e_re356( EMT ):
Six1 induces ZEB1 and EMT through transcriptional repression of miR200.
Feedback loop between ZEB1, ZEB2 and MIR200 family
ZEB1 inhibits expression of MIR200 family
SNAI1 represses expression of all MIR200 family members.
e_re366( EMT ):
SNAI1 inhibits miR-203
SNAI1 represses miR-203 and miR-200b expression
p53 activates expression of miR-203
Feedback loop: ZEB1 inhibits expression of MIR203 and MIR183
ZEB1 directly controls transcription of the miR-203 and miR-183 and miR-200 family genes
ZEB2 inhibits expression of MIR203
In compartment: Nucleus
Participates in complexes:
Participates in reactions:
As Reactant or Product: