HEY1_2__at_Nucleus HEY1_2__at_Nucleus 16940750 pubmed PIK3R1 HGNC PIK3R2 HGNC GJA5 GJA5 ITGB1 ITGB1 TIMP2 HGNC PIK3R3 HGNC COL1A2 COL1A2 12080085 pubmed EZH1 EZH1 GJB1_Occludin GJB1_Occludin COL1A2 COL1A2 MMP10 MMP10 MMP10 MMP10 EZH2 EZH2 EZH2 EZH2 RUNX2_at_Nucleus RUNX2_at_Nucleus NICD_co_factors NICD_co_factors STAT6 STAT6 MMP10 MMP10 MMP2 MMP2 MMP10 MMP10 Rac1_GDIs Rac1_GDIs GJB1 GJB1 Desmoplakin Desmoplakin Occludin Occludin GJB1_ZO1_2 GJB1_ZO1_2 ZO1_2 ZO1_2 GJA1_ZO1 GJA1_ZO1 22154077 pubmed 12154066 pubmed GJB1 GJB1 OCLN HGNC GJA1_ZO2 GJA1_ZO2 ZO1 ZO1 COL6A2 COL6A2 ZO2 ZO2 G0_phase G0_phase This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. GJA1 GJA1 17072303 pubmed _CBF1__repressor_complex_1 _CBF1__repressor_complex_1 HEY1 HEY1 Afadin Afadin HEY1 HEY1 ZO1 ZO1 MIR141 HGNC Actin_cytoskeletal__Afadin Actin_cytoskeletal__Afadin ZO1_2 ZO1_2 ZO1_3 ZO1_3 Integrin_A8B1_AVB1_AVB5_AVB6_AVB8__LTBP1_Latency_associated_protein Integrin_A8B1_AVB1_AVB5_AVB6_AVB8__LTBP1_Latency_associated_protein ITGB8 ITGB8 CIR1_at_Nucleus CIR1_at_Nucleus SIN3A_at_Nucleus SIN3A_at_Nucleus _CBF1__activator_complex _CBF1__activator_complex _CBF1__repressor_complex_2 _CBF1__repressor_complex_2 ITGA6 HGNC BCL2_XL__at_Mitochondria BCL2_XL__at_Mitochondria ETS1 ETS1 GJC1 GJC1 ETS1 ETS1 GJC1_ZO1_3 GJC1_ZO1_3 ARHGEF3 HGNC MIR205 MIR205 ARHGEF4 HGNC MIR205 MIR205 CDTYPE:PHYSICAL_STIMULATION RUNX2 RUNX2 ARHGEF1 HGNC MIR106B_25 MIR106B_25 HEY1_2__RUNX2 HEY1_2__RUNX2 ARHGEF2 HGNC L1CAM L1CAM GJD2_ZO1_2_3 GJD2_ZO1_2_3 MIR21 MIR21 ETS1 ETS1 SIX1 SIX1 ZO1_3 ZO1_3 HEY1 HEY1 HEY2 HEY2 HEY2 HEY2 HEY2 HEY2 RUNX2 RUNX2 HEY1_2 HEY1_2 RUNX2 RUNX2 MIR192 MIR192 ACTIVATION CDTYPE:CATALYSIS MIR192 MIR192 MAPK3 HGNC CDTYPE:PHYSICAL_STIMULATION MAP3K7 HGNC MIR34 MIR34 MIR200 MIR200 MIR34 MIR34 MIR31 MIR31 MIR1_1 MIR1_1 E2F1 E2F1 MAPK1 HGNC MIR31 MIR31 MIR449A MIR449A MIR449A MIR449A MSN MSN 17127310 pubmed MIR203 MIR203 INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS TNF TNF ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION MIR34A MIR34A MIR203 MIR203 JAG1_MIR34A JAG1_MIR34A LRP6_MIR34 LRP6_MIR34 JAG1_MIR200 JAG1_MIR200 MIR34A MIR34A MIR34A_NOTCH1 MIR34A_NOTCH1 CLDN8 HGNC CLDN7 HGNC CyclinD2 CyclinD2 CLDN5 HGNC 7613634 pubmed CLDN4 HGNC HDAC1 HDAC1 CLDN2 HGNC CLDN1 HGNC BMI1_Cyclin_D1 BMI1_Cyclin_D1 _alpha_2_Actin _alpha_2_Actin rTIAM1 rTIAM1 rLRP6 rLRP6 arMIR34 arMIR34 MYH7B HGNC 19448627 pubmed TGFBR1 HGNC VEGFA VEGFA rWNT1 rWNT1 arMIR34 arMIR34 rWNT3 rWNT3 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS 15169839 pubmed ADAM17 ADAM17 CDTYPE:PHYSICAL_STIMULATION 17537911 pubmed JAG1_ubi JAG1_ubi UBE2D2 UBE2D2 MAP3K11 HGNC Cadherin Cadherin CDTYPE:PHYSICAL_STIMULATION 9604935 pubmed 15689496 pubmed PIP5K1C PIP5K1C MIR429 HGNC CDTYPE:PHYSICAL_STIMULATION ZAP70 HGNC INHIBITION CDTYPE:INHIBITION AKT2 AKT2 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION INHIBITION CDTYPE:INHIBITION PSEN1 PSEN1 NICD NICD NICD NICD 11927608 pubmed ADAM10_ADAM17 ADAM10_ADAM17 CDTYPE:PHYSICAL_STIMULATION NOTCH1_NUMB NOTCH1_NUMB UBE2D1 UBE2D1 INHIBITION CDTYPE:UNKNOWN_INHIBITION ZO2 ZO2 INHIBITION CDTYPE:INHIBITION TRAF6 TRAF6 TRAF6 TRAF6 MAP3K7 MAP3K7 E_protein__ID E_protein__ID COL1A2 COL1A2 GJD2 GJD2 GJC1 GJC1 NCOR2 NCOR2 CBF1__at_Nucleus CBF1__at_Nucleus GJC1 GJC1 NICD__at_Nucleus NICD__at_Nucleus GJB5 GJB5 CBF1 CBF1 GJD2 GJD2 ZO1_2_3 ZO1_2_3 GJD2 GJD2 VEGFR2 VEGFR2 CBF1__at_Nucleus CBF1__at_Nucleus NCOR2_at_Nucleus NCOR2_at_Nucleus NCOR1_at_Nucleus NCOR1_at_Nucleus MYH10 HGNC MYH11 HGNC CyclinD3 CyclinD3 CIR1 CIR1 NCOR1 NCOR1 MYH13 HGNC Microtubule_stability Microtubule_stability This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Stress_fiber_formation Stress_fiber_formation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. BAX HGNC Fibronectin Fibronectin Actin_polymerization Actin_polymerization This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. HDAC1_at_Nucleus HDAC1_at_Nucleus CBF1__at_Nucleus CBF1__at_Nucleus Lamellipodium_formation Lamellipodium_formation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. HDAC2_at_Nucleus HDAC2_at_Nucleus Filopodium_formation Filopodium_formation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CyclinD3 CyclinD3 CyclinD3 CyclinD3 MYH15 HGNC MYH14 HGNC 12547828 pubmed Fibronectin Fibronectin R_Cadherin R_Cadherin NUMB_at_Lysosome NUMB_at_Lysosome map_kinase-activated map_kinase-activated Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr BAX_at_Mitochondria BAX_at_Mitochondria CFL1 CFL1 p53__at_Nucleus p53__at_Nucleus LIMK1 LIMK1 NICD NICD _beta__Catenin__at_Lysosome _beta__Catenin__at_Lysosome GJA1 HGNC CDTYPE:PHYSICAL_STIMULATION PDGFRB HGNC CDTYPE:MODULATION PDGFRA HGNC ACTIVATION CDTYPE:CATALYSIS 19435915 pubmed CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS CDTYPE:PHYSICAL_STIMULATION ITGAE HGNC LIN7C HGNC NOTCH1 NOTCH1 UBE2D1 UBE2D1 NICD NICD NICD NICD ID3 ID3 ID3 ID3 E_protein__at_Nucleus E_protein__at_Nucleus E_protein E_protein CDTYPE:PHYSICAL_STIMULATION SMAD9 HGNC AKT2 AKT2 11331603 pubmed 9155017 pubmed 10970850 pubmed MYH2 MYH2 RAC1 HGNC SMAD1 HGNC MCF2 HGNC MMP2 MMP2 ITGA2 ITGA2 MIR192 MIR192 KIT KIT 22315516 pubmed GJB1 HGNC GJB2 HGNC CyclinD2 CyclinD2 FGFR1_ligands FGFR1_ligands TGFB1 HGNC 9746763 pubmed CLDN1 HGNC GJA3 HGNC MIR200B HGNC MIR200C HGNC CTNNB1 HGNC GJA8 HGNC MMP14 MMP14 10843989 pubmed CLDN16 HGNC 15761148 pubmed CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION CDTYPE:MODULATION CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION LAMB4 HGNC MMP14 HGNC LAMB3 HGNC 21572392 pubmed MMP2 MMP2 MAPK9 HGNC CDTYPE:PHYSICAL_STIMULATION LIN2 LIN2 15761153 pubmed 20498632 pubmed LAMC2 HGNC 16492141 pubmed MYH6 HGNC MIR200A HGNC CRB3 HGNC MYH4 HGNC MMP10 MMP10 ITGB2 HGNC MIR31 HGNC ARHGDIG HGNC CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION LRP5_6 LRP5_6 CDTYPE:PHYSICAL_STIMULATION 10593980 pubmed CDTYPE:PHYSICAL_STIMULATION SRC HGNC ACTIVATION CDTYPE:CATALYSIS 17680028 pubmed INHIBITION CDTYPE:INHIBITION MIR192 HGNC ARHGEF4 HGNC ZEB1 HGNC ARHGEF2 HGNC LAMA2 HGNC LAMA3 HGNC HBEGF HGNC KDR HGNC ARHGAP26 HGNC MMP9 MMP9 FOXO1 FOXO1 MIR200C HGNC CyclinD1 CyclinD1 MIR200B HGNC JUNB HGNC p27KIP1 p27KIP1 MIR200A HGNC CyclinD1 CyclinD1 Latency_associated_protein__hm2_at_Extracellular_space Latency_associated_protein__hm2_at_Extracellular_space SNAI1_at_Nucleus SNAI1_at_Nucleus TGFB1_hm2_at_Extracellular_space TGFB1_hm2_at_Extracellular_space TGFB1_hm2_at_Extracellular_space TGFB1_hm2_at_Extracellular_space MYLPF HGNC 15459715 pubmed MEK2 MEK2 MDM2 HGNC 11978007 pubmed BMI1 BMI1 9334353 pubmed arMIR34 arMIR34 PARD6A PARD6A SOS2 SOS2 rBMI1 rBMI1 BIRC5 BIRC5 arMIR34 arMIR34 rLEF1 rLEF1 arMIR34 arMIR34 CyclinE1 CyclinE1 SMAD9 SMAD9 22074495 pubmed SIX1 HGNC PRKCB HGNC FGF10 FGF10 ITGA2 HGNC TIMP1 TIMP1 GJA8 HGNC CDKN1A HGNC GJA1 HGNC GJA3 HGNC PROK1 HGNC GJA4 HGNC Plakoglobin Plakoglobin ARHGDIG HGNC ARHGDIB HGNC ARHGDIA HGNC COL6A2 HGNC module_ADHERENS_JUNCTIONS module_ADHERENS_JUNCTIONS Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr RHOB RHOB ACTC1 HGNC JAM2 JAM2 ITGA9 HGNC MMP16 HGNC CCND1 HGNC 17143292 pubmed 17143294 pubmed 17143293 pubmed GJB2 GJB2 ITGB6 ITGB6 9819392 pubmed MYLL1 HGNC ROCK1 HGNC MMP1 HGNC PLCB2 HGNC PLCB1 HGNC CDKN2B HGNC PLCB4 HGNC PLCB3 HGNC PATJ PATJ PALS1 PALS1 AXIN2 HGNC GNB HGNC 11248548 pubmed TIAM1 HGNC Claudin1_5_8 Claudin1_5_8 ITGAE ITGAE DSG1 HGNC DSG2 HGNC ITGAX ITGAX SIN3A HGNC DSP HGNC GDP_RAC1 GDP_RAC1 AXIN1 HGNC GTP_RAC1 GTP_RAC1 PKN1 PKN1 GDP GDP WASP_NWASP WASP_NWASP PTK2B HGNC DIAPH1 HGNC SOS2 HGNC VEGFR2 VEGFR2 MAP3K7_10_11 MAP3K7_10_11 SOS1 HGNC p57KIP2 p57KIP2 MAP3K10 MAP3K10 JNK_pathway JNK_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. SP1_at_Nucleus SP1_at_Nucleus ATP ATP PAK PAK PAK PAK GTP GTP TGFBR2 TGFBR2 RAC1 RAC1 VEGFR2 VEGFR2 ARHGEF10L HGNC PAR6 PAR6 PARD6B PARD6B ADP ADP HDAC1 HDAC1 ARP2_3 ARP2_3 _alpha_2_Actin _alpha_2_Actin _alpha_1_Actin _alpha_1_Actin PIP5K1B PIP5K1B PARD6G PARD6G PIP5K1 PIP5K1 PIP5K1C PIP5K1C arMIR34A arMIR34A GDP GDP RhoB_GDIs RhoB_GDIs RHOB RHOB Angiogenesis Angiogenesis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. RhoB_GEFs RhoB_GEFs MCF2 MCF2 DIAPH2 DIAPH2 CDTYPE:PHYSICAL_STIMULATION PKP2 HGNC C16orf70 HGNC PKP1 HGNC PKP3 HGNC 225147423 pubmed PKP2 HGNC AKT2 AKT2 CDK2_CyclinE1 CDK2_CyclinE1 CTNNB1 HGNC PKP4 HGNC p15INK4B p15INK4B RHPN1 RHPN1 SNAI1 HGNC ITGA5 ITGA5 CDK4_6 CDK4_6 RhoA_cytoskeletal_effectors RhoA_cytoskeletal_effectors CDK2 CDK2 MIR200B MIR200B RhoA_cytoskeletal_effectors RhoA_cytoskeletal_effectors 11889037 pubmed RhoB_cytoskeletal_effectors RhoB_cytoskeletal_effectors FGF1 FGF1 RHOA RHOA FGF1 FGF1 GTP GTP 21483453 pubmed arMIR200B arMIR200B GTP_RHOB_RhoB_cytoskeletal_effectors GTP_RHOB_RhoB_cytoskeletal_effectors GTP_RHOA_RhoA_cytoskeletal_effectors GTP_RHOA_RhoA_cytoskeletal_effectors CDTYPE:PHYSICAL_STIMULATION RhoB_cytoskeletal_effectors RhoB_cytoskeletal_effectors INHIBITION CDTYPE:INHIBITION CyclinE1 CyclinE1 p27KIP1 p27KIP1 BAD HGNC CDK4_6__CyclinD1__p27KIP1 CDK4_6__CyclinD1__p27KIP1 CDK4_CyclinD1__p21CIP1 CDK4_CyclinD1__p21CIP1 CDK4_6 CDK4_6 CDK2_4 CDK2_4 CDK4_6 CDK4_6 GTP GTP FGF1 FGF1 RHOB RHOB SMAD3 SMAD3 PKN1_RhoA_B PKN1_RhoA_B HDAC2 HGNC Endosomal_trafficking Endosomal_trafficking This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. SMAD2 SMAD2 p27KIP1 p27KIP1 RhoA_B RhoA_B RhoA_B RhoA_B 12181570 pubmed Plakoglobin Plakoglobin 19854168 pubmed p27KIP1 p27KIP1 FOXO3 FOXO3 Cell_matrix_adhesions Cell_matrix_adhesions This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ERM ERM ERM ERM PDPK1 PDPK1 MSN MSN TIMP2 HGNC RDX RDX ARHGAP32 ARHGAP32 DIA__active_open DIA__active_open GTP GTP EGFR EGFR PDGFRB HGNC AKT1 AKT1 PDGFRA HGNC Cell_cell_adhesions Cell_cell_adhesions This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ITGB4 ITGB4 22286765 pubmed AXIN1 HGNC RhoB_cytoskeletal_effectors RhoB_cytoskeletal_effectors NEURL NEURL MIB2 MIB2 JAG1 JAG1 JAG1 JAG1 16232121 pubmed NUMB NUMB 11080163 pubmed CyclinD2 CyclinD2 CyclinD2 CyclinD2 CyclinD2 CyclinD2 PTEN PTEN module_CELL_CELL_ADHESIONS module_CELL_CELL_ADHESIONS Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr PTEN PTEN PTEN PTEN GTP GTP 22286770 pubmed GTP_RHOB GTP_RHOB GDP_RHOB GDP_RHOB CDH1 HGNC CDH3 HGNC CDH2 HGNC CDH5 HGNC CDH4 HGNC 9753323 pubmed 9753324 pubmed ROCK ROCK PTK6 PTK6 GDP GDP RhoA_GEFs RhoA_GEFs RhoA_and_CDC42_GDIs RhoA_and_CDC42_GDIs RhoA_GAPs RhoA_GAPs TAF5L HGNC CRB3 CRB3 9490022 pubmed 15308668 pubmed GDP_RHOA GDP_RHOA RHOA RHOA GTP_RHOA GTP_RHOA GTP GTP MDM2 MDM2 JAM1_2_3 JAM1_2_3 MYH6 MYH6 ITGA2B HGNC MOD:01148 MOD DIA DIA ARHGEF2 HGNC ROCK1 ROCK1 FGF2 HGNC RHOA RHOA FGF1 HGNC ROCK2 ROCK2 ROCK__active_open ROCK__active_open GTP GTP ROCK ROCK GTP_RHOA_ROCK GTP_RHOA_ROCK DIA__GTP_RHOA DIA__GTP_RHOA RHOA RHOA SARA SARA ARHGAP17 HGNC WAS HGNC ATP ATP Plakoglobin_binding_partners Plakoglobin_binding_partners FOXC2 FOXC2 UBE2D1 UBE2D1 10428961 pubmed PTEN PTEN 19751508 pubmed 22363487 pubmed NICD_co_factors NICD_co_factors CDTYPE:PHYSICAL_STIMULATION CDTYPE:MODULATION CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS SMAD2 HGNC ACTR2 ACTR2 21502402 pubmed ITGA3 HGNC 15070779 pubmed PPP1CC HGNC PAK4 HGNC 9857026 pubmed CDTYPE:PHYSICAL_STIMULATION STAT5B STAT5B CD3D HGNC SMAD3_S422_pho_S423_pho_S425_pho_at_Nucleus SMAD3_S422_pho_S423_pho_S425_pho_at_Nucleus SMAD4_at_Nucleus SMAD4_at_Nucleus CyclinD1 CyclinD1 MYL6B MYL6B 11740560 pubmed LAMA3 LAMA3 19935649 pubmed 7542250 pubmed arMIR34A arMIR34A MIR34A HGNC MIR34B HGNC arMIR34 arMIR34 MIR34C HGNC arMIR21 arMIR21 IGF1R HGNC 15699036 pubmed rZEB2 rZEB2 arMIR205 arMIR205 KAT5 HGNC arMIR106B_25 arMIR106B_25 arMIR34 arMIR34 arMIR192 arMIR192 ARP2_3__Actin_cytoskeletal ARP2_3__Actin_cytoskeletal Actin_cytoskeletal Actin_cytoskeletal Actin_cytoskeletal__WASF2 Actin_cytoskeletal__WASF2 Actin_cytoskeletal Actin_cytoskeletal WASF2 WASF2 NCK1_NCKAP1 NCK1_NCKAP1 9588211 pubmed CDTYPE:PHYSICAL_STIMULATION _gamma__Actin _gamma__Actin TIMP3 TIMP3 CDTYPE:PHYSICAL_STIMULATION _alpha__Actin _alpha__Actin _beta__Actin _beta__Actin SMAD7 HGNC ARHGAP31 ARHGAP31 ZO1_2_3 ZO1_2_3 11740559 pubmed DTX1 DTX1 22949611 pubmed 14712077 pubmed MYH10 HGNC MIR21 MIR21 NCKAP1 NCKAP1 RHPN2 HGNC ROCK1 HGNC ROCK2 HGNC ITGAM HGNC RAC1 RAC1 19726885 pubmed 19284610 pubmed FGF1 HGNC 18049480 pubmed MYH13 HGNC MIR25 HGNC p120 p120 SMURF SMURF PRKCZ PRKCZ phosphorylated 15023524 pubmed JUP HGNC COL4A1 HGNC MMP10 MMP10 COL4A2 HGNC COL4A3 HGNC MYL6B HGNC PDGFRA HGNC PDGFRB HGNC MYL6 MYL6 FGFR3 FGFR3 8636223 pubmed HDAC1 HDAC1 SNAI1 HGNC PIP5K1 PIP5K1 Epherin_A1 Epherin_A1 TJP1 HGNC Talin_partners Talin_partners COL4A6 HGNC COL4A5 HGNC STAT3 STAT3 COL4A4 HGNC 17928543 pubmed TJP2 HGNC CDK2 HGNC TJP3 HGNC TGFBR1 TGFBR1 14673164 pubmed CDH3 HGNC SOX2 HGNC 10461188 pubmed 12663502 pubmed 21386132 pubmed N_Cadherin N_Cadherin DEF6 HGNC 15558297 pubmed ITGA2 HGNC E2F1 HGNC 21199805 pubmed CDH3 HGNC TCF3 TCF3 MYL10 HGNC TIMP3 HGNC PDGFR_family PDGFR_family FURIN HGNC Truncated_Laminin5 Truncated_Laminin5 FBLN2 HGNC MAP3K5 HGNC NCKAP1 NCKAP1 11950587 pubmed SMAD2_TGFBR1 SMAD2_TGFBR1 ABR HGNC Collagen1 Collagen1 CSNK2A1 HGNC DSP HGNC 11992112 pubmed FGF16 FGF16 ROS ROS Collagen2_partners Collagen2_partners FGD4 HGNC 15866889 pubmed 14517404 pubmed WNT3 WNT3 22349261 pubmed KIFAP3 KIFAP3 CSK HGNC Heparin Heparin 9312003 pubmed 16377081 pubmed PPP1CA HGNC PKP1 HGNC PKP2 HGNC FAK1 FAK1 PKP3 HGNC PKP4 HGNC SNAI1 SNAI1 _beta__Catenin _beta__Catenin MYC HGNC MEK2 MEK2 BMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2 BMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2 11708773 pubmed ERK2 ERK2 ERK1 ERK1 MEK1 MEK1 ERK1 ERK1 MEK2 MEK2 ERK2 ERK2 ARHGEF3 HGNC ARHGEF2 HGNC ACTIVATION CDTYPE:CATALYSIS CLDN1 HGNC CLDN8 HGNC ACTIVATION CDTYPE:CATALYSIS 22022608 pubmed INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS CLDN5 HGNC ACTIVATION CDTYPE:CATALYSIS 9789025 pubmed ACTIVATION CDTYPE:CATALYSIS MKNK2 MKNK2 MKNK1 MKNK1 ERK2 ERK2 ERK1 ERK1 EIF4E EIF4E EIF4E EIF4E MKNK2 MKNK2 MKNK1 MKNK1 MIR203 HGNC HIF1A HIF1A CCND2 HGNC HIF_alpha HIF_alpha MIR449A HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS FRS2 FRS2 SP1 SP1 17464323 pubmed INHIBITION CDTYPE:INHIBITION CLDN7 HGNC ZEB2 HGNC ACTIVATION CDTYPE:CATALYSIS ZEB1 HGNC RhoA_GEFs RhoA_GEFs MIR203 MIR203 ACTIVATION CDTYPE:CATALYSIS ITGA7 ITGA7 ACTIVATION CDTYPE:CATALYSIS DSC1 HGNC GTP GTP RAF1 RAF1 INADL HGNC CDH1 HGNC RAF1 RAF1 GTP_RAF1_YWHAB GTP_RAF1_YWHAB GTP_HRAS_RAF1 GTP_HRAS_RAF1 DSTN DSTN GTP GTP CFL1 CFL1 HRAS HRAS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS RAF1_S259_pho_S621_pho_S_pho_closed RAF1_S259_pho_S621_pho_S_pho_closed Actin_cytoskeletal Actin_cytoskeletal DSTN DSTN ACTIVATION CDTYPE:UNKNOWN_CATALYSIS Actin_cytoskeletal__DSTN Actin_cytoskeletal__DSTN ACTIVATION CDTYPE:CATALYSIS 17486063 pubmed VIM HGNC 18758450 pubmed ACTIVATION CDTYPE:CATALYSIS CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION HRAS HRAS 22881460 pubmed HRAS HRAS YWHAB YWHAB CDC42EP CDC42EP RAF1_S259_pho_S621_pho_S_pho_closed RAF1_S259_pho_S621_pho_S_pho_closed WASP_NWASP WASP_NWASP CDC42_GTP_PAR6 CDC42_GTP_PAR6 CDC42_CDC42EP CDC42_CDC42EP CDC42EP CDC42EP GTP GTP PAR6 PAR6 TGFB2 HGNC CDC42 CDC42 RAF1 RAF1 TCF3 TCF3 RAC1 RAC1 AXIN1 AXIN1 ACTIVATION CDTYPE:CATALYSIS RAF1 RAF1 RAF1_YWHAB RAF1_YWHAB CRK HGNC YWHAB YWHAB Rac1_GDIs Rac1_GDIs TLN2 TLN2 Rac1_GAPs Rac1_GAPs NCK1 NCK1 RAC1 RAC1 GTP_HRAS GTP_HRAS RAF1_S259_pho_S621_pho_S_pho_open RAF1_S259_pho_S621_pho_S_pho_open LCP2 LCP2 YWHAB YWHAB Rac1_GEFs Rac1_GEFs Caspase Caspase GTP GTP NCK1_RAC1 NCK1_RAC1 NCK1 NCK1 Latency_associated_protein Latency_associated_protein KLF4 KLF4 COL6A3 HGNC 17045588 pubmed RAF1 RAF1 CDC42 CDC42 MEK1 MEK1 15265686 pubmed GTP GTP LIMK2 LIMK2 GDP GDP LIMK1 LIMK1 LIMK1_2 LIMK1_2 DSTN DSTN 17018611 pubmed MCF2 MCF2 CDC42_GDP CDC42_GDP CDC42_GTP CDC42_GTP CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION RAC1 HGNC CDTYPE:PHYSICAL_STIMULATION PRKCA PRKCA CDTYPE:PHYSICAL_STIMULATION 10873802 pubmed DIA DIA Collagen2 Collagen2 ITGA1 HGNC Plakophilin1 Plakophilin1 APC HGNC MyosinLC MyosinLC MYL2 MYL2 CyclinE1 CyclinE1 MyosinII MyosinII ITGA1_ITGB1 ITGA1_ITGB1 VEGFA VEGFA PGGT1B HGNC MMP1 MMP1 MMP3 MMP3 MIR106B_25 MIR106B_25 TCF4 HGNC TCF3 HGNC MYH2 MYH2 MYH3 MYH3 MYH4 MYH4 Claudin3 Claudin3 NOTCH1 NOTCH1 ADAM17 HGNC ITGA2 ITGA2 MYH13 MYH13 MYH9 MYH9 ITGB1 ITGB1 ITGB3 ITGB3 ITGA2B ITGA2B ITGA2_ITGB1 ITGA2_ITGB1 ITGA2B_ITGB3 ITGA2B_ITGB3 20592490 pubmed MYH14 MYH14 MIR449A MIR449A 20008297 pubmed 12604349 pubmed 19244118 pubmed DOCK1 HGNC ITGA7 ITGA7 CD19 CD19 CDC42_GAPs CDC42_GAPs CDC42_GEFs CDC42_GEFs BNIP2 BNIP2 BNIP2_pho BNIP2_pho ARHGAP1 ARHGAP1 ARHGAP5_RASA1 ARHGAP5_RASA1 RASA1 RASA1 ARHGAP5 ARHGAP5 MMP9 HGNC MMP13 MMP13 LAMC3 HGNC DSC1 HGNC MMP9 MMP9 ARHGAP1_BNIP2 ARHGAP1_BNIP2 ARP2_3 ARP2_3 Actin_cytoskeletal__CFL1 Actin_cytoskeletal__CFL1 KLF4 HGNC ITGA11 ITGA11 Actin_cytoskeletal Actin_cytoskeletal 15451019 pubmed CFL1 CFL1 KRT18 HGNC MMP2 MMP2 17498653 pubmed VEGFR1 VEGFR1 FN1 HGNC GJB1 HGNC MMP16 MMP16 10712905 pubmed KRT5 HGNC MYH15 MYH15 ACTIVATION CDTYPE:CATALYSIS 21518799 pubmed ARHGDIA ARHGDIA BBC3 HGNC 15151915 pubmed ITGB4 HGNC ACTIVATION CDTYPE:CATALYSIS MYL3 MYL3 ACTIVATION CDTYPE:CATALYSIS MYL1 MYL1 ITGA1 ITGA1 ITGB1 ITGB1 ITGA3 ITGA3 ITGA3_ITGB1 ITGA3_ITGB1 ITGA4_ITGB1 ITGA4_ITGB1 ZEB2 HGNC ITGB1 ITGB1 SMAD5 HGNC CDC42BPA HGNC ITGA4 ITGA4 ITGA4_ITGB7 ITGA4_ITGB7 ITGB1 ITGB1 SPATA13 HGNC PDGFA PDGFA 11989976 pubmed Claudin1_2_3_4 Claudin1_2_3_4 11394904 pubmed ACTIVATION CDTYPE:CATALYSIS ITGB1 ITGB1 ITGA5_ITGB1 ITGA5_ITGB1 ACTIVATION CDTYPE:CATALYSIS ITGA4 ITGA4 ITGB7 ITGB7 ITGB1 ITGB1 ITGA6_ITGB1 ITGA6_ITGB1 ITGA5 ITGA5 MIR106B HGNC 7929268 pubmed BAX BAX MIR200B HGNC TIAM1 HGNC Claudin2 Claudin2 HDAC1 HGNC EPHA1 HGNC CDH2 HGNC COL1A1 COL1A1 JAK1 JAK1 ITGA6 HGNC PIP5K1A PIP5K1A DSG1 HGNC TNK2 HGNC TIMP1 TIMP1 DSG3 HGNC ACTN1 ACTN1 DSG2 HGNC 10954424 pubmed MMP10 MMP10 20706219 pubmed LIN10 LIN10 FOXC2 HGNC SMAD6 HGNC SOX2 HGNC p38 p38 MCF2L HGNC 17681699 pubmed WNT3 HGNC HER3 HER3 ACTIVATION CDTYPE:CATALYSIS KRT14 KRT14 CDC42EP2 HGNC CDC42EP3 HGNC TIAM1 HGNC PDGFRA PDGFRA MYH1 MYH1 Truncated_Fibronectin Truncated_Fibronectin p15INK4B p15INK4B SMAD1 SMAD1 HDAC3 HDAC3 STAT3 HGNC COL4A1 COL4A1 EIF4E HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ETS1 ETS1 SRF SRF Claudin18 Claudin18 ZAP70 ZAP70 FGFR1 FGFR1 ZEB2 ZEB2 JAG1 HGNC module_EMT_REGULATORS module_EMT_REGULATORS Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr BCR HGNC SNAI1 SNAI1 FZD1 HGNC FZD4 HGNC ACTIVATION CDTYPE:CATALYSIS FZD5 HGNC FZD2 HGNC FZD3 HGNC FZD8 HGNC FZD9 HGNC FZD6 HGNC Desmocolin3 Desmocolin3 FZD7 HGNC CRB3 HGNC PPP1C PPP1C VEGFR2 VEGFR2 ACTIVATION CDTYPE:CATALYSIS CDKN2A HGNC ITGB7 HGNC CLDN1 HGNC VAV1 VAV1 COL4A5 HGNC CyclinD3 CyclinD3 MYH9 MYH9 ITGAV ITGAV 20044598 pubmed STAT5A HGNC STAT5B HGNC PRKCD PRKCD CDC42SE1 CDC42SE1 NCOR2 NCOR2 MIR449A HGNC PTK6 HGNC ACTG1 HGNC RASA1 HGNC a6b1__a6b4 a6b1__a6b4 PAR6 PAR6 PDGFD PDGFD 12667443 pubmed PDGFA PDGFA c_MET c_MET SMAD7 HGNC DIAPH2 DIAPH2 RHOA HGNC YWHAB YWHAB ITGB1 HGNC RHOB HGNC 1720120 pubmed DSC3 HGNC DSC2 HGNC CDKN2A HGNC CFL1 HGNC 18177979 pubmed FGF1 HGNC MYL3 MYL3 19020754 pubmed SMAD5 SMAD5 23691193 pubmed DSC1 HGNC ITGA3 ITGA3 TIAM1 TIAM1 ACTB HGNC 11429692 pubmed 15331592 pubmed 12444011 pubmed MAP3K10 HGNC FGF_family FGF_family MAP3K11 HGNC Claudin14 Claudin14 ATF3 ATF3 DSP HGNC 15688067 pubmed MIR93 HGNC 18005931 pubmed CyclinD2 CyclinD2 16567498 pubmed 2288140 pubmed VE_Cadherin VE_Cadherin 22921829 pubmed DSG3 HGNC DSG2 HGNC DSG1 HGNC SMAD5 SMAD5 ACTIVATION CDTYPE:CATALYSIS 15020669 pubmed ACTIVATION CDTYPE:CATALYSIS 8527459 pubmed 15640618 pubmed ARHGAP14 ARHGAP14 GJA3 GJA3 ITGA6 ITGA6 MMP1 MMP1 TGFB1 TGFB1 19931509 pubmed FGFR2 FGFR2 Desmoglein1 Desmoglein1 16519628 pubmed TWIST2 HGNC LAMC1 HGNC 22311119 pubmed CDKN1B HGNC MIR429 MIR429 p15INK4B p15INK4B LAMB1 HGNC MIR192 MIR192 MIR30E MIR30E 11121431 pubmed PAR3 PAR3 12809600 pubmed ROCK2 HGNC LAMA1 HGNC p300 p300 EZH2 EZH2 p57KIP2 p57KIP2 CDK4 HGNC ITGB2 ITGB2 SMAD3 SMAD3 17318175 pubmed CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS COL1A2 HGNC 9739078 pubmed PALS1 PALS1 CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ITGB3 ITGB3 L1CAM L1CAM PKC PKC L1CAM L1CAM L1CAM L1CAM ITGAV ITGAV p21CIP1 p21CIP1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 9808620 pubmed TGFB1_hm2_active TGFB1_hm2_active TGFBR2_hm2 TGFBR2_hm2 TGFBR1_hm2 TGFBR1_hm2 CRB3 CRB3 PATJ PATJ ITGAD HGNC RASA1 RASA1 HEY1 HEY1 TGFB3 TGFB3 9843499 pubmed PCAF PCAF TGFB3 TGFB3 PI_3_4_5_P3 PI_3_4_5_P3 HIF_alpha___at_Nucleus HIF_alpha___at_Nucleus L1CAM L1CAM VEGFR1 VEGFR1 VEGFR1 VEGFR1 Latency_associated_protein__hm2_at_Extracellular_space Latency_associated_protein__hm2_at_Extracellular_space LTBP1_at_Extracellular_space LTBP1_at_Extracellular_space EG_VEGF EG_VEGF 19411070 pubmed EG_VEGF EG_VEGF EG_VEGF EG_VEGF DVL1 DVL1 ARHGAP35 ARHGAP35 CDC42_GEFs CDC42_GEFs VEGFR1 VEGFR1 VEGFR2 VEGFR2 VEGFA_VEGFR2 VEGFA_VEGFR2 VEGFR2__hm2_active VEGFR2__hm2_active MIR106B MIR106B VEGFA VEGFA L1CAM L1CAM L1CAM_VEGFR2 L1CAM_VEGFR2 VEGFR2__hm2_active VEGFR2__hm2_active ITGAE ITGAE ITGAE HGNC SNAI1 HGNC BMI1 HGNC PRKCE_ZEB1_ZEB2 PRKCE_ZEB1_ZEB2 JUNB HGNC CDTYPE:PHYSICAL_STIMULATION 21051664 pubmed INHIBITION CDTYPE:INHIBITION CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS KRT14 KRT14 KRT14 KRT14 ITGB6 HGNC 10551883 pubmed KRT19 KRT19 KRT19 KRT19 HIF1B HIF1B KRT19 KRT19 KRT18 KRT18 KRT14 KRT14 KRT18 KRT18 KRT18 KRT18 FGF2 FGF2 ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS PDGF_family PDGF_family Vimentin Vimentin COL1A1 HGNC COL1A2 HGNC HIF1B HIF1B HIF1B__HIF_alpha HIF1B__HIF_alpha HIF1B__at_Nucleus HIF1B__at_Nucleus COL4A4 COL4A4 CDTYPE:PHYSICAL_STIMULATION INHIBITION CDTYPE:UNKNOWN_INHIBITION 8524413 pubmed Identifiers_end pubmed COL1A2 HGNC ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS p15INK4B p15INK4B ACTIVATION CDTYPE:CATALYSIS 18775330 pubmed ACTIVATION CDTYPE:CATALYSIS BCL2L1 HGNC NCKAP1 HGNC DSG1 HGNC DSG2 HGNC 21373966 pubmed MYH9 HGNC module_ECM module_ECM Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr ARHGEF10L ARHGEF10L SMAD9 SMAD9 ACTIVATION CDTYPE:CATALYSIS 19726682 pubmed Desmoglein1_binding_partners Desmoglein1_binding_partners MPDZ HGNC Afadin Afadin ARHGDIB ARHGDIB FGFR2_ligands FGFR2_ligands Galectin_3 Galectin_3 SOS SOS AXIN2 AXIN2 MYL12A HGNC MPP5 HGNC FYN HGNC 16716598 pubmed MIR200A MIR200A CASK HGNC Armadillo_proteins Armadillo_proteins PDGFB PDGFB DSC2 HGNC DSC1 HGNC ITGAX HGNC PIP5K1A HGNC 21828089 pubmed EMILIN1 HGNC ID ID ARHGEF12 HGNC ZFYVE9 HGNC ARHGEF12 ARHGEF12 MMP14 HGNC TCF4 HGNC TCF3 HGNC ID3 ID3 TWIST1 TWIST1 10102271 pubmed 8655584 pubmed CLDN11 HGNC MAPK12 HGNC 9215638 pubmed NUMB NUMB TCF4 HGNC ITGA2 ITGA2 16607286 pubmed FGFR4 HGNC JAM3 HGNC 17490644 pubmed EFNA1 HGNC CRK CRK BAIAP2 BAIAP2 CBX4 CBX4 ARHGDIA HGNC ZO1 ZO1 PTP4A3 PTP4A3 LMO2 LMO2 CSK HGNC Vimentin Vimentin SMAD4 HGNC CLDN2 HGNC MYL5 MYL5 ABR ABR 19412634 pubmed DLC1 HGNC LIMK2 LIMK2 STAT3 HGNC STAT1 HGNC CAR CAR PXN HGNC 15077116 pubmed ITGA3 HGNC 8365569 pubmed KITLG KITLG COL1A2 HGNC FOS HGNC MIR34 MIR34 ITGB6 HGNC MIR93 MIR93 ITGB1 ITGB1 FBLN1 HGNC FBLN2 HGNC ECT2 HGNC DR1 HGNC PAK2 PAK2 STAT5 STAT5 ERBB3 HGNC DOCK11 HGNC 10816584 pubmed CTBP1 HGNC MIR200 MIR200 ETS1 ETS1 CTNNB1 HGNC ITGA8 ITGA8 TGFB3 TGFB3 ITGA10 HGNC Rac1_GEFs Rac1_GEFs OCLN HGNC MIR429 HGNC FOXO3 FOXO3 ACTN4 HGNC JUNB JUNB ACTN1 HGNC ACTN2 HGNC MIB2 MIB2 TWIST2 TWIST2 KRT14 KRT14 ITGAE HGNC FGF2 HGNC FGF1 HGNC Occludin_Claudin1_2_4_5_7_8_16 Occludin_Claudin1_2_4_5_7_8_16 THBS1 HGNC CAV1 HGNC DOCK6 DOCK6 16831886 pubmed KRT14 HGNC 16887934 pubmed Ephrin_B1 Ephrin_B1 ZEB1 HGNC PLCE1 HGNC MMP2 HGNC ZEB2 HGNC TIMP3 HGNC ITGB5 HGNC ITGB8 HGNC ARHGEF3 ARHGEF3 ARHGEF2 ARHGEF2 10490598 pubmed p53 p53 Claudin5 Claudin5 TIMP2 HGNC ITGB7 ITGB7 Desmosomal_cadherins Desmosomal_cadherins MYL4 HGNC 12767520 pubmed TIMP2 TIMP2 LIN7C LIN7C ITGB5 HGNC 17145883 pubmed TGFBR2 HGNC LIN2 LIN2 CDK4_6 CDK4_6 Truncated_Collagen4 Truncated_Collagen4 7639691 pubmed 11967263 pubmed ZEB2 HGNC LIN10 LIN10 ARHGEF10L HGNC LIN10 LIN10 15235127 pubmed LIN10 LIN10 LIN7C LIN7C LIN7C LIN7C LIN2 LIN2 LIN2 LIN2 LIN10__LIN2__LIN7C LIN10__LIN2__LIN7C LIN10 LIN10 MIR429 HGNC v_SRC v_SRC 20351093 pubmed 17823410 pubmed CRB3 CRB3 LIN2 LIN2 MYH8 MYH8 TJP1 HGNC 7565670 pubmed 12221096 pubmed AKT1 HGNC RHOB HGNC PALS1 PALS1 HMGA2 HMGA2 ECT2 HGNC FGFR4_ligands FGFR4_ligands PAK PAK CDTYPE:POSITIVE_INFLUENCE Desmocollin2 Desmocollin2 ACTIVATION CDTYPE:CATALYSIS 8893010 pubmed ITGB1 HGNC 8893017 pubmed 15548370 pubmed MYL5 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 9779982 pubmed AKT2 HGNC MYH3 MYH3 INHIBITION CDTYPE:INHIBITION PAK2 HGNC IRS1 IRS1 ITGA2 HGNC G_beta G_beta SMAD3 SMAD3 SPATA13 SPATA13 TJP2 HGNC INHIBITION CDTYPE:INHIBITION SFN HGNC RELA HGNC MMP13 HGNC TJP1 HGNC DSG3 HGNC ITGA7 HGNC BCR BCR DSC2 HGNC DSC1 HGNC 8207064 pubmed 8349738 pubmed ITGAD ITGAD DSC3 HGNC CLDN2 HGNC PIP5K1C HGNC ITGB3 ITGB3 EPHA1 HGNC CDTYPE:PHYSICAL_STIMULATION MPP5 HGNC CDTYPE:PHYSICAL_STIMULATION LTA LTA ACTIVATION CDTYPE:CATALYSIS module_CYTOSKELETON_POLARITY module_CYTOSKELETON_POLARITY Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr ACTIVATION CDTYPE:CATALYSIS ARHGAP32 ARHGAP32 Claudin7 Claudin7 17563753 pubmed PDPK1 HGNC UBE2D2 UBE2D2 12426320 pubmed 11035016 pubmed ZEB2 HGNC BCAR1 BCAR1 CASK HGNC MSN HGNC CASP3 HGNC CASP1 HGNC INHIBITION CDTYPE:UNKNOWN_INHIBITION 15377999 pubmed Claudin3 Claudin3 18832382 pubmed ADAM17 ADAM17 ITGA1 HGNC 6368220 pubmed ITGA2 HGNC I_SMAD__SMURF I_SMAD__SMURF I_SMAD__at_Nucleus I_SMAD__at_Nucleus SMURF__at_Nucleus SMURF__at_Nucleus ITGA6 ITGA6 7529872 pubmed 19567869 pubmed Laminin5 Laminin5 Truncated_Laminin1 Truncated_Laminin1 Claudin2 Claudin2 SMURF2 SMURF2 CHUK CHUK I_SMAD__SMURF I_SMAD__SMURF I_SMAD I_SMAD SMURF SMURF GJA8 GJA8 KIT_KITLG KIT_KITLG KIT KIT KITLG KITLG HDAC3 HDAC3 CTBP1_2 CTBP1_2 CTBP2 CTBP2 BCR HGNC TLN2 HGNC KITLG KITLG R_Cadherin R_Cadherin p21CIP1 p21CIP1 SMAD7 SMAD7 12808044 pubmed 14633674 pubmed ACTIVATION CDTYPE:CATALYSIS 15292177 pubmed ACTIVATION CDTYPE:CATALYSIS HDAC1 HDAC1 MDM2 MDM2 HDAC2 HDAC2 HDAC1 HDAC1 SNAI2_at_Nucleus SNAI2_at_Nucleus HDAC3_at_Nucleus HDAC3_at_Nucleus MDM2 MDM2 CTBP1_2__HDAC1_HDAC3_SNAI2 CTBP1_2__HDAC1_HDAC3_SNAI2 HDAC1_at_Nucleus HDAC1_at_Nucleus CCND2 HGNC MIR31 HGNC CTBP1_2__at_Nucleus CTBP1_2__at_Nucleus _beta__Catenin _beta__Catenin AKT2 AKT2 AKT2 AKT2 SIN3A SIN3A SIN3A SIN3A MKNK1 MKNK1 HDAC2 HDAC2 12051714 pubmed MIR200C MIR200C STAT1 STAT1 FYN HGNC 8943284 pubmed ADP ADP WASP WASP FBLN1 FBLN1 TP53 HGNC PPP1CB PPP1CB TCF3 HGNC MYH11 HGNC 12788081 pubmed MMP9 HGNC LAMB1 LAMB1 INHIBITION CDTYPE:INHIBITION 16156666 pubmed 15140942 pubmed HIF1B HIF1B 11074002 pubmed ACTIVATION CDTYPE:CATALYSIS CDKN1B HGNC INHIBITION CDTYPE:INHIBITION INHIBITION CDTYPE:INHIBITION INHIBITION CDTYPE:INHIBITION INHIBITION CDTYPE:INHIBITION PALS1 PALS1 PALS1 PALS1 PALS1 PALS1 rAXIN1 rAXIN1 Senescence Senescence This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 12554650 pubmed Metastasis Metastasis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Gap_junctions Gap_junctions This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Establishment_of_cell_polarity Establishment_of_cell_polarity This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 10982819 pubmed 22128289 pubmed TGFBR2 TGFBR2 MLLT4 HGNC ITGA1 HGNC GNAQ HGNC GNAL HGNC CRB3_PALS1 CRB3_PALS1 HEY1 HEY1 ITGB4 ITGB4 IGF1 HGNC CLDN16 HGNC 10581160 pubmed MMP9 MMP9 C16orf70 HGNC MMP3 MMP3 MMP9 MMP9 MMP9 MMP9 MMP2 MMP2 Desmocollin2 Desmocollin2 12724770 pubmed MMP2 MMP2 MMP2 MMP2 Desmocollin2 Desmocollin2 Desmocollin2 Desmocollin2 RALBP1 RALBP1 R_Cadherin R_Cadherin PATJ PATJ Invasiveness Invasiveness This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Self_renewal Self_renewal This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Desmosomes Desmosomes This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Tight_junctions Tight_junctions This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Fibronectin Fibronectin Fibronectin Fibronectin MMP14 MMP14 MMP14 MMP14 ATF3 ATF3 MMP14 MMP14 ATF3 ATF3 ATF3 ATF3 ID3 ID3 ID__at_Nucleus ID__at_Nucleus SMAD2_SMAD3 SMAD2_SMAD3 SMAD2_3__at_Nucleus SMAD2_3__at_Nucleus SMAD2_3__SMAD4 SMAD2_3__SMAD4 SMAD2_3 SMAD2_3 SMAD2_3__SMAD4 SMAD2_3__SMAD4 SMAD2_3 SMAD2_3 SMAD4 SMAD4 CyclinD3 CyclinD3 Claudin4 Claudin4 Claudin4 Claudin4 Desmoplakin Desmoplakin Desmoplakin Desmoplakin Desmoplakin Desmoplakin Plakophilin3 Plakophilin3 Plakophilin3 Plakophilin3 Plakophilin3 Plakophilin3 10581193 pubmed HMGA2_SMAD2_3__SMAD4 HMGA2_SMAD2_3__SMAD4 SMAD2_3__at_Nucleus SMAD2_3__at_Nucleus SMAD2_3__at_Nucleus SMAD2_3__at_Nucleus ATF3_SMAD2_3__SMAD4 ATF3_SMAD2_3__SMAD4 SMAD2_3__SMAD4_ZEB1 SMAD2_3__SMAD4_ZEB1 SMAD4_at_Nucleus SMAD4_at_Nucleus SMAD2_3__at_Nucleus SMAD2_3__at_Nucleus VIM HGNC JUNB JUNB N_Cadherin N_Cadherin ATF3_at_Nucleus ATF3_at_Nucleus JUNB JUNB P_Cadherin P_Cadherin Vimentin Vimentin BMI1 HGNC P_Cadherin P_Cadherin ARHGAP9 ARHGAP9 P_Cadherin P_Cadherin R_Cadherin R_Cadherin R_Cadherin R_Cadherin Vimentin Vimentin Vimentin Vimentin N_Cadherin N_Cadherin N_Cadherin N_Cadherin ITGA9 ITGA9 JUNB JUNB SHC1_p66_p52 SHC1_p66_p52 16474430 pubmed SHC1_p66_p52 SHC1_p66_p52 SMAD1 SMAD1 GRB2 GRB2 SOS2 SOS2 SOS1 SOS1 SOS SOS CLDN7 HGNC SPATA13 HGNC 19072724 pubmed GRB2 GRB2 SHC1_p66_p52__Y_pho_S_pho_active SHC1_p66_p52__Y_pho_S_pho_active SOS SOS HIF1A HGNC SMAD3 SMAD3 RhoA_cytoskeletal_effectors RhoA_cytoskeletal_effectors BCL2 BCL2 11728826 pubmed BCL2_XL BCL2_XL SMAD2 SMAD2 I_SMAD I_SMAD I_SMAD I_SMAD SMURF SMURF SMURF1 SMURF1 ERK1_2 ERK1_2 CDC42 CDC42 CDC42 CDC42 BBC3 BBC3 UBE2D1 HGNC BAK1_at_Mitochondria BAK1_at_Mitochondria IGF2 IGF2 BCL2_at_Mitochondria BCL2_at_Mitochondria BAK1_p53 BAK1_p53 p53__at_Mitochondria p53__at_Mitochondria ACTA1 HGNC FMN1 HGNC TIMP2 TIMP2 9335505 pubmed BAK1_BCL2_XL BAK1_BCL2_XL BAK1_BCL2 BAK1_BCL2 BAK1 BAK1 15121845 pubmed BBC3_at_Mitochondria BBC3_at_Mitochondria BCL2_at_Mitochondria BCL2_at_Mitochondria BBC3_BCL2 BBC3_BCL2 MMP1 MMP1 p53__at_Mitochondria p53__at_Mitochondria 9335507 pubmed MDM2 HGNC BAX_at_Mitochondria BAX_at_Mitochondria BCL2_at_Mitochondria BCL2_at_Mitochondria BCL2_p53 BCL2_p53 BCL2_XL__p53 BCL2_XL__p53 10582334 pubmed BAX_p53 BAX_p53 BAX_BCL2_XL BAX_BCL2_XL TGFBR1 HGNC BAX_BCL2 BAX_BCL2 LAMC1 HGNC RDX HGNC BCL2_XL__at_Mitochondria BCL2_XL__at_Mitochondria p53 p53 BCL2_XL__at_Mitochondria BCL2_XL__at_Mitochondria p53__at_Mitochondria p53__at_Mitochondria BCL2_at_Mitochondria BCL2_at_Mitochondria Endothelin1 Endothelin1 RHPN2 RHPN2 _beta__Catenin _beta__Catenin NCK1 NCK1 19356150 pubmed MIR449A MIR449A LEF1_TCF3_4 LEF1_TCF3_4 HER4 HER4 9278421 pubmed BIRC5 BIRC5 OCLN HGNC ITGAL HGNC MYH14 MYH14 EZH2 EZH2 BMI1 BMI1 HDAC2 HDAC2 E_Cadherin E_Cadherin _beta__Catenin _beta__Catenin DNMT1 DNMT1 PCR1 PCR1 PCR2 PCR2 HDAC1 HDAC1 MYC HGNC 10197981 pubmed PTK2B PTK2B GJB2 HGNC R_Cadherin R_Cadherin ITGB6 ITGB6 P_Cadherin P_Cadherin E_Cadherin E_Cadherin VE_Cadherin VE_Cadherin CDTYPE:PHYSICAL_STIMULATION N_Cadherin N_Cadherin P_Cadherin P_Cadherin VE_Cadherin VE_Cadherin N_Cadherin N_Cadherin R_Cadherin R_Cadherin VE_Cadherin VE_Cadherin JUP HGNC 9278444 pubmed ACTIVATION CDTYPE:CATALYSIS _beta__Catenin__p120_1_Plakoglobin__Plakophilin4 _beta__Catenin__p120_1_Plakoglobin__Plakophilin4 P_Cadherin P_Cadherin N_Cadherin N_Cadherin ABR HGNC R_Cadherin R_Cadherin SMAD2 HGNC ZO3 ZO3 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION INHIBITION CDTYPE:UNKNOWN_INHIBITION 14976548 pubmed HEY1_2 HEY1_2 KRT8 HGNC ITGB3 ITGB3 SIN3A SIN3A KRT1 HGNC 8805275 pubmed Plakophilin2_binding_partners Plakophilin2_binding_partners ITGB1 HGNC MIR21 HGNC ARHGAP1 HGNC ITGA9 HGNC LIN7C LIN7C CDK4 HGNC CDK6 HGNC 7657702 pubmed VEGFA HGNC Plakophilin4 Plakophilin4 ITGA2 HGNC ITGA3 HGNC 19401151 pubmed TIMP3 HGNC ITGAV HGNC Plakophilin3 Plakophilin3 WASF2 WASF2 DIAPH1 DIAPH1 7957046 pubmed PI3KC1_catalytic PI3KC1_catalytic SRF HGNC 8898967 pubmed INHIBITION CDTYPE:UNKNOWN_INHIBITION SMAD4 HGNC PAR3 PAR3 PRKCA HGNC MYLL1 HGNC TJP3 HGNC CDKN2B HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 11566883 pubmed _gamma__Actin _gamma__Actin RDX HGNC Goosecoid Goosecoid GNB5 HGNC RALBP1 HGNC GNB4 HGNC GNB3 HGNC GNB2 HGNC GNB1 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CyclinD1 CyclinD1 10047517 pubmed MYL2 MYL2 CyclinD3 CyclinD3 ACTIVATION CDTYPE:CATALYSIS BMI1 HGNC ACTIVATION CDTYPE:CATALYSIS EZH1 EZH1 16542650 pubmed ITGA1 HGNC ACTIVATION CDTYPE:CATALYSIS SMAD2 HGNC CDKN1C HGNC KLF8 HGNC EGFR EGFR CDTYPE:PHYSICAL_STIMULATION Claudin4 Claudin4 FN1 HGNC ITGA7 HGNC NF__kappa_B_p65 NF__kappa_B_p65 MYL12A MYL12A ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS GJB3 GJB3 ACTIVATION CDTYPE:CATALYSIS ZO3 ZO3 LIN10 LIN10 ITGA11 HGNC CXADR HGNC EZH2 HGNC CDTYPE:PHYSICAL_STIMULATION 9823899 pubmed PKP1 HGNC 14749719 pubmed PARD6A PARD6A 18172008 pubmed 16919435 pubmed COL2A1 HGNC JAM1 JAM1 GJA8 HGNC 10454538 pubmed 9744077 pubmed MIR31 MIR31 ARHGAP32 HGNC ARHGAP31 HGNC CDH2 HGNC RUNX2 HGNC YWHAB HGNC 10048576 pubmed 17615296 pubmed CCND3 HGNC LIN7C HGNC 19597490 pubmed ARNT HGNC RhoB_GDIs RhoB_GDIs CDC42BPA CDC42BPA DSC3 HGNC 7962210 pubmed MMP13 HGNC ACTIVATION CDTYPE:CATALYSIS 17093497 pubmed CDH2 HGNC CDTYPE:PHYSICAL_STIMULATION PLCG1 HGNC FGFR2 HGNC EDNRA EDNRA LAMA4 HGNC SIN3A SIN3A SMAD2 SMAD2 ITGA9 ITGA9 22079635 pubmed 7768934 pubmed TGFB3 HGNC TCF12 HGNC GJB3 HGNC MMP15 MMP15 PKP1 HGNC PKP2 HGNC FGFR3 HGNC ITGA4 ITGA4 ARHGAP17 HGNC PKP3 HGNC PKP4 HGNC JUP HGNC ITGAM ITGAM ACTIVATION CDTYPE:CATALYSIS 2786007 pubmed ID1 ID1 ITGB7 ITGB7 DSTN DSTN DLC1 DLC1 PI_3_4_P2 PI_3_4_P2 LRP6 LRP6 17161586 pubmed 21841793 pubmed 22270359 pubmed HGF HGNC LAMC1 LAMC1 CDH1 HGNC PTP4A3 PTP4A3 JAM1 JAM1 ITGA4 HGNC 14576341 pubmed KRT14 HGNC BAD_binding_partners BAD_binding_partners WASL HGNC LIMK1 HGNC LIMK2 HGNC PDGFC PDGFC DIAPH2 HGNC GJD2 GJD2 15609097 pubmed MMP13 MMP13 SNAI1 SNAI1 16391805 pubmed KIFAP3 HGNC 9931372 pubmed VEGFR2 VEGFR2 PI3KC1_regulator PI3KC1_regulator FLT1 HGNC APC APC FGFR3_ligands FGFR3_ligands 8662891 pubmed CyclinE1 CyclinE1 DAG DAG JAG1 JAG1 21685935 pubmed HIF3_alpha HIF3_alpha CyclinD1 CyclinD1 GSK3_beta GSK3_beta p15INK4B p15INK4B TGFB3 TGFB3 SNAI1 SNAI1 GSK3_beta GSK3_beta GSK3_beta GSK3_beta 22363130 pubmed MyosinII MyosinII ZO2_3 ZO2_3 MAPK10 HGNC EZR HGNC MAPK12 MAPK12 22017973 pubmed MIR205 HGNC ARHGEF10L HGNC MMP3 MMP3 KRT19 HGNC ZEB1 HGNC NCK1 HGNC 19568798 pubmed 7945242 pubmed 12361600 pubmed RHPN2 HGNC ITGA3 ITGA3 MAPK1 HGNC MYL12B HGNC MIR200 MIR200 CBX4 HGNC a1b1__a2b1 a1b1__a2b1 ITGA9 HGNC GJA3_8_GJB1_GJB2 GJA3_8_GJB1_GJB2 TRAF6 TRAF6 10871288 pubmed ACTIVATION CDTYPE:CATALYSIS ITGA11 HGNC DOCK11 HGNC ITGB6 ITGB6 MYH14 HGNC CLDN14 HGNC LIMK2 HGNC ACTIVATION CDTYPE:UNKNOWN_CATALYSIS GJB3 GJB3 WNT1 HGNC WNT2 HGNC 10679481 pubmed SMAD3 HGNC WNT6 HGNC WNT3 HGNC WNT4 HGNC ACTIVATION CDTYPE:CATALYSIS CDTYPE:PHYSICAL_STIMULATION 16272825 pubmed ACTIVATION CDTYPE:CATALYSIS SMAD9 HGNC SNAI2 HGNC 2153105 pubmed ID2 ID2 RASA1 HGNC PARD6B PARD6B Src_family_kinases Src_family_kinases COL1A2 COL1A2 21909923 pubmed ITGA10 HGNC CDTYPE:PHYSICAL_STIMULATION 7512751 pubmed SMURF1 HGNC PLD1 HGNC CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS SMAD6 SMAD6 10712429 pubmed ACTIVATION CDTYPE:CATALYSIS ROCK ROCK FGFR_family FGFR_family Claudin11 Claudin11 Caspase Caspase CDK6 CDK6 ITGB3 ITGB3 EZR HGNC 15471980 pubmed 21224848 pubmed ACTIVATION CDTYPE:CATALYSIS DSG3 HGNC DSG2 HGNC DSG1 HGNC CDTYPE:PHYSICAL_STIMULATION MIR192 HGNC HEY2 HEY2 RhoA_and_CDC42_GDIs RhoA_and_CDC42_GDIs CDH4 HGNC EG_VEGF EG_VEGF 9490638 pubmed ZYX ZYX 8226933 pubmed ACTIVATION CDTYPE:CATALYSIS ITGAX ITGAX MMP3 MMP3 ITGAM ITGAM ITGB3 ITGB3 ITGB2 ITGB2 ITGB1 ITGB1 ITGAV ITGAV MYL7 HGNC ACTIVATION CDTYPE:CATALYSIS 16112081 pubmed INHIBITION CDTYPE:UNKNOWN_INHIBITION SMAD9 HGNC ITGB8 ITGB8 ITGA2 ITGA2 ITGA1 ITGA1 ITGA3 ITGA3 ITGA2B ITGA2B SIN3A HGNC ITGA5 ITGA5 ITGA4 ITGA4 VTN HGNC 11309411 pubmed FGF1 HGNC HRAS HRAS FGF2 HGNC ITGB4 ITGB4 ITGB5 ITGB5 ITGB6 ITGB6 ITGB7 ITGB7 CDKN2A HGNC INHIBITION CDTYPE:UNKNOWN_INHIBITION 15155580 pubmed ARHGDIG ARHGDIG ARP2_3 ARP2_3 MIR1-1 HGNC ARHGAP1 HGNC TJP3 HGNC P_Cadherin P_Cadherin WASF1 HGNC ITGA2B ITGA2B LMO2 HGNC ARHGAP35 HGNC ARHGAP32 HGNC ITGA3 ITGA3 ITGA4 ITGA4 19260824 pubmed ITGA5 ITGA5 ITGA6 ITGA6 ITGA7 ITGA7 ITGA8 ITGA8 ACTIVATION CDTYPE:CATALYSIS ITGA9 ITGA9 ITGA10 ITGA10 ITGA11 ITGA11 8360177 pubmed ITGAD ITGAD ARHGAP26 HGNC ITGAL ITGAL ITGAM ITGAM ITGAE ITGAE ITGB2 ITGB2 ITGAX ITGAX ITGAV ITGAV ITGB5 ITGB5 ITGB3 ITGB3 ITGB4 ITGB4 VAV1 HGNC ITGA7 ITGA7 ITGA6 ITGA6 ITGA8 ITGA8 Elastin_partners Elastin_partners ITGA11 HGNC ITGAE ITGAE 8358790 pubmed ITGAL ITGAL FGFR1 HGNC ITGAM ITGAM FGFR2 HGNC ITGAX ITGAX FGFR3 HGNC ITGA9 ITGA9 FGFR4 HGNC ITGA10 ITGA10 ITGA11 ITGA11 ITGAD ITGAD ITGB1 ITGB1 ITGA6 ITGA6 ITGAV ITGAV GSK3_beta GSK3_beta PKP2 HGNC ITGB1 HGNC ITGB2 ITGB2 NOTCH1 NOTCH1 ITGA1 ITGA1 ITGA2 ITGA2 LAMA1 LAMA1 ITGB7 ITGB7 CDC42EP2 CDC42EP2 ITGB8 ITGB8 ITGB5 ITGB5 ITGB6 ITGB6 ITGB3 ITGB3 ITGB4 ITGB4 19050695 pubmed Desmoplakin Desmoplakin SNAI2 HGNC 15592504 pubmed INHIBITION CDTYPE:INHIBITION PAK3 HGNC ACTA2 HGNC BBC3_at_Mitochondria BBC3_at_Mitochondria ACTA1 HGNC BAK1_at_Mitochondria BAK1_at_Mitochondria rSMAD7 rSMAD7 BCL2_XL__at_Mitochondria BCL2_XL__at_Mitochondria ITGA3 HGNC 10837491 pubmed PRKCE HGNC NOTCH1 NOTCH1 DLL1 DLL1 ATM ATM 19487819 pubmed TGFB3 HGNC TGFB2 HGNC TGFB1 HGNC 12045227 pubmed WNT1 WNT1 EPHA2 EPHA2 Desmoglein Desmoglein 17496910 pubmed ADAM10 ADAM10 arMIR34 arMIR34 ITGB7 ITGB7 CCND3 HGNC ITGB6 ITGB6 ITGB8 ITGB8 a5b1__aVb3 a5b1__aVb3 KDR HGNC CAR CAR ITGAE ITGAE SIX1 SIX1 FGF8 FGF8 SNAI2 SNAI2 22330899 pubmed 22039431 pubmed r_beta__Catenin r_beta__Catenin ITGB8 ITGB8 11487578 pubmed ITGAE ITGAE ITGAL ITGAL ITGAL HGNC 16371504 pubmed ITGA5 ITGA5 ITGA6 ITGA6 ITGA7 ITGA7 ITGA8 ITGA8 ITGA9 ITGA9 ITGA10 ITGA10 ITGA11 ITGA11 15810077 pubmed ITGAD ITGAD COL3A1 COL3A1 INADL HGNC MKNK1 HGNC MMP2 HGNC HDAC1 HGNC PKP3 HGNC ITGA4 ITGA4 ITGA2B ITGA2B ITGA3 ITGA3 TGFBR2_hm2 TGFBR2_hm2 ACTC1 HGNC ITGA1 ITGA1 10201372 pubmed ETS1 HGNC ITGA2 ITGA2 11114293 pubmed ACTN2 ACTN2 MIR183 MIR183 PCR1 PCR1 MYC MYC 9311995 pubmed NOTCH1 HGNC 12151385 pubmed PDGFRA HGNC FOXC2 FOXC2 Laminin1 Laminin1 YWHAZ HGNC 19601831 pubmed KRT5 KRT5 Actin_cytoskeletal Actin_cytoskeletal YWHAE HGNC YWHAH HGNC YWHAG HGNC 12727824 pubmed YWHAQ HGNC MMP15 HGNC CDH3 HGNC 9618481 pubmed F11R HGNC YWHAB HGNC ARHGDIB HGNC JUP HGNC BMI1 BMI1 21081489 pubmed IGF1R IGF1R SRGAP3 HGNC VEGFR1 VEGFR1 ACTG1 HGNC 12123611 pubmed 15020233 pubmed 19273627 pubmed MMP14 MMP14 15327768 pubmed SNAI1 SNAI1 17145773 pubmed CCND2 HGNC 22710166 pubmed ACTIVATION CDTYPE:CATALYSIS TNK2 TNK2 ITGA3 ITGA3 Plakophilin3 Plakophilin3 19208835 pubmed 9819415 pubmed CTNND1 HGNC KRT19 KRT19 ITGB1 ITGB1 CDTYPE:PHYSICAL_STIMULATION SMAD7 HGNC CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:UNKNOWN_CATALYSIS CTNNB1 HGNC MAPK11 HGNC 10679324 pubmed PAK1 PAK1 Desmocolin1 Desmocolin1 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION MIR30E MIR30E 21640127 pubmed 10469653 pubmed ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION ERM ERM 16931767 pubmed INHIBITION CDTYPE:INHIBITION JNK2 JNK2 ITGAL HGNC Desmocollin2 Desmocollin2 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION HBEGF HGNC CDTYPE:PHYSICAL_STIMULATION CBF1 CBF1 ITGA10 ITGA10 ITGA8 ITGA8 INHIBITION CDTYPE:INHIBITION PDGFRA HGNC CHN2 HGNC CDTYPE:PHYSICAL_STIMULATION PDGFRB HGNC ATF3 ATF3 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS CDTYPE:PHYSICAL_STIMULATION ERK1 ERK1 CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS MIR30E HGNC 16079281 pubmed CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS MIR200A HGNC ACTIVATION CDTYPE:CATALYSIS Galectin_3_partners Galectin_3_partners GJB3 HGNC TIMP2 TIMP2 ACTIVATION CDTYPE:CATALYSIS 11792802 pubmed CDTYPE:PHYSICAL_STIMULATION 7522194 pubmed STAT5A HGNC TGFA HGNC CDTYPE:PHYSICAL_STIMULATION SMURF1 SMURF1 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION BCAR1 HGNC HDAC2 HGNC FGF2 HGNC MIR34A MIR34A MIR205 MIR205 TJP1 HGNC CDTYPE:PHYSICAL_STIMULATION PALS1 PALS1 KRT1 HGNC INHIBITION CDTYPE:INHIBITION VEGFR1 VEGFR1 TLN1 HGNC AKT2 AKT2 SMURF1 HGNC ITGAM ITGAM WNK4 WNK4 MYH7 MYH7 12054568 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ZEB2 ZEB2 SMAD5 SMAD5 COL5A1 COL5A1 ZO1 ZO1 CCND1 HGNC ITGAX ITGAX Claudin1 Claudin1 EGF_family EGF_family LIN7C LIN7C PATJ PATJ CRB3_LIN7C_PALS1__PATJ CRB3_LIN7C_PALS1__PATJ LIN7C LIN7C PATJ PATJ CDTYPE:PHYSICAL_STIMULATION 10331086 pubmed PALS1 PALS1 ITGA2 HGNC ITGA1 HGNC CD3 CD3 JNK1 JNK1 INHIBITION CDTYPE:INHIBITION 14663202 pubmed FN1 HGNC ITGB3 HGNC MIR21 MIR21 ITGAV HGNC LMO2 LMO2 Vimentin Vimentin ITGB1 HGNC 16001073 pubmed ZBTB17 HGNC TGFB2 TGFB2 TGFBR1 TGFBR1 TGFBR2 TGFBR2 14739162 pubmed CTNNA1 HGNC TGFB1_TGFBR1_TGFBR2 TGFB1_TGFBR1_TGFBR2 TGFB1_TGFBR2 TGFB1_TGFBR2 TGFB3 TGFB3 15980428 pubmed ARNT HGNC ARHGEF1 HGNC AXIN2 AXIN2 BAK1_at_Mitochondria BAK1_at_Mitochondria CRB3 CRB3 arMIR31 arMIR31 BBC3 BBC3 GJA1_4_GJC1 GJA1_4_GJC1 LTBP1 HGNC BBC3_BCL2_XL BBC3_BCL2_XL rTIAM1 rTIAM1 Truncated_Collagen1 Truncated_Collagen1 p53 p53 BAX BAX MIR106B_25 MIR106B_25 14681219 pubmed THBS1 THBS1 CRB3 CRB3 SMAD3 HGNC SMAD2 HGNC 9362522 pubmed LTBP1 LTBP1 RAP1GDS1 RAP1GDS1 PIP5K1A HGNC PIP5K1B HGNC PIP5K1C HGNC Occludin Occludin FGF6 FGF6 COL4A3 COL4A3 LAMA1 HGNC SNAI2 SNAI2 id_14_3_3 id_14_3_3 Latency_associated_protein Latency_associated_protein LTBP1_at_Extracellular_space LTBP1_at_Extracellular_space SMAD6 HGNC SMAD7 HGNC NOTCH1 HGNC MIZ1__at_Nucleus MIZ1__at_Nucleus MYC_at_Nucleus MYC_at_Nucleus CDK2 CDK2 MIZ1 MIZ1 HDAC2 HGNC SMAD3_S423_pho_S425_pho_hm2_at_Nucleus SMAD3_S423_pho_S425_pho_hm2_at_Nucleus EGFR HGNC 10671552 pubmed PKN1 PKN1 LAMB3 LAMB3 CyclinE1 CyclinE1 SARA__at_Early_Endosome SARA__at_Early_Endosome GJB5 HGNC CyclinE1 CyclinE1 CyclinE1 CyclinE1 MAPK11 MAPK11 p21CIP1 p21CIP1 p21CIP1 p21CIP1 MIR34A HGNC G2_phase G2_phase This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 16506207 pubmed ACTIVATION CDTYPE:CATALYSIS LEF1 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS S_phase S_phase This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Late_G1_phase Late_G1_phase This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. GSK3_beta GSK3_beta 9641915 pubmed GSK3_beta GSK3_beta CyclinD1 CyclinD1 Occludin Occludin CyclinD1 CyclinD1 MYC MYC FOXO1 FOXO1 GSK3_beta GSK3_beta CDC25A CDC25A FGF1 FGF1 SMAD6 HGNC 18342983 pubmed arMIR34 arMIR34 17012742 pubmed p21CIP1 p21CIP1 CDK4 CDK4 RACGAP1 RACGAP1 arMIR34A arMIR34A CDK4_6__CyclinD1 CDK4_6__CyclinD1 Claudin16 Claudin16 p16INK4A p16INK4A rMYC rMYC VIM HGNC p21CIP1 p21CIP1 p27KIP1 p27KIP1 CyclinD1 CyclinD1 FGF3 FGF3 SOX2 SOX2 INHIBITION CDTYPE:INHIBITION ITGA5 HGNC KLF4 KLF4 ITGA2 HGNC PAR3 PAR3 PAK3 PAK3 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS PAK2 PAK2 11114741 pubmed PAK1 PAK1 RAC1 RAC1 CDK6 CDK6 CDK4 CDK4 COL4A6 COL4A6 INHIBITION CDTYPE:INHIBITION SP1_at_Nucleus SP1_at_Nucleus CDTYPE:PHYSICAL_STIMULATION SP1 SP1 14963330 pubmed Early_to_mid_G1_phase Early_to_mid_G1_phase This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. PAR3 PAR3 SMAD2_SMAD3_SMAD4_SP1 SMAD2_SMAD3_SMAD4_SP1 PAR3 PAR3 arMIR200 arMIR200 PAR3 PAR3 rJAG1 rJAG1 Latency_associated_protein__hm2_at_Extracellular_space Latency_associated_protein__hm2_at_Extracellular_space SMAD2_S467_pho_S464_pho_S465_pho_at_Nucleus SMAD2_S467_pho_S464_pho_S465_pho_at_Nucleus LTBP1_at_Extracellular_space LTBP1_at_Extracellular_space Talin Talin PRKCE HGNC 18337545 pubmed p15INK4B p15INK4B p15INK4B p15INK4B SARA__at_Early_Endosome SARA__at_Early_Endosome TGFBR2_Ser_pho_hm2 TGFBR2_Ser_pho_hm2 CDC42SE1 CDC42SE1 CDC42EP3 CDC42EP3 CDC42EP2 CDC42EP2 PRKCZ PRKCZ ACTIVATION CDTYPE:CATALYSIS PROK1 HGNC LIMK2 LIMK2 TGFB1_hm2_active TGFB1_hm2_active PAK4 PAK4 TGFBR1_Ser_pho_hm2_active TGFBR1_Ser_pho_hm2_active MAP3K11 MAP3K11 ADP ADP BAIAP2 BAIAP2 CYFIP2 CYFIP2 RAP1GDS1 HGNC THBS2 THBS2 SARA__TGFB1_TGFBR1_TGFBR2 SARA__TGFB1_TGFBR1_TGFBR2 HIF1A HGNC WASF2 WASF2 12165654 pubmed ITGB3 HGNC WASF1 WASF1 N_WASP N_WASP ITGB1 HGNC WASP WASP ITGAV HGNC ACTIVATION CDTYPE:CATALYSIS ACTR3 ACTR3 ITGA8 HGNC ACTR2 ACTR2 CDTYPE:PHYSICAL_STIMULATION CDC42BPA CDC42BPA CDTYPE:PHYSICAL_STIMULATION VEGFR2 VEGFR2 rSNAI2 rSNAI2 DSP HGNC 15716380 pubmed rSNAI1 rSNAI1 15743413 pubmed DLL1 DLL1 rSNAI2 rSNAI2 MMP3 HGNC TGFB2 TGFB2 JUP HGNC 16212495 pubmed Integrin_A8B1_AVB1_AVB5_AVB6_AVB8__at_Extracellular_space Integrin_A8B1_AVB1_AVB5_AVB6_AVB8__at_Extracellular_space LTA LTA KRT1 KRT1 Desmoplakin_binding_partners Desmoplakin_binding_partners 10871881 pubmed Desmoplakin Desmoplakin ARHGAP9 ARHGAP9 Desmoplakin_binding_partners__Desmoplakin Desmoplakin_binding_partners__Desmoplakin Desmoplakin_binding_partners Desmoplakin_binding_partners Plakophilin2 Plakophilin2 Plakophilin2_binding_partners Plakophilin2_binding_partners _Plakophilin_2__Plakophilin_2_binding_partners _Plakophilin_2__Plakophilin_2_binding_partners NCK1 NCK1 NCKAP1 NCKAP1 PIP5K1A PIP5K1A ARHGEF14 ARHGEF14 MOD:00696 MOD ABR ABR ARHGAP1 ARHGAP1 RALBP1 RALBP1 16359940 pubmed ARFIP2 ARFIP2 ARHGEF12 HGNC HIF1A HIF1A CDTYPE:PHYSICAL_STIMULATION KRT8 KRT8 Plakophilin2_binding_partners Plakophilin2_binding_partners KRT5 KRT5 __beta__Catenin__LEF_TCF __beta__Catenin__LEF_TCF ACTIVATION CDTYPE:CATALYSIS CDC42EP CDC42EP Desmocolin1_binding_partners Desmocolin1_binding_partners 17346241 pubmed VAV2 HGNC Cingulin Cingulin _Actin_cytoskeletal___alpha__Catenin _Actin_cytoskeletal___alpha__Catenin _APC_AXIN1_S45_beta__Catenin _APC_AXIN1_S45_beta__Catenin STAT5A STAT5A _APC_AXIN1_S33_S37_T41_beta__Catenin _APC_AXIN1_S33_S37_T41_beta__Catenin CHUK HGNC Actin_cytoskeletal Actin_cytoskeletal FGF1 FGF1 LAMA3 HGNC COL4A1 HGNC 12717440 pubmed KRT18 KRT18 11741095 pubmed ARHGAP32 HGNC SMAD5 HGNC _beta__Catenin__p120_1_Plakoglobin__Plakophilin4 _beta__Catenin__p120_1_Plakoglobin__Plakophilin4 _beta__Catenin__p120_1_Plakoglobin__Plakophilin4 _beta__Catenin__p120_1_Plakoglobin__Plakophilin4 Plakophilin Plakophilin ITGA11 ITGA11 E_Cadherin E_Cadherin _alpha__Catenin _alpha__Catenin _alpha__Catenin__hm2 _alpha__Catenin__hm2 p120 p120 _beta__Catenin _beta__Catenin KRT18 HGNC Actin_cytoskeletal Actin_cytoskeletal 20702634 pubmed p120 p120 _alpha__Catenin _alpha__Catenin ARHGEF1 ARHGEF1 KRT19 KRT19 MMP1 HGNC CDTYPE:PHYSICAL_STIMULATION Desmoglein1 Desmoglein1 MMP3 HGNC Desmoglein1_binding_partners Desmoglein1_binding_partners Plakoglobin_binding_partners Plakoglobin_binding_partners HER2 HER2 _Plakoglobin__Plakoglobin_binding_partners _Plakoglobin__Plakoglobin_binding_partners Plakoglobin_binding_partners Plakoglobin_binding_partners PPP1CC PPP1CC Plakoglobin Plakoglobin Desmocolin1 Desmocolin1 Desmocolin1_binding_partners Desmocolin1_binding_partners _Desmoglein_1__Desmoglein_1_binding_partners _Desmoglein_1__Desmoglein_1_binding_partners Desmoglein1_binding_partners Desmoglein1_binding_partners MIZ1__SMAD2_SMAD3_SMAD4_SP1 MIZ1__SMAD2_SMAD3_SMAD4_SP1 SMAD4_at_Nucleus SMAD4_at_Nucleus SMAD3_S423_pho_S425_pho_hm2_at_Nucleus SMAD3_S423_pho_S425_pho_hm2_at_Nucleus COL1A2 COL1A2 MAP3K7 MAP3K7 COL1A2 COL1A2 16710477 pubmed MIR141 HGNC Desmoglein3 Desmoglein3 Vitronectin Vitronectin Desmosomal_cadherins Desmosomal_cadherins DOCK9 DOCK9 Desmocolin1_binding_partners Desmocolin1_binding_partners _Desmocolin_1__Desmocolin_1_binding_partners _Desmocolin_1__Desmocolin_1_binding_partners Desmocolin Desmocolin Desmoglein Desmoglein Desmocolin3 Desmocolin3 Desmocolin1 Desmocolin1 Armadillo_proteins Armadillo_proteins Desmoglein1 Desmoglein1 7479854 pubmed SMAD4_at_Nucleus SMAD4_at_Nucleus MIZ1__at_Nucleus MIZ1__at_Nucleus SP1_at_Nucleus SP1_at_Nucleus SMAD2_S467_pho_S464_pho_S465_pho_at_Nucleus SMAD2_S467_pho_S464_pho_S465_pho_at_Nucleus SMAD3_S422_pho_S423_pho_S425_pho_at_Nucleus SMAD3_S422_pho_S423_pho_S425_pho_at_Nucleus GJA1 GJA1 LAMB2 HGNC TJP2 HGNC 10809728 pubmed 15713627 pubmed FGF1 FGF1 BNIP2 HGNC SMAD3 SMAD3 _beta__Catenin _beta__Catenin ID3 ID3 15465828 pubmed SHC1_p66_p52 SHC1_p66_p52 ECT2 HGNC 19703993 pubmed AKT2 HGNC ITGB1 HGNC WNK4 HGNC 19646399 pubmed 17568974 pubmed _VE_Cadherin___beta__Catenin__p120_1_Plakoglobin__Plakophilin4 _VE_Cadherin___beta__Catenin__p120_1_Plakoglobin__Plakophilin4 Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin Cadherin __beta__Catenin__Cadherin___alpha__Catenin __beta__Catenin__Cadherin___alpha__Catenin _Cadherin__p120 _Cadherin__p120 __alpha__Catenin___beta__Catenin__p120__Cadherin __alpha__Catenin___beta__Catenin__p120__Cadherin Rac1_GAPs Rac1_GAPs Homo sapiens 19439604 pubmed KRT19 HGNC _beta__Catenin _beta__Catenin Truncated_Elastin Truncated_Elastin MIR141 MIR141 MIR200C MIR200C 1312256 pubmed ACTIVATION CDTYPE:CATALYSIS MIR200A MIR200A VEGFA VEGFA arMIR200A arMIR200A MIR429 MIR429 IGF1R HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CCNE1 HGNC ACTIVATION CDTYPE:CATALYSIS _alpha_1_Actin _alpha_1_Actin ACTIVATION CDTYPE:CATALYSIS DLC1 HGNC MIR31 MIR31 DSC2 HGNC DSC1 HGNC DSC3 HGNC SP1 HGNC FN1 HGNC BAK1 HGNC LAMB1 HGNC 19564415 pubmed ZO1_2 ZO1_2 13678960 pubmed 17987801 pubmed ITGB2 ITGB2 SMAD4 SMAD4 LAMA1 HGNC PIP5K1B HGNC 12799363 pubmed ACTN2 HGNC 11557048 pubmed HDAC3 HGNC ITGA8 HGNC FOXC2 HGNC TIMP1 TIMP1 ARHGAP12 HGNC ACTIVATION CDTYPE:CATALYSIS 10455125 pubmed 16199880 pubmed AKT2 HGNC EGF EGF ITGB3 HGNC PXN PXN ACTIVATION CDTYPE:CATALYSIS MAP3K5 MAP3K5 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CYFIP2 HGNC LAMC1 HGNC STAT5B HGNC ACTIVATION CDTYPE:CATALYSIS TGFBR1 TGFBR1 STAT5A HGNC ITGA4 ITGA4 SMAD7 SMAD7 10833514 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:UNKNOWN_CATALYSIS DSP HGNC HEY1 HEY1 COL6A3 COL6A3 COL1A1 HGNC THBS1 THBS1 11368848 pubmed COL1A2 HGNC LIN7C HGNC 15094799 pubmed Integrin_A8B1_AVB1_AVB5_AVB6_AVB8 Integrin_A8B1_AVB1_AVB5_AVB6_AVB8 ITGB4 ITGB4 EIF4E EIF4E Nectin Nectin 20152177 pubmed 11553709 pubmed 15024084 pubmed 9592087 pubmed SMAD2_3 SMAD2_3 TLN2 HGNC TLN1 HGNC 14718565 pubmed MIR141 HGNC CYFIP2 CYFIP2 21897371 pubmed 8078588 pubmed JAG1 HGNC TYK2 TYK2 MAPK8 HGNC TIMP_family TIMP_family MIR21_TIAM1 MIR21_TIAM1 16617148 pubmed AXIN1_MIR34 AXIN1_MIR34 MIR34__SNAI1 MIR34__SNAI1 LEF1_MIR34 LEF1_MIR34 7479768 pubmed MIR31_TIAM1 MIR31_TIAM1 MIR192_ZEB2 MIR192_ZEB2 MIR34___beta__Catenin MIR34___beta__Catenin MIR449A_NOTCH1 MIR449A_NOTCH1 MPDZ MPDZ KRT18 HGNC FGF1 HGNC ETS1 HGNC JAG1_NOTCH1 JAG1_NOTCH1 NOTCH1_NUMB__beta__Catenin NOTCH1_NUMB__beta__Catenin 12655147 pubmed DLL1_NOTCH1 DLL1_NOTCH1 ID2 ID2 CD19 HGNC PLC_beta PLC_beta DOCK9 HGNC GSK3_beta GSK3_beta MIR34__MYC MIR34__MYC KRT8 HGNC RUNX2 RUNX2 RALBP1 HGNC DIAPH3 HGNC FGF1 FGF1 MAPK14 HGNC EMILIN1 EMILIN1 STAT1 HGNC MIR34__WNT1 MIR34__WNT1 MMP13 MMP13 CDTYPE:PHYSICAL_STIMULATION MMP13 MMP13 MMP13 MMP13 MIR34__WNT3 MIR34__WNT3 Latency_associated_protein__hm2_at_Extracellular_space Latency_associated_protein__hm2_at_Extracellular_space TGFB1_hm2_at_Extracellular_space TGFB1_hm2_at_Extracellular_space AXIN2_MIR34 AXIN2_MIR34 TWIST2 HGNC TIMP3 TIMP3 truncated_Galectin_3 truncated_Galectin_3 9878069 pubmed DVL1 DVL1 Claudin3 Claudin3 HDAC2 HDAC2 Caspase1 Caspase1 MYLL1 MYLL1 FOXO1 HGNC Plakophilin3 Plakophilin3 ETS1_WASF3_WAVE3 ETS1_WASF3_WAVE3 ITGB8 ITGB8 APC_pho APC_pho AXIN1 AXIN1 SMAD7 SMAD7 17952127 pubmed AXIN1_pho AXIN1_pho _beta__Catenin__at_Nucleus _beta__Catenin__at_Nucleus ARHGAP31 HGNC ID1 ID1 NICD__p53 NICD__p53 HIF1A HGNC ITGAL ITGAL APC APC DVL1 DVL1 AXIN1 AXIN1 FN1 HGNC LIN7C LIN7C CK1_alpha CK1_alpha 19704010 pubmed _beta__Catenin__pho _beta__Catenin__pho _beta__Catenin__pho_pho_pho_pho _beta__Catenin__pho_pho_pho_pho CTBP1 HGNC CTBP2 HGNC PRKCD HGNC DSC2 HGNC PDGFR_family PDGFR_family MIR1-1 HGNC 19030972 pubmed GJA5 HGNC MIR205 MIR205 c_SRC c_SRC Actin_cytoskeletal Actin_cytoskeletal Vinculin Vinculin ITGA3 HGNC PXN_pho PXN_pho BCAR1 BCAR1 Talin Talin TNF HGNC Actinin Actinin FAK1__Y_pho_pho_active FAK1__Y_pho_pho_active TIAM1 TIAM1 Actinin Actinin PTEN PTEN 12490555 pubmed GRB2 GRB2 15574337 pubmed 14657501 pubmed BAD BAD ITGB1 HGNC _Focal_adhesion_complex_Actinin__Actin__ARP2_3 _Focal_adhesion_complex_Actinin__Actin__ARP2_3 ARP2_3 ARP2_3 ACTIVATION CDTYPE:CATALYSIS _Integrin_Large_Latent_Complex _Integrin_Large_Latent_Complex KRT8 HGNC _Actin__Integrin__Large_Latent_Complex _Actin__Integrin__Large_Latent_Complex ACTIVATION CDTYPE:CATALYSIS KRT5 HGNC ITGAX ITGAX _Small_latent_Complex _Small_latent_Complex _Large_Latent__complex _Large_Latent__complex GJB3 GJB3 _Focal_adhesion_complex_Actinin__Actin _Focal_adhesion_complex_Actinin__Actin _Focal_adhesion_complex _Focal_adhesion_complex 9872359 pubmed _Pro_TGFB1_complex _Pro_TGFB1_complex _Pre_TGFB1_complex _Pre_TGFB1_complex ZYX ZYX BCAR1 BCAR1 SNAI2 HGNC _Mature_focal_adhesion_complex _Mature_focal_adhesion_complex ZYX ZYX CyclinE1 CyclinE1 PXN_pho PXN_pho Talin Talin FAK1__Y_pho_pho_active FAK1__Y_pho_pho_active DOCK6 HGNC 21965293 pubmed TGFA TGFA TNF TNF EGF EGF FGF2 FGF2 Vinculin Vinculin c_SRC c_SRC Actinin Actinin Actin_cytoskeletal Actin_cytoskeletal 7579708 pubmed Fibronectin Fibronectin BCAR1 BCAR1 Actin_cytoskeletal Actin_cytoskeletal CTNNB1 HGNC BCAR1 BCAR1 PAR3 PAR3 Vinculin Vinculin CDTYPE:PHYSICAL_STIMULATION PXN_pho PXN_pho FAK1__Y_pho_pho_active FAK1__Y_pho_pho_active INHIBITION CDTYPE:INHIBITION DIAPH1 HGNC PTEN PTEN Talin Talin c_SRC c_SRC 11149925 pubmed SOS2 HGNC VCL HGNC 11278251 pubmed Laminin5 Laminin5 Vinculin Vinculin DIAPH3 HGNC CAR CAR ACTIVATION CDTYPE:CATALYSIS MMP14 MMP14 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION CDTYPE:BOOLEAN_LOGIC_GATE_AND MMP12 MMP12 CDTYPE:PHYSICAL_STIMULATION ZEB1 ZEB1 ZEB2 ZEB2 SNAI1 SNAI1 SNAI2 SNAI2 SNAI2 SNAI2 INHIBITION CDTYPE:INHIBITION ZEB1 ZEB1 TWIST1 TWIST1 SNAI1 SNAI1 CTBP2 HGNC VIM HGNC HGF HGF MMP1 MMP1 ZEB2 ZEB2 MYC HGNC LIMK1 HGNC Fibronectin_partners Fibronectin_partners 18403754 pubmed 16472676 pubmed ITGA4 ITGA4 TJP1 HGNC MYL4 MYL4 PTPN11 HGNC ACTIVATION CDTYPE:CATALYSIS CDK6 HGNC PPP1CA HGNC TGFB2 HGNC 17884187 pubmed G_gamma G_gamma BCL2 BCL2 8910292 pubmed ARHGAP12 ARHGAP12 CRB3 HGNC RTK RTK 14744429 pubmed 8522586 pubmed FOS FOS HRAS_GAPs HRAS_GAPs 11713255 pubmed LEF1_TCF3_4__at_Nucleus LEF1_TCF3_4__at_Nucleus ITGA9 ITGA9 APC_pho APC_pho AXIN1_pho AXIN1_pho _beta__Catenin _beta__Catenin APC_AXIN1__beta__Catenin APC_AXIN1__beta__Catenin MMP9 MMP9 PARD6A HGNC 10613909 pubmed APC_pho APC_pho 8910277 pubmed RHOA RHOA 16944320 pubmed _alpha__Catenin _alpha__Catenin _beta__Catenin _beta__Catenin 10613913 pubmed CHUK CHUK LAMB3 HGNC _Integrin_aVb3_L1CAM _Integrin_aVb3_L1CAM _E_Cadherin__Integrin_aEb7 _E_Cadherin__Integrin_aEb7 FRAT1 FRAT1 AXIN1_DVL1_FRAT1 AXIN1_DVL1_FRAT1 INHIBITION CDTYPE:INHIBITION FRAT1 FRAT1 GSK3B HGNC TGFB3 HGNC CK2_alpha CK2_alpha E_Cadherin E_Cadherin N_Cadherin N_Cadherin _beta__Catenin _beta__Catenin APC_AXIN1 APC_AXIN1 AXIN1 AXIN1 APC APC VE_Cadherin VE_Cadherin E_Cadherin E_Cadherin SOX2 SOX2 CDC42 HGNC SNAI2 SNAI2 PPP1CC PPP1CC PPP1C PPP1C DSG1 HGNC PPP1CA PPP1CA PPP1CB PPP1CB 22406545 pubmed AXIN1_pho AXIN1_pho 17872466 pubmed SMAD2 SMAD2 APC_pho APC_pho AXIN1_pho AXIN1_pho APC_AXIN1 APC_AXIN1 COL1A1 HGNC FOS FOS COL5A1 HGNC KRT18 KRT18 ITGB7 HGNC VAV2 VAV2 ACTIVATION CDTYPE:CATALYSIS 24376839 pubmed 15247287 pubmed RHPN1 HGNC 18802401 pubmed MYL3 HGNC IL2 IL2 11013220 pubmed COL4A5 COL4A5 GJB3 HGNC MAPK14 MAPK14 CDK2 CDK2 BIRC5 HGNC AXIN2 HGNC FLT1 HGNC ACTIVATION CDTYPE:CATALYSIS JAM2 HGNC JAM3 HGNC INHIBITION CDTYPE:UNKNOWN_INHIBITION CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ARHGDIA HGNC 10934479 pubmed 10934475 pubmed 10934474 pubmed GJC1 GJC1 ARHGAP9 HGNC CTBP1_2 CTBP1_2 ACTIVATION CDTYPE:CATALYSIS PRKCE PRKCE ATM HGNC HIF2_alpha HIF2_alpha 114518 pubmed E2F1 E2F1 MYLPF HGNC ACTIVATION CDTYPE:CATALYSIS ZO3 ZO3 MEK1 MEK1 10022831 pubmed ACTIVATION CDTYPE:UNKNOWN_CATALYSIS PTPN11 PTPN11 _beta__Catenin__ZEB1_ZEB2 _beta__Catenin__ZEB1_ZEB2 BMI1 HGNC NOTCH1 HGNC CDTYPE:PHYSICAL_STIMULATION 9003039 pubmed MYH7B MYH7B RAC1 RAC1 MAP3K7 HGNC 10403805 pubmed 11689568 pubmed RTKN RTKN 16288286 pubmed DR1 DR1 VEGFA VEGFA TWIST1 TWIST1 15003621 pubmed GNAI1 HGNC 17196961 pubmed LAMB1 HGNC DEF6 HGNC GNAI3 HGNC GNAI2 HGNC KRT14 HGNC CDTYPE:PHYSICAL_STIMULATION WASL HGNC ITGA6 HGNC Laminin8 Laminin8 ITGB1 HGNC PSEN1 PSEN1 SMAD6 HGNC 7731720 pubmed MAPK14 MAPK14 MAPK13 MAPK13 GNAO1 HGNC MAPK12 MAPK12 HIF1A HGNC 12134164 pubmed ACTIVATION CDTYPE:CATALYSIS Plakophilin2 Plakophilin2 12857875 pubmed p38 p38 MAPK11 MAPK11 SNAI1_at_Nucleus SNAI1_at_Nucleus HDAC1_at_Nucleus HDAC1_at_Nucleus HDAC2_at_Nucleus HDAC2_at_Nucleus EZH2_at_Nucleus EZH2_at_Nucleus SIN3A_at_Nucleus SIN3A_at_Nucleus EZH2_HDAC1_HDAC2_SNAI1 EZH2_HDAC1_HDAC2_SNAI1 MYL5 HGNC MYL4 HGNC MMP9 HGNC MYL3 HGNC SIN3A SIN3A MYL2 HGNC HDAC1_at_Nucleus HDAC1_at_Nucleus MYL7 HGNC MYL6 HGNC MYL1 HGNC MIR1_1 MIR1_1 MMP10 MMP10 LAP__SNAI2 LAP__SNAI2 LTBP1_at_Extracellular_space LTBP1_at_Extracellular_space arMIR200 arMIR200 PTEN PTEN arMIR1_1 arMIR1_1 MDM2 MDM2 MIR200__SNAI2 MIR200__SNAI2 MMP13 MMP13 arMIR200C arMIR200C BMI1_at_Nucleus BMI1_at_Nucleus BMI1_TWIST1 BMI1_TWIST1 DTX1 DTX1 UBE2D2 UBE2D2 12040186 pubmed DTX1_UBE2D1_UBE2D2 DTX1_UBE2D1_UBE2D2 16204230 pubmed DTX1 DTX1 ITGA1 ITGA1 ROS ROS _MIR200C_SMAD2_TGFB2 _MIR200C_SMAD2_TGFB2 _MIR200C_BIM1_KLF4_SOX2 _MIR200C_BIM1_KLF4_SOX2 16288291 pubmed rBIM1_KLF4_SOX2 rBIM1_KLF4_SOX2 SOX2 SOX2 SOX2 SOX2 18297062 pubmed VEGFA HGNC NOTCH1 NOTCH1 11790723 pubmed JNK JNK JNK1 JNK1 ZO2 ZO2 JNK2 JNK2 RAC1 HGNC JNK3 JNK3 TWIST1 TWIST1 BMI1 BMI1 BMI1 BMI1 SMAD9 SMAD9 SMAD9 SMAD9 SARA SARA SMAD9 SMAD9 MDM2 MDM2 TGFB1 TGFB1 p53 p53 MDM2_p53 MDM2_p53 SARA__at_Early_Endosome SARA__at_Early_Endosome SARA__at_Early_Endosome SARA__at_Early_Endosome SMAD2_at_Early_Endosome SMAD2_at_Early_Endosome TLN1 TLN1 ARHGAP26 ARHGAP26 MDM2_S186_pho MDM2_S186_pho p53 p53 MDM2 MDM2 p53__at_Nucleus p53__at_Nucleus MDM2_S186_pho_at_Nucleus MDM2_S186_pho_at_Nucleus MDM2_p53 MDM2_p53 SMAD5 SMAD5 SMAD5 SMAD5 SMAD4 SMAD4 CDTYPE:TRIGGER CDK4_6 CDK4_6 ACTIVATION CDTYPE:CATALYSIS CDK4_6 CDK4_6 ACTIVATION CDTYPE:CATALYSIS TWIST1_S68_pho_at_Nucleus TWIST1_S68_pho_at_Nucleus 16129888 pubmed SMAD7 SMAD7 SMAD7 SMAD7 SMAD7 SMAD7 SMAD6 SMAD6 SMAD6 SMAD6 SMAD6 SMAD6 SMAD5 SMAD5 11224571 pubmed CDKN2A CDKN2A p16INK4A p16INK4A p16INK4A p16INK4A CDK4_6__p15INK4B CDK4_6__p15INK4B CDK4_6__p16INK4A CDK4_6__p16INK4A 17959595 pubmed Goosecoid Goosecoid FOXC2 FOXC2 SMAD1 SMAD1 SMAD1 SMAD1 SMAD2 SMAD2 FZD FZD SMAD2 SMAD2 SMAD3 SMAD3 SMAD3 SMAD3 SMAD4 SMAD4 SMAD4 SMAD4 LTBP1_at_Extracellular_space LTBP1_at_Extracellular_space LAMC1 HGNC ID1 ID1 ID1 ID1 ID1 ID1 RAC1 RAC1 RAC1 RAC1 CDTYPE:PHYSICAL_STIMULATION RAC1 RAC1 RAC1B RAC1B ERK1_2 ERK1_2 SP1 SP1 p53__at_Nucleus p53__at_Nucleus SNAI2_at_Nucleus SNAI2_at_Nucleus MDM2_SNAI2_p53 MDM2_SNAI2_p53 22118458 pubmed Actin_cytoskeletal Actin_cytoskeletal IGF1 HGNC NF__kappa_B_pathway NF__kappa_B_pathway This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. CSN2 CSN2 MDM2_S186_pho_at_Nucleus MDM2_S186_pho_at_Nucleus FOXC2 FOXC2 FOXC2 FOXC2 KLF8 KLF8 NF__kappa_B_p65 NF__kappa_B_p65 FGD1 HGNC FGD4 HGNC LAMA1 HGNC HMGA2_at_Nucleus HMGA2_at_Nucleus 22211245 pubmed ERK1_2 ERK1_2 SMAD4_at_Nucleus SMAD4_at_Nucleus HIF1A HIF1A HIF3_alpha HIF3_alpha ITGB4 HGNC HMGA2 HMGA2 ID2 ID2 HIF2_alpha HIF2_alpha ID ID SRGAP3 HGNC ARHGEF27 ARHGEF27 9822663 pubmed Claudin7 Claudin7 RAC1B RAC1B ID2 ID2 ID2 ID2 Endothelin1 Endothelin1 Endothelin1 Endothelin1 LYRIC LYRIC LAMB1 HGNC Endothelin1 Endothelin1 EDNRA EDNRA Hypoxia Hypoxia This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. ROS ROS KRT18 HGNC ITGB2 ITGB2 SARA__SMAD3 SARA__SMAD3 SARA__at_Early_Endosome SARA__at_Early_Endosome MYH7B HGNC SARA__SMAD2 SARA__SMAD2 SMAD5 HGNC PRKCE PRKCE HDAC2 HDAC2 11336673 pubmed RHPN1 RHPN1 18497317 pubmed MMP3 MMP3 MYL7 MYL7 NEURL NEURL TSPAN3 HGNC 12545156 pubmed ARHGEF3 HGNC SMAD2 SMAD2 SMAD2_S467_pho_S465_pho_at_Early_Endosome SMAD2_S467_pho_S465_pho_at_Early_Endosome FGFR4 FGFR4 CLDN4 HGNC MIR203 MIR203 9822620 pubmed 22024162 pubmed MAP3K7_10_11 MAP3K7_10_11 FLT4 HGNC MAPK13 MAPK13 FGF2 HGNC FLT1 HGNC FGF1 HGNC PTK2 HGNC FLT3 HGNC CLDN7 HGNC FGD4 FGD4 FGFR1 HGNC ARHGAP5 HGNC PKP4 HGNC SMAD6 SMAD6 Claudin19 Claudin19 JUP HGNC MYL6 HGNC TWIST2 TWIST2 GPR12 HGNC FURIN FURIN ABL1 ABL1 CK2_alpha CK2_alpha 10023776 pubmed CDH1 HGNC PRKCE HGNC CyclinD1 CyclinD1 MYL12A HGNC MYL12B HGNC map_emtcellmotility map_emtcellmotility Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr MMP13 MMP13 ZEB1 HGNC FOS FOS EZH2 HGNC TGFB3 HGNC 16917499 pubmed MIR200B MIR200B 7539918 pubmed EZH2 EZH2 GNGT1 HGNC Elastin Elastin MYH10 MYH10 9822605 pubmed p27KIP1 p27KIP1 EGFR HGNC MIR106B_25 MIR106B_25 MYLPF MYLPF 22671595 pubmed MYH13 MYH13 16968698 pubmed 8638126 pubmed 18287519 pubmed CDH4 HGNC FOXO3 HGNC 8571126 pubmed 21733352 pubmed CDK2_4 CDK2_4 Occludin Occludin 10545505 pubmed TJP3 HGNC 23064052 pubmed INHIBITION CDTYPE:INHIBITION SMAD2 HGNC VAV2 HGNC 15866170 pubmed Claudin4 Claudin4 7528107 pubmed DOCK9 HGNC TSPAN3 TSPAN3 DOCK6 HGNC EFNA1 HGNC 16325583 pubmed HBEGF HBEGF GJA4 HGNC GJA1 HGNC JAG1 JAG1 CDTYPE:PHYSICAL_STIMULATION GSK3B HGNC CASK HGNC 11528470 pubmed PAK3 PAK3 22945800 pubmed INHIBITION CDTYPE:INHIBITION CDTYPE:PHYSICAL_STIMULATION CDTYPE:BOOLEAN_LOGIC_GATE_AND 20428755 pubmed ROCK1 ROCK1 FN1 HGNC GJC1 HGNC 9389648 pubmed ITGA5 ITGA5 PIP5K1B PIP5K1B FGF19 FGF19 1823643 pubmed ZEB2 ZEB2 VAV2 HGNC WNT5A-AS1 HGNC VAV1 HGNC PI3KC3_regulator PI3KC3_regulator ITGA8 HGNC CTNND1 HGNC CDH1 HGNC CDH2 HGNC CDH3 HGNC ARFIP2 HGNC CDH5 HGNC HIF1A HGNC EP300 HGNC JNK3 JNK3 LIMK1 LIMK1 9427749 pubmed BMI1 BMI1 12791379 pubmed CDC42_GAPs CDC42_GAPs INHIBITION CDTYPE:INHIBITION 14623871 pubmed CRB3 CRB3 ROCK2 ROCK2 COL4A4 HGNC GJB2 GJB2 RALBP1 HGNC SMAD3_S423_pho_S425_pho_at_Early_Endosome SMAD3_S423_pho_S425_pho_at_Early_Endosome SMAD3 SMAD3 TIMP2 HGNC CTNNA1 HGNC SARA__SMAD3 SARA__SMAD3 SMAD3_at_Early_Endosome SMAD3_at_Early_Endosome GJA4 GJA4 22134354 pubmed ID2 ID2 SOS1 SOS1 KDR HGNC ACTIVATION CDTYPE:CATALYSIS SARA__SMAD2 SARA__SMAD2 16650609 pubmed p16INK4A p16INK4A VEGFA VEGFA TGFB1_hm2_active_at_Early_Endosome TGFB1_hm2_active_at_Early_Endosome 16682805 pubmed TGFBR2_Ser_pho_hm2_at_Early_Endosome TGFBR2_Ser_pho_hm2_at_Early_Endosome PAK1 HGNC KRT14 HGNC ZO2 ZO2 KRT18 HGNC rBMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2 rBMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2 BMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2 BMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2 FGFR4 HGNC FGFR3 HGNC ETS1 ETS1 FGFR2 HGNC arMIR449A arMIR449A TIMP3 TIMP3 FGFR1 HGNC _MIR200A__beta__Catenin__ZEB1_ZEB2 _MIR200A__beta__Catenin__ZEB1_ZEB2 PRKCE PRKCE _beta__Catenin__ZEB1_ZEB2 _beta__Catenin__ZEB1_ZEB2 r_beta__Catenin__ZEB1_ZEB2 r_beta__Catenin__ZEB1_ZEB2 TGFB1_TGFBR1_TGFBR2 TGFB1_TGFBR1_TGFBR2 TGFBR1_Ser_pho_hm2_active_at_Early_Endosome TGFBR1_Ser_pho_hm2_active_at_Early_Endosome MYC MYC ITGA11 ITGA11 ACTIVATION CDTYPE:CATALYSIS NOTCH1_at_Lysosome NOTCH1_at_Lysosome Latency_associated_protein__at_Extracellular_space Latency_associated_protein__at_Extracellular_space MYC MYC MYC MYC ACTA2 HGNC EPHB2_pho_hm2_active EPHB2_pho_hm2_active EPHA2_pho_hm2 EPHA2_pho_hm2 Epherin_A1 Epherin_A1 _Ephrin_B1_EPHB2 _Ephrin_B1_EPHB2 11163210 pubmed Ephrin_B1 Ephrin_B1 CTNNB1 HGNC TGFB1_at_Extracellular_space TGFB1_at_Extracellular_space NOTCH1_at_Lysosome NOTCH1_at_Lysosome FURIN FURIN NUMB_at_Lysosome NUMB_at_Lysosome 17332325 pubmed DSP HGNC Latency_associated_protein__hm2_at_Extracellular_space Latency_associated_protein__hm2_at_Extracellular_space Epherin_A1 Epherin_A1 ADAM9 ADAM9 Ephrin_B1 Ephrin_B1 EPHB2 EPHB2 _Ephrin_A1_EPHA2 _Ephrin_A1_EPHA2 EPH_family EPH_family c_SRC c_SRC c_MET__hm2_active c_MET__hm2_active HGF HGF PRKCZ HGNC _HGF_c_MET _HGF_c_MET HGF HGF SMAD2_S467_pho_S465_pho SMAD2_S467_pho_S465_pho SMAD3_S423_pho_S425_pho SMAD3_S423_pho_S425_pho SMAD4_at_Nucleus SMAD4_at_Nucleus LMO2_ZEB1 LMO2_ZEB1 rNOTCH1 rNOTCH1 LTBP1_Latency_associated_protein LTBP1_Latency_associated_protein E_Cadherin E_Cadherin c_MET c_MET IGF1R_Y_pho_hm2_active IGF1R_Y_pho_hm2_active 21909380 pubmed IGF_family IGF_family 12718878 pubmed _IGF_family_IGF1R _IGF_family_IGF1R PTP4A3 PTP4A3 Plakoglobin Plakoglobin Plakoglobin Plakoglobin PTP4A3 PTP4A3 IGF_family IGF_family Latency_associated_protein__hm2_at_Extracellular_space Latency_associated_protein__hm2_at_Extracellular_space TGFB1_hm2_at_Extracellular_space TGFB1_hm2_at_Extracellular_space PARD6A PARD6A 18931829 pubmed rNOTCH1 rNOTCH1 14701795 pubmed SMAD3_SMAD4_SNAI1 SMAD3_SMAD4_SNAI1 SMAD4_at_Nucleus SMAD4_at_Nucleus rJAG1 rJAG1 CAR CAR arMIR30E arMIR30E MIR30E_ZEB2 MIR30E_ZEB2 JUNB HGNC rZEB2 rZEB2 SMAD3_S423_pho_S425_pho_hm2_at_Nucleus SMAD3_S423_pho_S425_pho_hm2_at_Nucleus SMAD4_at_Nucleus SMAD4_at_Nucleus VIM HGNC MIR93 MIR93 MIR106B MIR106B MIR25 MIR25 MIR106B_25__SMAD7 MIR106B_25__SMAD7 PTP4A3 PTP4A3 SMAD7_TGFBR1 SMAD7_TGFBR1 PTP4A3 PTP4A3 SMAD7 SMAD7 MAP3K5 MAP3K5 TGFBR1_hm2 TGFBR1_hm2 INADL HGNC BCL2L1 HGNC SMAD3_SMAD4 SMAD3_SMAD4 SMAD3_SMAD4 SMAD3_SMAD4 NICD__at_Nucleus NICD__at_Nucleus SMAD3_S423_pho_S425_pho_hm2 SMAD3_S423_pho_S425_pho_hm2 SMAD4 SMAD4 TGFBR1 TGFBR1 TGFBR1 TGFBR1 rSMAD2_TGFBR1 rSMAD2_TGFBR1 arMIR141 arMIR141 17299729 pubmed ITGAL ITGAL ARHGAP24 ARHGAP24 GNA11 HGNC MIR30E MIR30E PARD3 HGNC Desmoplakin_binding_partners Desmoplakin_binding_partners _MIR141_SMAD2_TGFBR1 _MIR141_SMAD2_TGFBR1 GNA14 HGNC arMIR30E arMIR30E 9295307 pubmed WASF2 HGNC GNA15 HGNC rSMAD2 rSMAD2 CDTYPE:PHYSICAL_STIMULATION GNA12 HGNC MIR30E MIR30E GNA13 HGNC MIR30E_SMAD2 MIR30E_SMAD2 PARD6A HGNC ETS1 HGNC MYH4 MYH4 TCF3 HGNC ZEB1_at_Nucleus ZEB1_at_Nucleus Claudin3 Claudin3 arMIR200C arMIR200C Claudin3 Claudin3 SMAD4_at_Nucleus SMAD4_at_Nucleus rETS1_WASF3_WAVE3 rETS1_WASF3_WAVE3 19240756 pubmed ETS1_WASF3_WAVE3 ETS1_WASF3_WAVE3 Claudin3 Claudin3 SMAD2_TGFB2 SMAD2_TGFB2 GJA3 HGNC _MIR200B_ETS1_WASF3_WAVE3 _MIR200B_ETS1_WASF3_WAVE3 _MIR203_BMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2 _MIR203_BMI1_BIRC5_KLF4_SOX2_SNAI1_ZEB2 SMAD2_TGFBR1 SMAD2_TGFBR1 GJA8 HGNC rSMAD2_TGFB2 rSMAD2_TGFB2 DSC1 HGNC ZO2 ZO2 ZO2 ZO2 ZO2 ZO2 ZO1 ZO1 ZO1 ZO1 ZO1 ZO1 CDKN1A HGNC 11739775 pubmed rAXIN2 rAXIN2 CAR CAR arMIR183 arMIR183 ACTIVATION CDTYPE:CATALYSIS CAR CAR rBIM1_KLF4_SOX2 rBIM1_KLF4_SOX2 _MIR183_BIM1_KLF4_SOX2 _MIR183_BIM1_KLF4_SOX2 BIM1_KLF4_SOX2 BIM1_KLF4_SOX2 MYL10 MYL10 MIR183 MIR183 MIR183 MIR183 rZEB1_ZEB2 rZEB1_ZEB2 arMIR200 arMIR200 DSTN HGNC _MIR200__ZEB1_ZEB2 _MIR200__ZEB1_ZEB2 ACTIVATION CDTYPE:CATALYSIS 20731704 pubmed ZEB1_ZEB2 ZEB1_ZEB2 JAM1_2_3 JAM1_2_3 MMP9 HGNC ACTN4 ACTN4 TGFBR1 TGFBR1 PRKCE PRKCE _MIR205_ZEB1_ZEB2 _MIR205_ZEB1_ZEB2 PRKCE_ZEB1_ZEB2 PRKCE_ZEB1_ZEB2 PRKCE PRKCE HDAC1_HDAC2_SIN3A_SNAI1 HDAC1_HDAC2_SIN3A_SNAI1 PRKCE_ZEB1_ZEB2 PRKCE_ZEB1_ZEB2 HDAC2_at_Nucleus HDAC2_at_Nucleus SNAI1_at_Nucleus SNAI1_at_Nucleus KRT18 KRT18 MPP5 HGNC ITGAX HGNC 10826997 pubmed EZH1 EZH1 HDAC2 HDAC2 21317430 pubmed MIR200C HGNC arMIR203 arMIR203 MMP3 HGNC ADP ADP TGFB1_hm2_active TGFB1_hm2_active MAPK10 HGNC EZR EZR GJC1 HGNC ATP ATP 12829734 pubmed MMP2 HGNC FGF9 FGF9 TGFBR1 TGFBR1 CSN2 CSN2 ZO1 ZO1 MIZ1__MYC MIZ1__MYC N_Cadherin N_Cadherin ROCK2 ROCK2 ITGAL ITGAL 11463392 pubmed ITGB2 ITGB2 F11R HGNC 11463391 pubmed ITGA11 ITGA11 ITGB1 ITGB1 CRK_DOCK1_PXN CRK_DOCK1_PXN ARHGAP1 ARHGAP1 MAPK13 HGNC PARD6A_SMURF1 PARD6A_SMURF1 7673236 pubmed PAK2 HGNC PAK3 HGNC PAK1 HGNC 15111329 pubmed 15181457) pubmed FRS2 HGNC ITGA1 ITGA1 ECT2 HGNC F11R HGNC MYH11 MYH11 14704854 pubmed GNG11 HGNC GNG12 HGNC GNG13 HGNC MIR183 HGNC GNG10 HGNC 19017651 pubmed 14585353 pubmed ATP ATP CDK4 CDK4 _alpha__Catenin _alpha__Catenin 16195317 pubmed LIN2 LIN2 SMAD2 HGNC CDKN1B HGNC ITGA2B ITGA2B MAPK8 HGNC MAPK9 HGNC _beta__Actin _beta__Actin MYH1 HGNC MMP14 MMP14 11283613 pubmed 11283614 pubmed ARHGAP5 ARHGAP5 ITGAD ITGAD FBLN2 FBLN2 LRP6 HGNC 22370643 pubmed RUNX2 RUNX2 HER2 HER2 LEF1 HGNC TCF4 HGNC ATM ATM ACTIVATION CDTYPE:CATALYSIS CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS 10678166 pubmed LAMA5 LAMA5 BIM1_KLF4_SOX2 BIM1_KLF4_SOX2 ERK2 ERK2 ATF3 ATF3 SMAD2 SMAD2 CLDN4 HGNC LAMA5 HGNC BCL2 HGNC 21667018 pubmed ROS ROS ITGA7 HGNC FRAT1 HGNC AXIN1 AXIN1 C16orf70 HGNC ERBB2 HGNC TJP2 HGNC THBS2 HGNC WAS HGNC ITGA6 HGNC KRT19 KRT19 CASP3 HGNC ZYX HGNC E_protein E_protein 21883379 pubmed ROCK1 HGNC 17587822 pubmed COL4A6 HGNC MMP16 HGNC TCF3 TCF3 MMP13 HGNC CTBP1 CTBP1 EZH2 HGNC ARHGEF31 ARHGEF31 19839049 pubmed 9127006 pubmed ACTN1 HGNC ACTR3 HGNC ARHGDIG HGNC GSK3B HGNC ARHGDIA HGNC NGEF HGNC CDC42 CDC42 ITGA2 HGNC a2b1__a3b1 a2b1__a3b1 MIR141 MIR141 19161977 pubmed 17671186 pubmed 21336307 pubmed 22943793 pubmed RUNX2 HGNC CLDN5 HGNC Endothelin1 Endothelin1 JUP HGNC CLDN3 HGNC TGFBR1 HGNC P_Cadherin P_Cadherin GNG7 HGNC GNG5 HGNC 15501236 pubmed GNG4 HGNC GNG8 HGNC TWIST1 HGNC ITGB4 HGNC Cingulin Cingulin 9864376 pubmed LIN10 LIN10 15157156 pubmed PDGFR_family PDGFR_family Endothelin1 Endothelin1 RhoB_GEFs RhoB_GEFs ATP ATP 15241418 pubmed GNG2 HGNC GNG3 HGNC LIN2 LIN2 22006115 pubmed ITGB1 ITGB1 ITGA5 HGNC Claudin8 Claudin8 NCOR1 NCOR1 ITGA10 HGNC CDKN2B HGNC 2409071 pubmed LAMA4 LAMA4 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION 20818389 pubmed TGFBR1 TGFBR1 ACTR2 HGNC Caspase3 Caspase3 MCF2 HGNC SMAD9 SMAD9 E_Cadherin E_Cadherin ACTIVATION CDTYPE:UNKNOWN_CATALYSIS FGD1 HGNC ITGB7 ITGB7 SOX2 SOX2 CDTYPE:PHYSICAL_STIMULATION 11313345 pubmed ITGA5 HGNC Truncated_Laminin1 Truncated_Laminin1 Plasmin Plasmin DEF6 HGNC _Laminin1_Laminin_1_partners _Laminin1_Laminin_1_partners Laminin_1_partners Laminin_1_partners 2190045 pubmed Elastin_partners Elastin_partners Truncated_Elastin Truncated_Elastin Laminin_1_partners__at_Extracellular_space Laminin_1_partners__at_Extracellular_space Laminin1__at_Extracellular_space Laminin1__at_Extracellular_space RAP1GDS1 HGNC 11706054 pubmed _Elastin_Elastin_partners _Elastin_Elastin_partners Elastin_partners__at_Extracellular_space Elastin_partners__at_Extracellular_space Elastin__at_Extracellular_space Elastin__at_Extracellular_space ITGAV HGNC Collagen1_partners__at_Extracellular_space Collagen1_partners__at_Extracellular_space _Collagen1_Collagen1_partners _Collagen1_Collagen1_partners Collagen1_partners Collagen1_partners _Galectin_3_Galectin_3_partners _Galectin_3_Galectin_3_partners CDC42EP3 HGNC Collagen1__at_Extracellular_space Collagen1__at_Extracellular_space Collagen2_partners Collagen2_partners Collagen4 Collagen4 _Collagen1_Collagen1_partners _Collagen1_Collagen1_partners Collagen2_partners__at_Extracellular_space Collagen2_partners__at_Extracellular_space COL2A1_at_Extracellular_space COL2A1_at_Extracellular_space 8939998 pubmed _Fibronectin_Fibronectin_partners _Fibronectin_Fibronectin_partners Fibronectin_partners Fibronectin_partners Fibronectin__at_Extracellular_space Fibronectin__at_Extracellular_space Fibronectin_partners__at_Extracellular_space Fibronectin_partners__at_Extracellular_space _Talin_Talin_partners _Talin_Talin_partners Talin_partners Talin_partners SMAD2_TGFB2 SMAD2_TGFB2 8262969 pubmed PCR2 PCR2 MMP14 MMP14 MMP13 MMP13 Talin Talin Talin_partners Talin_partners AXIN2 AXIN2 9548756 pubmed PRKCB PRKCB MMP12 MMP12 Truncated_Collagen1 Truncated_Collagen1 ITGAV ITGAV MMP3 MMP3 MMP10 MMP10 ARHGEF14 ARHGEF14 MMP15 MMP15 MMP16 MMP16 MMP2 MMP2 SIN3A SIN3A Collagen3 Collagen3 COL3A1 COL3A1 SNAI1 HGNC Collagen2 Collagen2 ITGA2 ITGA2 TIMP1_at_Extracellular_space TIMP1_at_Extracellular_space LAMC1 HGNC 19955337 pubmed MMP13__at_Extracellular_space MMP13__at_Extracellular_space TIMP_family__at_Extracellular_space TIMP_family__at_Extracellular_space Truncated_Laminin5 Truncated_Laminin5 _MMP12_TIMP _MMP12_TIMP TIMP_family TIMP_family _MMP1_TIMP1 _MMP1_TIMP1 MMP1__at_Extracellular_space MMP1__at_Extracellular_space MIR205 HGNC Truncated_Fibronectin Truncated_Fibronectin Truncated_Collagen4 Truncated_Collagen4 MIR34 MIR34 GJB1 GJB1 _FRS2_GRB2_SOS_FGFR_family _FRS2_GRB2_SOS_FGFR_family IGF_binding_partners IGF_binding_partners IGF_family IGF_family PTEN HGNC IGF2 IGF2 IGF_family__at_Extracellular_space IGF_family__at_Extracellular_space LAMB1 HGNC IGF_binding_partners__at_Extracellular_space IGF_binding_partners__at_Extracellular_space _IGF_family_IGF_binding_partners _IGF_family_IGF_binding_partners LAMA4 HGNC 8537347 pubmed CDC42SE1 HGNC IGF1R_hm2 IGF1R_hm2 _IGF_family_IGF1R _IGF_family_IGF1R id_14_3_3 id_14_3_3 Occludin_Claudin1_2_4_5_7_8_16 Occludin_Claudin1_2_4_5_7_8_16 id_14_3_3 id_14_3_3 IGFBP6 HGNC BAD_at_Mitochondria BAD_at_Mitochondria ARHGAP9 HGNC IGFBP3 HGNC RAF1 RAF1 2344615 pubmed ZO1_2_3 ZO1_2_3 BAD_pho BAD_pho IGFBP1 HGNC ZO1_2_3 ZO1_2_3 WNT10B HGNC BAD_binding_partners__at_Mitochondria BAD_binding_partners__at_Mitochondria _BAD_BAD_binding_partner _BAD_BAD_binding_partner CDKN1A HGNC ARHGAP1 HGNC BAD_binding_partners BAD_binding_partners WNT10A HGNC BAD BAD JNK JNK ZO1__ZO2_3 ZO1__ZO2_3 JAM1_2_3 JAM1_2_3 ZO2_3 ZO2_3 ZO2_3 ZO2_3 IRS1 IRS1 JAM1_2_3__ZO1 JAM1_2_3__ZO1 Occludin Occludin BAD BAD IGF_family IGF_family IRS1 IRS1 SMAD1 SMAD1 GJB1_v_SRC GJB1_v_SRC GJB1 GJB1 WNT1 HGNC GJB1 GJB1 ACTIVATION CDTYPE:CATALYSIS PRKCB PRKCB v_SRC v_SRC INHIBITION CDTYPE:INHIBITION GJA1_4_GJC1 GJA1_4_GJC1 INHIBITION CDTYPE:INHIBITION 12802084 pubmed GJA1_3_4_8_GJB2 GJA1_3_4_8_GJB2 GJA1_3_4_8_GJB2__GJA3 GJA1_3_4_8_GJB2__GJA3 INHIBITION CDTYPE:INHIBITION TGFA HGNC GJA1_3_4_8_GJB2 GJA1_3_4_8_GJB2 GJA1_5_GJC1__GJA5 GJA1_5_GJC1__GJA5 CDTYPE:PHYSICAL_STIMULATION GJA1_5_GJC1 GJA1_5_GJC1 Claudin4 Claudin4 Plakoglobin Plakoglobin 22836101 pubmed GJA1_GJA1_4_GJC1 GJA1_GJA1_4_GJC1 GJA1 GJA1 GJA1_4_GJC1 GJA1_4_GJC1 INHIBITION CDTYPE:INHIBITION Actin_cytoskeletal__ZO1_2 Actin_cytoskeletal__ZO1_2 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS DSG2 HGNC ZO1_2 ZO1_2 INHIBITION CDTYPE:INHIBITION ZO1_2_3 ZO1_2_3 INHIBITION CDTYPE:INHIBITION FOXO3 FOXO3 Claudin1_2_3_4 Claudin1_2_3_4 _BAD_14_3_3_family _BAD_14_3_3_family Claudin1_2_3_4 Claudin1_2_3_4 MAP3K5 MAP3K5 id_14_3_3__at_Nucleus id_14_3_3__at_Nucleus _FOXO3_14_3_3_family _FOXO3_14_3_3_family FOXO3 FOXO3 15229651 pubmed FOXO3_at_Nucleus FOXO3_at_Nucleus Claudin1_5_8 Claudin1_5_8 Cingulin__ZO1_2_3 Cingulin__ZO1_2_3 Claudin1_5_8 Claudin1_5_8 Claudin1_5_8__MPDZ Claudin1_5_8__MPDZ ITGA4_ITGB1 ITGA4_ITGB1 ITGB8 HGNC ITGA2_ITGB1 ITGA2_ITGB1 Integrin_A8B1_AVB1_AVB5_AVB6_AVB8__at_Extracellular_space Integrin_A8B1_AVB1_AVB5_AVB6_AVB8__at_Extracellular_space ITGA4_ITGB7 ITGA4_ITGB7 ITGA3_ITGB1 ITGA3_ITGB1 ITGA6_ITGB4 ITGA6_ITGB4 ITGA5_ITGB1 ITGA5_ITGB1 ITGA8_ITGB1 ITGA8_ITGB1 ITGA6_ITGB1 ITGA6_ITGB1 GJA3_8 GJA3_8 PVRL1 HGNC ITGA8 ITGA8 GJA3_8__ZO1 GJA3_8__ZO1 GJA3_8 GJA3_8 ZO1 ZO1 Actin_cytoskeletal__at_Extracellular_space Actin_cytoskeletal__at_Extracellular_space LEF1_TCF3_4 LEF1_TCF3_4 Occludin_Claudin1_2_4_5_7_8_16 Occludin_Claudin1_2_4_5_7_8_16 INHIBITION CDTYPE:INHIBITION Occludin_Claudin1_2_4_5_7_8_16__ZO1_2_3 Occludin_Claudin1_2_4_5_7_8_16__ZO1_2_3 CDTYPE:PHYSICAL_STIMULATION Integrin_A8B1_AVB1_AVB5_AVB6_AVB8__at_Extracellular_space Integrin_A8B1_AVB1_AVB5_AVB6_AVB8__at_Extracellular_space TJP3 HGNC TJP1 HGNC SIRT1 HGNC ITGA2B_ITGB3 ITGA2B_ITGB3 GJA1_5_GJC1 GJA1_5_GJC1 CDC42EP3 CDC42EP3 TWIST2 HGNC Integrin_A8B1_AVB1_AVB5_AVB6_AVB8 Integrin_A8B1_AVB1_AVB5_AVB6_AVB8 GJA3_8_GJB1_GJB2__GJB1 GJA3_8_GJB1_GJB2__GJB1 ITGA1_ITGB1 ITGA1_ITGB1 PKC PKC MIR183 HGNC INHIBITION CDTYPE:INHIBITION GJA3_8_GJB1_GJB2 GJA3_8_GJB1_GJB2 CDTYPE:PHYSICAL_STIMULATION GJA3_8_GJB1_GJB2 GJA3_8_GJB1_GJB2 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION BAK1 BAK1 GJA5 GJA5 PTEN HGNC ZEB1 ZEB1 15782139 pubmed MIR106B HGNC VEGFA HGNC CDTYPE:PHYSICAL_STIMULATION SOX2 HGNC CDTYPE:BOOLEAN_LOGIC_GATE_AND SMAD1 HGNC PKP3 HGNC 22753312 pubmed LCP2 LCP2 HEY2 HEY2 MDM2 HGNC SOX2 SOX2 HBEGF HGNC ACTIVATION CDTYPE:CATALYSIS Desmoglein2 Desmoglein2 12778124 pubmed CDH4 HGNC CASP1 HGNC 11724822 pubmed MMP14 HGNC LAMC1 HGNC Epherin_family Epherin_family LAMB1 HGNC CDTYPE:PHYSICAL_STIMULATION TJP2 HGNC TJP3 HGNC ITGB2 HGNC LAMA1 HGNC FBLN2 HGNC FBLN1 HGNC INHIBITION CDTYPE:INHIBITION DOCK1 DOCK1 MCF2 HGNC RAF1 HGNC 11340065 pubmed Collagen3 Collagen3 IL2 HGNC INHIBITION CDTYPE:INHIBITION JAK_family JAK_family EPH_family EPH_family 10511705 pubmed SMAD4 HGNC 19418635 pubmed ITGA9 ITGA9 DSC2 HGNC FBLN1 HGNC CDTYPE:PHYSICAL_STIMULATION 10544215 pubmed COL4A2 COL4A2 Desmocollin2 Desmocollin2 G_alpha G_alpha 9113980 pubmed CDTYPE:PHYSICAL_STIMULATION JAK2 JAK2 MYL1 MYL1 FRAT1 FRAT1 GJA1_3_4_8_GJB2 GJA1_3_4_8_GJB2 INADL HGNC ITGA10 ITGA10 12175651 pubmed APC HGNC GJA3 GJA3 PRKCE PRKCE GJA1 GJA1 DSP HGNC ZO1_3 ZO1_3 LAMB4 LAMB4 HRAS HGNC 10559936 pubmed 11312109 pubmed DIAPH3 DIAPH3 TWIST1 HGNC 15820557 pubmed FGD1 FGD1 F11R HGNC MYH15 MYH15 22514743 pubmed ITGA8 ITGA8 PLC_gamma PLC_gamma MYH15 HGNC 21919891 pubmed 11274345 pubmed MMP3 MMP3 22160706 pubmed NUMB HGNC TGFBR1 HGNC INHIBITION CDTYPE:INHIBITION ARHGAP12 HGNC BCL2_XL BCL2_XL 12297042 pubmed ACTB HGNC 16678097 pubmed LAMC3 LAMC3 Desmocolin Desmocolin CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION ACTR2 HGNC ACTR3 HGNC LAMC2 HGNC SIRT1 SIRT1 CTBP2 CTBP2 ITGA5 HGNC GSK3_beta GSK3_beta ZEB1 ZEB1 9287351 pubmed p27KIP1 p27KIP1 ERBB4 HGNC ERBB3 HGNC ERBB2 HGNC FGF4 FGF4 RAF1 RAF1 BMI1 BMI1 ITGA10 HGNC PRKCG HGNC ITGAV HGNC PTEN HGNC EZH1 EZH1 HIF1A HIF1A ZEB1 ZEB1 CyclinD1 CyclinD1 GJD2 GJD2 CLDN1 HGNC GJA1 GJA1 GJC1 GJC1 ITGA10 ITGA10 GJB2 GJB2 MIR34A HGNC PRKCA PRKCA 22433869 pubmed HIF_alpha HIF_alpha PRKCG PRKCG STAT_family STAT_family p16INK4A p16INK4A STAT1 STAT1 Claudin1 Claudin1 MYO9B HGNC CLDN4 HGNC MIZ1 MIZ1 18375391 pubmed CDH5 HGNC GJA4 GJA4 p27KIP1 p27KIP1 GJA3 GJA3 GJA4 GJA4 GJA4 GJA4 GJA5 GJA5 GJA8 GJA8 MYH2 HGNC CDTYPE:PHYSICAL_STIMULATION GJA8 GJA8 ABL1 HGNC GJB1 GJB1 GJA8 GJA8 GJB1 GJB1 RAP1GDS1 HGNC PDGFR_family__hm2_active PDGFR_family__hm2_active PDGFRB PDGFRB ITGAX HGNC PDGF_family__hm2 PDGF_family__hm2 PDGFA PDGFA PDGF_family PDGF_family SMAD1 HGNC PDGF_family PDGF_family PDGFD PDGFD CLDN1 HGNC FGF_family FGF_family PDGFB PDGFB PDGFC PDGFC CLDN4 HGNC CLDN2 HGNC CLDN3 HGNC ITGA10 HGNC MYL1 HGNC FGF4 FGF4 FGF3 FGF3 ITGA2B ITGA2B GJA4 HGNC FGF7 FGF7 FGF8 FGF8 FGF9 FGF9 FGF10 FGF10 FGF16 FGF16 LAMA3 HGNC FGF19 FGF19 FGFR1_ligands FGFR1_ligands FGFR2_ligands FGFR2_ligands FGF6 FGF6 12668723 pubmed ITGA2B HGNC ARHGAP1 HGNC STAT1 STAT1 FOS FOS STAT6 STAT6 17522712 pubmed STAT5 STAT5 ERBB4 HGNC TIMP2 TIMP2 RTKN HGNC TIMP2 TIMP2 LAMB3 HGNC TIMP1 TIMP1 TIMP1 TIMP1 STAT3 STAT3 MYL12B MYL12B TIMP1 TIMP1 FOXC2 HGNC ITGB4 HGNC PLD1 PLD1 ACTR3 ACTR3 16293614 pubmed PTP4A3 PTP4A3 ERBB3 HGNC TIMP3 TIMP3 9265657 pubmed ERBB2 HGNC TIMP3 TIMP3 TIMP2 TIMP2 TIMP3 TIMP3 _PDGF_PDGFR _PDGF_PDGFR PDGFRA PDGFRA ARHGAP5 HGNC TIMP1 TIMP1 LAMC2 HGNC FOS FOS FOS FOS PPP1CB HGNC PDGFR_family PDGFR_family PDGFR_family PDGFR_family PDGFA PDGFA PDGFA PDGFA PDGFA PDGFA Actin_cytoskeletal Actin_cytoskeletal _Actin_Formin _Actin_Formin PTPN11 PTPN11 Actin_cytoskeletal Actin_cytoskeletal Nectin Nectin Cingulin__Occludin Cingulin__Occludin Occludin Occludin Cingulin Cingulin DNMT1 HGNC Afadin__ZO1 Afadin__ZO1 16000375 pubmed EGFR_family EGFR_family _GRB2_SOS__SHC1_p66_p52_EGFR_family _GRB2_SOS__SHC1_p66_p52_EGFR_family RhoA_GAPs RhoA_GAPs FRS2_pho_active FRS2_pho_active ARFIP2 ARFIP2 MPDZ MPDZ FGFR_family FGFR_family JAM1__MPDZ JAM1__MPDZ SOS SOS JAM1 JAM1 SMAD3 HGNC GRB2 GRB2 Afadin Afadin ITGB5 ITGB5 Afadin__JAM1 Afadin__JAM1 JAM1 JAM1 MPDZ MPDZ LAMC2 LAMC2 Afadin Afadin ubiquitinated FGFR3 FGFR3 FGFR2 FGFR2 FGFR1 FGFR1 KRT8 KRT8 FRS2 FRS2 DOCK11 DOCK11 PLC_gamma PLC_gamma Afadin Afadin PLC_gamma PLC_gamma SOX2 HGNC FGFR4 FGFR4 ITGA7 ITGA7 Cingulin Cingulin FRS2 FRS2 ADP ADP OCLN HGNC NISCH NISCH GJB2 GJB2 FGF2 HGNC CDTYPE:PHYSICAL_STIMULATION Heparin Heparin FGFR4_ligands FGFR4_ligands FGFR_family FGFR_family _Heparin_FGF_FGFR _Heparin_FGF_FGFR Heparin_hm2 Heparin_hm2 INHIBITION CDTYPE:INHIBITION FGF_family__hm2 FGF_family__hm2 FGF1 HGNC FGFR3_ligands FGFR3_ligands 19074825 pubmed JUNB JUNB LEF1 LEF1 TCF4 TCF4 GJA1 GJA1 CCND3 HGNC GJA3 GJA3 22796940 pubmed Claudin1 Claudin1 Claudin2 Claudin2 Claudin2 Claudin2 PI PI SMAD3 HGNC 10685062 pubmed ITGB1 ITGB1 Caveolin1__ITGB1 Caveolin1__ITGB1 TSPAN3 TSPAN3 Claudin11 Claudin11 Claudin4 Claudin4 Claudin1 Claudin1 8666229 pubmed Caveolin1 Caveolin1 ITGB1 ITGB1 LAMB2 LAMB2 8625410 pubmed BIRC5 HGNC MYH8 HGNC TSPAN3 TSPAN3 Claudin11__ITGB1_TSPAN3 Claudin11__ITGB1_TSPAN3 Claudin2 Claudin2 ITGAM HGNC Caveolin1 Caveolin1 Occludin Occludin Caveolin1__Claudin2 Caveolin1__Claudin2 Caveolin1 Caveolin1 MMP9 MMP9 Occludin Occludin Caveolin1 Caveolin1 Caveolin1__Occludin Caveolin1__Occludin Actin_cytoskeletal Actin_cytoskeletal KLF8 KLF8 ADAM10 ADAM10 Laminin_1_partners Laminin_1_partners Actin_cytoskeletal__Occludin Actin_cytoskeletal__Occludin ZO1 ZO1 Galectin_3__at_Extracellular_space Galectin_3__at_Extracellular_space LYRIC LYRIC Occludin Occludin Elastin Elastin LYRIC__Occludin LYRIC__Occludin MMP9 MMP9 LYRIC LYRIC MMP1 MMP1 Occludin Occludin E_Cadherin E_Cadherin LYRIC__ZO1 LYRIC__ZO1 Nectin__Occludin Nectin__Occludin Nectin Nectin Formin Formin Galectin_3 Galectin_3 truncated_Galectin_3 truncated_Galectin_3 MIR1_1 MIR1_1 Galectin_3_partners Galectin_3_partners 22564737 pubmed Galectin_3_partners__at_Extracellular_space Galectin_3_partners__at_Extracellular_space Nectin Nectin JUNB JUNB Afadin Afadin Afadin__Nectin Afadin__Nectin PRKCG HGNC PRKCE HGNC PRKCB HGNC 10413675 pubmed 12193595 pubmed PRKCA HGNC CDTYPE:PHYSICAL_STIMULATION 13130303 pubmed MKNK2 HGNC MYC MYC ITGAV HGNC ITGB3 HGNC ITGB1 HGNC ACTIVATION CDTYPE:CATALYSIS ITGAV_ITGB6 ITGAV_ITGB6 ITGAV ITGAV PRKCZ HGNC ITGB6 ITGB6 ITGAV_ITGB8 ITGAV_ITGB8 MIR106B HGNC ITGB5 ITGB5 ITGAV ITGAV ITGB8 ITGB8 ITGA5 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ITGAV_ITGB1 ITGAV_ITGB1 ITGB1 ITGB1 ITGB2 ITGB2 HBEGF HBEGF ITGAX ITGAX ITGB3 ITGB3 ITGAV ITGAV ITGAV ITGAV PARD3 HGNC ITGAV_ITGB3 ITGAV_ITGB3 ITGAV_ITGB5 ITGAV_ITGB5 ITGAV ITGAV INHIBITION CDTYPE:INHIBITION CDTYPE:PHYSICAL_STIMULATION RhoA_B RhoA_B CDTYPE:PHYSICAL_STIMULATION ITGAE_ITGB7 ITGAE_ITGB7 ITGB7 ITGB7 DIAPH1 HGNC ITGAE ITGAE ITGAM_ITGB2 ITGAM_ITGB2 PKN1 HGNC ITGAM ITGAM ITGB2 ITGB2 ITGAL_ITGB2 ITGAL_ITGB2 ITGAX_ITGB2 ITGAX_ITGB2 CCND1 HGNC MIR1_1 MIR1_1 ITGA8 ITGA8 21109948 pubmed ITGB2 ITGB2 ARHGAP32 HGNC ITGAD ITGAD ITGAD_ITGB2 ITGAD_ITGB2 ITGA11_ITGB1 ITGA11_ITGB1 KLF4 HGNC ITGA9_ITGB1 ITGA9_ITGB1 ITGB1 ITGB1 ITGA10 ITGA10 TIMP3 HGNC ITGA10_ITGB1 ITGA10_ITGB1 BNIP2 BNIP2 CDTYPE:PHYSICAL_STIMULATION ACTIVATION CDTYPE:CATALYSIS ACTN4 HGNC ACTIVATION CDTYPE:CATALYSIS PRKCG PRKCG ACTIVATION CDTYPE:CATALYSIS ARHGAP24 HGNC ITGA7 ITGA7 ITGB1 ITGB1 ITGB1 ITGB1 ITGA8_ITGB1 ITGA8_ITGB1 ITGA6 ITGA6 ITGA6_ITGB4 ITGA6_ITGB4 CDTYPE:PHYSICAL_STIMULATION ITGA7_ITGB1 ITGA7_ITGB1 ITGB4 ITGB4 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION ITGA6 ITGA6 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION 9751730 pubmed 21051859 pubmed MYL6B HGNC ARHGAP17 ARHGAP17 ARHGEF4 HGNC LTBP1 LTBP1 11166270 pubmed PI_4_5_P2 PI_4_5_P2 HEY2 HEY2 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION STAT5B HGNC MYO9B HGNC MIR34C HGNC MIR34B HGNC PATJ PATJ PATJ PATJ ITGB6 HGNC E_Cadherin E_Cadherin MMP13 HGNC E_Cadherin E_Cadherin CRB3 CRB3 CRB3 CRB3 TCF3 TCF3 E_Cadherin E_Cadherin 14747478 pubmed CDC25A CDC25A CHN2 CHN2 SRC HGNC ZO3 ZO3 JAM1 JAM1 PARD6B HGNC ERBB2 HGNC Claudin7 Claudin7 JAM1 JAM1 Claudin7 Claudin7 Claudin7 Claudin7 Occludin Occludin 18376396 pubmed N_Cadherin N_Cadherin Occludin Occludin 17217948 pubmed MSN HGNC GJB3 GJB3 Claudin4 Claudin4 ZO3 ZO3 CDTYPE:PHYSICAL_STIMULATION ZO3 ZO3 GJB2 GJB2 GJB2 GJB2 21041997 pubmed GJB3 GJB3 19339212 pubmed GJB3 GJB3 20501702 pubmed RACGAP1 HGNC MYH7 HGNC BMI1 HGNC ITGAM HGNC GJB5 GJB5 ITGB1 HGNC TGFA TGFA 17934056 pubmed COL4A3 COL4A3 COL4A4 COL4A4 WNT WNT Laminin8__at_Extracellular_space Laminin8__at_Extracellular_space COL4A2 COL4A2 Laminin1__at_Extracellular_space Laminin1__at_Extracellular_space HIF1A HGNC a6b1__a6b4__at_Extracellular_space a6b1__a6b4__at_Extracellular_space SHC1 HGNC CBX4 CBX4 DR1 DR1 SRF SRF p300 p300 IL2 IL2 SMAD3 SMAD3 MCF2L HGNC PCAF PCAF MMP15 HGNC MYL2 HGNC COL4A6 COL4A6 COL4A5 COL4A5 MMP12 MMP12 Collagen4 Collagen4 ITGA5 ITGA5 MMP1 MMP1 ITGAV_ITGB3 ITGAV_ITGB3 SMAD1 SMAD1 ITGB3 ITGB3 SMAD2 SMAD2 ITGAV ITGAV ARHGAP35 ARHGAP35 ITGA5_ITGB1 ITGA5_ITGB1 ITGB1 ITGB1 ITGAD HGNC ZEB1_ZEB2 ZEB1_ZEB2 PKP3 HGNC Caveolin1 Caveolin1 MMP1 MMP1 Cytoskeleton_remodeling Cytoskeleton_remodeling This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Proliferation Proliferation This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Adherens_junctions Adherens_junctions This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. Cell_migration Cell_migration This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. VEGFA VEGFA p53 p53 CXADR HGNC MDM2 MDM2 GDP GDP GDP_HRAS GDP_HRAS MMP1 HGNC ARHGAP35 ARHGAP35 RASA1 RASA1 ARHGAP35_pho ARHGAP35_pho HRAS_GAPs HRAS_GAPs ARHGAP35_RASA1 ARHGAP35_RASA1 Vinculin Vinculin TLN1 TLN1 PI3KC3_catalytic PI3KC3_catalytic PXN PXN MIR200 MIR200 JAM2 HGNC 21900405 pubmed DVL1 HGNC E_Cadherin E_Cadherin Talin Talin TLN2 TLN2 DIAPH1 HGNC ACTN2 ACTN2 LMO2_at_Nucleus LMO2_at_Nucleus ACTN4 ACTN4 DIAPH3 HGNC Actinin Actinin MYH6 MYH6 MYH7 MYH7 DNMT1 DNMT1 MYH7B MYH7B ZEB1_at_Nucleus ZEB1_at_Nucleus TCF3 TCF3 17325197 pubmed Apoptosis Apoptosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. 21641962 pubmed VEGFA VEGFA WASF1 WASF1 MMP1 MMP1 ACTN1 ACTN1 TCF3 TCF3 Afadin Afadin Cingulin Cingulin ABR HGNC Cingulin__JAM1 Cingulin__JAM1 Cingulin Cingulin JAM1 JAM1 MYH1 MYH1 Afadin__Cingulin Afadin__Cingulin Cingulin__MyosinII Cingulin__MyosinII 9865696 pubmed MMP15 MMP15 CDTYPE:PHYSICAL_STIMULATION SMAD6 SMAD6 INHIBITION CDTYPE:UNKNOWN_INHIBITION INHIBITION CDTYPE:INHIBITION 18922473 pubmed PI3KC1_catalytic PI3KC1_catalytic PI3KC1_regulator PI3KC1_regulator 10579713 pubmed EGFR HGNC PI PI MAP3K10 MAP3K10 PI3KC2 PI3KC2 11085534 pubmed 16702231 pubmed TCF4 TCF4 Catenin Catenin BAX BAX BAX BAX PI3KC3_regulator PI3KC3_regulator PI3KC3_catalytic PI3KC3_catalytic _PI3KC3 _PI3KC3 _PI3KC1 _PI3KC1 14570575 pubmed p21CIP1 p21CIP1 ITGA2B HGNC CLDN19 HGNC MMP14 MMP14 11413131 pubmed 11413130 pubmed PDPK1 PDPK1 _PDPK1_PIP3 _PDPK1_PIP3 PI_3_4_5_P3 PI_3_4_5_P3 COPS2 HGNC PDPK1 PDPK1 I_1_4_5_P3 I_1_4_5_P3 JAM3 JAM3 21159887 pubmed TGFB3 TGFB3 ITGA3 HGNC 7644501 pubmed KLF4 HGNC Occludin Occludin Occludin Occludin Claudin1 Claudin1 Claudin1__Claudin3 Claudin1__Claudin3 Occludin Occludin Claudin3 Claudin3 Claudin2__Claudin3 Claudin2__Claudin3 Claudin5 Claudin5 FYN FYN Claudin14 Claudin14 Claudin14 Claudin14 CXADR HGNC HDAC1 HGNC module_TIGHT_JUNCTIONS module_TIGHT_JUNCTIONS Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr PDGFA PDGFA Claudin2__Occludin Claudin2__Occludin Claudin1__Occludin Claudin1__Occludin Claudin3 Claudin3 Claudin5 Claudin5 19336515 pubmed Claudin3 Claudin3 FLT1 HGNC Claudin2 Claudin2 Claudin3__Claudin5 Claudin3__Claudin5 JAM2 JAM2 JAM1 JAM1 Occludin Occludin MMP2 MMP2 Occludin Occludin Claudin2 Claudin2 11348595 pubmed RHOA HGNC Claudin1 Claudin1 ITGAM ITGAM ACTIVATION CDTYPE:CATALYSIS GJA1_5_GJC1 GJA1_5_GJC1 8388392 pubmed ITGA2B ITGA2B ZO1 ZO1 JAM2_at_Extracellular_space JAM2_at_Extracellular_space JAM3_at_Extracellular_space JAM3_at_Extracellular_space JAM2_JAM3 JAM2_JAM3 ZO1 ZO1 JAM3 JAM3 GJA3_8 GJA3_8 ZEB1 HGNC ARHGEF4 ARHGEF4 ZEB2 HGNC MIR21 HGNC LIN7C LIN7C RDX RDX MIR203 HGNC ID3 ID3 COL2A1 HGNC EGF HGNC Plakophilin2 Plakophilin2 SMURF2 SMURF2 Plakophilin1 Plakophilin1 COL1A1 COL1A1 Exocytosis Exocytosis This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. EGF_family EGF_family EGFR_family__pho_hm2_active EGFR_family__pho_hm2_active E_Cadherin E_Cadherin JAK1 JAK1 JAK2 JAK2 ITGAD ITGAD EGFR_family__pho_hm2_active EGFR_family__pho_hm2_active ITGAE ITGAE JAK_family JAK_family STAT3 STAT3 E_Cadherin__hm2 E_Cadherin__hm2 FBLN2 FBLN2 STAT_family STAT_family ITGB7 ITGB7 FBLN1 FBLN1 STAT1 STAT1 STAT5 STAT5 COL5A1 COL5A1 COL6A3 COL6A3 COL6A2 COL6A2 MIR183 MIR183 Desmoglein2 Desmoglein2 Plakophilin4 Plakophilin4 Plakoglobin Plakoglobin ITGA5 ITGA5 MIR21 MIR21 MMP15 MMP15 MMP16 MMP16 LAMA4 LAMA4 EGFR_family__hm2 EGFR_family__hm2 LAMA5 LAMA5 _EGF_family_EGFR _EGF_family_EGFR COL2A1 COL2A1 FGF7 FGF7 LAMA1 LAMA1 COL4A1 COL4A1 THBS2 THBS2 PARD6A HGNC L1CAM HGNC 17575049 pubmed PARD6A PARD6A RHPN1 HGNC 10652228 pubmed EPHB2 EPHB2 Claudin1 Claudin1 PARD3 HGNC Claudin1 Claudin1 Claudin2 Claudin2 Claudin2 Claudin2 Claudin3 Claudin3 Claudin3 Claudin3 Claudin5 Claudin5 LEF1 HGNC STAT6 STAT6 STAT3 STAT3 STAT_family STAT_family FOS FOS STAT5A STAT5A MDM2 MDM2 TIMP2 TIMP2 STAT5B STAT5B TYK2 TYK2 PDGFRB PDGFRB TIMP3 TIMP3 FOS FOS STAT6 STAT6 STAT5 STAT5 Plakophilin Plakophilin 19238148 pubmed Occludin__PARD6A_TGFB1_TGFBR1_TGFBR2 Occludin__PARD6A_TGFB1_TGFBR1_TGFBR2 TGFB1_hm2_active TGFB1_hm2_active Occludin Occludin FOXC2 FOXC2 CLDN2 HGNC CDTYPE:PHYSICAL_STIMULATION HER4 HER4 HER3 HER3 MMP16 MMP16 GJA3 HGNC FGFR3 FGFR3 FGFR2 FGFR2 ITGB5 HGNC FGFR_family FGFR_family EGFR_family EGFR_family ACTIVATION CDTYPE:CATALYSIS EGF_family EGF_family ITGB5 ITGB5 CDTYPE:PHYSICAL_STIMULATION RAC1B RAC1B ITGA2B HGNC HBEGF HBEGF HBEGF HBEGF ADAM9 ADAM9 ADAM9 ADAM9 RUNX2 RUNX2 MMP1 MMP1 9660866 pubmed v_SRC v_SRC INHIBITION CDTYPE:INHIBITION ACTIVATION CDTYPE:CATALYSIS MYO9B MYO9B CDTYPE:BOOLEAN_LOGIC_GATE_OR ACTIVATION CDTYPE:CATALYSIS EGF_family EGF_family GJA8 GJA8 _EGF_family_EGFR _EGF_family_EGFR GJA5 GJA5 GJB2 GJB2 GJB1 GJB1 GJD2 GJD2 GJC1 GJC1 ITGB8 HGNC Occludin__PARD6A_TGFBR1 Occludin__PARD6A_TGFBR1 CTNND1 HGNC SMAD4 SMAD4 _alpha__Actin _alpha__Actin PI3KC2 PI3KC2 20179713 pubmed KRT1 KRT1 KIT_hm2_active KIT_hm2_active RTK RTK RTK RTK COL2A1 COL2A1 PDGFRA PDGFRA PDGFR_family PDGFR_family TGFBR1_hm2 TGFBR1_hm2 INHIBITION CDTYPE:INHIBITION PDGFRB PDGFRB FGFR4 FGFR4 PKP2 HGNC PARD6A PARD6A PKP1 HGNC CDTYPE:PHYSICAL_STIMULATION PARD6A PARD6A PKP4 HGNC PKP3 HGNC ACTIVATION CDTYPE:CATALYSIS DPCR1 HGNC MYL12A MYL12A ACTIVATION CDTYPE:CATALYSIS MYL12B MYL12B MYLPF MYLPF NISCH NISCH MyosinII MyosinII MYL10 MYL10 NISCH NISCH ITGA5 ITGA5 ITGA5_NISCH ITGA5_NISCH MAPK3 HGNC CTNNA1 HGNC CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION CSNK1A1 HGNC MYH11 MYH11 MYH10 MYH10 MYL5 MYL5 MYL4 MYL4 ZEB2 HGNC MYL6B MYL6B MYL6 MYL6 MYL7 MYL7 MYLL1 MYLL1 MYH8 MYH8 21777377 pubmed CTNNB1 HGNC FAK1 FAK1 CTBP1 CTBP1 TIP60 TIP60 11278410 pubmed SIRT1 SIRT1 15181457 pubmed ZEB1 ZEB1 ZEB2 ZEB2 TWIST1 TWIST1 TWIST2 TWIST2 c_SRC c_SRC FAK1__Y_pho_pho_active FAK1__Y_pho_pho_active FAK1__c_SRC FAK1__c_SRC FAK1 FAK1 18829532 pubmed 9157999 pubmed SNAI2 SNAI2 SNAI1 SNAI1 ACTIVATION CDTYPE:CATALYSIS NISCH NISCH TWIST2 TWIST2 NISCH_PAK1 NISCH_PAK1 TWIST2 TWIST2 Src_family_kinases Src_family_kinases PAK1 PAK1 MMP3 MMP3 EMT EMT This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. TWIST1 TWIST1 MMP3 MMP3 PTK2B PTK2B FAK1 FAK1 ABL1 ABL1 INHIBITION CDTYPE:INHIBITION SOX2 HGNC c_SRC c_SRC ACTIVATION CDTYPE:CATALYSIS FAK1__Y_pho_pho_active FAK1__Y_pho_pho_active Talin Talin ITGB1 ITGB1 PXN_pho PXN_pho PIK3CD HGNC PIK3CG HGNC 15534005 pubmed LRP5 HGNC 15534002 pubmed LRP6 HGNC PIK3CA HGNC EZH2 EZH2 PIK3CB HGNC ITGAD HGNC DOCK1 DOCK1 Membrane_spreading Membrane_spreading This is a CellDesigner PHENOTYPE entity, representing an abstract biological process. BCAR1 BCAR1 Actinin Actinin MAP2K2 HGNC PXN PXN CRK CRK PXN_pho PXN_pho CRK CRK DOCK1 DOCK1 ITGB1 HGNC CDTYPE:MODULATION INHIBITION CDTYPE:INHIBITION INHIBITION CDTYPE:INHIBITION Claudin1 Claudin1 19153598 pubmed LAMA2 LAMA2 17673906 pubmed Latency_associated_protein__hm2_at_Extracellular_space Latency_associated_protein__hm2_at_Extracellular_space 17353278 pubmed TGFB1_hm2_at_Extracellular_space TGFB1_hm2_at_Extracellular_space JAM1 JAM1 CDTYPE:PHYSICAL_STIMULATION MMP9 MMP9 16847462 pubmed CDTYPE:PHYSICAL_STIMULATION INHIBITION CDTYPE:INHIBITION CDTYPE:PHYSICAL_STIMULATION LIMK1_2 LIMK1_2 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION TWIST2 TWIST2 CDTYPE:PHYSICAL_STIMULATION CDTYPE:PHYSICAL_STIMULATION ADP ADP WNT2B HGNC CDKN2A CDKN2A ITGAV HGNC ATP ATP ITGB5 HGNC WNT11 HGNC DSP HGNC AKT1 AKT1 ITGB3 HGNC Fibronectin Fibronectin EG_VEGF EG_VEGF INHIBITION CDTYPE:INHIBITION WNT16 HGNC PROK1 HGNC GRB2 HGNC PDGFRB HGNC ITGB2 HGNC 16292343 pubmed BAIAP2 HGNC TWIST1 HGNC 19010789 pubmed 9670020 pubmed CDTYPE:PHYSICAL_STIMULATION COL4A2 HGNC 15383321 pubmed ACTIVATION CDTYPE:CATALYSIS ITGB1 ITGB1 ITGA1 ITGA1 19020303 pubmed Collagen1_partners Collagen1_partners ITGB1 ITGB1 ITGB1 ITGB1 ITGB4 ITGB4 ITGA7_ITGB1 ITGA7_ITGB1 ITGA7 ITGA7 ITGB1_at_Extracellular_space ITGB1_at_Extracellular_space MAP3K11 MAP3K11 ITGA6 ITGA6 ITGA5_at_Extracellular_space ITGA5_at_Extracellular_space RUNX2 HGNC 9832503 pubmed ITGA4 ITGA4 CDC42EP2 HGNC ITGB7 ITGB7 ITGB1 ITGB1 ITGA2 ITGA2 ITGB3 ITGB3 ITGA2B ITGA2B ITGB1 ITGB1 ITGA3 ITGA3 ACTIVATION CDTYPE:UNKNOWN_CATALYSIS PAK4 PAK4 TJP2 HGNC PRKCE HGNC ACTIVATION CDTYPE:CATALYSIS 14557817 pubmed CLDN3 HGNC TWIST1 TWIST1 17699774 pubmed 10421629 pubmed GJA3 GJA3 GJA4 GJA4 MAP3K10 HGNC PARD6A PARD6A TGFBR1_hm2 TGFBR1_hm2 Occludin__PARD6A_TGFB1_TGFBR1_TGFBR2 Occludin__PARD6A_TGFB1_TGFBR1_TGFBR2 GJA1 GJA1 TGFBR2_hm2 TGFBR2_hm2 Claudin19 Claudin19 Claudin18 Claudin18 Occludin Occludin WNK4 WNK4 PI_3_P PI_3_P LYRIC LYRIC TGFB1_hm2_active TGFB1_hm2_active TGFBR1_Ser_pho_hm2_active TGFBR1_Ser_pho_hm2_active PARD6A_S345_pho_active PARD6A_S345_pho_active TGFBR2_Ser_pho_hm2 TGFBR2_Ser_pho_hm2 PARD6A PARD6A Occludin Occludin ARHGDIB HGNC EZH1 EZH1 EZH1 EZH1 16443747 pubmed NICD NICD WNT WNT SMURF1 SMURF1 PARD6A_S345_pho_active PARD6A_S345_pho_active SMURF1 SMURF1 KRT14 KRT14 SMAD3_SMAD4_SP1 SMAD3_SMAD4_SP1 RHOA RHOA LEF1 LEF1 JAM1 JAM1 MMP12 MMP12 Formin Formin 15252039 pubmed Catenin Catenin PTPN11 PTPN11 21209780 pubmed 11955436 pubmed c_SRC c_SRC BCL2 HGNC RHOA RHOA AXIN2 HGNC INHIBITION CDTYPE:UNKNOWN_INHIBITION Claudin16 Claudin16 Claudin11 Claudin11 Claudin14 Claudin14 COL1A2 COL1A2 Plasmin Plasmin Cingulin Cingulin MPDZ MPDZ Claudin5 Claudin5 Claudin8 Claudin8 Claudin1 Claudin1 Claudin2 Claudin2 MAP2K1 HGNC EMILIN1 EMILIN1 8900189 pubmed ARHGEF1 ARHGEF1 RAP1GDS1 RAP1GDS1 PLD1 PLD1 ITGB5 ITGB5 IGF1R IGF1R IGF1 IGF1 GNG HGNC ARHGEF27 ARHGEF27 KIFAP3 KIFAP3 EPHA2 EPHA2 Epherin_family Epherin_family ID1 ID1 PTK6 PTK6 BCR HGNC ARHGEF12 ARHGEF12 12354099 pubmed MyosinLC MyosinLC p120 p120 CK1_alpha CK1_alpha _alpha__Catenin _alpha__Catenin PARD6G PARD6G ARHGAP26 ARHGAP26 MYO9B MYO9B COL4A3 HGNC MIR30E HGNC PKP4 HGNC FYN FYN RASA1 RASA1 ARHGAP17 ARHGAP17 ARHGAP31 ARHGAP31 DOCK6 DOCK6 FGD1 FGD1 DOCK11 DOCK11 DOCK9 DOCK9 SPATA13 SPATA13 FGD4 FGD4 ARHGAP5 ARHGAP5 GJB2 HGNC TRAF6 HGNC MYH4 HGNC PKP3 HGNC Desmoglein3 Desmoglein3 MYH3 HGNC PKP2 HGNC MYH2 HGNC PKP1 HGNC MYH1 HGNC ARHGEF3 ARHGEF3 RHOB RHOB INHIBITION CDTYPE:UNKNOWN_INHIBITION DEF6 DEF6 PKP4 HGNC PKN1 PKN1 LCP2 HGNC ARHGAP35 HGNC RHPN2 RHPN2 RTKN RTKN 15337769 pubmed MYH9 HGNC ARHGEF10L ARHGEF10L MYH8 HGNC MYH7 HGNC DIAPH3 DIAPH3 MYH6 HGNC DIAPH1 DIAPH1 10940259 pubmed PLCE1 PLCE1 15448698 pubmed PPP1CA PPP1CA Desmoplakin Desmoplakin 9069260 pubmed CD19 CD19 CD3 CD3 MCF2 MCF2 PGGT1B PGGT1B 21540285 pubmed ARHGEF31 ARHGEF31 TNK2 TNK2 PGGT1B PGGT1B ARHGDIG ARHGDIG BNIP2 BNIP2 FGFR1 FGFR1 DLC1 DLC1 TIAM1 TIAM1 DEF6 DEF6 ITGA1 ITGA1 SOS1 HGNC Caspase1 Caspase1 ARHGDIB ARHGDIB ARHGDIA ARHGDIA GJC1 HGNC IGF_binding_partners IGF_binding_partners VAV1 VAV1 VAV2 VAV2 Caspase3 Caspase3 EZR EZR LCP2 LCP2 ZAP70 ZAP70 ARHGEF2 ARHGEF2 PLCE1 PLCE1 ARHGEF4 ARHGEF4 ITGB3 HGNC ITGAL ITGAL 8836113 pubmed Formin Formin 10467124 pubmed GJB2 HGNC BCR BCR RACGAP1 RACGAP1 ARHGAP32 ARHGAP32 MIR25 MIR25 CHN2 CHN2 ARHGAP12 ARHGAP12 ARHGAP24 ARHGAP24 ARHGAP14 ARHGAP14 PARD6G HGNC CCNE1 HGNC CIR1 CIR1 R_Cadherin R_Cadherin 21123622 pubmed GJA5 HGNC GJA1 HGNC GTP GTP PLC_beta PLC_beta ACTIVATION CDTYPE:CATALYSIS PRKCD PRKCD DAG DAG 19825827 pubmed 11133108 pubmed ARHGAP24 HGNC 21195665 pubmed MMP12 HGNC NGEF HGNC PLC_beta PLC_beta _G_alpha__PLC_beta _G_alpha__PLC_beta _G_alpha__GTP _G_alpha__GTP G_alpha G_alpha ITGAV ITGAV GJD2 HGNC 12432077 pubmed G_beta G_beta G_alpha G_alpha CDTYPE:PHYSICAL_STIMULATION WNT WNT ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS Endothelin1 Endothelin1 Endothelin1 Endothelin1 _Endotherin1_Endotherin_A_receptor _Endotherin1_Endotherin_A_receptor EDNRA EDNRA ACTIVATION CDTYPE:CATALYSIS _Endotherin_A_receptor_G_proteins _Endotherin_A_receptor_G_proteins ACTIVATION CDTYPE:CATALYSIS GDP GDP ACTIVATION CDTYPE:CATALYSIS CLDN18 HGNC G_gamma G_gamma 10318916 pubmed 21776389 pubmed AXIN2_at_Nucleus AXIN2_at_Nucleus MKNK2 MKNK2 AXIN2_GSK3_beta AXIN2_GSK3_beta GSK3_beta___at_Nucleus GSK3_beta___at_Nucleus KRT19 HGNC ITGA4 HGNC CCNE1 HGNC G_gamma G_gamma G_beta G_beta GDP GDP _Frizzled_G_proteins _Frizzled_G_proteins G_alpha G_alpha FZD FZD ITGB3 HGNC LRP5_6 LRP5_6 _Dishevelled_Frizzled_WNT_LRP _Dishevelled_Frizzled_WNT_LRP NISCH HGNC CGN HGNC PIK3C2B HGNC MMP3 HGNC PIK3C2A HGNC ETS1 ETS1 AXIN1 HGNC PARD6A HGNC DVL1 DVL1 ACTIVATION CDTYPE:CATALYSIS WNT WNT LRP5_6 LRP5_6 PARD6B HGNC FZD FZD AXIN2 AXIN2 PARD6G HGNC AXIN2 AXIN2 AXIN2 AXIN2 LRP5_6 LRP5_6 FZD FZD MYL10 HGNC 20519943 pubmed ACTIVATION CDTYPE:CATALYSIS I_1_4_5_P3 I_1_4_5_P3 _Frizzled_WNT_LRP _Frizzled_WNT_LRP GTP GTP ACTIVATION CDTYPE:CATALYSIS G_alpha G_alpha P_Cadherin P_Cadherin _G_beta__G_gamma _G_beta__G_gamma DSC2 HGNC G_gamma G_gamma G_beta G_beta WNT9B HGNC ITGAV ITGAV 18719708 pubmed ITGAV_ITGB8 ITGAV_ITGB8 ITGB6 ITGB6 UBE2D2 HGNC ITGAV ITGAV MMP2 HGNC ITGAV_ITGB6 ITGAV_ITGB6 ITGB5 ITGB5 EGF HGNC ITGAV ITGAV ITGAV_ITGB5 ITGAV_ITGB5 ACTIVATION CDTYPE:CATALYSIS ITGAV_at_Extracellular_space ITGAV_at_Extracellular_space ITGB3_at_Extracellular_space ITGB3_at_Extracellular_space WNT9A HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS Claudin2 Claudin2 MAPK13 HGNC MAPK14 HGNC TIP60 TIP60 ITGAV ITGAV ITGB1 ITGB1 ITGAV_ITGB3 ITGAV_ITGB3 ITGB2 ITGB2 ITGAL_ITGB2 ITGAL_ITGB2 ITGAV_ITGB1 ITGAV_ITGB1 ITGAL ITGAL ITGAX_ITGB2 ITGAX_ITGB2 EG_VEGF EG_VEGF MYH3 HGNC 19920116 pubmed ITGAX ITGAX ITGB2 ITGB2 CDTYPE:PHYSICAL_STIMULATION INHIBITION CDTYPE:INHIBITION CDTYPE:PHYSICAL_STIMULATION SMAD4 SMAD4 16510505 pubmed ITGAM ITGAM 10769036 pubmed ITGAM_ITGB2 ITGAM_ITGB2 ITGB2 ITGB2 ITGAD ITGAD WNT7A HGNC ITGAE ITGAE ITGB7 ITGB7 ITGAE_ITGB7 ITGAE_ITGB7 WNT7B HGNC ITGB2 ITGB2 ITGAD_ITGB2 ITGAD_ITGB2 MIR34A MIR34A ITGB1 ITGB1 ITGA10 ITGA10 9159130 pubmed ITGA9_ITGB1 ITGA9_ITGB1 ITGB1 ITGB1 ITGA9 ITGA9 ITGB1 ITGB1 ITGA11 ITGA11 ITGA11_ITGB1 ITGA11_ITGB1 WNT8B HGNC ITGA10_ITGB1 ITGA10_ITGB1 WNT8A HGNC ITGB1 ITGB1 11729192 pubmed IGF1 IGF1 ITGA6 ITGA6 ETS1 HGNC CLDN8 HGNC ITGB7 HGNC Vinculin Vinculin ITGB1 ITGB1 ITGA4 ITGA4 I_SMAD I_SMAD Claudin7 Claudin7 JUP HGNC CDC25A HGNC Laminin8 Laminin8 a6b1__a6b4 a6b1__a6b4 Laminin1 Laminin1 LAMC2 LAMC2 LAMC3 LAMC3 LAMB4 LAMB4 LAMC1 LAMC1 WNT5A HGNC WNT5B HGNC Laminin8__a6b1__a6b4 Laminin8__a6b1__a6b4 Laminin1__a2b1__a3b1 Laminin1__a2b1__a3b1 MTDH HGNC aVb3__aVb5__at_Extracellular_space aVb3__aVb5__at_Extracellular_space PIK3C3 HGNC Vitronectin__at_Extracellular_space Vitronectin__at_Extracellular_space CHN2 HGNC LAMA2 LAMA2 LAMA3 LAMA3 aVb3__aVb5 aVb3__aVb5 Vitronectin__aVb3__aVb5 Vitronectin__aVb3__aVb5 Vitronectin Vitronectin LAMB1 LAMB1 LAMB2 LAMB2 LAMB3 LAMB3 HIF1B HIF1B SIN3A HGNC CLDN3 HGNC COL4A1_at_Extracellular_space COL4A1_at_Extracellular_space Fibronectin__a5b1__aVb3 Fibronectin__a5b1__aVb3 N_WASP N_WASP a2b1__a3b1__at_Extracellular_space a2b1__a3b1__at_Extracellular_space Fibronectin__at_Extracellular_space Fibronectin__at_Extracellular_space aVb3__aVb5 aVb3__aVb5 Fibronectin Fibronectin a5b1__aVb3 a5b1__aVb3 WNT3A HGNC a5b1__aVb3__at_Extracellular_space a5b1__aVb3__at_Extracellular_space MMP13 MMP13 TCF3 HGNC Actinin Actinin ITGA4 HGNC CHN2 HGNC c_SRC c_SRC 12556535 pubmed COL4A2 HGNC COL4A1 HGNC ITGB8 ITGB8 PI_3_4_5_P3 PI_3_4_5_P3 Collagen1 Collagen1 COL4A1_a2b1__a3b1 COL4A1_a2b1__a3b1 PI_4_5_P2 PI_4_5_P2 a1b1__a2b1 a1b1__a2b1 Collagen1__a1b1__a2b1 Collagen1__a1b1__a2b1 a1b1__a2b1__at_Extracellular_space a1b1__a2b1__at_Extracellular_space INHIBITION CDTYPE:INHIBITION CFL1 CFL1 MMP14 HGNC MAPK11 HGNC PI_3_P PI_3_P Collagen1__at_Extracellular_space Collagen1__at_Extracellular_space CDTYPE:PHYSICAL_STIMULATION MAPK12 HGNC PI_3_4_P2 PI_3_4_P2 a2b1__a3b1 a2b1__a3b1 CDTYPE:PHYSICAL_STIMULATION COL4A4 HGNC a2b1__a3b1__at_Extracellular_space a2b1__a3b1__at_Extracellular_space COL4A3 HGNC COL4A6 HGNC CDTYPE:PHYSICAL_STIMULATION COL4A5 HGNC INHIBITION CDTYPE:INHIBITION 11018042 pubmed 17550342 pubmed LEF1 LEF1