PPARG PPARG MEL_18 MEL_18 BAF250 BAF250 MXD3 HGNC SSR4 HGNC BRCA1 BRCA1 12527885 pubmed module_CYCLINB module_CYCLINB Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr KNTC2 KNTC2 module_CYCLINA module_CYCLINA Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr TYMS HGNC module_CYCLIND module_CYCLIND Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr module_CYCLINC module_CYCLINC Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr RPA2 RPA2 module_CYCLINE module_CYCLINE Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr BTRC BTRC ZNF451 ZNF451 WDR36 WDR36 SIVA1 HGNC CDC25A HGNC module_CYCLINH module_CYCLINH Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr MCAM MCAM 8832394 pubmed CSDA CSDA 15133492 pubmed 16580749 pubmed 10998368 pubmed module_P21CIP module_P21CIP Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr CDK1 CDK1 8380224 pubmed TUBA1A HGNC PCNA PCNA POLA2 HGNC POLA1 HGNC CDCA4 HGNC RBBP4 HGNC 15829956 pubmed SLC25A14 SLC25A14 16135794 pubmed RBM25 HGNC PRKDC PRKDC CBP CBP 9268380 pubmed 1384126 pubmed SOAT2 SOAT2 1510543 pubmed DUSP2 DUSP2 EXOSC8 HGNC CyclinA2 CyclinA2 TP53 HGNC MAD2L1 HGNC ACTIVATION CDTYPE:CATALYSIS HDAC1 HDAC1 16325355 pubmed SNRPE SNRPE TP73 HGNC E2F1_alone E2F1_alone CDT1 HGNC CYC1 HGNC 12851486 pubmed AKT1 HGNC 16741925 pubmed RBBP8 RBBP8 11937641 pubmed CHEK2 CHEK2 MNAT1 MNAT1 8119945 pubmed 12150994 pubmed 9736735 pubmed 11034215 pubmed WEE1 WEE1 PMAIP1 HGNC ACTIVATION CDTYPE:CATALYSIS 10753885 pubmed 12838312 pubmed MOD:00696 MOD FBXO5 FBXO5 15782160 pubmed CDC25C CDC25C CyclinH CyclinH CDK7 CDK7 BCL2L11 BCL2L11 ACTIVATION CDTYPE:CATALYSIS 10567569 pubmed E2F6 HGNC 15769944 pubmed MCM6 MCM6 HRK HGNC 16179649 pubmed 8348613 pubmed CSTF1 CSTF1 RPL32 HGNC AXIN2 AXIN2 p14ARF p14ARF MTHFD1 MTHFD1 15210709 pubmed 14990995 pubmed MELK MELK 11598127 pubmed MYCN HGNC 12444919 pubmed 12717421 pubmed RBM25 RBM25 15361834 pubmed NBS1 NBS1 11090622 pubmed SERTAD1 HGNC p14ARF__at_Nucleus p14ARF__at_Nucleus 16732330 pubmed p16INK4A p16INK4A 12909625 pubmed SERTAD1 SERTAD1 TP53INP1 TP53INP1 map_cellcycle map_cellcycle Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr CSTF1 HGNC GSK3_beta GSK3_beta H19 H19 AKT1 AKT1 GSK3_beta GSK3_beta 15580623 pubmed MDM2 MDM2 ACTN4 ACTN4 MDM2 MDM2 ECE1 HGNC MCM7 MCM7 11331603 pubmed ATM ATM RBL1 RBL1 E2F2_alone E2F2_alone CDKN1A HGNC PPP1R2 HGNC E2F1_alone E2F1_alone E2F_Family E2F_Family This is a CellDesigner UNKNOWN entity. E2F3_alone E2F3_alone ANAPC2 HGNC E2F7 E2F7 PMAIP1 PMAIP1 SNRPE SNRPE ANAPC1 HGNC p53 p53 ANAPC7 HGNC UHRF1 HGNC ANAPC4 HGNC ANAPC5 HGNC LGALS1 HGNC p21CIP1 p21CIP1 p53 p53 CHEK1 CHEK1 CHEK2 CHEK2 ATR ATR p68 p68 RRM1 RRM1 SLC25A14 HGNC CES1 HGNC RRM2 RRM2 RING1 RING1 CES2 HGNC PBK PBK CLSPN CLSPN RPL32 RPL32 CES3 HGNC GTF2H2B HGNC GTF2H2C HGNC GTF2H2D HGNC 9190208 pubmed DP1 DP1 11237530 pubmed DP1 DP1 E2F4 E2F4 MNAT1 MNAT1 UBB HGNC DP2 DP2 7681363 pubmed E2F1 HGNC 16135806 pubmed CSDA HGNC BTRC HGNC 16792505 pubmed 12478465 pubmed E2F4 E2F4 CDKN2C HGNC 15713665 pubmed 15464731 pubmed FGFR1 HGNC CASP9 HGNC TP53 HGNC PLAU PLAU UBB UBB Tubulin__alpha_1A Tubulin__alpha_1A TRIM55 TRIM55 TYMS TYMS WWOX WWOX ZNF83 ZNF83 ZNF451 ZNF451 WDR36 WDR36 Homo sapiens CyclinE CyclinE SPAG7 SPAG7 16782892 pubmed CCNA2 HGNC WEE1 HGNC 12214268 pubmed CCNA1 HGNC SRPR SRPR SSR4 SSR4 THEM2 THEM2 TP53INP1 TP53INP1 SUZ12 SUZ12 STMN1 STMN1 CCND3 HGNC TOP2A TOP2A CCND2 HGNC UHRF1 UHRF1 CCND1 HGNC TP53BP2 TP53BP2 SIN3B HGNC TOPBP1 TOPBP1 NRP1 NRP1 PLAU PLAU 15140942 pubmed p53 p53 NBS1 NBS1 CBX5 CBX5 p53 p53 CCNE1 HGNC CDKN1B HGNC SLC3A2 SLC3A2 module_P27KIP module_P27KIP Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr SLC25A14 SLC25A14 SNX19 SNX19 SOAT2 SOAT2 ECE1 ECE1 p27KIP1 p27KIP1 FOXO3 FOXO3 SIVA1 SIVA1 CDK7 HGNC FOXO1 FOXO1 CyclinE CyclinE TK1 TK1 CHEK1 CHEK1 CHEK1 CHEK1 ATM ATM p73 p73 UDG1A UDG1A SKP2 SKP2 TERT TERT 12459251 pubmed DUSP2 DUSP2 11883315 pubmed MCM8 MCM8 miR_17_92 miR_17_92 CDK2_CyclinA__p130 CDK2_CyclinA__p130 CDK2_CyclinA__p107 CDK2_CyclinA__p107 DP1__E2F1_PCAF DP1__E2F1_PCAF FOXO3 HGNC DP1__E2F6 DP1__E2F6 p130__pho_at_Nucleus p130__pho_at_Nucleus p107__at_Nucleus p107__at_Nucleus ATM_NBS1 ATM_NBS1 BAF250__DP1__E2F1_HDAC1_RB1_SUV39H1 BAF250__DP1__E2F1_HDAC1_RB1_SUV39H1 BMI1_MEL_18__PHC1_RING1_RYBP BMI1_MEL_18__PHC1_RING1_RYBP MDM2 HGNC RBBP4 RBBP4 CDK2_Thr160_pho_at_Nucleus CDK2_Thr160_pho_at_Nucleus CyclinE__at_Nucleus CyclinE__at_Nucleus TOPBP1 TOPBP1 ACTG1 ACTG1 CyclinE__at_Nucleus CyclinE__at_Nucleus p130__pho_at_Nucleus p130__pho_at_Nucleus CyclinE1 CyclinE1 CDK2_Thr160_pho_at_Nucleus CDK2_Thr160_pho_at_Nucleus EED EED 10733529 pubmed PKMYT1 PKMYT1 CCNA2 HGNC PURA HGNC CyclinA__at_Nucleus CyclinA__at_Nucleus CDK2_at_Nucleus CDK2_at_Nucleus p107__at_Nucleus p107__at_Nucleus CyclinA__at_Nucleus CyclinA__at_Nucleus CDK2_at_Nucleus CDK2_at_Nucleus p21CIP1 p21CIP1 8741839 pubmed BARD1 HGNC CDK1 HGNC 15897325 pubmed E2F8 HGNC TK1 TK1 ATM ATM METAP2 METAP2 CDC20 CDC20 PURALPHA PURALPHA CDCA4 CDCA4 MCM3 HGNC CDCA7 CDCA7 UXT UXT 1717476 pubmed BMI1 BMI1 BRD7 BRD7 RQCD1 RQCD1 JMY JMY FGFR2 FGFR2 16984923 pubmed RBL1 HGNC 16107498 pubmed 8137237 pubmed CyclinC CyclinC PPP1R13B PPP1R13B 11520855 pubmed RPL8 RPL8 15024084 pubmed 12077144 pubmed CDKN2B HGNC E2F1 HGNC 15107615 pubmed 9425340 pubmed JPH2 JPH2 8078588 pubmed TP53IN91 HGNC 11157749 pubmed TERT HGNC CCNC HGNC 15798220 pubmed MEL_18__at_Nucleus MEL_18__at_Nucleus E2F1 E2F1 p107 p107 DP1__E2F1 DP1__E2F1 12089160 pubmed 11171983 pubmed APC_C__CDC20 APC_C__CDC20 CDK1 CDK1 DP1__E2F1_TOPBP1 DP1__E2F1_TOPBP1 CyclinE CyclinE CDK1_CyclinB CDK1_CyclinB CDK2_CyclinE__p27KIP1 CDK2_CyclinE__p27KIP1 CDK2_CyclinE CDK2_CyclinE CDK2_CyclinA__p27KIP1 CDK2_CyclinA__p27KIP1 MGA HGNC CNAP1 CNAP1 COX4I1 HGNC E2F1 E2F1 MGA_at_Nucleus MGA_at_Nucleus CDK1_CyclinB CDK1_CyclinB RYBP_at_Nucleus RYBP_at_Nucleus CDK1_CyclinB CDK1_CyclinB CDK1_CyclinB CDK1_CyclinB CDK6_CyclinD CDK6_CyclinD CDK1_CyclinB CDK1_CyclinB HDAC1 HDAC1 CDK7_CyclinH__MNAT1 CDK7_CyclinH__MNAT1 RING1_at_Nucleus RING1_at_Nucleus E2F6 E2F6 SKP2 HGNC CDK6_CyclinD__p27KIP1 CDK6_CyclinD__p27KIP1 CDK7_CyclinH__MNAT1 CDK7_CyclinH__MNAT1 CDK4_CyclinD__p27KIP1 CDK4_CyclinD__p27KIP1 CDK4_CyclinD CDK4_CyclinD E2F8 HGNC 15494392 pubmed GSK3_beta GSK3_beta 16144839 pubmed JPH2 HGNC CDC37_CDK4 CDC37_CDK4 METAP2 HGNC CDK4_CyclinD CDK4_CyclinD CDC37_CDK4_HSP90 CDC37_CDK4_HSP90 CDK4_CyclinD CDK4_CyclinD CDK6_CyclinD CDK6_CyclinD CDK6_p16INK4A CDK6_p16INK4A CDK4_p16INK4A CDK4_p16INK4A CDK4_p15INK4B CDK4_p15INK4B CDK4_CyclinD CDK4_CyclinD CDC37_HSP90 CDC37_HSP90 CLSPN CLSPN MYCN MYCN 8618861 pubmed Caspase3 Caspase3 15195143 pubmed CDK6_p15INK4B CDK6_p15INK4B CDK1_CyclinB CDK1_CyclinB E2F1 E2F1 CDK1_CyclinB CDK1_CyclinB CDK1_CyclinB CDK1_CyclinB CDK6_at_Nucleus CDK6_at_Nucleus CyclinD__at_Nucleus CyclinD__at_Nucleus CDK6_CyclinD__p21CIP1 CDK6_CyclinD__p21CIP1 p21CIP1__at_Nucleus p21CIP1__at_Nucleus CDK1_CyclinB CDK1_CyclinB PCNA_p21CIP1 PCNA_p21CIP1 ACTIVATION CDTYPE:CATALYSIS PSMA4 PSMA4 NRP1 NRP1 CDT1 CDT1 p21CIP1__at_Nucleus p21CIP1__at_Nucleus 11274364 pubmed CyclinD__at_Nucleus CyclinD__at_Nucleus MOD:00394 MOD MYBL2 MYBL2 MCM3 MCM3 MLH1 MLH1 KPNA2 KPNA2 ACTN4 HGNC CDK4_at_Nucleus CDK4_at_Nucleus CDK4_CyclinD__p21CIP1 CDK4_CyclinD__p21CIP1 CDK2_Thr160_pho_at_Nucleus CDK2_Thr160_pho_at_Nucleus CDK2_CyclinE__p21CIP1 CDK2_CyclinE__p21CIP1 CyclinE__at_Nucleus CyclinE__at_Nucleus CDK2_CyclinA__p21CIP1 CDK2_CyclinA__p21CIP1 EXOSC8 EXOSC8 SRPR SRPR BUB1 HGNC ACTIVATION CDTYPE:CATALYSIS STMN1 STMN1 ACTIVATION CDTYPE:CATALYSIS CyclinA__at_Nucleus CyclinA__at_Nucleus p21CIP1__at_Nucleus p21CIP1__at_Nucleus p27KIP1 p27KIP1 10030670 pubmed CyclinB__at_Nucleus CyclinB__at_Nucleus 12438307 pubmed CDK1_CyclinB__p21CIP1 CDK1_CyclinB__p21CIP1 DUSP2 HGNC TYMS TYMS 9836640 pubmed CDK1_Thr161_pho_at_Nucleus CDK1_Thr161_pho_at_Nucleus 1828290 pubmed BMI1 BMI1 MDM2 MDM2 PSMA4 HGNC ACTIVATION CDTYPE:CATALYSIS 8428594 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 15838517 pubmed 15838516 pubmed RPL32 RPL32 12411508 pubmed ZNF83 ZNF83 PNRC2 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 15470680 pubmed E2F5 HGNC PLK1 HGNC CDC20 HGNC ACR HGNC 15574337 pubmed RB1_pho_at_Nucleus RB1_pho_at_Nucleus E2F1_at_Nucleus E2F1_at_Nucleus BAF250__at_Nucleus BAF250__at_Nucleus DP1__at_Nucleus DP1__at_Nucleus HDAC1_at_Nucleus HDAC1_at_Nucleus E2F1_at_Nucleus E2F1_at_Nucleus RB1_pho_pho_at_Nucleus RB1_pho_pho_at_Nucleus BAF250__at_Nucleus BAF250__at_Nucleus DP1__at_Nucleus DP1__at_Nucleus p16INK4A p16INK4A 16582100 pubmed SLC3A2 HGNC 11063929 pubmed 9733514 pubmed CES4A HGNC 9733515 pubmed DP1__at_Nucleus DP1__at_Nucleus 1501447 pubmed SUV39H1_at_Nucleus SUV39H1_at_Nucleus HDAC1_at_Nucleus HDAC1_at_Nucleus BAF250__at_Nucleus BAF250__at_Nucleus EZH2 EZH2 EPC1 EPC1 DP1__at_Nucleus DP1__at_Nucleus E2F1_at_Nucleus E2F1_at_Nucleus RB1_at_Nucleus RB1_at_Nucleus PPP1R13B HGNC DDX11 HGNC HP1gamma__at_Nucleus HP1gamma__at_Nucleus MCM5 MCM5 MCM5 HGNC 15456846 pubmed TOP2A HGNC BAF250__at_Nucleus BAF250__at_Nucleus HP1gamma__at_Nucleus HP1gamma__at_Nucleus ARID1A HGNC SUV39H1_at_Nucleus SUV39H1_at_Nucleus HDAC1_at_Nucleus HDAC1_at_Nucleus E2F4_at_Nucleus E2F4_at_Nucleus p107__pho_at_Nucleus p107__pho_at_Nucleus SUV39H1_at_Nucleus SUV39H1_at_Nucleus E2F1_at_Nucleus E2F1_at_Nucleus RB1_at_Nucleus RB1_at_Nucleus HDAC1_at_Nucleus HDAC1_at_Nucleus DP2__at_Nucleus DP2__at_Nucleus SUV39H1_at_Nucleus SUV39H1_at_Nucleus SUV39H1_at_Nucleus SUV39H1_at_Nucleus DP2__at_Nucleus DP2__at_Nucleus HDAC1_at_Nucleus HDAC1_at_Nucleus DP2__at_Nucleus DP2__at_Nucleus FOXO1 HGNC POLA POLA p107__at_Nucleus p107__at_Nucleus SERTAD1 SERTAD1 E2F4_at_Nucleus E2F4_at_Nucleus SNRPE HGNC DP1__at_Nucleus DP1__at_Nucleus E2F4_at_Nucleus E2F4_at_Nucleus E2F1_at_Nucleus E2F1_at_Nucleus p130__pho_at_Nucleus p130__pho_at_Nucleus E2F4_at_Nucleus E2F4_at_Nucleus 15121871 pubmed DP2__at_Nucleus DP2__at_Nucleus E2F1_pho_Lys_ace_at_Nucleus E2F1_pho_Lys_ace_at_Nucleus DP1__pho_at_Nucleus DP1__pho_at_Nucleus CES5A HGNC MCAM HGNC E2F1_Lys_ace_at_Nucleus E2F1_Lys_ace_at_Nucleus DP1__at_Nucleus DP1__at_Nucleus DP1__at_Nucleus DP1__at_Nucleus E2F1_at_Nucleus E2F1_at_Nucleus RB1_at_Nucleus RB1_at_Nucleus E2F1_Lys_ace_at_Nucleus E2F1_Lys_ace_at_Nucleus BAF250__DP1__E2F1_HDAC1_RB1 BAF250__DP1__E2F1_HDAC1_RB1 DP1__at_Nucleus DP1__at_Nucleus HDAC1_at_Nucleus HDAC1_at_Nucleus BAF250__at_Nucleus BAF250__at_Nucleus APC_C APC_C E2F1_at_Nucleus E2F1_at_Nucleus DP1__at_Nucleus DP1__at_Nucleus E2F4_at_Nucleus E2F4_at_Nucleus E2F6_at_Nucleus E2F6_at_Nucleus DP1__at_Nucleus DP1__at_Nucleus p130__at_Nucleus p130__at_Nucleus EPC1_at_Nucleus EPC1_at_Nucleus 9556498 pubmed 15304485 pubmed 15456871 pubmed CDK2_CyclinE CDK2_CyclinE 15033491 pubmed 9632134 pubmed DP1__E2F1 DP1__E2F1 RB1_at_Nucleus RB1_at_Nucleus CDK2_CyclinA CDK2_CyclinA DP1__E2F1_RB1 DP1__E2F1_RB1 PHC1_at_Nucleus PHC1_at_Nucleus DP1__E2F1_RB1 DP1__E2F1_RB1 BMI1_at_Nucleus BMI1_at_Nucleus RBL1 HGNC RING1_at_Nucleus RING1_at_Nucleus CDK3_CyclinC CDK3_CyclinC MEL_18__at_Nucleus MEL_18__at_Nucleus DP1__E2F1 DP1__E2F1 DP2__at_Nucleus DP2__at_Nucleus RYBP_at_Nucleus RYBP_at_Nucleus BMI1_at_Nucleus BMI1_at_Nucleus DP2 DP2 E2F6_at_Nucleus E2F6_at_Nucleus BAF250 BAF250 CDK2_CyclinA CDK2_CyclinA CHEK2 HGNC MDM2_p53 MDM2_p53 MDM2_p14ARF MDM2_p14ARF DP1__p14ARF DP1__p14ARF DIRAS3 DIRAS3 E2F8 E2F8 E2F1_p14ARF E2F1_p14ARF PHC1_at_Nucleus PHC1_at_Nucleus DP1__E2F1_PCAF DP1__E2F1_PCAF PLAU HGNC DP1__E2F1 DP1__E2F1 MCL1 MCL1 CDK4_CyclinD__p27KIP1 CDK4_CyclinD__p27KIP1 12766152 pubmed CDK6_CyclinD__p27KIP1 CDK6_CyclinD__p27KIP1 CDK2_CyclinE CDK2_CyclinE CDK4 CDK4 CDK2_CyclinE CDK2_CyclinE CyclinA CyclinA CDK2 CDK2 CDK6 CDK6 CyclinD CyclinD APC_C__at_Nucleus APC_C__at_Nucleus CDC20_pho_at_Nucleus CDC20_pho_at_Nucleus APC_C__at_Nucleus APC_C__at_Nucleus MYC HGNC SIVA1 SIVA1 p300 p300 CBP CBP SUV39H1 SUV39H1 JMY HGNC module_CDC25 module_CDC25 Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr CyclinE__at_Nucleus CyclinE__at_Nucleus ATP5J ATP5J CDK2_Tyr14_pho_Tyr15_pho_at_Nucleus CDK2_Tyr14_pho_Tyr15_pho_at_Nucleus CyclinE__Thr380_pho_at_Nucleus CyclinE__Thr380_pho_at_Nucleus CDK2_Thr160_pho_at_Nucleus CDK2_Thr160_pho_at_Nucleus CDK2_at_Nucleus CDK2_at_Nucleus DP1__at_Nucleus DP1__at_Nucleus 10778858 pubmed 15105433 pubmed KAT2B HGNC 16775416 pubmed 7629134 pubmed PCNA_at_Nucleus PCNA_at_Nucleus MDM2_at_Nucleus MDM2_at_Nucleus p53__at_Nucleus p53__at_Nucleus CDK2_at_Nucleus CDK2_at_Nucleus CyclinA__at_Nucleus CyclinA__at_Nucleus FGFR2 HGNC CyclinD__at_Nucleus CyclinD__at_Nucleus CDK6_at_Nucleus CDK6_at_Nucleus 12836612 pubmed PBK PBK CDK6 HGNC DP1 DP1 15105421 pubmed CyclinE__at_Nucleus CyclinE__at_Nucleus EED HGNC CyclinD__at_Nucleus CyclinD__at_Nucleus CyclinD__at_Nucleus CyclinD__at_Nucleus CDK4_Thr172_pho_at_Nucleus CDK4_Thr172_pho_at_Nucleus E2F1_at_Nucleus E2F1_at_Nucleus CDK4_at_Nucleus CDK4_at_Nucleus phosphorylated 9843217 pubmed Caspase8 Caspase8 CDK6_Thr_pho_at_Nucleus CDK6_Thr_pho_at_Nucleus 11158323 pubmed 9372959 pubmed CyclinD__at_Nucleus CyclinD__at_Nucleus DBF4 DBF4 DBF4 HGNC 15706352 pubmed CCND3 HGNC CDK1_Tyr15_pho_at_Cytoplasm CDK1_Tyr15_pho_at_Cytoplasm CyclinB__at_Cytoplasm CyclinB__at_Cytoplasm E2F6_at_Nucleus E2F6_at_Nucleus 7606716 pubmed CyclinD3 CyclinD3 E2F1 E2F1 p107 p107 WDR36 HGNC CyclinA2 CyclinA2 ATP5J ATP5J 17178835 pubmed APAF1 APAF1 ACTN4 ACTN4 ACTG1 ACTG1 CBX5 CBX5 BCL2L11 BCL2L11 BBC3 BBC3 AXIN2 AXIN2 E2F7 HGNC E2F6_at_Nucleus E2F6_at_Nucleus MGA_at_Nucleus MGA_at_Nucleus MAX_at_Nucleus MAX_at_Nucleus DP1__at_Nucleus DP1__at_Nucleus APAF1 APAF1 17482685 pubmed CyclinE CyclinE BAT8__at_Nucleus BAT8__at_Nucleus MGA_at_Nucleus MGA_at_Nucleus DP1__at_Nucleus DP1__at_Nucleus 15126619 pubmed BAF250 BAF250 UXT HGNC MAX_at_Nucleus MAX_at_Nucleus CCNB2 HGNC p21CIP1 p21CIP1 CDK1 CDK1 carboxylesterase carboxylesterase p18INK4C p18INK4C ATM HGNC EED EED COX4I1 COX4I1 EZH2 EZH2 MYB HGNC CDK2 HGNC BRCA1 HGNC EHMT1_at_Nucleus EHMT1_at_Nucleus HOXA3 HGNC 10498883 pubmed BAT8__at_Nucleus BAT8__at_Nucleus HP1gamma__at_Nucleus HP1gamma__at_Nucleus DP1__at_Nucleus DP1__at_Nucleus E2F6_at_Nucleus E2F6_at_Nucleus MGA_at_Nucleus MGA_at_Nucleus E2F6_at_Nucleus E2F6_at_Nucleus BARD1 BARD1 MAX_at_Nucleus MAX_at_Nucleus PFKFB2 HGNC PFKFB1 HGNC DP1__at_Nucleus DP1__at_Nucleus PFKFB4 HGNC SOAT2 HGNC PFKFB3 HGNC HSP90 HSP90 FHIT FHIT FGFR2 FGFR2 EXOSC8 EXOSC8 EIF2AK2 EIF2AK2 DNMT1 DNMT1 DDX11 DDX11 CNAP1 CNAP1 12004135 pubmed CDT1 CDT1 15123636 pubmed CBX3 HGNC MYC MYC GAB2 GAB2 EZH2_at_Nucleus EZH2_at_Nucleus EPC1_at_Nucleus EPC1_at_Nucleus EPC1_at_Nucleus EPC1_at_Nucleus E2F6_at_Nucleus E2F6_at_Nucleus EED_at_Nucleus EED_at_Nucleus E2F7 HGNC CSDA CSDA ESR1 ESR1 PCNA PCNA FSHR FSHR DIRAS3 DIRAS3 MYBL2 MYBL2 HRK HRK MAX HGNC E2F4_cofactors E2F4_cofactors This is a CellDesigner UNKNOWN entity. E2F8 E2F8 CHEK2 CHEK2 E2F6_cofactors E2F6_cofactors This is a CellDesigner UNKNOWN entity. RAD51AP1 RAD51AP1 MRPL27 MRPL27 MSH2 MSH2 EED EED MTHFD1 MTHFD1 NEK2 NEK2 MYCN MYCN PTGS2 PTGS2 MAD2 MAD2 MCM5 MCM5 METAP2 METAP2 MLH1 MLH1 SKP2 SKP2 ACTIVATION CDTYPE:CATALYSIS carboxylesterase carboxylesterase CDC25A CDC25A TP53BP2 TP53BP2 BRCA1 BRCA1 Caspase9 Caspase9 STMN1 HGNC E2F1 HGNC CDC14A CDC14A MCM6 HGNC POLA POLA PRKDC PRKDC PLK1 PLK1 AURKB AURKB BIRC5 BIRC5 PSMA4 PSMA4 RAD54L RAD54L 15190204 pubmed UHRF1 UHRF1 E2F8_cofactors E2F8_cofactors This is a CellDesigner UNKNOWN entity. E2F7_cofactors E2F7_cofactors This is a CellDesigner UNKNOWN entity. H19 HGNC RPL8 RPL8 CyclinE1 CyclinE1 CyclinB2 CyclinB2 H19 H19 PPARG PPARG PPP1R13B PPP1R13B RPA2 RPA2 CDK3 CDK3 SLC3A2 SLC3A2 90001421 pubmed 15711575 pubmed ESR1 ESR1 PTGS2 PTGS2 MELK MELK CyclinB1 CyclinB1 CDC6 CDC6 Caspase7 Caspase7 Caspase8 Caspase8 RBM25 RBM25 BCL2 BCL2 10827953 pubmed CDK2 CDK2 PFKFB PFKFB E2F5_cofactors E2F5_cofactors This is a CellDesigner UNKNOWN entity. ACTIVATION CDTYPE:CATALYSIS SRPR HGNC 12149244 pubmed UDG1A UDG1A 17135268 pubmed SNX19 SNX19 SERPINE1 SERPINE1 BARD1 BARD1 ACR ACR CHEK1 CHEK1 BTRC BTRC CSTF3 CSTF3 CSTF1 CSTF1 FBXO5 FBXO5 DRF1 DRF1 BUB1 BUB1 CyclinB1 CyclinB1 16123593 pubmed CDC14A HGNC JPH2 JPH2 HOXA3 HOXA3 ECE1 ECE1 FGFR1 FGFR1 CDTYPE:UNKNOWN_POSITIVE_INFLUENCE DBF4 DBF4 RQCD1 RQCD1 RFC5 RFC5 KNTC2 KNTC2 ATP5J HGNC DHFR DHFR CYC1 CYC1 Caspase3 Caspase3 E2F4 HGNC miR_17_92 miR_17_92 ATM HGNC CDC25A CDC25A 12789259 pubmed ISYNA1 HGNC 11484059 pubmed 11390642 pubmed E2F1 E2F1 ATR ATR NPAT NPAT TP53BP1 HGNC COX4I1 COX4I1 PPP1CC HGNC PPP1CB HGNC PPP1CA HGNC ATR HGNC PHC1 HGNC 11960696 pubmed SUV39H1 SUV39H1 POLD3 HGNC 11799067 pubmed CDC6 HGNC DP2__E2F4 DP2__E2F4 10548110 pubmed ACTIVATION CDTYPE:CATALYSIS DP2__E2F4 DP2__E2F4 DP1__E2F6 DP1__E2F6 DP2__E2F4_p130 DP2__E2F4_p130 DP2__E2F4_p130 DP2__E2F4_p130 HDAC1_SIN3B HDAC1_SIN3B Tubulin__alpha_1A Tubulin__alpha_1A MNAT1 HGNC CDKN3 HGNC DP2__E2F6 DP2__E2F6 MAX_MGA MAX_MGA BAF250__DP1__E2F1_HDAC1_RB1 BAF250__DP1__E2F1_HDAC1_RB1 BAF250__DP1__E2F1_HDAC1_HP1gamma__RB1_SUV39H1 BAF250__DP1__E2F1_HDAC1_HP1gamma__RB1_SUV39H1 HP1gamma__SUV39H1 HP1gamma__SUV39H1 12566389 pubmed DP2__E2F4_HDAC1_SIN3B_SUV39H1_p130 DP2__E2F4_HDAC1_SIN3B_SUV39H1_p130 DP2__E2F4_HDAC1_SIN3B_SUV39H1_p130 DP2__E2F4_HDAC1_SIN3B_SUV39H1_p130 10859163 pubmed 10859164 pubmed E2F8 E2F8 DP2__E2F4_p107 DP2__E2F4_p107 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS p15INK4B__at_Cytoplasm p15INK4B__at_Cytoplasm p15INK4B__at_Cytoplasm p15INK4B__at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS p15INK4B p15INK4B DP1__E2F6_EPC1 DP1__E2F6_EPC1 ACTIVATION CDTYPE:CATALYSIS CDKN3 CDKN3 DHFR HGNC SERPINE1 HGNC EIF2AK2 HGNC p21CIP1__at_Nucleus p21CIP1__at_Nucleus module_APOPTOSIS_ENTRY module_APOPTOSIS_ENTRY Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr DP2__E2F6 DP2__E2F6 BAT8__DP1__E2F6_EHMT1_HP1gamma__MAX_MGA BAT8__DP1__E2F6_EHMT1_HP1gamma__MAX_MGA RQCD1 HGNC E2F2 E2F2 DP1__E2F6_MAX_MGA DP1__E2F6_MAX_MGA DP2__E2F4_p107 DP2__E2F4_p107 BMI1 HGNC TOPBP1 HGNC DP1__E2F6_EED_EPC1_EZH2_SIN3B DP1__E2F6_EED_EPC1_EZH2_SIN3B DP1__E2F6_EED_EPC1_EZH2 DP1__E2F6_EED_EPC1_EZH2 BMI1_DP2__E2F6_MEL_18__PHC1_RING1_RYBP BMI1_DP2__E2F6_MEL_18__PHC1_RING1_RYBP p14ARF p14ARF module_WEE module_WEE Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr ACTIVATION CDTYPE:CATALYSIS CDK1 CDK1 MELK HGNC 15731768 pubmed HRK HRK EPC1 HGNC p27KIP1__at_Nucleus p27KIP1__at_Nucleus CDC25C CDC25C p27KIP1__at_Nucleus p27KIP1__at_Nucleus p21CIP1 p21CIP1 p27KIP1__at_Nucleus p27KIP1__at_Nucleus p130 p130 FSHR FSHR p27KIP1__at_Nucleus p27KIP1__at_Nucleus p27KIP1__at_Nucleus p27KIP1__at_Nucleus p27KIP1__at_Nucleus p27KIP1__at_Nucleus BCL2 HGNC p27KIP1 p27KIP1 p27KIP1 p27KIP1 p27KIP1 p27KIP1 p27KIP1 p27KIP1 15590326 pubmed 10373560 pubmed RRM1 RRM1 p53 p53 CBX5 HGNC RFC5 RFC5 SIN3B_at_Nucleus SIN3B_at_Nucleus SIN3B_at_Nucleus SIN3B_at_Nucleus SIN3B_at_Nucleus SIN3B_at_Nucleus CDK4 CDK4 PRKDC HGNC SIN3B SIN3B SIN3B_at_Nucleus SIN3B_at_Nucleus E2F2 HGNC TOPBP1 TOPBP1 TOPBP1_at_Nucleus TOPBP1_at_Nucleus 15536069 pubmed TFIIH TFIIH DP2 DP2 CDK1 CDK1 PCAF PCAF PCAF__at_Nucleus PCAF__at_Nucleus PCAF__at_Nucleus PCAF__at_Nucleus CDK2_Thr160_pho_at_Nucleus CDK2_Thr160_pho_at_Nucleus CyclinA__at_Nucleus CyclinA__at_Nucleus E2F1 E2F1 DDX11 DDX11 ANAPC11 HGNC CyclinE__at_Nucleus CyclinE__at_Nucleus CDK2_at_Nucleus CDK2_at_Nucleus GTF2H1 HGNC ANAPC13 HGNC CDK2_Thr160_pho_at_Nucleus CDK2_Thr160_pho_at_Nucleus GTF2H2 HGNC CyclinE__at_Nucleus CyclinE__at_Nucleus MNAT1_at_Nucleus MNAT1_at_Nucleus 7799941 pubmed CyclinH__at_Nucleus CyclinH__at_Nucleus ANAPC10 HGNC CDKN3 CDKN3 NEK2 NEK2 CDK7_Thr170_pho_at_Nucleus CDK7_Thr170_pho_at_Nucleus 10385618 pubmed 9106657 pubmed MNAT1_at_Nucleus MNAT1_at_Nucleus ATM ATM CHEK2 CHEK2 CyclinH__at_Nucleus CyclinH__at_Nucleus CDK7_at_Nucleus CDK7_at_Nucleus CDK1_Tyr15_pho_at_Nucleus CDK1_Tyr15_pho_at_Nucleus ACTIVATION CDTYPE:CATALYSIS CyclinB__at_Nucleus CyclinB__at_Nucleus CDK1_Thr14_pho_at_Cytoplasm CDK1_Thr14_pho_at_Cytoplasm TRIM55 HGNC BRD7 BRD7 GMNN HGNC DRF1 DRF1 E2F6 E2F6 CASP3 HGNC ACTIVATION CDTYPE:CATALYSIS PCNA HGNC ACTIVATION CDTYPE:CATALYSIS MSH2 MSH2 14532106 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS FHIT HGNC ACTIVATION CDTYPE:CATALYSIS 8441401 pubmed EHMT1 HGNC p53 p53 CDKN2A HGNC TOPBP1 TOPBP1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 15867357 pubmed 16360315 pubmed 15867358 pubmed GTF2H5 HGNC GTF2H4 HGNC GTF2H3 HGNC NPAT HGNC FOXO3 FOXO3 15313206 pubmed FZR1 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 8861947 pubmed AURKB AURKB 16158053 pubmed ACTIVATION CDTYPE:CATALYSIS ESR1 HGNC CyclinD CyclinD WWOX WWOX ACTIVATION CDTYPE:CATALYSIS INHIBITION CDTYPE:INHIBITION p107 p107 16131838 pubmed UNG HGNC BIRC5 BIRC5 ACTIVATION CDTYPE:CATALYSIS ZNF451 HGNC ACTIVATION CDTYPE:CATALYSIS 9001210 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS MCM8 HGNC CDCA7 HGNC 11857079 pubmed 8440392 pubmed 7736585 pubmed 15985428 pubmed BCL2 BCL2 MTHFD1 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 16331253 pubmed 15766563 pubmed ACOT13 HGNC CLSPN HGNC 11980909 pubmed DP1 DP1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 12625370 pubmed TOPBP1 HGNC BAT8 BAT8 CDK4_at_Cytoplasm CDK4_at_Cytoplasm p16INK4A__at_Cytoplasm p16INK4A__at_Cytoplasm E2F4 E2F4 CyclinD__at_Nucleus CyclinD__at_Nucleus RPL8 HGNC CyclinD__Thr286_pho_at_Nucleus CyclinD__Thr286_pho_at_Nucleus CDK4_at_Nucleus CDK4_at_Nucleus CyclinD__at_Cytoplasm CyclinD__at_Cytoplasm HSP90__hm2_at_Cytoplasm HSP90__hm2_at_Cytoplasm CDK4_at_Cytoplasm CDK4_at_Cytoplasm 14688249 pubmed CDK4_at_Cytoplasm CDK4_at_Cytoplasm ACTIVATION CDTYPE:CATALYSIS HSP90__hm2_at_Cytoplasm HSP90__hm2_at_Cytoplasm CDC37_at_Cytoplasm CDC37_at_Cytoplasm RAD51AP1 HGNC 15070733 pubmed CDK4_at_Cytoplasm CDK4_at_Cytoplasm RAD54L HGNC 15279789 pubmed CDK4_at_Nucleus CDK4_at_Nucleus RAD51AP1 RAD51AP1 12139485 pubmed FGFR1 FGFR1 CDK3 CDK3 CyclinC CyclinC CyclinD__Thr286_pho_at_Cytoplasm CyclinD__Thr286_pho_at_Cytoplasm CDC25C HGNC TOP2A TOP2A CDK6 CDK6 MGA MGA CDK1 CDK1 11355576 pubmed BAT8 BAT8 PNRC2 PNRC2 EHMT1 EHMT1 E2F2 HGNC HP1gamma HP1gamma MAX MAX E2F2_alone E2F2_alone 15840442 pubmed 15840440 pubmed module_E2F1 module_E2F1 Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr module_E2F4 module_E2F4 Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr CDC37_at_Cytoplasm CDC37_at_Cytoplasm module_E2F6 module_E2F6 Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr PPP1C__at_Nucleus PPP1C__at_Nucleus MLH1 HGNC 17471234 pubmed CyclinD__at_Nucleus CyclinD__at_Nucleus CDK6_at_Nucleus CDK6_at_Nucleus CyclinD__at_Cytoplasm CyclinD__at_Cytoplasm CDK6_at_Cytoplasm CDK6_at_Cytoplasm E2F1_Lys_ace_Ser364_pho_at_Nucleus E2F1_Lys_ace_Ser364_pho_at_Nucleus RB1 RB1 MIR17HG HGNC DP1__at_Nucleus DP1__at_Nucleus DP1__at_Nucleus DP1__at_Nucleus 11704823 pubmed CDC37 CDC37 WEE1 WEE1 ACTIVATION CDTYPE:CATALYSIS E2F1_Lys_ace_Ser31_pho_at_Nucleus E2F1_Lys_ace_Ser31_pho_at_Nucleus DP1__at_Nucleus DP1__at_Nucleus E2F1_Lys_ace_Ser31_pho_at_Nucleus E2F1_Lys_ace_Ser31_pho_at_Nucleus DP1__at_Nucleus DP1__at_Nucleus CDK2_at_Nucleus CDK2_at_Nucleus ACTIVATION CDTYPE:CATALYSIS CyclinA__at_Nucleus CyclinA__at_Nucleus NBS1__pho_at_Nucleus NBS1__pho_at_Nucleus ATM_Ser_1981_pho_at_Nucleus ATM_Ser_1981_pho_at_Nucleus EZH2 HGNC E2F8 E2F8 PLK1 PLK1 12556884 pubmed CDK6_at_Cytoplasm CDK6_at_Cytoplasm MCM7 HGNC CyclinC__at_Nucleus CyclinC__at_Nucleus CHEK2 HGNC CDK3_at_Nucleus CDK3_at_Nucleus ACTIVATION CDTYPE:CATALYSIS MDM2_at_Nucleus MDM2_at_Nucleus EED HGNC ACTIVATION CDTYPE:CATALYSIS 8515817 pubmed PBK HGNC E2F4_at_Cytoplasm E2F4_at_Cytoplasm DP2__at_Cytoplasm DP2__at_Cytoplasm E2F6_at_Cytoplasm E2F6_at_Cytoplasm DP2__at_Cytoplasm DP2__at_Cytoplasm p130__at_Cytoplasm p130__at_Cytoplasm GMNN GMNN p27KIP1 p27KIP1 E2F4_at_Nucleus E2F4_at_Nucleus p130__at_Nucleus p130__at_Nucleus ACTIVATION CDTYPE:CATALYSIS 11420722 pubmed MCM8 MCM8 RB1_pho_pho_pho_at_Nucleus RB1_pho_pho_pho_at_Nucleus E2F1_at_Nucleus E2F1_at_Nucleus 12446760 pubmed E2F6_at_Nucleus E2F6_at_Nucleus DP1__at_Nucleus DP1__at_Nucleus E2F6_at_Nucleus E2F6_at_Nucleus 11420729 pubmed DP2__at_Nucleus DP2__at_Nucleus DP2__at_Nucleus DP2__at_Nucleus 12861053 pubmed 10395539 pubmed MXD3 MXD3 MCM3 MCM3 MCL1 MCL1 12771133 pubmed MYB MYB MCM10 MCM10 JMY JMY CCNH HGNC ISYNA1 ISYNA1 MCAM MCAM LGALS1 LGALS1 16181749 pubmed CyclinB CyclinB GMNN GMNN NCAPD2 HGNC 11959842 pubmed 12944911 pubmed KPNA2 KPNA2 CDC20 CDC20 PPP1C PPP1C BUB1 BUB1 ACTIVATION CDTYPE:CATALYSIS RBBP8 RBBP8 RBBP4 RBBP4 PNRC2 PNRC2 CDKN2A HGNC MGA MGA PMAIP1 PMAIP1 PCNA PCNA p14ARF p14ARF NPAT NPAT TERT TERT CyclinD3 CyclinD3 11313881 pubmed E2F6 E2F6 E2F_cofactors E2F_cofactors This is a CellDesigner UNKNOWN entity. 12611887 pubmed E2F1 E2F1 CHEK1 HGNC CDK3 HGNC acetylated MCM6 MCM6 MYB MYB E2F7 E2F7 E2F2 E2F2 KPNA2 HGNC 12781359 pubmed p18INK4C p18INK4C ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS UXT UXT GSK3B HGNC MAD2 MAD2 E2F7 E2F7 15037762 pubmed RBL2 HGNC 11756542 pubmed HDAC1_at_Nucleus HDAC1_at_Nucleus p130 p130 p130 p130 EZH2 EZH2 RB1 RB1 MAX_at_Nucleus MAX_at_Nucleus RB1 RB1 EHMT2 HGNC 9278512 pubmed CSTF3 CSTF3 BRD7 HGNC CDK1_at_Nucleus CDK1_at_Nucleus CyclinB__at_Nucleus CyclinB__at_Nucleus CDC37_at_Cytoplasm CDC37_at_Cytoplasm CDK4_at_Cytoplasm CDK4_at_Cytoplasm 11959850 pubmed CDK4_NF_don_at_Cytoplasm CDK4_NF_don_at_Cytoplasm CDK1_Tyr15_pho_Thr14_pho_at_Cytoplasm CDK1_Tyr15_pho_Thr14_pho_at_Cytoplasm CyclinB__at_Cytoplasm CyclinB__at_Cytoplasm CyclinB__at_Nucleus CyclinB__at_Nucleus CDCA4 CDCA4 CDC6 CDC6 RYBP HGNC RRM2 RRM2 CDK1 HGNC CyclinB__at_Nucleus CyclinB__at_Nucleus CyclinB__at_Nucleus CyclinB__at_Nucleus CDK1_Thr14_pho_at_Nucleus CDK1_Thr14_pho_at_Nucleus E2F4_at_Cytoplasm E2F4_at_Cytoplasm CDK1_at_Cytoplasm CDK1_at_Cytoplasm CyclinB__at_Cytoplasm CyclinB__at_Cytoplasm CDK1_Tyr15_pho_Thr14_pho_at_Nucleus CDK1_Tyr15_pho_Thr14_pho_at_Nucleus CREBBP HGNC DP2__at_Cytoplasm DP2__at_Cytoplasm E2F8 E2F8 CyclinB__at_Cytoplasm CyclinB__at_Cytoplasm EED EED EP300 HGNC 12015319 pubmed FZR1 FZR1 CyclinB CyclinB CDC14 CDC14 ACTIVATION CDTYPE:CATALYSIS PCNA PCNA ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CDC20 CDC20 FZR1 FZR1 BMI1 BMI1 SPAG7 HGNC HDAC1 HGNC DBF4B HGNC AKT1 AKT1 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 12210082 pubmed CDC25C CDC25C NEK2 HGNC FSHR HGNC 11559537 pubmed Caspase9 Caspase9 MSH2 HGNC ACTIVATION CDTYPE:CATALYSIS CSTF3 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS CHEK1 HGNC 15271987 pubmed AURKB HGNC PCNA HGNC INHIBITION CDTYPE:INHIBITION 15572025 pubmed ACTIVATION CDTYPE:CATALYSIS PURALPHA PURALPHA 9670027 pubmed 12748276 pubmed 11231573 pubmed CyclinA CyclinA 15044096 pubmed DIRAS3 HGNC 15460900 pubmed MYC MYC MRPL27 MRPL27 12006580 pubmed CDKN1B HGNC RRM1 HGNC SUZ12 HGNC PKMYT1 PKMYT1 CDC25C CDC25C SNX19 HGNC ISYNA1 ISYNA1 CDC20 CDC20 CyclinD CyclinD 12766778 pubmed ACTIVATION CDTYPE:CATALYSIS MYBL2 HGNC E2F6 E2F6 p300 p300 PTGS2 HGNC CCNB1 HGNC EZH2 EZH2 CDC20 CDC20 APC_C APC_C CDK4 HGNC EPC1 EPC1 10973490 pubmed TFDP1 HGNC NBN HGNC CDK2 CDK2 10688648 pubmed CyclinE CyclinE CHEK2 CHEK2 ACTIVATION CDTYPE:CATALYSIS CDK7 CDK7 RYBP RYBP 9819415 pubmed TFIIH TFIIH p21CIP1 p21CIP1 p73 p73 12446714 pubmed MRPL27 HGNC SERPINE1 SERPINE1 NDC80 HGNC ACTIVATION CDTYPE:CATALYSIS 9679058 pubmed PCAF PCAF DNMT1 DNMT1 12368233 pubmed 15175242 pubmed PFKFB PFKFB AXIN2 HGNC ACTIVATION CDTYPE:CATALYSIS 15510213 pubmed FHIT FHIT p68 p68 ACTIVATION CDTYPE:CATALYSIS CDKN1A HGNC ACTIVATION CDTYPE:CATALYSIS 9889122 pubmed ACTIVATION CDTYPE:CATALYSIS PCGF2 HGNC PHC1 PHC1 RAD54L RAD54L 10964686 pubmed BMI1 HGNC ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS GAB2 GAB2 ACTIVATION CDTYPE:CATALYSIS MCL1 HGNC UBB UBB APAF1 HGNC SSR4 SSR4 8760872 pubmed E2F5 E2F5 ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS 11533237 pubmed ACTIVATION CDTYPE:CATALYSIS ACTIVATION CDTYPE:CATALYSIS PPP1R1C HGNC PPP1R1A HGNC 9315635 pubmed ACTIVATION CDTYPE:CATALYSIS 15574595 pubmed SIN3B SIN3B Caspase7 Caspase7 15272308 pubmed module_INK4 module_INK4 Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr CyclinH CyclinH CDC16 HGNC CDC26 HGNC module_APC module_APC Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr CDC23 HGNC p15INK4B p15INK4B CDC27 HGNC PPP1R3D HGNC ACTIVATION CDTYPE:CATALYSIS TFDP2 HGNC CYC1 CYC1 FBXO5 HGNC HP1gamma HP1gamma 16275992 pubmed E2F5 E2F5 ACR ACR 15558010 pubmed 12110166 pubmed 8259215 pubmed GAB2 HGNC RB1 HGNC 11883935 pubmed MXD3 MXD3 FZR1_at_Nucleus FZR1_at_Nucleus 12389032 pubmed 11897663 pubmed 12524548 pubmed HOXA3 HOXA3 HSP90AA1 HGNC WWOX HGNC 8001816 pubmed 15177020 pubmed 11564866 pubmed PPP1R PPP1R CDKN2A HGNC CDC37 HGNC CDK4 CDK4 DHFR DHFR PKMYT1 HGNC CASP8 HGNC BBC3 BBC3 PPARG HGNC E2F6 HGNC THEM2 THEM2 RPA2 HGNC CDCA7 CDCA7 SUZ12 SUZ12 NBS1 NBS1 14576826 pubmed DNMT1 HGNC 15936277 pubmed E2F3_alone E2F3_alone TRIM55 TRIM55 CHEK1 CHEK1 15231644 pubmed ACTIVATION CDTYPE:CATALYSIS E2F3 HGNC CCNE1 HGNC CCNE2 HGNC ACTIVATION CDTYPE:CATALYSIS ZNF83 HGNC MCM10 HGNC 10766737 pubmed CASP7 HGNC ACTG1 HGNC ATM ATM RBL1 RBL1 SUV39H1 HGNC EIF2AK2 EIF2AK2 BIRC5 HGNC CyclinB2 CyclinB2 p14ARF__at_Nucleolus p14ARF__at_Nucleolus p14ARF__at_Nucleus p14ARF__at_Nucleus 12665581 pubmed CyclinD__Thr286_pho_at_Cytoplasm CyclinD__Thr286_pho_at_Cytoplasm 15014447 pubmed CDK6_CyclinD CDK6_CyclinD FZR1 FZR1 CDK6_at_Cytoplasm CDK6_at_Cytoplasm p14ARF__at_Nucleolus p14ARF__at_Nucleolus p14ARF p14ARF p14ARF__at_Nucleus p14ARF__at_Nucleus EHMT1 EHMT1 12814430 pubmed CDC20 HGNC p14ARF__at_Nucleolus p14ARF__at_Nucleolus TK1 HGNC CCNB3 HGNC CCNB2 HGNC CCNB1 HGNC 16431910 pubmed MCM7 MCM7 11313986 pubmed LGALS1 LGALS1 10773440 pubmed RRM2 HGNC 14633988 pubmed 16512785 pubmed E2F7 E2F7 BAT8__DP1__E2F6_EHMT1_MAX_MGA BAT8__DP1__E2F6_EHMT1_MAX_MGA PPP1R__at_Nucleus PPP1R__at_Nucleus CDK2_CyclinE__p130 CDK2_CyclinE__p130 FOXO1 FOXO1 CDK2_CyclinE__p107 CDK2_CyclinE__p107 BAF250__DP1__E2F1_RB1 BAF250__DP1__E2F1_RB1 SPAG7 SPAG7 HSP90 HSP90 CDC37 CDC37 HSP90 HSP90 12697828 pubmed BBC3 HGNC WEE1 WEE1 E2F6 E2F6 12773400 pubmed RING1 HGNC EZH2 HGNC p21CIP1__at_Nucleus p21CIP1__at_Nucleus E2F1_p14ARF E2F1_p14ARF E2F1_at_Nucleolus E2F1_at_Nucleolus p21CIP1__at_Nucleus p21CIP1__at_Nucleus CDK2_Thr160_pho_at_Nucleus CDK2_Thr160_pho_at_Nucleus 16213134 pubmed EED_at_Nucleus EED_at_Nucleus p21CIP1 p21CIP1 DP1__at_Nucleus DP1__at_Nucleus EZH2_at_Nucleus EZH2_at_Nucleus CCNE1 HGNC CCNE2 HGNC 14684737 pubmed 15577895 pubmed MAX MAX DP1__at_Nucleolus DP1__at_Nucleolus CDK1_Thr161_pho_at_Nucleus CDK1_Thr161_pho_at_Nucleus CyclinB CyclinB DP2__at_Nucleus DP2__at_Nucleus p21CIP1 p21CIP1 DP1__p14ARF DP1__p14ARF MDM2_at_Nucleolus MDM2_at_Nucleolus MDM2_p14ARF MDM2_p14ARF RBBP8 HGNC NRP1 HGNC DP1__at_Cytoplasm DP1__at_Cytoplasm CDK6_at_Cytoplasm CDK6_at_Cytoplasm p16INK4A__at_Cytoplasm p16INK4A__at_Cytoplasm APC_C__FZR1 APC_C__FZR1 module_RB module_RB Pathway generated automatically from CellDesigner xml file using BiNoM software http://binom.curie.fr PPP1C__PPP1R PPP1C__PPP1R CDC25C CDC25C CDC25C CDC25C 11313932 pubmed E2F6_at_Cytoplasm E2F6_at_Cytoplasm PKMYT1 PKMYT1 MCM10 MCM10 p53 p53 BCL2L11 HGNC MDM2_at_Cytoplasm MDM2_at_Cytoplasm 14597855 pubmed p53__at_Cytoplasm p53__at_Cytoplasm MDM2 MDM2 MDM2_p53 MDM2_p53 EHMT1_at_Nucleus EHMT1_at_Nucleus