XIAP

Protein XIAP map

Identifiers
X-linked inhibitor of apoptosis
HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 GENECARDS:XIAP REACTOME:50850 KEGG:331 ATLASONC:GC_XIAP WIKI:XIAP
API3 “baculoviral IAP repeat-containing 4″ BIRC4

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / CASPASES  map
 Survival  map  / WNT_CANONICAL  map

XIAP@Cytoplasm

References
a_re489:( Apoptosis  map ) PMID:14645242
a_re491:( Apoptosis  map ) reactionType:is.a
a_re645( Apoptosis  map ):
PMID:14645242
autoubiquitinylation

XIAP|​S87_pho@Cytoplasm

References
a_re489:( Apoptosis  map ) PMID:14645242
a_re492:( Apoptosis  map ) reactionType:is.a

XIAP|​S87_unk@Cytoplasm

References
a_re491:( Apoptosis  map ) reactionType:is.a
a_re505( Apoptosis  map ):
PMID:12620238
cristal structure of the complex
a_re665( Apoptosis  map ):
PMID:11583623
PMID:12835328
PMID:12815069
a_re666( Apoptosis  map ):
PMID:11175744
in vitro, Y2H
in vitro, GST pulldown
in transfected Hela cells, coIP
in Hela cells expressing fluorescent proein fusions, XAF1 is nuclear and its co-expression with XIAP induces XIAP nuclear retention
in vitro, XIAP mediated inhibition of CASP3 activity is blocked by XAF1
in HEL-299 human embryonic lung cells, XAF1 expression reverts the protective effect of XIAP expression toward serum deprivation-induced cell death
a_re673:( Apoptosis  map ) PMID:15029247
a_re675( Apoptosis  map ):
PMID:12865429
cleaved GSPT1 harbors a IAP binding motif at tis C-terminal, AKPF, related to those found in DIABLO or HTRA2
in vitro, cleaved GSPT1 and XIAP interact
in HEK293, interaction between endogenous proteins
in HEK293 cytoplasmic extract (S100 fraction), cleaved GSPT1 increases CYCS+ATP induced cleavage of CASP3
a_re734( Apoptosis  map ):
PMID:17967870
in HEK293
a_re736( Apoptosis  map ):
PMID:10929711
identification of DIABLO as an inhibitor of XIAP
PMID:11140637
structure of XIAP BIR3 complexed to a peptide from DIABLO
PMID:15078891
DIABLO inhibits XIAP ubiquitin-ligase activity
a_re740:( Apoptosis  map ) PMID:11157976

XIAP|​ubi@Cytoplasm

References
a_re645( Apoptosis  map ):
PMID:14645242
autoubiquitinylation

XIAP@Nucleus

References
s_wca3_re39( Survival  map ):
Its suggested that XIAP constitutively ubiquitinate TLE
PMID:22304967
s_wca3_re40( Survival  map ):
Not sure if ubiquitination by XIAP is necessary for replacement of TLE by b-catenin upon canonical WNT signaling
s_s_wca3_re40( Survival  map ):


Modifications:
In compartment: Cytoplasm
  1. XIAP@Cytoplasm map

  2. XIAP|​ubi@Cytoplasm map
  3. XIAP|​S87_pho@Cytoplasm map
  4. XIAP|​S87_unk@Cytoplasm map

In compartment: Nucleus

  1. XIAP@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. SEPT4:​XIAP|​S87_unk@Cytoplasm map

  2. DIABLO:​XIAP|​S87_unk@Cytoplasm map
  3. XIAP|​S87_unk:​cleaved~GSPT1*@Cytoplasm map
  4. XIAP|​S87_unk:​cleaved~Caspase9*@Cytoplasm map
  5. Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk:​XIAP|​S87_unk|​hm2@Cytoplasm map

In compartment: Nucleus

  1. XAF1:​XIAP|​S87_unk@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. rXIAP@Nucleus map map XIAP@Cytoplasm map

  2. XIAP@Cytoplasm map map XIAP|​S87_pho@Cytoplasm map
  3. XIAP@Cytoplasm map map XIAP|​S87_unk@Cytoplasm map
  4. XIAP|​S87_pho@Cytoplasm map map XIAP|​S87_unk@Cytoplasm map
  5. XIAP|​S87_unk@Cytoplasm map + Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk@Cytoplasm map map Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk:​XIAP|​S87_unk|​hm2@Cytoplasm map
  6. XIAP@Cytoplasm map map XIAP|​ubi@Cytoplasm map
  7. XIAP|​ubi@Cytoplasm map map degraded
  8. XIAP|​S87_unk@Cytoplasm map map degraded
  9. XIAP|​S87_unk@Cytoplasm map + XAF1@Nucleus map map XAF1:​XIAP|​S87_unk@Nucleus map
  10. XIAP|​S87_unk@Cytoplasm map + SEPT4@Cytoplasm map map SEPT4:​XIAP|​S87_unk@Cytoplasm map
  11. XIAP|​S87_unk@Cytoplasm map + cleaved~GSPT1*@Cytoplasm map map XIAP|​S87_unk:​cleaved~GSPT1*@Cytoplasm map
  12. XIAP|​S87_unk@Cytoplasm map + DIABLO@Cytoplasm map map DIABLO:​XIAP|​S87_unk@Cytoplasm map
  13. XIAP|​S87_unk@Cytoplasm map + cleaved~Caspase9*@Cytoplasm map map XIAP|​S87_unk:​cleaved~Caspase9*@Cytoplasm map

As Catalyser:

  1. cleaved~AIFM1*@Cytoplasm map map cleaved~AIFM1*|​ubi@Cytoplasm map

  2. TLE*@Nucleus map map TLE*|​ubi@Nucleus map
  3. HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus map map HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map

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