WRN

Protein WRN map

Identifiers
Werner syndrome, RecQ helicase-like
HUGO:WRN HGNC:12791 ENTREZ:7486 UNIPROT:Q14191 GENECARDS:WRN KEGG:7486 ATLASONC:WRNID284 WIKI:WRN

Maps_Modules
 DNA repair  map  / BER  map
 DNA repair  map  / A_NHEJ  map
 DNA repair  map  / HR  map

References
PMID:20691907
For A_NHEJ pathway
(alt_NHEJ or B_NHEJ or MMEJ)
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
, PMID:21376743, PMID:24050180, PMID:22743550
For HR pathway
PMID:19490890, PMID:22657828
For BER pathway
PMID:17116323, PMID:18398454, PMID:16449207, PMID:15385537, PMID:18558713, PMID:23161013
WRN in telomere maintenance
PMID:23253856
Resolving stalled replication fork
Inhibiting WNT kills alt_NHEJ pathway
PMID:24036544
PARP1 inhibits WRN
PMID:23082994
WRN inhibits C_NHEJ by sequestering DNA-PKs
PMID:12202749
Activation of WRN in cancers
http://www.intechopen.com/download/get/type/pdfs/id/22156
http://www.intechopen.com/download/get/type/pdfs/id/19301
PMID:18524993

WRN@Nucleus

References
d_re122( DNA repair  map ):
PMID:20064462,
MRN complex in A_NHEJ: PMID:19362533, PMID:19654615, PMID:19892829
d_re566( DNA repair  map ):
Binding between Ku70/80/DNA-PK and WRN inhibits Ku activity
PMID:17303082
PMID:12202749
WRN is a key activator of alt_NHEJ pathway
PMID:18524993
C_NHEJ and A_NHEJ are competing mechanisms
PMID:24050180

WRN|​unk@default

References
d_re564:( DNA repair  map ) PMID:23082994

WRN|​ace@default

References
d_re22( DNA repair  map ):
PMID:18398454
PMID:16449207
RECQL5 activates BER via XRCC1 and PARP1
PMID:22973052


Modifications:
In compartment: Nucleus
  1. WRN@Nucleus map

In compartment: default

  1. WRN|​ace@default map

  2. WRN|​unk@default map

Participates in complexes:
In compartment: Nucleus

  1. DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map

  2. ATM|​pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​NBS1*|​S343_pho:​WRN@Nucleus map

In compartment: default

  1. LIG3:​WRN@default map

  2. FEN1:​PCNA:​WRN@default map
  3. APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default map
  4. PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map
  5. PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map

Participates in reactions:
As Reactant or Product:

  1. ATM|​pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + CTIP*|​emp@default map + WRN@Nucleus map map ATM|​pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​NBS1*|​S343_pho:​WRN@Nucleus map

  2. LIG3@default map + WRN@Nucleus map map LIG3:​WRN@default map
  3. POLB@default map + XRCC1|​pho@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map + WRN|​ace@default map + PNK*@default map map PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map
  4. PCNA@default map + FEN1@default map + WRN@Nucleus map map FEN1:​PCNA:​WRN@default map
  5. WRN@Nucleus map map WRN|​ace@default map
  6. PARP2|​unk|​pho@default map + WRN|​ace@default map + PNK*@default map + XRCC1|​pho@default map + POLB@default map map PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map
  7. WRN@Nucleus map map Telomere maintenance@Nucleus map
  8. WRN@Nucleus map map WRN|​unk@default map
  9. Ku80*@default map + Ku70*@default map + WRN@Nucleus map + DNA-PK*@default map map DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  10. Mg2+@default map + APE*|​Thr233_pho|​ubi@default map + PCNA@default map + WRN@Nucleus map map APE*|​Thr233_pho|​ubi:​Mg2+:​PCNA:​WRN@default map

As Catalyser:

  1. gBER_M-glyc_DNA_st2*@Nucleus map map gBER_M-glyc_DNA_st3*@Nucleus map

  2. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map
  3. gA_NHEJ_DNA_st5*@Nucleus map map gA_NHEJ_DNA_st6*@Nucleus map
  4. gHR_DNA_st5*@Nucleus map map gHR_DNA_st6*@Nucleus map
  5. gFanconi_DNA_st2*@Nucleus map map gFanconi_DNA_st3*@Nucleus map
  6. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus map + dNTPs@Nucleus map map gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus map
  7. DNA-PK*@default map map DNA-PK*|​hm2|​active@default map
  8. gBER_B-glyc_DNA_st3*@Nucleus map map gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus map + 3′ddR5P@default map
  9. gLnP_BER_M-glyc_st4*@Nucleus map map gLnP_BER_M-glyc_st5*@Nucleus map + Modified 2-12 nucl fragment@default map

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