12606575 pubmed REF__at_Cytoplasm REF__at_Cytoplasm RNPS1_at_Cytoplasm RNPS1_at_Cytoplasm MLST8_at_Cytoplasm MLST8_at_Cytoplasm MAP3K2_3 MAP3K2_3 RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Cytoplasm RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Cytoplasm MTOR_S1261_pho_S2448_emp_S2481_pho_at_Cytoplasm MTOR_S1261_pho_S2448_emp_S2481_pho_at_Cytoplasm MLST8_at_Cytoplasm MLST8_at_Cytoplasm RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Cytoplasm RPTOR_S696_pho_T706_pho_S855_pho_S863_pho_S877_pho_S859_pho_at_Cytoplasm MTOR_S1261_pho_S2448_emp_S2481_pho_at_Cytoplasm MTOR_S1261_pho_S2448_emp_S2481_pho_at_Cytoplasm MTOR_S1261_pho_S2448_emp_S2481_pho_at_Cytoplasm MTOR_S1261_pho_S2448_emp_S2481_pho_at_Cytoplasm 9106657 pubmed RBX1_at_Cytoplasm RBX1_at_Cytoplasm CASP3 HGNC ATROGIN_1__at_Cytoplasm ATROGIN_1__at_Cytoplasm ATROGIN_1__CUL1_RBX1_SKP1 ATROGIN_1__CUL1_RBX1_SKP1 ROR2_pho_at_Cytoplasm ROR2_pho_at_Cytoplasm TAK1__emp_at_Cytoplasm TAK1__emp_at_Cytoplasm TAB2_at_Cytoplasm TAB2_at_Cytoplasm NFKB1_p50__RELA__beta__Catenin NFKB1_p50__RELA__beta__Catenin TAB1_at_Cytoplasm TAB1_at_Cytoplasm NFKB1_p50__at_Nucleus NFKB1_p50__at_Nucleus PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm TAB1_TAB2_TAK1 TAB1_TAB2_TAK1 ACTIVATION CDTYPE:CATALYSIS Sonic_hedgehog_pathway Sonic_hedgehog_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PPP3CB_at_Cytoplasm PPP3CB_at_Cytoplasm CASR_Ca2 CASR_Ca2 _beta__Catenin _beta__Catenin APC APC Ca2__at_Cytoplasm Ca2__at_Cytoplasm CASR_at_Cytoplasm CASR_at_Cytoplasm CASR CASR Ca2 Ca2 17569865 pubmed Caspase9__at_Cytoplasm Caspase9__at_Cytoplasm 16129881 pubmed BAX BAX Cytochrome_C Cytochrome_C APAF1_Caspase9 APAF1_Caspase9 Caspase9__at_Cytoplasm Caspase9__at_Cytoplasm Y14__at_Cytoplasm Y14__at_Cytoplasm REF__at_Cytoplasm REF__at_Cytoplasm Cytochrome_C Cytochrome_C id_14_3_3__FOXO3 id_14_3_3__FOXO3 ROR2 ROR2 RNPS1_at_Cytoplasm RNPS1_at_Cytoplasm MDM2 MDM2 CRM1 CRM1 PPP3CB_sub_trunc_endsub___at_Cytoplasm PPP3CB_sub_trunc_endsub___at_Cytoplasm RCAN__T192_pho_at_Cytoplasm RCAN__T192_pho_at_Cytoplasm RCAN RCAN ERK ERK Calmodulin__at_Cytoplasm Calmodulin__at_Cytoplasm Ca2__at_Cytoplasm Ca2__at_Cytoplasm PPP3CB_at_Cytoplasm PPP3CB_at_Cytoplasm FZD FZD PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm Calmodulin__at_Cytoplasm Calmodulin__at_Cytoplasm Ca2__at_Cytoplasm Ca2__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS 19684112 pubmed Ca2__Calmodulin Ca2__Calmodulin 22705350 pubmed 20889716 pubmed NFAT NFAT NFAT NFAT GSK3 GSK3 CK1 CK1 RCAN RCAN ACTIVATION CDTYPE:CATALYSIS MEF2 MEF2 MEF2 MEF2 CUL1_at_Cytoplasm CUL1_at_Cytoplasm SKP1_at_Cytoplasm SKP1_at_Cytoplasm E2 E2 E1 E1 PPP3CB_at_Cytoplasm PPP3CB_at_Cytoplasm estrogen estrogen ACTIVATION CDTYPE:CATALYSIS Calpain Calpain CAIN CAIN CAIN_sub_TRUNC_endsub CAIN_sub_TRUNC_endsub PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS CAIN__at_Cytoplasm CAIN__at_Cytoplasm CBP__S92_pho_at_Nucleus CBP__S92_pho_at_Nucleus ACTIVATION CDTYPE:CATALYSIS PYGO__at_Nucleus PYGO__at_Nucleus PYGO__at_Nucleus PYGO__at_Nucleus PPP3CB_sub_trunc_endsub___PPP3R PPP3CB_sub_trunc_endsub___PPP3R BCL9_at_Nucleus BCL9_at_Nucleus HHIP1 HHIP1 PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm BCL9_CBP__PYGO___beta__Catenin BCL9_CBP__PYGO___beta__Catenin gWRE__at_Nucleus gWRE__at_Nucleus MEF2 MEF2 WGEF WGEF LEF_TCF__at_Nucleus LEF_TCF__at_Nucleus RCAN RCAN MAPK_pathway MAPK_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. FOXO3 FOXO3 SMARCE1 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS Necroptosis Necroptosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ACTIVATION CDTYPE:CATALYSIS Apoptosis Apoptosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ACTIVATION CDTYPE:CATALYSIS G_beta___at_Vaceolae G_beta___at_Vaceolae MYC MYC G_gamma___at_Vaceolae G_gamma___at_Vaceolae BAX_sub_TRUNC_endsub BAX_sub_TRUNC_endsub GTP_at_Vaceolae GTP_at_Vaceolae BCL9_PYGO__SMAD1_TCF4__beta__Catenin__p300 BCL9_PYGO__SMAD1_TCF4__beta__Catenin__p300 BAX_BID_sub_TRUNC_endsub BAX_BID_sub_TRUNC_endsub MOMP MOMP This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. MYC MYC TCF4_at_Nucleus TCF4_at_Nucleus BAX_at_Mitochondria BAX_at_Mitochondria BID_sub_TRUNC_endsub___at_Mitochondria BID_sub_TRUNC_endsub___at_Mitochondria p300__at_Nucleus p300__at_Nucleus HOMER3_NFAT HOMER3_NFAT PYGO__at_Nucleus PYGO__at_Nucleus INHIBITION CDTYPE:INHIBITION NFAT__pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_at_Cytoplasm NFAT__pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_pho_at_Cytoplasm _beta__Catenin__K345_ace_ace_at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus ACTIVATION CDTYPE:CATALYSIS BCL9_at_Nucleus BCL9_at_Nucleus HOMER3 HOMER3 CDTYPE:BOOLEAN_LOGIC_GATE_AND TAB2_at_Cytoplasm TAB2_at_Cytoplasm CDTYPE:BOOLEAN_LOGIC_GATE_AND HOMER3 HOMER3 ERK1_2 ERK1_2 CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS p300__at_Nucleus p300__at_Nucleus RCAN__TAB1_TAB2_TAK1 RCAN__TAB1_TAB2_TAK1 RCAN__S94_pho_S136_pho_at_Cytoplasm RCAN__S94_pho_S136_pho_at_Cytoplasm TAB1_at_Cytoplasm TAB1_at_Cytoplasm 16434164 pubmed TAK1__pho_at_Cytoplasm TAK1__pho_at_Cytoplasm BCL9_at_Nucleus BCL9_at_Nucleus BID BID BID_sub_TRUNC_endsub BID_sub_TRUNC_endsub BCL9_PYGO___beta__Catenin__p300 BCL9_PYGO___beta__Catenin__p300 BAX BAX CASR HGNC p300 p300 H H Calpastatin Calpastatin G_alpha_o__at_Cytoplasm G_alpha_o__at_Cytoplasm PKC PKC PRR__at_Endosome PRR__at_Endosome EMT EMT This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. WNT3 WNT3 PI4_5_P2 PI4_5_P2 LRP6 LRP6 BCL2_XL__at_Mitochondria BCL2_XL__at_Mitochondria PRR__at_Vaceolae PRR__at_Vaceolae _beta__Catenin _beta__Catenin BAX_sub_TRUNC_endsub___at_Mitochondria BAX_sub_TRUNC_endsub___at_Mitochondria SMAD1 SMAD1 BAX_sub_TRUNC_endsub___BCL2_XL BAX_sub_TRUNC_endsub___BCL2_XL ACTIVATION CDTYPE:CATALYSIS DYRK1A DYRK1A LRP6 LRP6 _beta__Catenin _beta__Catenin KPNB1 KPNB1 LEF1 LEF1 Tubulin__alpha Tubulin__alpha WNT1 WNT1 Ca2__at_Nucleus Ca2__at_Nucleus Calmodulin__at_Nucleus Calmodulin__at_Nucleus PPP3R__at_Nucleus PPP3R__at_Nucleus PPP3CB_at_Nucleus PPP3CB_at_Nucleus NFAT NFAT Unknown_kinase Unknown_kinase This is a CellDesigner UNKNOWN entity. HOMER3_at_Cytoplasm HOMER3_at_Cytoplasm CBP CBP BAX_at_Mitochondria BAX_at_Mitochondria CBP CBP BCL2_XL__at_Mitochondria BCL2_XL__at_Mitochondria BRD7_at_Nucleus BRD7_at_Nucleus BCL2_XL BCL2_XL BAX_BCL2_XL BAX_BCL2_XL _beta__actin__at_Nucleus _beta__actin__at_Nucleus id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm RELA_at_Nucleus RELA_at_Nucleus _beta__Catenin__at_Nucleus _beta__Catenin__at_Nucleus id_14_3_3__BAD id_14_3_3__BAD id_14_3_3__BAD id_14_3_3__BAD DKK1 DKK1 NF__kappa_B_pathway NF__kappa_B_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. NOS2 NOS2 NFKB1_p50__RELA NFKB1_p50__RELA NOS2 NOS2 TNPO1_at_Cytoplasm TNPO1_at_Cytoplasm HDAC2 HDAC2 Calmodulin__at_Cytoplasm Calmodulin__at_Cytoplasm BAF155__at_Nucleus BAF155__at_Nucleus BAF60A__at_Nucleus BAF60A__at_Nucleus RAD51 HGNC BAF53A__at_Nucleus BAF53A__at_Nucleus CAMK2__at_Cytoplasm CAMK2__at_Cytoplasm BAF47__at_Nucleus BAF47__at_Nucleus BAF45A__at_Nucleus BAF45A__at_Nucleus Ca2__at_Cytoplasm Ca2__at_Cytoplasm BAF57__at_Nucleus BAF57__at_Nucleus CSE1L_KPNB1_LRRK2_NFAT__NRON_PPP3CB_sub_trunc_endsub___PPP3R__TNPO1_Tubulin__alpha CSE1L_KPNB1_LRRK2_NFAT__NRON_PPP3CB_sub_trunc_endsub___PPP3R__TNPO1_Tubulin__alpha CAMK2__Ca2__Calmodulin CAMK2__Ca2__Calmodulin TNPO1_at_Cytoplasm TNPO1_at_Cytoplasm Calpastatin Calpastatin Calpain__Calpastatin Calpain__Calpastatin BAF__at_Nucleus BAF__at_Nucleus ACTIVATION CDTYPE:CATALYSIS Calpastatin__pho_at_Cytoplasm Calpastatin__pho_at_Cytoplasm BRG1__at_Nucleus BRG1__at_Nucleus Calpain__at_Cytoplasm Calpain__at_Cytoplasm BAF250__at_Nucleus BAF250__at_Nucleus Ca2 Ca2 BAF180__at_Nucleus BAF180__at_Nucleus 19705439 pubmed HES1 HES1 id_14_3_3 id_14_3_3 id_14_3_3__at_Mitochondria id_14_3_3__at_Mitochondria BAK1 HGNC CTGF HGNC HES1 HES1 BAD_pho_pho_pho_at_Mitochondria BAD_pho_pho_pho_at_Mitochondria RELA_at_Nucleus RELA_at_Nucleus NFKB1_p50__at_Nucleus NFKB1_p50__at_Nucleus id_14_3_3__BAD id_14_3_3__BAD 21285253 pubmed TGF__beta__pathway TGF__beta__pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. SMAD1_pho_at_Nucleus SMAD1_pho_at_Nucleus TAB1_TAB2_TAK1 TAB1_TAB2_TAK1 NICD NICD ACTIVATION CDTYPE:CATALYSIS TGF__beta__pathway TGF__beta__pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. NICD___beta__Catenin NICD___beta__Catenin _beta__Catenin__at_Nucleus _beta__Catenin__at_Nucleus NICD__at_Nucleus NICD__at_Nucleus PPP3R__at_Cytoplasm PPP3R__at_Cytoplasm RPB2__at_Nucleus RPB2__at_Nucleus INHIBITION CDTYPE:INHIBITION PPP3CB_at_Cytoplasm PPP3CB_at_Cytoplasm HCF2__at_Nucleus HCF2__at_Nucleus ACTIVATION CDTYPE:CATALYSIS WDR5_at_Nucleus WDR5_at_Nucleus ACTIVATION CDTYPE:CATALYSIS RCAN RCAN MLL2_at_Nucleus MLL2_at_Nucleus TAB1_at_Cytoplasm TAB1_at_Cytoplasm TAK1__pho_active_at_Cytoplasm TAK1__pho_active_at_Cytoplasm DPY30_at_Nucleus DPY30_at_Nucleus ACTIVATION CDTYPE:CATALYSIS Menin__at_Nucleus Menin__at_Nucleus id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm TAB2_at_Cytoplasm TAB2_at_Cytoplasm BAD_pho_pho_at_Cytoplasm BAD_pho_pho_at_Cytoplasm ASH2L_at_Nucleus ASH2L_at_Nucleus Survival Survival This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. RBBP5_at_Nucleus RBBP5_at_Nucleus BAD_pho_pho_pho_at_Cytoplasm BAD_pho_pho_pho_at_Cytoplasm Reptin__at_Nucleus Reptin__at_Nucleus id_14_3_3__NFAT id_14_3_3__NFAT Ca2 Ca2 11493558 pubmed MIR29B MIR29B JNK JNK NFAT NFAT MIR204 MIR204 id_14_3_3 id_14_3_3 19853559 pubmed NFAT__emp_S289_pho_S272_pho_at_Cytoplasm NFAT__emp_S289_pho_S272_pho_at_Cytoplasm 12970747 pubmed p38 p38 ASK1 ASK1 ASK1 ASK1 KCTD11 HGNC FLT4 HGNC ACTIVATION CDTYPE:CATALYSIS FZD__at_Cytoplasm FZD__at_Cytoplasm FAF FAF NLK NLK FZD__ROR2_WNT3 FZD__ROR2_WNT3 PAX9 HGNC FZD FZD WNT3_at_Cytoplasm WNT3_at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm FZD__ROR2_WNT3 FZD__ROR2_WNT3 ROR2_at_Cytoplasm ROR2_at_Cytoplasm 18606138 pubmed SIX1 SIX1 KIF3A_KIF3B KIF3A_KIF3B FLT1 HGNC KIF3B_at_Cytoplasm KIF3B_at_Cytoplasm FLT3 HGNC ELK1 ELK1 EGR1 EGR1 20463034 pubmed IGFBP6 IGFBP6 CNA CNA WNT5A WNT5A 10984057 pubmed CDK1 CDK1 ROR2 ROR2 WDR5 HGNC WNT__at_Vaceolae WNT__at_Vaceolae FZD__at_Vaceolae FZD__at_Vaceolae G_alpha_o__at_Vaceolae G_alpha_o__at_Vaceolae BOC BOC 14536078 pubmed PRR PRR PRR__at_Vaceolae PRR__at_Vaceolae DKK3 DKK3 CHUK HGNC C_FES C_FES FZD4 HGNC RNF146 HGNC CK2_alpha CK2_alpha 20709625 pubmed CDH1 HGNC FOXP3 FOXP3 MMP13 MMP13 HCF2 HCF2 MBD3 HGNC CTBP CTBP MBD2 HGNC 20006983 pubmed SKP1 SKP1 GLI3_83_sub_TRUNC_endsub GLI3_83_sub_TRUNC_endsub CK2_beta___at_Cytoplasm CK2_beta___at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS CK2_alpha____at_Cytoplasm CK2_alpha____at_Cytoplasm CK2_alpha___at_Cytoplasm CK2_alpha___at_Cytoplasm GNGT1 HGNC APC5 APC5 SAE1 HGNC 18372913 pubmed 17549397 pubmed p27KIP1 p27KIP1 DUSP6 DUSP6 EGFR HGNC AXIN AXIN CK1_alpha CK1_alpha 17312394 pubmed 10747897 pubmed FOXO3 HGNC 19701191 pubmed PIN1 PIN1 17666529 pubmed 19941614 pubmed NDUFA6 NDUFA6 CSNK1G2 HGNC CSNK1G1 HGNC CSNK1G3 HGNC IP3 IP3 SMAD2 HGNC DAG DAG PIP2 PIP2 PLCG1 PLCG1 SRC SRC SRC_at_Plasma_Membrane SRC_at_Plasma_Membrane MKNK1 HGNC MKNK2 HGNC BRD8 BRD8 KSR1_at_Cytoplasm KSR1_at_Cytoplasm MEK__at_Cytoplasm MEK__at_Cytoplasm ELK1 ELK1 RASGRP1 RASGRP1 17439715 pubmed PKD1 PKD1 21059263 pubmed 18695042 pubmed GSK3B HGNC MIR493 MIR493 MEK__at_Cytoplasm MEK__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS 15531880 pubmed Caspase9 Caspase9 CDTYPE:BOOLEAN_LOGIC_GATE_AND CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS Caspase9 Caspase9 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 11864996 pubmed BID HGNC IMP__at_Cytoplasm IMP__at_Cytoplasm IMP IMP CHD4 HGNC CHD3 HGNC SUR_8 SUR_8 ACTIVATION CDTYPE:CATALYSIS CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS GSK3 GSK3 19577357 pubmed WNT5A-AS1 HGNC ACTIVATION CDTYPE:CATALYSIS G_beta___at_Cytoplasm G_beta___at_Cytoplasm G_alpha_o__at_Cytoplasm G_alpha_o__at_Cytoplasm CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS p120__S268_pho_S269_pho_at_Endosome p120__S268_pho_S269_pho_at_Endosome ACTIVATION CDTYPE:CATALYSIS BRAF_pho_at_Plasma_Membrane BRAF_pho_at_Plasma_Membrane CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome RAS__pho_at_Plasma_Membrane RAS__pho_at_Plasma_Membrane CK1_epsilon___p120 CK1_epsilon___p120 G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm GRB2_at_Plasma_Membrane GRB2_at_Plasma_Membrane CREBBP HGNC E_Cadherin E_Cadherin GF GF CDTYPE:BOOLEAN_LOGIC_GATE_AND XPO1 HGNC CDTYPE:BOOLEAN_LOGIC_GATE_AND CTNND2 HGNC CTNND1 HGNC IL2 IL2 KSR1_CTER__at_Cytoplasm KSR1_CTER__at_Cytoplasm SOS__at_Plasma_Membrane SOS__at_Plasma_Membrane KSR1_NTER__at_Plasma_Membrane KSR1_NTER__at_Plasma_Membrane _mTORC1 _mTORC1 _mTORC1 _mTORC1 CDTYPE:BOOLEAN_LOGIC_GATE_AND _mTORC1 _mTORC1 CDTYPE:BOOLEAN_LOGIC_GATE_AND _mTORC1 _mTORC1 EP300 HGNC _PP2A _PP2A ACTIVATION CDTYPE:CATALYSIS _PP2B _PP2B ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS _beta__Catenin _beta__Catenin _beta__Catenin__ace_at_Nucleus _beta__Catenin__ace_at_Nucleus INHIBITION CDTYPE:INHIBITION PCAF PCAF _beta__Catenin__K345_ace_ace_at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus map_survival map_survival Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr 20712011 pubmed 12791379 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 15147722 pubmed ACTIVATION CDTYPE:CATALYSIS 16286006 pubmed ACTIVATION CDTYPE:CATALYSIS KLF4 KLF4 p300__at_Nucleus p300__at_Nucleus 10601235 pubmed PYGO__at_Nucleus PYGO__at_Nucleus BCL9_at_Nucleus BCL9_at_Nucleus ACTIVATION CDTYPE:CATALYSIS 19718039 pubmed MAP2K6 HGNC RBM8A HGNC PPP3R1 HGNC PPP3R2 HGNC ACTIVATION CDTYPE:CATALYSIS NFATC4 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS GLI1 HGNC BRD8 HGNC ACTIVATION CDTYPE:CATALYSIS 18291711 pubmed ACTIVATION CDTYPE:CATALYSIS 8614832 pubmed ACTIVATION CDTYPE:CATALYSIS GLI2 HGNC INHIBITION CDTYPE:INHIBITION MAP3K5 HGNC SUFU HGNC ATG13_FIP200__ULK ATG13_FIP200__ULK ATG13_pho_at_Cytoplasm ATG13_pho_at_Cytoplasm FIP200__at_Cytoplasm FIP200__at_Cytoplasm INHIBITION CDTYPE:INHIBITION ERK ERK INHIBITION CDTYPE:INHIBITION RAF1_pho_at_Late_Endosomes RAF1_pho_at_Late_Endosomes ULK__at_Cytoplasm ULK__at_Cytoplasm ATG13_at_Cytoplasm ATG13_at_Cytoplasm FIP200__at_Cytoplasm FIP200__at_Cytoplasm CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS PPP1R9A HGNC ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS BAF45A BAF45A 18077375 pubmed MYC MYC ACTIVATION CDTYPE:UNKNOWN_CATALYSIS INHIBITION CDTYPE:INHIBITION MP1__at_Late_Endosomes MP1__at_Late_Endosomes p110__at_Cytoplasm p110__at_Cytoplasm INHIBITION CDTYPE:INHIBITION _mTORC2 _mTORC2 LAMTOR2_at_Late_Endosomes LAMTOR2_at_Late_Endosomes GRB2_at_Late_Endosomes GRB2_at_Late_Endosomes SOS__at_Late_Endosomes SOS__at_Late_Endosomes 21478859 pubmed KSR1_CTER KSR1_CTER ATG13_pho_at_Cytoplasm ATG13_pho_at_Cytoplasm RAF1_pho_at_Late_Endosomes RAF1_pho_at_Late_Endosomes COPS8 HGNC FIP200__pho_at_Cytoplasm FIP200__pho_at_Cytoplasm ULK__pho_at_Cytoplasm ULK__pho_at_Cytoplasm ATG13_FIP200__ULK ATG13_FIP200__ULK _PI3K _PI3K PPP1R9B HGNC VANGL2 HGNC p85__at_Cytoplasm p85__at_Cytoplasm VANGL1 HGNC ULK__pho_at_Cytoplasm ULK__pho_at_Cytoplasm Autophagy Autophagy This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ACTIVATION CDTYPE:CATALYSIS _mTORC2 _mTORC2 ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION NOS2 NOS2 NKX2-2 HGNC 21209331 pubmed _eIF3_mRNA_mTOR _eIF3_mRNA_mTOR _PIP3_PDK1 _PIP3_PDK1 _PIP3_AKT _PIP3_AKT _PIP3_AKT _PIP3_AKT 21115349 pubmed _eIF3_mRNA _eIF3_mRNA 19581346 pubmed _mTORC2 _mTORC2 _mTORC2 _mTORC2 CDTYPE:BOOLEAN_LOGIC_GATE_AND _mTORC2 _mTORC2 RASA4 RASA4 ACTIVATION CDTYPE:CATALYSIS _mTORC2 _mTORC2 NEDL1 NEDL1 KSR1 HGNC module_PI3K_AKT_MTOR module_PI3K_AKT_MTOR Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr _eIF3_mRNA_mTOR _eIF3_mRNA_mTOR _eIF3_mRNA_mTOR _eIF3_mRNA_mTOR 18077353 pubmed 21397842 pubmed TNKS HGNC AKT2 HGNC AKT3 HGNC AKT1 HGNC _mTORC1 _mTORC1 _mTORC1 _mTORC1 20027184 pubmed 20940030 pubmed ACTIVATION CDTYPE:CATALYSIS _TSC _TSC _TSC _TSC ACTIVATION CDTYPE:CATALYSIS _SCF _SCF _Apoptosome _Apoptosome Caspase3_sub_TRUNC_endsub Caspase3_sub_TRUNC_endsub _EJC _EJC _mTORC1 _mTORC1 _mTORC1 _mTORC1 _mTORC1 _mTORC1 _mTORC1 _mTORC1 21285348 pubmed HDAC1_2 HDAC1_2 XIAP XIAP HES1_TLE HES1_TLE HES1 HES1 TLE TLE TLE1 TLE1 Notch_pathway Notch_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. FOXQ1 FOXQ1 HES1_at_Nucleus HES1_at_Nucleus TLE__S239_pho_at_Nucleus TLE__S239_pho_at_Nucleus RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome 16925947 pubmed RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome MTOR_S1261_pho_S2448_emp_S2481_pho_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome NEDD4 HGNC RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome SPOP SPOP RAC1_at_Cytoplasm RAC1_at_Cytoplasm RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome RAC1_at_Membrane_Lysosome TAK1__T184_pho_T178_pho_T187_pho_S192_pho_at_Cytoplasm TAK1__T184_pho_T178_pho_T187_pho_S192_pho_at_Cytoplasm TAB1_at_Cytoplasm TAB1_at_Cytoplasm TAB2_at_Nucleus TAB2_at_Nucleus TAB2 TAB2 NARF NARF ANAPC13 HGNC LEF_TCF LEF_TCF 11694535 pubmed E1 E1 GNA11 HGNC HIPK2 HIPK2 RAC1_at_Lipid_Raft RAC1_at_Lipid_Raft GNA14 HGNC RAC1_at_Lipid_Raft RAC1_at_Lipid_Raft WNT11 HGNC GNA15 HGNC GNA12 HGNC TLE TLE RAC1_at_Lipid_Raft RAC1_at_Lipid_Raft GNA13 HGNC HDAC1_2 HDAC1_2 SGK1 SGK1 CUL1_RBX1_RICTOR CUL1_RBX1_RICTOR RICTOR_at_Cytoplasm RICTOR_at_Cytoplasm 20300203 pubmed PRAS40 PRAS40 EIF3 EIF3 NLK_T286_pho_hm2_active_at_Nucleus NLK_T286_pho_hm2_active_at_Nucleus TAK1__T184_pho_T178_pho_T187_pho_S192_pho_at_Nucleus TAK1__T184_pho_T178_pho_T187_pho_S192_pho_at_Nucleus TAB1_at_Nucleus TAB1_at_Nucleus TAB1_TAK1 TAB1_TAK1 TAK1__at_Cytoplasm TAK1__at_Cytoplasm TAB1_at_Cytoplasm TAB1_at_Cytoplasm MIR378 HGNC 10783894 pubmed TAB1_TAK1 TAB1_TAK1 RBX1_at_Cytoplasm RBX1_at_Cytoplasm CUL1_at_Cytoplasm CUL1_at_Cytoplasm HES1 HES1 CDT2 CDT2 TAB1_TAK1 TAB1_TAK1 CUL1_RBX1_RICTOR CUL1_RBX1_RICTOR RBX1_at_Cytoplasm RBX1_at_Cytoplasm CUL1_at_Cytoplasm CUL1_at_Cytoplasm id_14_3_3__RICTOR id_14_3_3__RICTOR 11882383 pubmed RBX1 RBX1 16599904 pubmed CUL1 CUL1 KPNB1 HGNC RICTOR RICTOR RICTOR_T1135_pho_at_Cytoplasm RICTOR_T1135_pho_at_Cytoplasm IL1R2 IL1R2 21285352 pubmed CDKN1A HGNC NLK NLK NLK NLK TAB1 TAB1 NLK NLK LEF_TCF LEF_TCF NLK NLK LEF_TCF LEF_TCF ATG13 ATG13 ULK ULK ATG13_FIP200__ULK ATG13_FIP200__ULK FIP200 FIP200 15657064 pubmed RICTOR_T1135_pho_at_Cytoplasm RICTOR_T1135_pho_at_Cytoplasm JUN HGNC 16273260 pubmed id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm MMP9 HGNC PPP1R17 HGNC ROR2_at_Cytoplasm ROR2_at_Cytoplasm FZD__ROR2_WNT1_3 FZD__ROR2_WNT1_3 PPP1R18 HGNC _PKA _PKA PKA_R__at_Nucleus PKA_R__at_Nucleus TAK1 TAK1 TAB1_at_Nucleus TAB1_at_Nucleus PPP1R11 HGNC NLK_TAB1_TAB2_TAK1 NLK_TAB1_TAB2_TAK1 PPP1R10 HGNC MAPRE3 HGNC MAPRE2 HGNC MAPRE1 HGNC PKA_C__at_Cytoplasm PKA_C__at_Cytoplasm 18362162 pubmed id_14_3_3__NFAT id_14_3_3__NFAT id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm NFAT__emp_S289_pho_S272_pho_at_Nucleus NFAT__emp_S289_pho_S272_pho_at_Nucleus id_14_3_3__at_Nucleus id_14_3_3__at_Nucleus PKA_R__at_Cytoplasm PKA_R__at_Cytoplasm TNKS2 HGNC _PKA _PKA ULK1 HGNC PPP1R27 HGNC ULK2 HGNC RNF146 RNF146 _Calcineurin_Calmodulin_Ca2__br_KPNB1_Tubulin__alpha _Calcineurin_Calmodulin_Ca2__br_KPNB1_Tubulin__alpha PPP1R26 HGNC DKK1 DKK1 _CnA_trun_CnB_KPNB1_Tubulin_alpha _CnA_trun_CnB_KPNB1_Tubulin_alpha DKK1 DKK1 CK2_alpha____at_Cytoplasm CK2_alpha____at_Cytoplasm CpG_hyper_methylation CpG_hyper_methylation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CBP__S92_pho_at_Nucleus CBP__S92_pho_at_Nucleus _Calcineurin_Calmodulin _Calcineurin_Calmodulin CK2_beta___at_Cytoplasm CK2_beta___at_Cytoplasm WNT1_3 WNT1_3 CK2_alpha____at_Cytoplasm CK2_alpha____at_Cytoplasm PPP1R21 HGNC CKS1B CKS1B ROR2 ROR2 CDK4 CDK4 FZD FZD NKX2_2 NKX2_2 WNT1_3__at_Cytoplasm WNT1_3__at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm PPP1R1B HGNC PPP1R1C HGNC _Calcineurin_CAIN _Calcineurin_CAIN _Calcineurin__br_RCAN _Calcineurin__br_RCAN PPP1R1A HGNC _Calcineurin _Calcineurin PKA_C__at_Nucleus PKA_C__at_Nucleus _Calcineurin_Calmodulin_Ca2__br_KPNB1_Tubulin__alpha _Calcineurin_Calmodulin_Ca2__br_KPNB1_Tubulin__alpha _Calcineurin _Calcineurin _Calcineurin__br_Calmodulin__br_Ca2 _Calcineurin__br_Calmodulin__br_Ca2 G_alpha__sub_13q_endsub G_alpha__sub_13q_endsub _Calcineurin__br_Calmodulin__br_Ca2 _Calcineurin__br_Calmodulin__br_Ca2 PPP1R35 HGNC LEF_TCF__at_Nucleus LEF_TCF__at_Nucleus TLE__at_Nucleus TLE__at_Nucleus PPP1R37 HGNC PPP1R36 HGNC gWRE__at_Nucleus gWRE__at_Nucleus PPP1R39 HGNC USP34 USP34 TNKS1_2 TNKS1_2 AXIN AXIN AXIN AXIN HDAC1_2__at_Nucleus HDAC1_2__at_Nucleus PPP1R32 HGNC MAPK10 HGNC TRADD HGNC module_WNT_CANONICAL module_WNT_CANONICAL Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr _Calcineurin__br_Calmodulin__br_Ca2 _Calcineurin__br_Calmodulin__br_Ca2 _Calcineurin__br_Calmodulin__br_Ca2 _Calcineurin__br_Calmodulin__br_Ca2 _beta__Catenin__K345_ace_ace_at_Nucleus _beta__Catenin__K345_ace_ace_at_Nucleus CSN2 CSN2 _beta__Catenin__ace_ace_at_Nucleus _beta__Catenin__ace_ace_at_Nucleus _beta__Catenin__K345_emp_ace_ace_at_Nucleus _beta__Catenin__K345_emp_ace_ace_at_Nucleus MIR214 MIR214 PPP1R42 HGNC PPP1R3F HGNC PPP1R3G HGNC PPP1R3D HGNC PPP1R3E HGNC 16525728 pubmed PPP1R3B HGNC PPP1R3C HGNC PPP1R3A HGNC 11113207 pubmed ARC ARC 18308511 pubmed PIPKI_gamma_i2 PIPKI_gamma_i2 ACTIVATION CDTYPE:CATALYSIS HSP90AB1 HGNC FRS2 HGNC 10023660 pubmed PINK1 HGNC 14704854 pubmed BCL2L11 HGNC GNG11 HGNC GNG12 HGNC GNG13 HGNC HSP90AA2 HGNC HSP90AA1 HGNC 16554443 pubmed GNG10 HGNC NRAS HGNC 14585353 pubmed PPP1R PPP1R IP3 IP3 _alpha__Catenin _alpha__Catenin GSK3__at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm CDKN1B HGNC SKI SKI TCF4 HGNC MAPK8 HGNC MAPK9 HGNC TNFRSF10A HGNC BRAF HGNC BMF BMF 10350048 pubmed ACTB HGNC AP2_alpha AP2_alpha LRP6 HGNC NFATC2 HGNC RUNX2 RUNX2 CK1_gamma___at_Vaceolae CK1_gamma___at_Vaceolae HER2 HER2 G_gamma___at_Endosome G_gamma___at_Endosome LEF1 HGNC ATM ATM 22370635 pubmed ERN1 ERN1 DYNC2H1 HGNC IGFBP6 HGNC ACTIVATION CDTYPE:CATALYSIS G_beta___at_Endosome G_beta___at_Endosome CUL1_at_Cytoplasm CUL1_at_Cytoplasm CK2_alpha___at_Cytoplasm CK2_alpha___at_Cytoplasm MP1__at_Late_Endosomes MP1__at_Late_Endosomes PKD__at_Cytoplasm PKD__at_Cytoplasm USP15_at_Cytoplasm USP15_at_Cytoplasm CSN8__at_Cytoplasm CSN8__at_Cytoplasm CSN7__at_Cytoplasm CSN7__at_Cytoplasm CSN6__at_Cytoplasm CSN6__at_Cytoplasm CSN5__at_Cytoplasm CSN5__at_Cytoplasm 17845852 pubmed ERK2 ERK2 VPS72 HGNC GSK3_alpha GSK3_alpha ACTIVATION CDTYPE:CATALYSIS CREB1 HGNC GRB2_at_Late_Endosomes GRB2_at_Late_Endosomes 16679021 pubmed SOS__at_Late_Endosomes SOS__at_Late_Endosomes LAMTOR2_at_Late_Endosomes LAMTOR2_at_Late_Endosomes CSN1__at_Cytoplasm CSN1__at_Cytoplasm NEDD8_at_Cytoplasm NEDD8_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS MP1__at_Late_Endosomes MP1__at_Late_Endosomes CSN3__at_Cytoplasm CSN3__at_Cytoplasm CSN2__at_Cytoplasm CSN2__at_Cytoplasm NEDD8 NEDD8 _beta_TRCP__at_Cytoplasm _beta_TRCP__at_Cytoplasm E1__at_Cytoplasm E1__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS RAD6__at_Cytoplasm RAD6__at_Cytoplasm RBX1_at_Cytoplasm RBX1_at_Cytoplasm G_gamma__sub_i_endsub G_gamma__sub_i_endsub 23022962 pubmed CDTYPE:PHYSICAL_STIMULATION IMPORTIN IMPORTIN CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CSN4__at_Cytoplasm CSN4__at_Cytoplasm 12522211 pubmed FASLG HGNC 18716620 pubmed BCL2 HGNC CCNB1 HGNC ACTIVATION CDTYPE:CATALYSIS INPP5D HGNC CDTYPE:BOOLEAN_LOGIC_GATE_AND CDTYPE:BOOLEAN_LOGIC_GATE_AND CDTYPE:BOOLEAN_LOGIC_GATE_AND CDTYPE:BOOLEAN_LOGIC_GATE_AND ENOS ENOS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS FBW7 FBW7 PREX PREX BRAF_pho_at_Plasma_Membrane BRAF_pho_at_Plasma_Membrane CUL1_at_Cytoplasm CUL1_at_Cytoplasm SKP__at_Cytoplasm SKP__at_Cytoplasm AXIN1 AXIN1 BRAF_pho_at_Plasma_Membrane BRAF_pho_at_Plasma_Membrane BRAF BRAF GSK3__at_Cytoplasm GSK3__at_Cytoplasm ERBB2 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ARHGEF19 HGNC CASP3 HGNC ACTIVATION CDTYPE:CATALYSIS CBLC HGNC 15611123 pubmed MIR374A MIR374A CBLB HGNC ATP6AP2 HGNC ATP6AP1 HGNC MMP13 HGNC DCAF13 HGNC DCAF11 HGNC DCAF12 HGNC DCAF17 HGNC DCAF15 HGNC ACTIVATION CDTYPE:CATALYSIS DCAF16 HGNC DCAF10 HGNC CDC34 CDC34 FOXO1 FOXO1 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:CATALYSIS FOXE1 HGNC 19662498 pubmed MAP3K10_11 MAP3K10_11 ULK1 ULK1 USP15_at_Cytoplasm USP15_at_Cytoplasm PKD__at_Cytoplasm PKD__at_Cytoplasm CSN7__at_Cytoplasm CSN7__at_Cytoplasm CSN8__at_Cytoplasm CSN8__at_Cytoplasm RAD6__at_Cytoplasm RAD6__at_Cytoplasm E1__at_Cytoplasm E1__at_Cytoplasm AP2_sigma AP2_sigma CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm 12606705 pubmed ACTIVATION CDTYPE:CATALYSIS NEDD8_at_Cytoplasm NEDD8_at_Cytoplasm RIPK1_at_Cytoplasm RIPK1_at_Cytoplasm TRAF2_at_Cytoplasm TRAF2_at_Cytoplasm SUFU SUFU RCAN1 HGNC SKP__at_Cytoplasm SKP__at_Cytoplasm 21871017 pubmed ACTIVATION CDTYPE:CATALYSIS RBX1_at_Cytoplasm RBX1_at_Cytoplasm RCAN3 HGNC _beta_TRCP__at_Cytoplasm _beta_TRCP__at_Cytoplasm RCAN2 HGNC CSN1__at_Cytoplasm CSN1__at_Cytoplasm CSN2__at_Cytoplasm CSN2__at_Cytoplasm CSN3__at_Cytoplasm CSN3__at_Cytoplasm CSN4__at_Cytoplasm CSN4__at_Cytoplasm CSN5__at_Cytoplasm CSN5__at_Cytoplasm MAP3K1_pho_at_Cytoplasm MAP3K1_pho_at_Cytoplasm CSN6__at_Cytoplasm CSN6__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS MP1 MP1 LAMTOR2 LAMTOR2 CSE1L CSE1L RUNX2 HGNC 19211835 pubmed BCL9 HGNC PYGO PYGO GATA_binding_site GATA_binding_site MIR373 MIR373 RAB23 HGNC 12711682 pubmed KCTD21 HGNC GNG7 HGNC GNG5 HGNC GNG4 HGNC 17635922 pubmed GNG8 HGNC 20710043 pubmed 12150925 pubmed MAP2K2 HGNC MAP2K1 HGNC GNG2 HGNC GNG3 HGNC PRICKLE1_pho_at_Cytoplasm PRICKLE1_pho_at_Cytoplasm 21751375 pubmed PAR6__at_Cytoplasm PAR6__at_Cytoplasm PAR6__at_Cytoplasm PAR6__at_Cytoplasm PAR6__at_Cytoplasm PAR6__at_Cytoplasm PRICKLE1_pho_at_Cytoplasm PRICKLE1_pho_at_Cytoplasm 22154485 pubmed PRICKLE1_pho_at_Cytoplasm PRICKLE1_pho_at_Cytoplasm PAR6__at_Endosome PAR6__at_Endosome E_Cadherin E_Cadherin PAR6__at_Endosome PAR6__at_Endosome E_Cadherin__S840_pho_S853_pho_S855_pho_S849_pho_at_Cytoplasm E_Cadherin__S840_pho_S853_pho_S855_pho_S849_pho_at_Cytoplasm WNT11 WNT11 Pi Pi RGS19 RGS19 MIR23B MIR23B Pi Pi GDP_at_Cytoplasm GDP_at_Cytoplasm SMURF1 SMURF1 GDP_G_alpha_o GDP_G_alpha_o DYNC1H1 HGNC DYRK1A HGNC DYRK1B HGNC _beta_TRCP _beta_TRCP GTP_at_Cytoplasm GTP_at_Cytoplasm GTP_G_alpha_o GTP_G_alpha_o CDKN2B HGNC 16476742 pubmed 9609833 pubmed FERMT2 HGNC MIR96 HGNC 10722653 pubmed DLG1 HGNC DLG3 HGNC DLG2 HGNC DLG5 HGNC 15160330 pubmed DLG4 HGNC Caspase3 Caspase3 E_Cadherin E_Cadherin PtdIns__4_5__P_sub_2_at_Cytoplasm PtdIns__4_5__P_sub_2_at_Cytoplasm AMER2_at_Cytoplasm AMER2_at_Cytoplasm 20978166 pubmed DVL DVL FOXA2 HGNC S100A7 S100A7 FOXA3 HGNC 20016067 pubmed INHIBITION CDTYPE:INHIBITION 22290435 pubmed EGR1 HGNC IL2 HGNC FOXA1 HGNC APC_at_Cytoplasm APC_at_Cytoplasm AMER2_APC_EB1__PtdIns AMER2_APC_EB1__PtdIns INHIBITION CDTYPE:INHIBITION _beta__Catenin _beta__Catenin PtdIns__4_5__P_sub_2_at_Cytoplasm PtdIns__4_5__P_sub_2_at_Cytoplasm EB1__at_Cytoplasm EB1__at_Cytoplasm AMER2_at_Cytoplasm AMER2_at_Cytoplasm Caspase8 Caspase8 Apoptosis Apoptosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. DVL DVL MIF HGNC PPP2CB HGNC CK1_epsilon___at_Vaceolae CK1_epsilon___at_Vaceolae 19183803 pubmed PPP2CA HGNC p120__at_Vaceolae p120__at_Vaceolae SIX3 SIX3 E_Cadherin__at_Vaceolae E_Cadherin__at_Vaceolae CK1_epsilon___E_Cadherin__FZD__GTP_G_alpha_o__G_beta___G_gamma___LRP5_6__PRR__WNT__p120 CK1_epsilon___E_Cadherin__FZD__GTP_G_alpha_o__G_beta___G_gamma___LRP5_6__PRR__WNT__p120 21642958 pubmed PPP2R1B HGNC PPP2R1A HGNC ACTIVATION CDTYPE:CATALYSIS Caspase8_sub_TRUNC_endsub Caspase8_sub_TRUNC_endsub ACTIVATION CDTYPE:CATALYSIS FOXO4 FOXO4 APC_sub_TRUNC_endsub___HTID1_40_kDA_isoform APC_sub_TRUNC_endsub___HTID1_40_kDA_isoform ACTIVATION CDTYPE:CATALYSIS APC_sub_TRUNC_endsub___at_Mitochondria APC_sub_TRUNC_endsub___at_Mitochondria HTID1_40_kDA_isoform__at_Mitochondria HTID1_40_kDA_isoform__at_Mitochondria APC_sub_TRUNC_endsub APC_sub_TRUNC_endsub Caspase3_sub_TRUNC_endsub Caspase3_sub_TRUNC_endsub APC_sub_TRUNC_endsub APC_sub_TRUNC_endsub HTID1_40_kDA_isoform HTID1_40_kDA_isoform HTID1_50_48_kDa_isoform HTID1_50_48_kDa_isoform _beta__Arrestin _beta__Arrestin ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS HSP70 HSP70 DVL DVL 19864431 pubmed APC_AXIN__Actin_cytoskeletal__DVL__HSC70__HSP70__HTID1_50_48_kDa_isoform APC_AXIN__Actin_cytoskeletal__DVL__HSC70__HSP70__HTID1_50_48_kDa_isoform Actin_cytoskeletal Actin_cytoskeletal HSC70 HSC70 CDTYPE:BOOLEAN_LOGIC_GATE_AND Actin_cytoskeletal__at_Cytoplasm Actin_cytoskeletal__at_Cytoplasm FZD8 FZD8 AXIN__at_Cytoplasm AXIN__at_Cytoplasm HSP70__at_Cytoplasm HSP70__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS HSC70__at_Cytoplasm HSC70__at_Cytoplasm FOXL1 FOXL1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS HTID1_50_48_kDa_isoform__at_Cytoplasm HTID1_50_48_kDa_isoform__at_Cytoplasm DVL__at_Cytoplasm DVL__at_Cytoplasm APC_at_Cytoplasm APC_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS _Adhesion_complex _Adhesion_complex _Adhesion_complex _Adhesion_complex _Adhesion_complex _Adhesion_complex _c_Myc_destruction_complex _c_Myc_destruction_complex _c_Myc_destruction_complex _c_Myc_destruction_complex _PP2A _PP2A _c_Myc_destruction_complex _c_Myc_destruction_complex ACTIVATION CDTYPE:CATALYSIS RBX1_at_Cytoplasm RBX1_at_Cytoplasm SKP__at_Cytoplasm SKP__at_Cytoplasm AXIN2 AXIN2 _beta__Catenin__S45_emp_T41_emp_S37_emp_S33_emp_at_Cytoplasm _beta__Catenin__S45_emp_T41_emp_S37_emp_S33_emp_at_Cytoplasm PERP PERP Unknown_kinase Unknown_kinase This is a CellDesigner UNKNOWN entity. CUL1_at_Cytoplasm CUL1_at_Cytoplasm LRRK2 LRRK2 HSC70 HSC70 PP2A_C__at_Cytoplasm PP2A_C__at_Cytoplasm PR55_alpha___at_Cytoplasm PR55_alpha___at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm PTH PTH JAG2 JAG2 SNAI1 HGNC 16977332 pubmed PR65_A__at_Cytoplasm PR65_A__at_Cytoplasm DYRK1A HGNC 16491118 pubmed XFZ7 XFZ7 RACK1__at_Cytoplasm RACK1__at_Cytoplasm DYRK1A DYRK1A WNT WNT FZD__at_Cytoplasm FZD__at_Cytoplasm LRP5_6__at_Vaceolae LRP5_6__at_Vaceolae Iversin Iversin 18042541 pubmed ACTIVATION CDTYPE:CATALYSIS 20059949 pubmed DDB1 DDB1 PTEN HGNC _beta_TRCP__at_Cytoplasm _beta_TRCP__at_Cytoplasm MEAF6 HGNC E1 E1 RAD6 RAD6 AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm APC_S1505_pho_S1501_pho_S1504_pho_S1507_pho_S1503_pho_S1510_pho_at_Cytoplasm APC_S1505_pho_S1501_pho_S1504_pho_S1507_pho_S1503_pho_S1510_pho_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_K19_ubi_K49_ubi_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_K19_ubi_K49_ubi_at_Cytoplasm HIPK2 HGNC 16710861 pubmed MIR29B*2 HGNC MIR29B*1 HGNC WDR5 WDR5 TGFB1 HGNC TGFB2 HGNC MMP11 HGNC TGFB3 HGNC BCOR HGNC BAF155 BAF155 PIP5KI_beta PIP5KI_beta IPO13 HGNC PtdIns PtdIns WNT10B HGNC IPO11 HGNC PFTK PFTK CDKN1A HGNC WNT10A HGNC JNK JNK GDP GDP CK2_alpha____at_Cytoplasm CK2_alpha____at_Cytoplasm GTP GTP E_Cadherin E_Cadherin PI4KII_alpha PI4KII_alpha G_beta___G_gamma G_beta___G_gamma CK2_alpha___at_Cytoplasm CK2_alpha___at_Cytoplasm FZD4 FZD4 UBA2 UBA2 CSNK1G1 HGNC CSNK1G2 HGNC 15994944 pubmed CSNK1G3 HGNC AMER1__CK1_epsilon___CK1_gamma___DVL__E_Cadherin__FZD__G_beta___G_gamma___LRP5_6__PRR__WNT___beta__Arrestin2__p120 AMER1__CK1_epsilon___CK1_gamma___DVL__E_Cadherin__FZD__G_beta___G_gamma___LRP5_6__PRR__WNT___beta__Arrestin2__p120 PtdIns_4_5__P2 PtdIns_4_5__P2 19541618 pubmed 20567632 pubmed PtdIns_4__P PtdIns_4__P WNT1 HGNC GTP GTP 20932932 pubmed FOXO1 FOXO1 SNAI1 SNAI1 11263497 pubmed SNAI1 SNAI1 PPID PPID SMAD2_pho_at_Nucleus SMAD2_pho_at_Nucleus _beta__Catenin__Y654_pho_at_Nucleus _beta__Catenin__Y654_pho_at_Nucleus Cytoskeleton Cytoskeleton This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. _alpha__Catenin _alpha__Catenin _alpha__Catenin__at_Cytoplasm _alpha__Catenin__at_Cytoplasm ITGA3 ITGA3 E_Cadherin E_Cadherin p120 p120 Cytoskeleton_at_Cytoplasm Cytoskeleton_at_Cytoplasm This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. S100A9 S100A9 8929532 pubmed 20452955 pubmed CRM1__FOXO1 CRM1__FOXO1 20553968 pubmed 18762249 pubmed DYRK1A DYRK1A _beta__Catenin _beta__Catenin CK1_alpha CK1_alpha FOXO1 FOXO1 CK1 CK1 FOXO1_T24_pho_S256_pho_S319_pho_at_Nucleus FOXO1_T24_pho_S256_pho_S319_pho_at_Nucleus _beta__Catenin__pho_at_Endosome _beta__Catenin__pho_at_Endosome 19383900 pubmed CDC53 CDC53 FOXO1_T24_pho_S256_pho_S319_pho_at_Cytoplasm FOXO1_T24_pho_S256_pho_S319_pho_at_Cytoplasm _beta__Catenin__Y654_pho_pho_at_Endosome _beta__Catenin__Y654_pho_pho_at_Endosome _beta__Catenin__pho_at_Cytoplasm _beta__Catenin__pho_at_Cytoplasm FOXO1 FOXO1 p14INK4A p14INK4A FOXO1 FOXO1 _beta__Catenin__pho_at_Cytoplasm _beta__Catenin__pho_at_Cytoplasm WNT5_signaling WNT5_signaling This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. FOXO1 FOXO1 ECM_genes ECM_genes 20375059 pubmed USP8 HGNC G_alpha__sub_12_endsub___p120 G_alpha__sub_12_endsub___p120 CRM1__at_Nucleus CRM1__at_Nucleus 11448771 pubmed G_alpha__sub_12_endsub G_alpha__sub_12_endsub ECM ECM This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ECM_proteins ECM_proteins RBBP4_7 RBBP4_7 SMARCD1 HGNC 16054198 pubmed CASP8 HGNC GADD45G HGNC SRC SRC GADD45B HGNC 21271217 pubmed GADD45A HGNC p120 p120 Cytoskeleton Cytoskeleton This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. E_Cadherin E_Cadherin _beta__Catenin _beta__Catenin ECM_genes ECM_genes FOXO1_T24_pho_S322_pho_S256_pho_S319_pho_S325_pho_S329_pho_at_Nucleus FOXO1_T24_pho_S322_pho_S256_pho_S319_pho_S325_pho_S329_pho_at_Nucleus UBAC1 HGNC TGF__beta___pathway TGF__beta___pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. RAF1 RAF1 PI3_4_P2 PI3_4_P2 _alpha__Catenin _alpha__Catenin FOXO4_T28_pho_S193_pho_S258_pho_at_Cytoplasm FOXO4_T28_pho_S193_pho_S258_pho_at_Cytoplasm NFAT NFAT PPP3PR2 HGNC EMT EMT This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. _beta__Catenin _beta__Catenin CRM1__at_Cytoplasm CRM1__at_Cytoplasm _beta__Catenin _beta__Catenin CRM1__FOXO1 CRM1__FOXO1 MEK1_2 MEK1_2 id_14_3_3__FOXO4 id_14_3_3__FOXO4 ERK1_2 ERK1_2 FOXO1_T24_pho_S322_pho_S256_pho_S319_pho_S325_pho_S329_pho_at_Cytoplasm FOXO1_T24_pho_S322_pho_S256_pho_S319_pho_S325_pho_S329_pho_at_Cytoplasm HRAS HRAS AMER2_PtdIns AMER2_PtdIns ERK2 ERK2 APC APC CREB1 CREB1 APC APC G_beta___at_Cytoplasm G_beta___at_Cytoplasm Microtubele_polymerisation Microtubele_polymerisation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. G_alpha_o__at_Cytoplasm G_alpha_o__at_Cytoplasm Ca2__at_Golgi_Apparatus Ca2__at_Golgi_Apparatus Caspase3 Caspase3 SMAD1 HGNC MIR19B1 HGNC FOXO3 FOXO3 Ca2__at_Golgi_Apparatus Ca2__at_Golgi_Apparatus id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm EB1 EB1 Actin_fibers Actin_fibers This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. IQGAP1 IQGAP1 DLG DLG AXIN__at_Cytoplasm AXIN__at_Cytoplasm MIR182 MIR182 G_alpha__sub_12_endsub___at_Cytoplasm G_alpha__sub_12_endsub___at_Cytoplasm FOXO1_MIR27A FOXO1_MIR27A RASGRP1_at_Golgi_Apparatus RASGRP1_at_Golgi_Apparatus FOXO1_MIR96 FOXO1_MIR96 Tight_junctions Tight_junctions This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. FOXO1_MIR182 FOXO1_MIR182 RAS__pho_at_Golgi_Apparatus RAS__pho_at_Golgi_Apparatus MDM2 HGNC GDP_at_Cytoplasm GDP_at_Cytoplasm AXIN__G_alpha__sub_12_endsub AXIN__G_alpha__sub_12_endsub MIR27A MIR27A AXIN AXIN Ca2 Ca2 MIR96 MIR96 TNFRSF10A HGNC _beta__Arrestin2__at_Plasma_Membrane _beta__Arrestin2__at_Plasma_Membrane TAK1 TAK1 E_Cadherin__at_Cytoplasm E_Cadherin__at_Cytoplasm SKP1_at_Cytoplasm SKP1_at_Cytoplasm FZD__GDP_G_alpha_o__G_beta___G_gamma FZD__GDP_G_alpha_o__G_beta___G_gamma G_alpha__sub_12_endsub___at_Cytoplasm G_alpha__sub_12_endsub___at_Cytoplasm CKS1B_at_Cytoplasm CKS1B_at_Cytoplasm p120__at_Cytoplasm p120__at_Cytoplasm 19666503 pubmed CKS1B_CUL1_SKP1_SKP2 CKS1B_CUL1_SKP1_SKP2 E_Cadherin__G_alpha__sub_12_endsub E_Cadherin__G_alpha__sub_12_endsub SKP2_at_Cytoplasm SKP2_at_Cytoplasm G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm G_alpha__sub_12_endsub___at_Cytoplasm G_alpha__sub_12_endsub___at_Cytoplasm CUL1_at_Cytoplasm CUL1_at_Cytoplasm arMIR27A_at_Nucleus arMIR27A_at_Nucleus arMIR96_at_Nucleus arMIR96_at_Nucleus INHIBITION CDTYPE:INHIBITION arMIR182_at_Nucleus arMIR182_at_Nucleus rFOXO1_at_Nucleus rFOXO1_at_Nucleus p120__at_Cytoplasm p120__at_Cytoplasm ITGA3_at_Cytoplasm ITGA3_at_Cytoplasm TGFB1_at_Cytoplasm TGFB1_at_Cytoplasm TGFB1_TGFBR TGFB1_TGFBR TGFBR__at_Cytoplasm TGFBR__at_Cytoplasm AP2M1 HGNC rFOXO1_at_Nucleus rFOXO1_at_Nucleus CDK4_6__CyclinD__p27KIP1 CDK4_6__CyclinD__p27KIP1 p27KIP1__pho_pho_pho_S157_pho_at_Nucleus p27KIP1__pho_pho_pho_S157_pho_at_Nucleus CDK4_6__at_Nucleus CDK4_6__at_Nucleus p27KIP1 p27KIP1 INHIBITION CDTYPE:INHIBITION ECM_or_cell_cell_contact_at_Cytoplasm ECM_or_cell_cell_contact_at_Cytoplasm This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CyclinD__T286_pho_at_Nucleus CyclinD__T286_pho_at_Nucleus CyclinD CyclinD E_Cadherin__ITGA3_TGFB1_TGFBR___beta__Catenin__p120 E_Cadherin__ITGA3_TGFB1_TGFBR___beta__Catenin__p120 ITGA3_at_Cytoplasm ITGA3_at_Cytoplasm p120__at_Cytoplasm p120__at_Cytoplasm E_Cadherin__ITGA3_TGFB1_TGFBR___beta__Catenin__p120 E_Cadherin__ITGA3_TGFB1_TGFBR___beta__Catenin__p120 CTHRC1_at_Cytoplasm CTHRC1_at_Cytoplasm _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm SYN4__at_Cytoplasm SYN4__at_Cytoplasm H2AFZ H2AFZ CRM1__at_Nucleus CRM1__at_Nucleus CyclinD__T286_pho_at_Nucleus CyclinD__T286_pho_at_Nucleus CRM1__CyclinD CRM1__CyclinD CDK4_6 CDK4_6 p27KIP1 p27KIP1 CRM1__at_Cytoplasm CRM1__at_Cytoplasm CyclinD__T286_pho_at_Cytoplasm CyclinD__T286_pho_at_Cytoplasm CRM1__CyclinD CRM1__CyclinD 19706736 pubmed rFOXO1_at_Nucleus rFOXO1_at_Nucleus 17484803 pubmed UBA2 HGNC 16648474 pubmed p21CIP1__at_Nucleus p21CIP1__at_Nucleus PCNA_at_Nucleus PCNA_at_Nucleus p21CIP1 p21CIP1 p21CIP1 p21CIP1 DNA_synthesis DNA_synthesis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PCNA PCNA PCNA_p21CIP1 PCNA_p21CIP1 p21CIP1 p21CIP1 RAF1 HGNC p21CIP1 p21CIP1 FZD6 FZD6 ECM_or_cell_cell_contact ECM_or_cell_cell_contact This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Disruption_of_cell_adhesion Disruption_of_cell_adhesion This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. p21CIP1__pho_pho_at_Nucleus p21CIP1__pho_pho_at_Nucleus CDK4_6__CyclinD__p21CIP1 CDK4_6__CyclinD__p21CIP1 SKP2 SKP2 CSNK1A1 HGNC PCNA_p21CIP1 PCNA_p21CIP1 APC13 APC13 CDT2__at_Nucleus CDT2__at_Nucleus DDB1__at_Nucleus DDB1__at_Nucleus CUL4__at_Nucleus CUL4__at_Nucleus RBX1_at_Nucleus RBX1_at_Nucleus CDT2__CUL4__DDB1__RBX1 CDT2__CUL4__DDB1__RBX1 CyclinD__T286_pho_at_Nucleus CyclinD__T286_pho_at_Nucleus CDK4_6__at_Nucleus CDK4_6__at_Nucleus 17604271 pubmed TGFB1_at_Endosome TGFB1_at_Endosome AES AES p120__at_Endosome p120__at_Endosome E_Cadherin__at_Endosome E_Cadherin__at_Endosome MMP11 MMP11 G_alpha_o G_alpha_o ITGA3_at_Endosome ITGA3_at_Endosome ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 18223681 pubmed ACTIVATION CDTYPE:CATALYSIS POLDIP3 HGNC SMAD2 SMAD2 TGFBR__at_Endosome TGFBR__at_Endosome SMAD2__beta__Catenin SMAD2__beta__Catenin E_Cadherin__at_Endosome E_Cadherin__at_Endosome ITGA3_at_Endosome ITGA3_at_Endosome module_PMID module_PMID Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr 18391071 pubmed TGFB1_at_Endosome TGFB1_at_Endosome p120__at_Endosome p120__at_Endosome E_Cadherin__ITGA3_TGFB1_TGFBR__p120 E_Cadherin__ITGA3_TGFB1_TGFBR__p120 MAP2K3 MAP2K3 TGFBR__at_Endosome TGFBR__at_Endosome WNT1 HGNC 19906571 pubmed G_alpha G_alpha MIR34C MIR34C RSK2 RSK2 TGF_beta__pathway TGF_beta__pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. _beta__Catenin _beta__Catenin SRC SRC EMT EMT This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. TCF_LEF__transcriptional_br_regulation TCF_LEF__transcriptional_br_regulation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CDTYPE:PHYSICAL_STIMULATION _beta__Catenin _beta__Catenin NOS2 HGNC TGFBR__at_Cytoplasm TGFBR__at_Cytoplasm TGFB1_at_Cytoplasm TGFB1_at_Cytoplasm 16307918 pubmed ACTIVATION CDTYPE:UNKNOWN_CATALYSIS TGFB1_at_Endosome TGFB1_at_Endosome E_Cadherin__ITGA3_TGFB1_TGFBR___beta__Catenin__p120 E_Cadherin__ITGA3_TGFB1_TGFBR___beta__Catenin__p120 TGFBR__at_Endosome TGFBR__at_Endosome 21693646 pubmed 19788417 pubmed ITGA3_at_Endosome ITGA3_at_Endosome p120__at_Endosome p120__at_Endosome E_Cadherin__at_Endosome E_Cadherin__at_Endosome 20818436 pubmed CDTYPE:PHYSICAL_STIMULATION TAOK TAOK COPS6 HGNC HB_EGF HB_EGF 23277359 pubmed HRAS HGNC 19652529 pubmed CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm G_alpha___at_Cytoplasm G_alpha___at_Cytoplasm E_Cadherin__at_Cytoplasm E_Cadherin__at_Cytoplasm p120__at_Cytoplasm p120__at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm LRP5_6__at_Cytoplasm LRP5_6__at_Cytoplasm GTP_at_Cytoplasm GTP_at_Cytoplasm 18925875 pubmed CK1_epsilon___E_Cadherin__FZD__GTP_G_alpha___G_beta___G_gamma___LGR5_LRP5_6__RSPO1_4__WNT__p120 CK1_epsilon___E_Cadherin__FZD__GTP_G_alpha___G_beta___G_gamma___LGR5_LRP5_6__RSPO1_4__WNT__p120 19652530 pubmed G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm 12820959 pubmed 10559945 pubmed CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRICKLE1_PRR__RACK1__ROR2_SMURF1_SYN4__VANGL__WNT___beta__Arrestin2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRICKLE1_PRR__RACK1__ROR2_SMURF1_SYN4__VANGL__WNT___beta__Arrestin2 ROR2_at_Cytoplasm ROR2_at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm 17297467 pubmed POSH POSH WNT__at_Cytoplasm WNT__at_Cytoplasm HES1 HGNC CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm CTHRC1_at_Cytoplasm CTHRC1_at_Cytoplasm SYN4__at_Cytoplasm SYN4__at_Cytoplasm 16868183 pubmed 23371553 pubmed LRRK2 HGNC HSPB1 HSPB1 PAR6__at_Cytoplasm PAR6__at_Cytoplasm PRICKLE1_pho_at_Cytoplasm PRICKLE1_pho_at_Cytoplasm 11274345 pubmed RACK1__at_Cytoplasm RACK1__at_Cytoplasm VANGL__at_Cytoplasm VANGL__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm SYN4__at_Cytoplasm SYN4__at_Cytoplasm CTHRC1_at_Cytoplasm CTHRC1_at_Cytoplasm CDK4 HGNC Degradation Degradation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Recycling Recycling This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. IKBKB HGNC HIP1 HGNC IKBKE HGNC HRAS HGNC IKBKG HGNC 7641885 pubmed NUMB HGNC 12297047 pubmed BCL2_XL BCL2_XL MIR34B MIR34B TGFBR TGFBR RBBP7 HGNC RBBP4 HGNC MAP2K6 MAP2K6 FZD4 FZD4 MOD:00394 MOD Unknown_enzyme Unknown_enzyme This is a CellDesigner UNKNOWN entity. FZD4 FZD4 DYNC2H1 DYNC2H1 NFATC1 HGNC 15618519 pubmed p101 p101 MIR29B MIR29B SMO_at_Cytoplasm SMO_at_Cytoplasm TRRAP TRRAP PTCH PTCH COPS4 HGNC Ligand Ligand CRIPTO_1__E_Cadherin__FZD__GTP_G_alpha_o__G_beta___G_gamma___LRP5_6__WNT CRIPTO_1__E_Cadherin__FZD__GTP_G_alpha_o__G_beta___G_gamma___LRP5_6__WNT GTP_at_Cytoplasm GTP_at_Cytoplasm Ligand_PTCH Ligand_PTCH GTP_G_alpha__sub_13q_endsub____beta__Arrestin GTP_G_alpha__sub_13q_endsub____beta__Arrestin G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm _beta__Arrestin__at_Cytoplasm _beta__Arrestin__at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm _beta__Arrestin__at_Cytoplasm _beta__Arrestin__at_Cytoplasm G_alpha_o__at_Cytoplasm G_alpha_o__at_Cytoplasm _beta__Arrestin _beta__Arrestin _beta__Arrestin__at_Cytoplasm _beta__Arrestin__at_Cytoplasm DVL__G_alpha__sub_13q_endsub____beta__Arrestin DVL__G_alpha__sub_13q_endsub____beta__Arrestin DVL__G_alpha__sub_13q_endsub____beta__Arrestin DVL__G_alpha__sub_13q_endsub____beta__Arrestin G_alpha__sub_13q_endsub___at_Cytoplasm G_alpha__sub_13q_endsub___at_Cytoplasm G_alpha__sub_13q_endsub___at_Cytoplasm G_alpha__sub_13q_endsub___at_Cytoplasm UBE2B HGNC CSNK2A1 HGNC CSNK2A2 HGNC FZD6 HGNC GLI3 GLI3 GLI2_185 GLI2_185 GDP GDP DVL__pho_at_Cytoplasm DVL__pho_at_Cytoplasm p27KIP1 p27KIP1 _beta__Arrestin__at_Cytoplasm _beta__Arrestin__at_Cytoplasm 23321667 pubmed DVL DVL DVL__pho_at_Cytoplasm DVL__pho_at_Cytoplasm _beta__Catenin _beta__Catenin _beta__catenin_stability _beta__catenin_stability This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ERBB4 HGNC _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm ERBB3 HGNC ERBB2 HGNC PRICKLE1_pho_at_Cytoplasm PRICKLE1_pho_at_Cytoplasm PAR6__at_Cytoplasm PAR6__at_Cytoplasm RSPO1_4 RSPO1_4 VANGL__at_Cytoplasm VANGL__at_Cytoplasm LGR5 LGR5 IFT140 HGNC RACK1__at_Cytoplasm RACK1__at_Cytoplasm _beta__Catenin _beta__Catenin RAF1 RAF1 ACTIVATION CDTYPE:CATALYSIS ASH2L HGNC _CK2 _CK2 LGR5_at_Cytoplasm LGR5_at_Cytoplasm _Destruction_complex _Destruction_complex RSPO1_4__at_Cytoplasm RSPO1_4__at_Cytoplasm XFZ7_at_Cytoplasm XFZ7_at_Cytoplasm _Xfz7_dimer _Xfz7_dimer LGR5_RSPO1_4 LGR5_RSPO1_4 PTEN HGNC CK2_beta___at_Cytoplasm CK2_beta___at_Cytoplasm LRP6_T1479_pho_S1490_pho_T1493_pho_at_Cytoplasm LRP6_T1479_pho_S1490_pho_T1493_pho_at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm _Xfz3_dimer _Xfz3_dimer XFZ3_at_Cytoplasm XFZ3_at_Cytoplasm E_Cadherin__at_Cytoplasm E_Cadherin__at_Cytoplasm LRP5_6__at_Cytoplasm LRP5_6__at_Cytoplasm CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm p120__at_Cytoplasm p120__at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm G_alpha___at_Cytoplasm G_alpha___at_Cytoplasm FZD4 FZD4 G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm WNT__at_Cytoplasm WNT__at_Cytoplasm USP8 USP8 CK1_epsilon___E_Cadherin__FZD__GTP_G_alpha___G_beta___G_gamma___LRP5_6__WNT__p120 CK1_epsilon___E_Cadherin__FZD__GTP_G_alpha___G_beta___G_gamma___LRP5_6__WNT__p120 FZD4 FZD4 10722742 pubmed _ECM_Integrin_adherence_junction _ECM_Integrin_adherence_junction TMEM198_at_Cytoplasm TMEM198_at_Cytoplasm _Signalosome_like _Signalosome_like MMP1 MMP1 19960541 pubmed Thrombin Thrombin PIPKI_gamma_i2 PIPKI_gamma_i2 DVL DVL G_beta___at_Cytoplasm G_beta___at_Cytoplasm E_Cadherin__FZD__GTP_G_alpha_o__G_beta___G_gamma___LRP5_6__WNT E_Cadherin__FZD__GTP_G_alpha_o__G_beta___G_gamma___LRP5_6__WNT 18987336 pubmed 19056682 pubmed MIR34A HGNC 22433869 pubmed G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm 15547943 pubmed GDP GDP DKK1_at_Endosome DKK1_at_Endosome CTHRC1_at_Cytoplasm CTHRC1_at_Cytoplasm DKK1_KRM__LRP5_6 DKK1_KRM__LRP5_6 WNT2B HGNC LRP5_6__at_Endosome LRP5_6__at_Endosome APAF1 APAF1 VANGL__emp_emp_emp_emp_at_Cytoplasm VANGL__emp_emp_emp_emp_at_Cytoplasm LRP5_6 LRP5_6 _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm DKK1 DKK1 SYN4__at_Cytoplasm SYN4__at_Cytoplasm 19759537 pubmed RNF146 RNF146 RNF146 RNF146 G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm WNT__at_Cytoplasm WNT__at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRICKLE1_RACK1__ROR2_SYN4__VANGL__WNT___beta__Arrestin2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRICKLE1_RACK1__ROR2_SYN4__VANGL__WNT___beta__Arrestin2 G_alpha__sub_13q_endsub___at_Cytoplasm G_alpha__sub_13q_endsub___at_Cytoplasm PAR1_sub_TRUNC_endsub___at_Cytoplasm PAR1_sub_TRUNC_endsub___at_Cytoplasm G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm RSK1 RSK1 G_beta___at_Cytoplasm G_beta___at_Cytoplasm GDP_at_Cytoplasm GDP_at_Cytoplasm TNKS2 TNKS2 18077588 pubmed AXIN AXIN AXIN AXIN TNKS1 TNKS1 22236966 pubmed TNKS2 TNKS2 DKK1 HGNC AXIN AXIN RNF146 RNF146 p27KIP1 p27KIP1 TNKS1 TNKS1 GTP GTP G_beta___G_gamma G_beta___G_gamma PAR1_sub_TRUNC_endsub PAR1_sub_TRUNC_endsub GTP_at_Cytoplasm GTP_at_Cytoplasm G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm SKP2 HGNC G_alpha__sub_13q_endsub___at_Cytoplasm G_alpha__sub_13q_endsub___at_Cytoplasm 20214616 pubmed FOXA FOXA ANAPC7 HGNC G_alpha__sub_13q_endsub___at_Cytoplasm G_alpha__sub_13q_endsub___at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm PAR1_sub_TRUNC_endsub___at_Cytoplasm PAR1_sub_TRUNC_endsub___at_Cytoplasm G_alpha_o__at_Endosome G_alpha_o__at_Endosome AXIN__CK1_alpha___GSK3__G_alpha_o___beta__Arrestin2 AXIN__CK1_alpha___GSK3__G_alpha_o___beta__Arrestin2 RAD6B RAD6B MIR19B1 MIR19B1 KRM__at_Endosome KRM__at_Endosome ACTIVATION CDTYPE:CATALYSIS DKK3_KRM DKK3_KRM WNT_canonical_pathway WNT_canonical_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. DKK3 DKK3 DKK3_KRM DKK3_KRM SOX9 HGNC DKK3_at_Endosome DKK3_at_Endosome DKK3_at_Cytoplasm DKK3_at_Cytoplasm AXIN__at_Cytoplasm AXIN__at_Cytoplasm APC APC CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm RHEB HGNC MIR19A MIR19A LRP5_6__T1479_pho_at_Vaceolae LRP5_6__T1479_pho_at_Vaceolae KRM__at_Cytoplasm KRM__at_Cytoplasm LRP5_6__at_Cytoplasm LRP5_6__at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm DKK1_at_Cytoplasm DKK1_at_Cytoplasm ROR2_at_Cytoplasm ROR2_at_Cytoplasm 22761442 pubmed MTOR HGNC WNT__at_Cytoplasm WNT__at_Cytoplasm CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm KRM__at_Cytoplasm KRM__at_Cytoplasm RSPO1_at_Cytoplasm RSPO1_at_Cytoplasm KRM__RSPO1 KRM__RSPO1 NFAT1 NFAT1 LRP5_6__at_Vaceolae LRP5_6__at_Vaceolae FZD__at_Vaceolae FZD__at_Vaceolae NFAT2 NFAT2 WNT__at_Vaceolae WNT__at_Vaceolae DVL__pho_S139_pho_S142_pho_at_Vaceolae DVL__pho_S139_pho_S142_pho_at_Vaceolae TGF_beta TGF_beta TGF__beta__pathway TGF__beta__pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 19734908 pubmed MYC MYC CK1_epsilon___at_Vaceolae CK1_epsilon___at_Vaceolae MYC MYC ROR2_S864_emp_emp_emp_at_Cytoplasm ROR2_S864_emp_emp_emp_at_Cytoplasm E_Cadherin__at_Cytoplasm E_Cadherin__at_Cytoplasm PRICKLE1_pho_at_Cytoplasm PRICKLE1_pho_at_Cytoplasm 16293631 pubmed G_beta___at_Cytoplasm G_beta___at_Cytoplasm G_alpha_o__at_Cytoplasm G_alpha_o__at_Cytoplasm GTP_at_Cytoplasm GTP_at_Cytoplasm G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm KRM KRM FZD__at_Cytoplasm FZD__at_Cytoplasm 17593948 pubmed KRM__at_Endosome KRM__at_Endosome RSPO1 RSPO1 DKK1_KRM__LRP5_6 DKK1_KRM__LRP5_6 E_Cadherin__at_Vaceolae E_Cadherin__at_Vaceolae PI3_4_5_P3 PI3_4_5_P3 p120__at_Vaceolae p120__at_Vaceolae CK1_gamma CK1_gamma MIR17 HGNC NOS2 HGNC WIF1 WIF1 ELK1 HGNC FASL FASL 21278340 pubmed MCL1 MCL1 NFAT1_2 NFAT1_2 NFAT1_2 NFAT1_2 WNT__at_Cytoplasm WNT__at_Cytoplasm E_Cadherin__FZD__GTP_G_alpha_o__G_beta___G_gamma___WNT E_Cadherin__FZD__GTP_G_alpha_o__G_beta___G_gamma___WNT rPTEN_at_Nucleus rPTEN_at_Nucleus TAB2 TAB2 DCAF8 HGNC DCAF6 HGNC WNT__at_Cytoplasm WNT__at_Cytoplasm MIF HGNC DCAF7 HGNC E_Cadherin__at_Cytoplasm E_Cadherin__at_Cytoplasm DCAF4 HGNC 11779461 pubmed DCAF5 HGNC 17641202 pubmed 8321321 pubmed G_alpha_o__at_Cytoplasm G_alpha_o__at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm MEK MEK G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm EIF4G EIF4G PTEN PTEN GTP_at_Cytoplasm GTP_at_Cytoplasm MIR214_PTEN MIR214_PTEN CRIPTO_1__at_Cytoplasm CRIPTO_1__at_Cytoplasm MCL1 MCL1 MIR214 MIR214 LRP5_6__at_Cytoplasm LRP5_6__at_Cytoplasm gpromoter_region_at_Nucleus gpromoter_region_at_Nucleus 21474452 pubmed FZD__at_Cytoplasm FZD__at_Cytoplasm MCL1 MCL1 gpromoter_region_at_Nucleus gpromoter_region_at_Nucleus FOXO1_RUNX2 FOXO1_RUNX2 RUNX2_at_Nucleus RUNX2_at_Nucleus RASGRP1_at_Golgi_Apparatus RASGRP1_at_Golgi_Apparatus DAG_at_Golgi_Apparatus DAG_at_Golgi_Apparatus RNPS1 HGNC KSR1_NTER KSR1_NTER APC2 APC2 arMIR214_at_Nucleus arMIR214_at_Nucleus FOXO1 FOXO1 RUNX2 RUNX2 module_MAPK-dependent module_MAPK-dependent Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr ubiquitinated 16054035 pubmed MEK__pho_pho_at_Early_Endosomes MEK__pho_pho_at_Early_Endosomes ERK__pho_pho_at_Early_Endosomes ERK__pho_pho_at_Early_Endosomes XFZ7 XFZ7 RAF1_pho_at_Early_Endosomes RAF1_pho_at_Early_Endosomes _beta__Arrestin2__at_Early_Endosomes _beta__Arrestin2__at_Early_Endosomes XFZ3 XFZ3 WNT WNT WNT__at_Cytoplasm WNT__at_Cytoplasm KRM__at_Cytoplasm KRM__at_Cytoplasm AXIN__at_Endosome AXIN__at_Endosome CK1_alpha___at_Endosome CK1_alpha___at_Endosome GSK3__at_Endosome GSK3__at_Endosome 19219074 pubmed PPP3CB PPP3CB HSPA8 HGNC ERK__at_Golgi_Apparatus ERK__at_Golgi_Apparatus GPCR GPCR SEF__at_Cytoplasm SEF__at_Cytoplasm ERK__pho_pho_at_Cytoplasm ERK__pho_pho_at_Cytoplasm MEK__pho_pho_at_Cytoplasm MEK__pho_pho_at_Cytoplasm CBP__at_Nucleus CBP__at_Nucleus MEK__at_Golgi_Apparatus MEK__at_Golgi_Apparatus 10026142 pubmed CBP__promoter_region CBP__promoter_region CBP CBP SEF__at_Golgi_Apparatus SEF__at_Golgi_Apparatus PCNA_at_Nucleus PCNA_at_Nucleus p21CIP1__ubi_at_Nucleus p21CIP1__ubi_at_Nucleus BCL2 BCL2 BCL2 BCL2 p110_beta__gamma p110_beta__gamma CREB CREB promoter_region promoter_region 17825467 pubmed JUNB JUNB SMO SMO CREB CREB 20122174 pubmed ACTIVATION CDTYPE:CATALYSIS ERK__at_Nucleus ERK__at_Nucleus GF_RTK GF_RTK ACTIVATION CDTYPE:CATALYSIS GF GF p110 p110 ERK__at_Cytoplasm ERK__at_Cytoplasm DUSP6_at_Cytoplasm DUSP6_at_Cytoplasm INHIBITION CDTYPE:INHIBITION DUSP5 DUSP5 ELK1 ELK1 SMAD3 HGNC 10980707 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS MIR34C HGNC REN REN INHIBITION CDTYPE:INHIBITION INHIBITION CDTYPE:INHIBITION _beta__Arrestin2 _beta__Arrestin2 20643644 pubmed RPB2 RPB2 EIF4E2 HGNC DUSP5_at_Nucleus DUSP5_at_Nucleus DUSP6 DUSP6 GLI1 GLI1 HERC1 HGNC RAF1 RAF1 18298802 pubmed GNAQ HGNC SKP1 HGNC ACTIVATION CDTYPE:CATALYSIS GNAL HGNC MEK__at_Late_Endosomes MEK__at_Late_Endosomes ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS MEK__pho_pho_at_Late_Endosomes MEK__pho_pho_at_Late_Endosomes NKX2-2 HGNC _PML_Nuclear_Body_PP2A _PML_Nuclear_Body_PP2A MEK__pho_pho_at_Late_Endosomes MEK__pho_pho_at_Late_Endosomes PML_at_Nucleus PML_at_Nucleus MEK__at_Late_Endosomes MEK__at_Late_Endosomes PP2A_C__at_Nucleus PP2A_C__at_Nucleus PP2A_B__at_Nucleus PP2A_B__at_Nucleus _FOXO_gene _FOXO_gene KLF8 KLF8 _FOXO_gene _FOXO_gene FOXO1_at_Nucleus FOXO1_at_Nucleus CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm RUNX2_at_Nucleus RUNX2_at_Nucleus AXIN__at_Cytoplasm AXIN__at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm PP2A_A__at_Nucleus PP2A_A__at_Nucleus G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm _PP2A _PP2A G_beta___at_Cytoplasm G_beta___at_Cytoplasm DUSP5 DUSP5 _FOXO_gene _FOXO_gene 17588722 pubmed MARK2 MARK2 E_Cadherin E_Cadherin MSIN3 MSIN3 ERK ERK PCNA PCNA RTK RTK ERK__pho_pho_at_Late_Endosomes ERK__pho_pho_at_Late_Endosomes PML_at_Nucleus PML_at_Nucleus _PML_Nuclear_Body _PML_Nuclear_Body _Runx2_gene _Runx2_gene FOS FOS MEK MEK SAP18 HGNC RTK RTK SUFU HGNC TMEM198 TMEM198 LRP6 LRP6 PRKCI HGNC E_Cadherin__S840_pho_S853_pho_S855_pho_S849_pho_at_Cytoplasm E_Cadherin__S840_pho_S853_pho_S855_pho_S849_pho_at_Cytoplasm PRKCH HGNC GSK3_beta GSK3_beta PRKCG HGNC PRKCE HGNC CK1__LRP6_TMEM198 CK1__LRP6_TMEM198 PRKCD HGNC PRKCB HGNC PRKCA HGNC 20627573 pubmed FZD8 HGNC 15037661 pubmed LRP6_at_Cytoplasm LRP6_at_Cytoplasm MIR17_5P MIR17_5P MYC MYC CK1 CK1 17688959 pubmed CK1__at_Cytoplasm CK1__at_Cytoplasm 15768032 pubmed 18787170 pubmed 11756412 pubmed 20025601 pubmed TMEM198_at_Cytoplasm TMEM198_at_Cytoplasm 20080742 pubmed RTKN HGNC RASGRP1 RASGRP1 20682799 pubmed PRKCQ HGNC DVL2_RIPK4 DVL2_RIPK4 RIPK4_at_Cytoplasm RIPK4_at_Cytoplasm DVL2_at_Cytoplasm DVL2_at_Cytoplasm RIPK4_at_Cytoplasm RIPK4_at_Cytoplasm 22275375 pubmed RIPK4 RIPK4 DVL2_RIPK4 DVL2_RIPK4 CK1__at_Cytoplasm CK1__at_Cytoplasm 17050667 pubmed EIF4E1B HGNC MIR23B MIR23B RNPS1 RNPS1 _beta__Catenin _beta__Catenin UBE2B UBE2B APC APC DVL2_S480_pho_S298_pho_at_Cytoplasm DVL2_S480_pho_S298_pho_at_Cytoplasm LRP6_at_Cytoplasm LRP6_at_Cytoplasm WNT3_stimulation WNT3_stimulation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. WIF1 HGNC cAMP cAMP DVL2_S480_pho_S298_pho_at_Cytoplasm DVL2_S480_pho_S298_pho_at_Cytoplasm DVL2_LRP6_RIPK4 DVL2_LRP6_RIPK4 RIPK4_at_Cytoplasm RIPK4_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS 21555371 pubmed 15140221 pubmed 19574223 pubmed AXIN__CK1_alpha___GSK3 AXIN__CK1_alpha___GSK3 GSK3__at_Cytoplasm GSK3__at_Cytoplasm 20673124 pubmed HECTD1 HECTD1 APC APC AXIN__at_Cytoplasm AXIN__at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm AXIN__at_Cytoplasm AXIN__at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm E2F1 E2F1 APC_K63_ubi_at_Cytoplasm APC_K63_ubi_at_Cytoplasm 19906679 pubmed FZD1 FZD1 ITGA9 ITGA9 ITGA9_at_Cytoplasm ITGA9_at_Cytoplasm _beta__Catenin__pho_at_Cytoplasm _beta__Catenin__pho_at_Cytoplasm E_Cadherin__ITGA9__beta__Catenin E_Cadherin__ITGA9__beta__Catenin E_Cadherin E_Cadherin E_Cadherin__S840_pho_S853_pho_S855_pho_S849_pho_at_Cytoplasm E_Cadherin__S840_pho_S853_pho_S855_pho_S849_pho_at_Cytoplasm 20606702 pubmed MMP11 HGNC E_Cadherin__ITGA9__beta__Catenin E_Cadherin__ITGA9__beta__Catenin 11402342 pubmed 16054021 pubmed 20935674 pubmed BBC3 BBC3 PML HGNC 11278750 pubmed E_Cadherin__S840_pho_S853_pho_S855_pho_S849_pho_at_Cytoplasm E_Cadherin__S840_pho_S853_pho_S855_pho_S849_pho_at_Cytoplasm 16707567 pubmed ITGA9_at_Cytoplasm ITGA9_at_Cytoplasm RASA4 RASA4 RASA4 RASA4 E_Cadherin__S840_pho_S853_pho_S855_pho_S849_pho_at_Cytoplasm E_Cadherin__S840_pho_S853_pho_S855_pho_S849_pho_at_Cytoplasm BAX_sub_TRUNC_endsub BAX_sub_TRUNC_endsub ITGA9_at_Cytoplasm ITGA9_at_Cytoplasm _beta__Catenin__Y654_pho_pho_at_Cytoplasm _beta__Catenin__Y654_pho_pho_at_Cytoplasm 19131971 pubmed CRIPTO_1__LRP5_6 CRIPTO_1__LRP5_6 CRIPTO_1__at_Cytoplasm CRIPTO_1__at_Cytoplasm LRP5_6__at_Cytoplasm LRP5_6__at_Cytoplasm E_Cadherin__ITGA9 E_Cadherin__ITGA9 LRP5_6__at_Cytoplasm LRP5_6__at_Cytoplasm CRIPTO_1 CRIPTO_1 WNT__at_Cytoplasm WNT__at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm E_Cadherin__at_Cytoplasm E_Cadherin__at_Cytoplasm 17297457 pubmed PPP3CA HGNC PPP3CB HGNC PPP3CC HGNC PPP2R2A HGNC 10050855 pubmed APC2__at_Cytoplasm APC2__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS LAMTOR3 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRICKLE1_PRR__RACK1__ROR2_SYN4__VANGL__WNT___beta__Arrestin2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRICKLE1_PRR__RACK1__ROR2_SYN4__VANGL__WNT___beta__Arrestin2 WNT__at_Cytoplasm WNT__at_Cytoplasm CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm ROR2_at_Cytoplasm ROR2_at_Cytoplasm DVL DVL GPR4 HGNC 14747478 pubmed GSK3__at_Cytoplasm GSK3__at_Cytoplasm GPR6 HGNC GPR1 HGNC ADCY1 HGNC GPR3 HGNC ADCY5 HGNC JUN JUN EIF4B HGNC ADCY4 HGNC NFAT NFAT ADCY3 HGNC ACTIVATION CDTYPE:CATALYSIS ADCY2 HGNC ADCY9 HGNC IL1R1_IRAK1_MYD88_TRAF6 IL1R1_IRAK1_MYD88_TRAF6 ADCY8 HGNC ADCY7 HGNC ADCY6 HGNC ATF2 ATF2 IRS2 IRS2 PPP2CB HGNC PPP2CA HGNC STK36 HGNC APC2__GSK3 APC2__GSK3 PRKAG3 HGNC PRKAG1 HGNC PRKAG2 HGNC ATP6V0C_D ATP6V0C_D ACTIVATION CDTYPE:CATALYSIS CABIN1 HGNC NKD1 NKD1 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRR__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 CK1_epsilon___CTHRC1_DVL__FZD__PAR6__PRR__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 PP2A_B55_alpha PP2A_B55_alpha DVL__pho_pho_pho_at_Endosome DVL__pho_pho_pho_at_Endosome INHIBITION CDTYPE:INHIBITION 16131541 pubmed 19114989 pubmed ACTIVATION CDTYPE:CATALYSIS CKS1B HGNC 15525529 pubmed APC2__CK1_epsilon___CTHRC1_DVL__FZD__GSK3__PAR6__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 APC2__CK1_epsilon___CTHRC1_DVL__FZD__GSK3__PAR6__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 17565603 pubmed FBXW5 HGNC WNT WNT HRK HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 21062979 pubmed CFL1 HGNC G_alpha___at_Cytoplasm G_alpha___at_Cytoplasm GDP_at_Cytoplasm GDP_at_Cytoplasm BCL2 HGNC G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm EIF4EBP1 HGNC ROR2_at_Cytoplasm ROR2_at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm p53 p53 ACTIVATION CDTYPE:CATALYSIS MDM2 MDM2 G_beta___at_Cytoplasm G_beta___at_Cytoplasm G_alpha___at_Cytoplasm G_alpha___at_Cytoplasm 21606194 pubmed APC3 APC3 WNT__at_Cytoplasm WNT__at_Cytoplasm MIR20A HGNC GTP_at_Cytoplasm GTP_at_Cytoplasm 12514186 pubmed G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm DVL1 HGNC GDP GDP 15668399 pubmed DCAF13 HGNC DCAF15 HGNC DCAF16 HGNC DCAF17 HGNC E_Cadherin E_Cadherin RIPK1 HGNC INHIBITION CDTYPE:INHIBITION DCAF10 HGNC PPP3CB HGNC DCAF11 HGNC DAXX DAXX DCAF12 HGNC CK1_epsilon CK1_epsilon RNF123 HGNC CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm IL2 IL2 HIST2H2BE HGNC CK1_epsilon___CTHRC1_FZD__GTP_G_alpha___G_beta___G_gamma___PAR6__PRICKLE1_PRR__RACK1__ROR2_SYN4__VANGL__WNT CK1_epsilon___CTHRC1_FZD__GTP_G_alpha___G_beta___G_gamma___PAR6__PRICKLE1_PRR__RACK1__ROR2_SYN4__VANGL__WNT CK1_epsilon___CTHRC1_FZD__PAR6__PRICKLE1_PRR__RACK1__ROR2_SYN4__VANGL__WNT CK1_epsilon___CTHRC1_FZD__PAR6__PRICKLE1_PRR__RACK1__ROR2_SYN4__VANGL__WNT 16406523 pubmed HSPB1 HGNC CUL3 CUL3 11433302 pubmed 16969074 pubmed CREB3 HGNC CREB1 HGNC CREB5 HGNC MAP3K10 MAP3K10 TCF4 TCF4 UBE2B HGNC 16406505 pubmed 20678582 pubmed DPY30 HGNC GPI HGNC PI3_4_5_P3 PI3_4_5_P3 TIAM1 TIAM1 _beta__actin _beta__actin F2R HGNC C_FES__Y713_pho_Y811_pho_hm2_at_Cytoplasm C_FES__Y713_pho_Y811_pho_hm2_at_Cytoplasm PI3_4_5_P3_TIAM1 PI3_4_5_P3_TIAM1 p85__at_Cytoplasm p85__at_Cytoplasm p85__at_Cytoplasm p85__at_Cytoplasm C_FES__p110__p85 C_FES__p110__p85 ACTIVATION CDTYPE:CATALYSIS p110__at_Cytoplasm p110__at_Cytoplasm p110__at_Cytoplasm p110__at_Cytoplasm MARK2 HGNC ACTIVATION CDTYPE:CATALYSIS 19351822 pubmed AP_1_ARRE_binding_sites AP_1_ARRE_binding_sites PTCH2 HGNC PTCH1 HGNC COPS2 HGNC CSN6 CSN6 19901072 pubmed C_FES C_FES CDTYPE:BOOLEAN_LOGIC_GATE_AND C_FES C_FES C_FES C_FES ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS p110_beta__gamma___at_Cytoplasm p110_beta__gamma___at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm KLF4 HGNC PI3K_AKT_MTOR_pathway PI3K_AKT_MTOR_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS RSPO1 RSPO1 19465923 pubmed GRK GRK G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS 12657629 pubmed 18078995 pubmed BID_sub_TRUNC_endsub BID_sub_TRUNC_endsub MAPKAPK5 HGNC CSE1L HGNC ACTIVATION CDTYPE:CATALYSIS MAPKAPK2 HGNC ACTIVATION CDTYPE:CATALYSIS p101__at_Cytoplasm p101__at_Cytoplasm MIR92A1 HGNC Sonic_hedgehog_pathway Sonic_hedgehog_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. MAPKAPK3 HGNC p110_beta__gamma___at_Cytoplasm p110_beta__gamma___at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS p101__at_Cytoplasm p101__at_Cytoplasm SMO SMO CyclinD CyclinD ACTIVATION CDTYPE:CATALYSIS 12514131 pubmed MRG15 MRG15 SFRP1 SFRP1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS KSR1 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CDTYPE:BOOLEAN_LOGIC_GATE_AND BCL9 HGNC G_beta___G_gamma G_beta___G_gamma GTP_G_alpha__sub_i_endsub GTP_G_alpha__sub_i_endsub CDTYPE:BOOLEAN_LOGIC_GATE_AND INHIBITION CDTYPE:UNKNOWN_INHIBITION CDTYPE:BOOLEAN_LOGIC_GATE_AND SMO SMO ACTIVATION CDTYPE:CATALYSIS G_beta___at_Cytoplasm G_beta___at_Cytoplasm 14724641 pubmed PRKAB2 HGNC ACTIVATION CDTYPE:CATALYSIS GRK__G_beta___G_gamma GRK__G_beta___G_gamma PRKAB1 HGNC GRK__at_Cytoplasm GRK__at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm IFT122 IFT122 G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm 10611249 pubmed ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:UNKNOWN_CATALYSIS RHOA HGNC ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION GTP GTP BCL2 BCL2 Ligand_at_Cytoplasm Ligand_at_Cytoplasm PTCH__at_Cytoplasm PTCH__at_Cytoplasm GTP_G_alpha__sub_i_endsub___G_beta___G_gamma___Ligand_PTCH__SMO GTP_G_alpha__sub_i_endsub___G_beta___G_gamma___Ligand_PTCH__SMO DEPTOR DEPTOR GDP GDP G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm 16885213 pubmed SMO_at_Cytoplasm SMO_at_Cytoplasm G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm PHLPP PHLPP GAB1 HGNC LAMTOR2 HGNC INHIBITION CDTYPE:INHIBITION CDTYPE:BOOLEAN_LOGIC_GATE_AND ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS KRAS HGNC ACTIVATION CDTYPE:CATALYSIS PTCH__at_Cytoplasm PTCH__at_Cytoplasm 12764189 pubmed SMO_at_Cytoplasm SMO_at_Cytoplasm HH_Ligand_at_Cytoplasm HH_Ligand_at_Cytoplasm 21304492 pubmed G_beta___at_Cytoplasm G_beta___at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS G_alpha__sub_i_endsub___at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm HSPC2 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS G_alpha__sub_i_endsub___at_Cytoplasm G_alpha__sub_i_endsub___at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS HES1 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 20540941 pubmed 19171760 pubmed 19379695 pubmed 19446321 pubmed 10949026 pubmed 18644865 pubmed 19581931 pubmed p70_beta p70_beta TNKS HGNC CRM1 CRM1 CRM1__p27KIP1 CRM1__p27KIP1 ACTIVATION CDTYPE:CATALYSIS Ligand_at_Cytoplasm Ligand_at_Cytoplasm PTCH__at_Cytoplasm PTCH__at_Cytoplasm CRM1 CRM1 p27KIP1__pho_at_Cytoplasm p27KIP1__pho_at_Cytoplasm ECM_genes ECM_genes p27KIP1 p27KIP1 p27KIP1__pho_at_Nucleus p27KIP1__pho_at_Nucleus CRM1__at_Nucleus CRM1__at_Nucleus CRM1__at_Cytoplasm CRM1__at_Cytoplasm CRM1__p27KIP1 CRM1__p27KIP1 CSN4 CSN4 KPC1__KPC2 KPC1__KPC2 ACTIVATION CDTYPE:CATALYSIS KPC1__at_Cytoplasm KPC1__at_Cytoplasm 21619876 pubmed 21799911 pubmed KPC2__at_Cytoplasm KPC2__at_Cytoplasm MDM2 MDM2 17368478 pubmed KPC1 KPC1 GDP_G_alpha__sub_i_endsub___G_beta___G_gamma___HH_Ligand_PTCH__SMO GDP_G_alpha__sub_i_endsub___G_beta___G_gamma___HH_Ligand_PTCH__SMO DAXX HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS GLI3 HGNC ACTIVATION CDTYPE:CATALYSIS PRICKLE1 PRICKLE1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS DDIT3 DDIT3 PLK1 PLK1 ACTIVATION CDTYPE:CATALYSIS RUNX2 RUNX2 WNT2B WNT2B RCHY1 HGNC PDCD4 HGNC MAPKAPK MAPKAPK 21442356 pubmed MAPKAPK MAPKAPK 19651775 pubmed 21909076 pubmed MNK MNK TMEM198 HGNC MNK MNK ACTIVATION CDTYPE:CATALYSIS HSPB1 HSPB1 ACTIVATION CDTYPE:CATALYSIS HSPB1 HSPB1 ACTIVATION CDTYPE:CATALYSIS DDIT3 DDIT3 ACTIVATION CDTYPE:CATALYSIS MYC MYC MAX MAX MAX MAX JNK JNK DCAF DCAF JNK JNK MAP2K7 MAP2K7 MAP2K7 MAP2K7 ACTIVATION CDTYPE:CATALYSIS UBC9 UBC9 ACTIVATION CDTYPE:CATALYSIS GADD45A HGNC IFT122 HGNC GADD45B HGNC PLC__beta PLC__beta 17178906 pubmed promoter_region promoter_region ACTIVATION CDTYPE:CATALYSIS MAP2K6 MAP2K6 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS MAP2K6 MAP2K6 ACTIVATION CDTYPE:CATALYSIS MAP3K5 MAP3K5 TXN TXN p38 p38 CyclinD CyclinD GADD45 GADD45 CyclinD CyclinD MAP3K4 MAP3K4 GPR20 HGNC CDC53__FBW7__RBX1_SKP1 CDC53__FBW7__RBX1_SKP1 GPR12 HGNC 12534294 pubmed GPR15 HGNC GPR18 HGNC GPR17 HGNC CDC53__RBX1_SKP1_SKP2 CDC53__RBX1_SKP1_SKP2 20138985 pubmed GPR19 HGNC MAP3K2_3 MAP3K2_3 FBW7__at_Nucleus FBW7__at_Nucleus TAB TAB p38 p38 MAP2K4 MAP2K4 MAP2K3 MAP2K3 p27KIP1__pho_pho_pho_S157_pho_at_Cytoplasm p27KIP1__pho_pho_pho_S157_pho_at_Cytoplasm CSNK1A1 HGNC p27KIP1__pho_pho_pho_S157_pho_at_Nucleus p27KIP1__pho_pho_pho_S157_pho_at_Nucleus FZD__at_Cytoplasm FZD__at_Cytoplasm SIRT1_2 SIRT1_2 MDM2 MDM2 p53 p53 GSK3A HGNC E2 E2 GSK3B HGNC MDM2 MDM2 RAD6 RAD6 TLE TLE MDM2 MDM2 BAF53A BAF53A MDM2 MDM2 8381049 pubmed p27KIP1 p27KIP1 p27KIP1 p27KIP1 PIRH2 PIRH2 BCL6 BCL6 CTGF CTGF MAP2K4 MAP2K4 MDM2 MDM2 FOXO4_promoter_region FOXO4_promoter_region p53 p53 FOXO3 FOXO3 MDM2 MDM2 p53 p53 18829525 pubmed 21346143 pubmed TAOK TAOK TAOK TAOK MAP3K10_11__pho_at_Cytoplasm MAP3K10_11__pho_at_Cytoplasm MAP2K3 MAP2K3 Pi Pi GDP_at_Cytoplasm GDP_at_Cytoplasm G_alpha___at_Cytoplasm G_alpha___at_Cytoplasm 9735050 pubmed AP2_mu AP2_mu RGS3 RGS3 MIR373 MIR373 IRAK1 HGNC CDK4_6__CyclinD__p27KIP1 CDK4_6__CyclinD__p27KIP1 RAC1_pho_at_Cytoplasm RAC1_pho_at_Cytoplasm CyclinD__at_Nucleus CyclinD__at_Nucleus HSP90B1 HGNC CDK4_6__at_Nucleus CDK4_6__at_Nucleus CDK4_6__CyclinD__p27KIP1 CDK4_6__CyclinD__p27KIP1 CKS1B_CUL1_SKP1_SKP2 CKS1B_CUL1_SKP1_SKP2 CKS1B_at_Nucleus CKS1B_at_Nucleus MAP3K10_11 MAP3K10_11 SKP2_at_Nucleus SKP2_at_Nucleus FZD7 HGNC CUL1_at_Nucleus CUL1_at_Nucleus GRB2_at_Plasma_Membrane GRB2_at_Plasma_Membrane SOS__at_Plasma_Membrane SOS__at_Plasma_Membrane S_phase S_phase This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. RAC1_pho_at_Plasma_Membrane RAC1_pho_at_Plasma_Membrane 18000759 pubmed RGS3 RGS3 LRP5 HGNC 15534002 pubmed LRP6 HGNC id_14_3_3__RGS3 id_14_3_3__RGS3 id_14_3_3 id_14_3_3 G_alpha___at_Cytoplasm G_alpha___at_Cytoplasm GTP_G_alpha GTP_G_alpha 12533515 pubmed SKP1_at_Nucleus SKP1_at_Nucleus BRG1 BRG1 SKP1_at_Nucleus SKP1_at_Nucleus GSK3_beta GSK3_beta SKP2_at_Nucleus SKP2_at_Nucleus CDC34 CDC34 PPP3CB HGNC CDC53__at_Nucleus CDC53__at_Nucleus FOXQ1 FOXQ1 CDK4_6__at_Cytoplasm CDK4_6__at_Cytoplasm _beta__Catenin _beta__Catenin CyclinD__at_Cytoplasm CyclinD__at_Cytoplasm RIPK1_at_Cytoplasm RIPK1_at_Cytoplasm _beta__Catenin _beta__Catenin RBX1_at_Nucleus RBX1_at_Nucleus TRAF2_at_Cytoplasm TRAF2_at_Cytoplasm CyclinD CyclinD G_alpha___at_Cytoplasm G_alpha___at_Cytoplasm RAC1 RAC1 GTP_at_Cytoplasm GTP_at_Cytoplasm GDP_G_alpha GDP_G_alpha RAC1_at_Cytoplasm RAC1_at_Cytoplasm GTP_PLC__beta___RAC1 GTP_PLC__beta___RAC1 GTP_at_Cytoplasm GTP_at_Cytoplasm CyclinE CyclinE CyclinE__T380_pho_S384_pho_at_Nucleus CyclinE__T380_pho_S384_pho_at_Nucleus APC12 APC12 E1 E1 CyclinE__T380_pho_at_Nucleus CyclinE__T380_pho_at_Nucleus CDK2_at_Nucleus CDK2_at_Nucleus CDK2_CyclinE CDK2_CyclinE ROS ROS TXN_at_Cytoplasm TXN_at_Cytoplasm ERK ERK CyclinE CyclinE RSK RSK CyclinE CyclinE CDK2_CyclinE CDK2_CyclinE CDK2_at_Nucleus CDK2_at_Nucleus 15509806 pubmed SEF SEF 18455992 pubmed CTHRC1 CTHRC1 GTP_at_Cytoplasm GTP_at_Cytoplasm ROR2 ROR2 14960582 pubmed TSC1 TSC1 id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm RGS3_S264_pho_at_Cytoplasm RGS3_S264_pho_at_Cytoplasm G_beta___at_Cytoplasm G_beta___at_Cytoplasm G_beta___G_gamma___PLC__beta G_beta___G_gamma___PLC__beta CDC53__at_Nucleus CDC53__at_Nucleus SKP1_at_Nucleus SKP1_at_Nucleus RBX1_at_Nucleus RBX1_at_Nucleus CyclinE__T380_pho_S384_pho_ubi_at_Nucleus CyclinE__T380_pho_S384_pho_ubi_at_Nucleus CDK2_at_Nucleus CDK2_at_Nucleus MCL1 HGNC CDK2_CyclinE CDK2_CyclinE MMP9 MMP9 16847462 pubmed PLC__beta___at_Cytoplasm PLC__beta___at_Cytoplasm RAC1_at_Cytoplasm RAC1_at_Cytoplasm 12709531 pubmed GTP_RAC1 GTP_RAC1 G_gamma___at_Cytoplasm G_gamma___at_Cytoplasm PLC__beta___at_Cytoplasm PLC__beta___at_Cytoplasm 11532962 pubmed RNA RNA FOXM1 HGNC 22833265 pubmed MINK1 MINK1 WNT2B HGNC ACTIVATION CDTYPE:CATALYSIS WNT11 HGNC H H ULK3 HGNC 17662023 pubmed AKT1 AKT1 WNT__at_Cytoplasm WNT__at_Cytoplasm FZD__at_Cytoplasm FZD__at_Cytoplasm CK1_epsilon___at_Cytoplasm CK1_epsilon___at_Cytoplasm 21380625 pubmed RAC1 RAC1 Death_receptor4 Death_receptor4 12138125 pubmed CK1_epsilon___CTHRC1_FZD__PAR6__PRICKLE1_RACK1__ROR2_SYN4__VANGL__WNT___beta__Arrestin2 CK1_epsilon___CTHRC1_FZD__PAR6__PRICKLE1_RACK1__ROR2_SYN4__VANGL__WNT___beta__Arrestin2 WNT16 HGNC 18851840 pubmed GRB2 HGNC 11801735 pubmed ACTIVATION CDTYPE:CATALYSIS DVL__pho_pho_pho_at_Endosome DVL__pho_pho_pho_at_Endosome ROR2_S864_pho_pho_pho_at_Endosome ROR2_S864_pho_pho_pho_at_Endosome APC2__CK1_epsilon___CTHRC1_DVL__FZD__GSK3__PAR6__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 APC2__CK1_epsilon___CTHRC1_DVL__FZD__GSK3__PAR6__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 USP15 USP15 TRADD TRADD VANGL__at_Endosome VANGL__at_Endosome RACK1__at_Endosome RACK1__at_Endosome 11050185 pubmed 19887899 pubmed CK2_alpha____at_Cytoplasm CK2_alpha____at_Cytoplasm PRICKLE1 PRICKLE1 PRICKLE1 PRICKLE1 BCL2L11 BCL2L11 CK1_delta CK1_delta ATP6V0C HGNC PP2A_C PP2A_C DVL__pho_pho_pho_at_Endosome DVL__pho_pho_pho_at_Endosome S100A9 HGNC SYN4__at_Endosome SYN4__at_Endosome RUNX2 HGNC _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome 20564213 pubmed CTHRC1_at_Endosome CTHRC1_at_Endosome 17986005 pubmed WNT__at_Endosome WNT__at_Endosome FZD__at_Endosome FZD__at_Endosome CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome GSK3__at_Endosome GSK3__at_Endosome AKT AKT APC2__at_Endosome APC2__at_Endosome ACTIVATION CDTYPE:CATALYSIS CK1_epsilon___at_Endosome CK1_epsilon___at_Endosome ACTIVATION CDTYPE:CATALYSIS WNT__at_Endosome WNT__at_Endosome ACTIVATION CDTYPE:CATALYSIS ROR2_S864_pho_active_at_Endosome ROR2_S864_pho_active_at_Endosome 15467454 pubmed FZD__at_Endosome FZD__at_Endosome 17000779 pubmed EMT EMT This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. SEC24B SEC24B VANGL VANGL 9765224 pubmed EPC1 EPC1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 18256687 pubmed ACTIVATION CDTYPE:CATALYSIS APC2__CK1_epsilon___CTHRC1_DVL__FZD__GSK3__PAR6__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 APC2__CK1_epsilon___CTHRC1_DVL__FZD__GSK3__PAR6__RACK1__ROR2_RSPO3_SYN4__VANGL__WNT___beta__Arrestin2 _beta__Arrestin2__at_Endosome _beta__Arrestin2__at_Endosome EIF4E EIF4E SYN4__at_Endosome SYN4__at_Endosome RACK1__at_Endosome RACK1__at_Endosome VANGL__at_Endosome VANGL__at_Endosome APC2__at_Endosome APC2__at_Endosome CTHRC1_at_Endosome CTHRC1_at_Endosome GSK3__at_Endosome GSK3__at_Endosome 19910923 pubmed CAMK2B HGNC CAMK2A HGNC MAP3K10 HGNC 15755954 pubmed AMER2 AMER2 TNFRSF1B TNFRSF1B id_4E_BP id_4E_BP CAMK2G HGNC 22007144 pubmed 15905173 pubmed CAMK2D HGNC VANGL__at_Cytoplasm VANGL__at_Cytoplasm 16443747 pubmed VANGL__at_Cytoplasm VANGL__at_Cytoplasm NICD NICD RACK1__at_Cytoplasm RACK1__at_Cytoplasm RACK1__at_Cytoplasm RACK1__at_Cytoplasm VANGL VANGL JAG2 JAG2 LEF1 LEF1 16489074 pubmed 16647304 pubmed 20398329 pubmed APC10 APC10 11955434 pubmed 11955436 pubmed PI4KII_alpha PI4KII_alpha AXIN2 HGNC 20920541 pubmed RIPK4 RIPK4 NOS3 HGNC MAP2K1 HGNC KIS KIS 11313479 pubmed GNG HGNC HERC1 HERC1 CK1_alpha CK1_alpha 11994454 pubmed RELA HGNC PABP5 HGNC PIP5K1C HGNC LGR5 HGNC 11997436 pubmed TRAF6 HGNC POLR2B HGNC FU FU TNKS2 TNKS2 AXIN1 HGNC PARP16 HGNC MINK1 HGNC PARP14 HGNC PARP15 HGNC 17030191 pubmed PARP12 HGNC FRK HGNC PARP10 HGNC PARP11 HGNC PTEN PTEN 11463845 pubmed PTEN PTEN PTEN PTEN BCL6 BCL6 PI4K2B HGNC BCL6 BCL6 17466953 pubmed PI4K2A HGNC BCL6 BCL6 IKK IKK 15060161 pubmed 18552861 pubmed SYN4 SYN4 FOXO4_at_Nucleus FOXO4_at_Nucleus gpromoter_region_at_Nucleus gpromoter_region_at_Nucleus GSK3_beta GSK3_beta FOXO1_promoter_region FOXO1_promoter_region gpromoter_region_at_Nucleus gpromoter_region_at_Nucleus FOXF1 FOXF1 FOXO1_promoter_region FOXO1_promoter_region gpromoter_region_at_Nucleus gpromoter_region_at_Nucleus HHIP HGNC FOXO1_T24_pho_S256_pho_S319_pho_at_Nucleus FOXO1_T24_pho_S256_pho_S319_pho_at_Nucleus FOXO1_at_Nucleus FOXO1_at_Nucleus ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS PPP2R4 HGNC AXIN AXIN E1 E1 E2 E2 12542976 pubmed p53 p53 19736394 pubmed FOXO3 FOXO3 GADD45 GADD45 FOXO3_promoter_region FOXO3_promoter_region GADD45 GADD45 FOXO3_S644_pho_at_Nucleus FOXO3_S644_pho_at_Nucleus 210606194 pubmed gpromoter_region_at_Nucleus gpromoter_region_at_Nucleus 19446450 pubmed WIF1 HGNC COPS3 HGNC FOXO3 FOXO3 FOXO3 FOXO3 ACTIVATION CDTYPE:CATALYSIS KLHL KLHL SOS__at_Cytoplasm SOS__at_Cytoplasm GRB2_at_Cytoplasm GRB2_at_Cytoplasm RAF1_pho_at_Plasma_Membrane RAF1_pho_at_Plasma_Membrane BAD BAD BAD BAD BCL2 BCL2 RAF1 RAF1 DAAM1 DAAM1 PIK3R2 HGNC PIK3R3 HGNC AXIN__S80_emp_S82_emp_S222_emp_S473_emp_at_Cytoplasm AXIN__S80_emp_S82_emp_S222_emp_S473_emp_at_Cytoplasm PIK3R1 HGNC _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm _beta__Catenin__S45_pho_T41_pho_S37_pho_S33_pho_at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm APC_at_Cytoplasm APC_at_Cytoplasm RSK RSK PR55_alpha___at_Cytoplasm PR55_alpha___at_Cytoplasm PP2A_C__at_Cytoplasm PP2A_C__at_Cytoplasm PR65_A__at_Cytoplasm PR65_A__at_Cytoplasm MSK MSK S100A9 S100A9 MSK MSK CREB1 CREB1 CREB1 CREB1 AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_S614_pho_S621_pho_at_Cytoplasm ECM_genes ECM_genes PPP1C__at_Cytoplasm PPP1C__at_Cytoplasm PPP1R__at_Cytoplasm PPP1R__at_Cytoplasm PPID PPID PPP1C__PPP1R PPP1C__PPP1R APC_AXIN__CK1_alpha___GSK3__PPP1C__PPP1R APC_AXIN__CK1_alpha___GSK3__PPP1C__PPP1R PPID PPID GSK3_beta GSK3_beta ERK ERK RSK__pho_at_Cytoplasm RSK__pho_at_Cytoplasm GSK3_beta___pho_at_Cytoplasm GSK3_beta___pho_at_Cytoplasm AXIN1 HGNC PARD6A HGNC LAMTOR2 LAMTOR2 TSC2 TSC2 p70_alpha p70_alpha 15806138 pubmed PPP1R__at_Cytoplasm PPP1R__at_Cytoplasm PPP1C__at_Cytoplasm PPP1C__at_Cytoplasm APC_at_Cytoplasm APC_at_Cytoplasm LEF_TCF LEF_TCF GSK3_beta GSK3_beta CK1_alpha___at_Cytoplasm CK1_alpha___at_Cytoplasm GSK3__at_Cytoplasm GSK3__at_Cytoplasm _beta__Catenin _beta__Catenin MAP3K2_3__pho_at_Cytoplasm MAP3K2_3__pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_at_Cytoplasm AXIN__S80_pho_S82_pho_S222_pho_S473_pho_at_Cytoplasm UBC4 UBC4 GRK GRK MAP3K2_3__pho_at_Cytoplasm MAP3K2_3__pho_at_Cytoplasm 16489008 pubmed WNT9B HGNC SIX3 HGNC AHI1 HGNC ERK__pho_pho_hm2_at_Cytoplasm ERK__pho_pho_hm2_at_Cytoplasm WNT9A HGNC ACTIVATION CDTYPE:CATALYSIS PLA2G4A PLA2G4A PLA2G4A PLA2G4A MEK__pho_pho_at_Cytoplasm MEK__pho_pho_at_Cytoplasm KSR1_at_Cytoplasm KSR1_at_Cytoplasm KLHL11 HGNC KLHL10 HGNC ACTIVATION CDTYPE:CATALYSIS MAPK13 HGNC GNAO1 HGNC MAPK14 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 21151179 pubmed KLHL14 HGNC KLHL15 HGNC KLHL12 HGNC KLHL13 HGNC MEK__pho_pho_at_Cytoplasm MEK__pho_pho_at_Cytoplasm KLHL18 HGNC ERK__pho_pho_at_Cytoplasm ERK__pho_pho_at_Cytoplasm KLHL17 HGNC MEK__at_Cytoplasm MEK__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS KLHL22 HGNC KLHL21 HGNC 11707428 pubmed RSK RSK KLHL20 HGNC ACTIVATION CDTYPE:CATALYSIS CDC20 HGNC KSR1_at_Cytoplasm KSR1_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS WNT7A HGNC FAF1 HGNC CRM1__FOXO4 CRM1__FOXO4 GLI2 GLI2 FAF2 HGNC WNT7B HGNC FOXO4_T28_pho_S193_pho_S258_pho_at_Cytoplasm FOXO4_T28_pho_S193_pho_S258_pho_at_Cytoplasm INHIBITION CDTYPE:INHIBITION MEK__pho_pho_at_Early_Endosomes MEK__pho_pho_at_Early_Endosomes CRM1__at_Cytoplasm CRM1__at_Cytoplasm ERK__pho_pho_at_Early_Endosomes ERK__pho_pho_at_Early_Endosomes FOXO4 FOXO4 PAR1_sub_TRUNC_endsub PAR1_sub_TRUNC_endsub 12391153 pubmed id_14_3_3__FOXO1 id_14_3_3__FOXO1 MIR34A MIR34A _beta__Arrestin2__at_Early_Endosomes _beta__Arrestin2__at_Early_Endosomes DYRK4 HGNC GRK__at_Early_Endosomes GRK__at_Early_Endosomes CRM1__at_Nucleus CRM1__at_Nucleus GNB2L1 HGNC DYRK2 HGNC DYRK3 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CCND1 HGNC CCND3 HGNC CCND2 HGNC WNT8B HGNC WNT8A HGNC GRK__at_Plasma_Membrane GRK__at_Plasma_Membrane id_14_3_3__at_Cytoplasm id_14_3_3__at_Cytoplasm GRK__at_Early_Endosomes GRK__at_Early_Endosomes id_14_3_3__at_Nucleus id_14_3_3__at_Nucleus id_14_3_3__FOXO1 id_14_3_3__FOXO1 INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS GRK__at_Plasma_Membrane GRK__at_Plasma_Membrane GRK GRK CDTYPE:BOOLEAN_LOGIC_GATE_AND ERK__pho_pho_hm2_at_Cytoplasm ERK__pho_pho_hm2_at_Cytoplasm MEK__pho_pho_at_Cytoplasm MEK__pho_pho_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS SEF__at_Cytoplasm SEF__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS FOXO4 FOXO4 MIR19A HGNC FOXO4_at_Nucleus FOXO4_at_Nucleus FOXO4_IMPORTIN FOXO4_IMPORTIN CRM1__FOXO4 CRM1__FOXO4 FOXO4_at_Nucleus FOXO4_at_Nucleus FOXO4_at_Cytoplasm FOXO4_at_Cytoplasm CRM1__at_Cytoplasm CRM1__at_Cytoplasm UBE2C HGNC 11960000 pubmed WNT5A HGNC WNT5B HGNC IRS2 IRS2 EIF4A EIF4A 22322943 pubmed ACTIVATION CDTYPE:CATALYSIS BOC HGNC ACTIVATION CDTYPE:CATALYSIS 21245165 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CRM1__FOXO4 CRM1__FOXO4 CRM1__at_Nucleus CRM1__at_Nucleus FOXO4_T28_pho_S193_pho_S258_pho_at_Nucleus FOXO4_T28_pho_S193_pho_S258_pho_at_Nucleus CRM1__FOXO4 CRM1__FOXO4 FOXO4 FOXO4 IMPORTIN IMPORTIN IMPORTIN__at_Cytoplasm IMPORTIN__at_Cytoplasm CSNK2B HGNC FOXO4_at_Cytoplasm FOXO4_at_Cytoplasm FOXO4_IMPORTIN FOXO4_IMPORTIN PAR6__PRICKLE1_RACK1__VANGL PAR6__PRICKLE1_RACK1__VANGL RACK1__at_Cytoplasm RACK1__at_Cytoplasm TSC1 HGNC AP2B1 HGNC 14684739 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CASP8 HGNC IMPORTIN IMPORTIN IMPORTIN__at_Nucleus IMPORTIN__at_Nucleus KLHL28 HGNC p15INK4B p15INK4B KLHL29 HGNC KLHL24 HGNC p19INK4D p19INK4D KLHL23 HGNC MAX MAX 12906858 pubmed p15INK4B p15INK4B KLHL26 HGNC PLK1 PLK1 KLHL25 HGNC p19INK4D p19INK4D WNT3A HGNC _beta__Arrestin2__at_Cytoplasm _beta__Arrestin2__at_Cytoplasm DVL___beta__Arrestin2 DVL___beta__Arrestin2 _beta__Arrestin2 _beta__Arrestin2 FBXW7 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS RACK1__at_Cytoplasm RACK1__at_Cytoplasm RACK1__VANGL RACK1__VANGL PHLPP1 HGNC VANGL__at_Cytoplasm VANGL__at_Cytoplasm PHLPP2 HGNC VANGL__at_Cytoplasm VANGL__at_Cytoplasm KLHL30 HGNC KLHL31 HGNC KLHL32 HGNC FOXO1 FOXO1 KLHL33 HGNC FOXO1 FOXO1 ACTIVATION CDTYPE:CATALYSIS p21CIP1 p21CIP1 ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION PINK1 PINK1 PINK1 PINK1 KLHL38 HGNC p110 p110 KLHL36 HGNC p110 p110 KLHL35 HGNC FOXO3 FOXO3 KLHL34 HGNC FOXO3 FOXO3 CTHRC1_at_Cytoplasm CTHRC1_at_Cytoplasm FTX HGNC MAPK11 HGNC MAPK12 HGNC CTHRC1_at_Cytoplasm CTHRC1_at_Cytoplasm 19725819 pubmed 12697810 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS SYN4 SYN4 CDTYPE:BOOLEAN_LOGIC_GATE_AND SYN4__at_Cytoplasm SYN4__at_Cytoplasm SYN4__at_Cytoplasm SYN4__at_Cytoplasm TRADD TRADD S100A9 HGNC SUR_8 SUR_8 PLK1 PLK1 ACTIVATION CDTYPE:CATALYSIS TRADD TRADD ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 19684618 pubmed