YWHAB

Protein YWHAB map

Identifiers
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB
“tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide”, YWHAA

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / CASPASES  map
 Survival  map  / WNT_NON_CANONICAL  map

References
YWHAB is so-called 14-3-3 alpha/beta
PMID:9069260

YWHAB@Cytoplasm

References
e_re385( EMT  map ):
PMID:9069260
Activated HRAS (GTP bound forn) is associated with the plasma membrane.
Inactive RAF1 is associated in the cytoplasm with YWHAB via S259 phosphorylation site and also binding site.
RAF1 has a RAS-binding Cysteine-rich domain (CRD) and an additional RAS-binding domain (RBD).
RAF1 binds activated HRAS via the RBD. This binding displaces YWHAB from Ser259 and unmasks the CRD.
e_re386( EMT  map ):
YWHAB has been displaced from S259 may now bind its higher affinity S621 site.
This stabilises an OPEN RAF1 conformation that is catalytically active.
Active and open RAF1 binds to RAS via both CRD and RBD domains.


Modifications:
In compartment: Cytoplasm
  1. YWHAB@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm map

  2. GTP:​RAF1|​S259_pho|​S621_pho|​S_pho|​open:​YWHAB@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. YWHAB@Cytoplasm map map 14-3-3*@Cytoplasm map

  2. Plakophilin2 binding partners*@Cytoplasm map map YWHAB@Cytoplasm map
  3. 14-3-3*@Cytoplasm map map YWHAB@Cytoplasm map
  4. RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm map + YWHAB@Cytoplasm map map RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm map
  5. RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm map + GTP:​HRAS@Cytoplasm map map GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm map + YWHAB@Cytoplasm map
  6. GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm map + YWHAB@Cytoplasm map map GTP:​RAF1|​S259_pho|​S621_pho|​S_pho|​open:​YWHAB@Cytoplasm map
  7. GTP:​RAF1|​S259_pho|​S621_pho|​S_pho|​open:​YWHAB@Cytoplasm map + ATP@Cytoplasm map map RAF1|​S259_pho|​S621_pho|​Y340_pho|​Y341_pho|​open@Cytoplasm map + ADP@Cytoplasm map
  8. YWHAB@Cytoplasm map + DACT1|​S237_pho|​S827_pho@Cytoplasm map map s_s_wnc1_s726

As Catalyser:

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