WNT_NON_CANONICAL

Module:WNT_non-canonical map
This module describes the non-canonical-wnt pathways: the Ca2+ and planar cell polarity pathway. The upper part of the module describes the signal transduction pathway in the cytosolic fraction and the lower part the nuclear fraction.
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PMID:2126816 Khanani RM, Hafeez A, Rab SM, Rasheed S (1990) AIDS and HIV associated disorders in Karachi. J Pak Med Assoc 40(4);82-5.
PMID:2550447 Hashimoto Y, Soderling TR (1989) Regulation of calcineurin by phosphorylation. Identification of the regulatory site phosphorylated by Ca2+/calmodulin-dependent protein kinase II and protein kinase C. J. Biol. Chem. 264(28);16524-9.
PMID:7641885 Bossemeyer D (1995) Protein kinases–structure and function. FEBS Lett. 369(1);57-61.
PMID:8545107 Bannister AJ, Oehler T, Wilhelm D, Angel P, Kouzarides T (1995) Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11(12);2509-14.
PMID:8655584 Torres MA, Yang-Snyder JA, Purcell SM, DeMarais AA, McGrew LL, Moon RT (1996) Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J. Cell Biol. 133(5);1123-37.
PMID:9228084 Harry A, Chen Y, Magnusson R, Iyengar R, Weng G (1997) Differential regulation of adenylyl cyclases by Galphas. J. Biol. Chem. 272(30);19017-21.
PMID:9585406 Kehlenbach RH, Dickmanns A, Gerace L (1998) Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro. J. Cell Biol. 141(4);863-74.
PMID:9765224 Stennicke HR, J–rgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS (1998) Pro-caspase-3 is a major physiologic target of caspase-8. J. Biol. Chem. 273(42);27084-90.
PMID:9859994 Yano S, Tokumitsu H, Soderling TR (1998) Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396(6711);584-7.
PMID:9932450 Becker W, Joost HG (1999) Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity. Prog. Nucleic Acid Res. Mol. Biol. 62;1-17.
PMID:10026142 Kloeker S, Wadzinski BE (1999) Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. J. Biol. Chem. 274(9);5339-47.
PMID:10094050 Zhu J, McKeon F (1999) NF-AT activation requires suppression of Crm1-dependent export by calcineurin. Nature 398(6724);256-60.
PMID:10350048 Averna M, De Tullio R, Salamino F, Melloni E, Pontremoli S (1999) Phosphorylation of rat brain calpastatins by protein kinase C. FEBS Lett. 450(1-2);13-6.
PMID:10611249 Chow CW, Davis RJ (1999) Integration of calcium and cyclic AMP signaling pathways by 14-3-3. Mol. Cell. Biol. 20(2);702-12.
PMID:10721693 Momand J, Wu HH, Dasgupta G (2000) MDM2–master regulator of the p53 tumor suppressor protein. Gene 242(1-2);15-29.
PMID:10788511 G–mez del Arco P, Mart–nez-Mart–nez S, Maldonado JL, Ortega-P–rez I, Redondo JM (2000) A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp. J. Biol. Chem. 275(18);13872-8.
PMID:10862767 Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G (2000) 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. J. Biol. Chem. 275(36);28167-72.
PMID:10949026 Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME (2000) 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol. Cell 6(1);41-51.
PMID:10995457 Sato S, Fujita N, Tsuruo T (2000) Modulation of Akt kinase activity by binding to Hsp90. Proc. Natl. Acad. Sci. U.S.A. 97(20);10832-7.
PMID:10999941 Scheschonka A, Dessauer CW, Sinnarajah S, Chidiac P, Shi CS, Kehrl JH (2000) RGS3 is a GTPase-activating protein for g(ialpha) and g(qalpha) and a potent inhibitor of signaling by GTPase-deficient forms of g(qalpha) and g(11alpha). Mol. Pharmacol. 58(4);719-28.
PMID:11030334 Okamura H, Aramburu J, Garc–a-Rodr–guez C, Viola JP, Raghavan A, Tahiliani M, Zhang X, Qin J, Hogan PG, Rao A (2000) Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol. Cell 6(3);539-50.
PMID:11136230 Meigs TE, Fields TA, McKee DD, Casey PJ (2001) Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. Proc. Natl. Acad. Sci. U.S.A. 98(2);519-24.
PMID:11226259 Luttrell LM, Roudabush FL, Choy EW, Miller WE, Field ME, Pierce KL, Lefkowitz RJ (2001) Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proc. Natl. Acad. Sci. U.S.A. 98(5);2449-54.
PMID:11274345 Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81(2);807-69.
PMID:11313945 Gual P, Giordano S, Anguissola S, Parker PJ, Comoglio PM (2001) Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling. Oncogene 20(2);156-66.
PMID:11395409 Rhee SG (2001) Regulation of phosphoinositide-specific phospholipase C. Annu. Rev. Biochem. 70;281-312.
PMID:11402342 Maci–n F, L–pez-Rodr–guez C, Rao A (2001) Partners in transcription: NFAT and AP-1. Oncogene 20(19);2476-89.
PMID:11694535 Paing MM, Stutts AB, Kohout TA, Lefkowitz RJ, Trejo J (2001) beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. J. Biol. Chem. 277(2);1292-300.
PMID:11715018 Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC (2001) HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol. 3(11);973-82.
PMID:11779461 Habas R, Kato Y, He X (2002) Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell 107(7);843-54.
PMID:11796223 McKinsey TA, Zhang CL, Olson EN (2002) MEF2: a calcium-dependent regulator of cell division, differentiation and death. Trends Biochem. Sci. 27(1);40-7.
PMID:11923280 Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K, Masuyama N, Gotoh Y (2002) Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J. Biol. Chem. 277(24);21843-50.
PMID:11940581 Saito Y, Hojo Y, Tanimoto T, Abe J, Berk BC (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J. Biol. Chem. 277(26);23216-22.
PMID:11980723 Rena G, Woods YL, Prescott AR, Peggie M, Unterman TG, Williams MR, Cohen P (2002) Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO J. 21(9);2263-71.
PMID:12011974 Katoh M (2002) GIPC gene family (Review). Int. J. Mol. Med. 9(6);585-9.
PMID:12040186 Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296(5573);1655-7.
PMID:12063245 Vega RB, Yang J, Rothermel BA, Bassel-Duby R, Williams RS (2002) Multiple domains of MCIP1 contribute to inhibition of calcineurin activity. J. Biol. Chem. 277(33);30401-7.
PMID:12107820 Baccarini M (2002) An old kinase on a new path: Raf and apoptosis. Cell Death Differ. 9(8);783-5.
PMID:12114545 Kim MJ, Jo DG, Hong GS, Kim BJ, Lai M, Cho DH, Kim KW, Bandyopadhyay A, Hong YM, Kim DH, Cho C, Liu JO, Snyder SH, Jung YK (2002) Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Proc. Natl. Acad. Sci. U.S.A. 99(15);9870-5.
PMID:12453415 Baksh S, Widlund HR, Frazer-Abel AA, Du J, Fosmire S, Fisher DE, DeCaprio JA, Modiano JF, Burakoff SJ (2002) NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol. Cell 10(5);1071-81.
PMID:12514131 Xu Z, Kukekov NV, Greene LA (2003) POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J. 22(2);252-61.
PMID:12529437 Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM (2003) CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis. Mol. Biol. Cell 14(1);201-13.
PMID:12533515 Habas R, Dawid IB, He X (2003) Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev. 17(2);295-309.
PMID:12534294 Hollinger S, Ramineni S, Hepler JR (2003) Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i. Biochemistry 42(3);811-9.
PMID:12657629 Snyder JT, Singer AU, Wing MR, Harden TK, Sondek J (2003) The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac. J. Biol. Chem. 278(23);21099-104.
PMID:12684003 Todd B, Moore D, Deivanayagam CC, Lin GD, Chattopadhyay D, Maki M, Wang KK, Narayana SV (2003) A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor. J. Mol. Biol. 328(1);131-46.
PMID:12747838 Zeng W, Mak DO, Li Q, Shin DM, Foskett JK, Muallem S (2003) A new mode of Ca2+ signaling by G protein-coupled receptors: gating of IP3 receptor Ca2+ release channels by Gbetagamma. Curr. Biol. 13(10);872-6.
PMID:12820959 Wu G, Xu G, Schulman BA, Jeffrey PD, Harper JW, Pavletich NP (2003) Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol. Cell 11(6);1445-56.
PMID:12839624 Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y (2003) The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8(7);645-54.
PMID:12941693 Jenny A, Darken RS, Wilson PA, Mlodzik M (2003) Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling. EMBO J. 22(17);4409-20.
PMID:12944472 Wu CC, Hsu SC, Shih HM, Lai MZ (2003) Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cells. Mol. Cell. Biol. 23(18);6442-54.
PMID:12958364 Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ (2003) Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science 301(5638);1391-4.
PMID:14585353 Luo J, Manning BD, Cantley LC (2003) Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4(4);257-62.
PMID:14612448 Altznauer F, Conus S, Cavalli A, Folkers G, Simon HU (2003) Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis. J. Biol. Chem. 279(7);5947-57.
PMID:14627704 Wu HY, Tomizawa K, Oda Y, Wei FY, Lu YF, Matsushita M, Li ST, Moriwaki A, Matsui H (2003) Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration. J. Biol. Chem. 279(6);4929-40.
PMID:14652070 Seeley S, Covic L, Jacques SL, Sudmeier J, Baleja JD, Kuliopulos A (2003) Structural basis for thrombin activation of a protease-activated receptor: inhibition of intramolecular liganding. Chem. Biol. 10(11);1033-41.
PMID:14681224 Cartron PF, Oliver L, Juin P, Meflah K, Vallette FM (2003) The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein. J. Biol. Chem. 279(12);11503-12.
PMID:14704854 Wang HY, Malbon CC (2004) Wnt-frizzled signaling to G-protein-coupled effectors. Cell. Mol. Life Sci. 61(1);69-75.
PMID:14741051 Shou Y, Li L, Prabhakaran K, Borowitz JL, Isom GE (2004) Calcineurin-mediated Bad translocation regulates cyanide-induced neuronal apoptosis. Biochem. J. 379(Pt 3);805-13.
PMID:14747478 Golan T, Yaniv A, Bafico A, Liu G, Gazit A (2004) The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. J. Biol. Chem. 279(15);14879-88.
PMID:14960582 Smit L, Baas A, Kuipers J, Korswagen H, van de Wetering M, Clevers H (2004) Wnt activates the Tak1/Nemo-like kinase pathway. J. Biol. Chem. 279(17);17232-40.
PMID:14976311 Raftopoulou M, Etienne-Manneville S, Self A, Nicholls S, Hall A (2004) Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303(5661);1179-81.
PMID:15036616 Yang L, Omori K, Suzukawa J, Inagaki C (2004) Calcineurin-mediated BAD Ser155 dephosphorylation in ammonia-induced apoptosis of cultured rat hippocampal neurons. Neurosci. Lett. 357(1);73-5.
PMID:15071497 Pintard L, Willems A, Peter M (2004) Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J. 23(8);1681-7.
PMID:15117942 Terui Y, Saad N, Jia S, McKeon F, Yuan J (2004) Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. J. Biol. Chem. 279(27);28257-65.
PMID:15121840 Okamura H, Garcia-Rodriguez C, Martinson H, Qin J, Virshup DM, Rao A (2004) A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol. Cell. Biol. 24(10);4184-95.
PMID:15169778 Feng J, Tamaskovic R, Yang Z, Brazil DP, Merlo A, Hess D, Hemmings BA (2004) Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. J. Biol. Chem. 279(34);35510-7.
PMID:15187187 Roux PP, Blenis J (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68(2);320-44.
PMID:15239952 Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E (2004) Sef is a spatial regulator for Ras/MAP kinase signaling. Dev. Cell 7(1);33-44.
PMID:15240885 Krakstad BF, Ardawatia VV, Aragay AM (2004) A role for Galpha12/Galpha13 in p120ctn regulation. Proc. Natl. Acad. Sci. U.S.A. 101(28);10314-9.
PMID:15265686 Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (2004) Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells. Exp. Cell Res. 298(2);369-87.
PMID:15340381 Cardozo T, Pagano M (2004) The SCF ubiquitin ligase: insights into a molecular machine. Nat. Rev. Mol. Cell Biol. 5(9);739-51.
PMID:15371335 Brembeck FH, Schwarz-Romond T, Bakkers J, Wilhelm S, Hammerschmidt M, Birchmeier W (2004) Essential role of BCL9-2 in the switch between beta-catenin’s adhesive and transcriptional functions. Genes Dev. 18(18);2225-30.
PMID:15375164 Kani S, Oishi I, Yamamoto H, Yoda A, Suzuki H, Nomachi A, Iozumi K, Nishita M, Kikuchi A, Takumi T, Minami Y (2004) The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon. J. Biol. Chem. 279(48);50102-9.
PMID:15388793 Billiard J, Way DS, Seestaller-Wehr LM, Moran RA, Mangine A, Bodine PV (2004) The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. Mol. Endocrinol. 19(1);90-101.
PMID:15489953 Li HH, Kedar V, Zhang C, McDonough H, Arya R, Wang DZ, Patterson C (2004) Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. J. Clin. Invest. 114(8);1058-71.
PMID:15526030 Rui Y, Xu Z, Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC (2004) Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23(23);4583-94.
PMID:15547943 Sharma C, Vomastek T, Tarcsafalvi A, Catling AD, Schaeffer HJ, Eblen ST, Weber MJ (2004) MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling. J. Cell. Biochem. 94(4);708-19.
PMID:15567848 Schlessinger J (2004) Common and distinct elements in cellular signaling via EGF and FGF receptors. Science 306(5701);1506-7.
PMID:15618519 Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ (2004) Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 306(5705);2257-60.
PMID:15657064 Li L, Li Z, Sacks DB (2005) The transcriptional activity of estrogen receptor-alpha is dependent on Ca2+/calmodulin. J. Biol. Chem. 280(13);13097-104.
PMID:15657420 Yang TT, Xiong Q, Graef IA, Crabtree GR, Chow CW (2005) Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex. Mol. Cell. Biol. 25(3);907-20.
PMID:15668399 Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM, Tindall DJ (2005) Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc. Natl. Acad. Sci. U.S.A. 102(5);1649-54.
PMID:15688063 Petroski MD, Deshaies RJ (2005) Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 6(1);9-20.
PMID:15707890 Boire A, Covic L, Agarwal A, Jacques S, Sherifi S, Kuliopulos A (2005) PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120(3);303-13.
PMID:15755874 Steigerwald K, Behbehani GK, Combs KA, Barton MC, Groden J (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Mol. Cancer Res. 3(2);78-89.
PMID:15782111 Cai Y, Stafford LJ, Bryan BA, Mitchell D, Liu M (2005) G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6. Oncogene 24(26);4293-300.
PMID:15793569 Li Z, Dong X, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D (2005) Regulation of PTEN by Rho small GTPases. Nat. Cell Biol. 7(4);399-404.
PMID:16039586 Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC (2005) Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol. Cell 19(2);159-70.
PMID:16054021 Higashiyama S, Nanba D (2005) ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk. Biochim. Biophys. Acta 1751(1);110-7.
PMID:16054198 Weber G (2005) Down-regulation of increased signal transduction capacity in human cancer cells. Adv. Enzyme Regul. 45;37-51.
PMID:16099633 Lilien J, Balsamo J (2005) The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin. Curr. Opin. Cell Biol. 17(5);459-65.
PMID:16129881 Franco SJ, Huttenlocher A (2005) Regulating cell migration: calpains make the cut. J. Cell. Sci. 118(Pt 17);3829-38.
PMID:16131541 Chan B, Greenan G, McKeon F, Ellenberger T (2005) Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 102(37);13075-80.
PMID:16263762 Schwarz-Romond T, Merrifield C, Nichols BJ, Bienz M (2005) The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. J. Cell. Sci. 118(Pt 22);5269-77.
PMID:16286006 Holz MK, Ballif BA, Gygi SP, Blenis J (2005) mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123(4);569-80.
PMID:16288286 Lian Z, Di Cristofano A (2005) Class reunion: PTEN joins the nuclear crew. Oncogene 24(50);7394-400.
PMID:16307918 Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A (2005) Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol. Cell 20(4);539-50.
PMID:16393692 Yoon S, Seger R (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24(1);21-44.
PMID:16396959 Carroll JS, Brown M (2006) Estrogen receptor target gene: an evolving concept. Mol. Endocrinol. 20(8);1707-14.
PMID:16402909 Harden TK, Sondek J (2006) Regulation of phospholipase C isozymes by ras superfamily GTPases. Annu. Rev. Pharmacol. Toxicol. 46;355-79.
PMID:16406523 Salomoni P, Khelifi AF (2006) Daxx: death or survival protein? Trends Cell Biol. 16(2);97-104.
PMID:16443747 Cadigan KM, Liu YI (2006) Wnt signaling: complexity at the surface. J. Cell. Sci. 119(Pt 3);395-402.
PMID:16446366 Zhang L, Gao X, Wen J, Ning Y, Chen YG (2006) Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. J. Biol. Chem. 281(13);8607-12.
PMID:16455648 Wu W, Misra RS, Russell JQ, Flavell RA, Rinc–n M, Budd RC (2006) Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3. J. Biol. Chem. 281(16);10682-90.
PMID:16476742 Taurin S, Sandbo N, Qin Y, Browning D, Dulin NO (2006) Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase. J. Biol. Chem. 281(15);9971-6.
PMID:16511445 Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A (2006) A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature 441(7093);646-50.
PMID:16525676 Bergmann S, Junker K, Henklein P, Hollenberg MD, Settmacher U, Kaufmann R (2006) PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration. Oncol. Rep. 15(4);889-93.
PMID:16604063 Mu–oz R, Moreno M, Oliva C, Orbenes C, Larra–n J (2006) Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos. Nat. Cell Biol. 8(5);492-500.
PMID:16648474 Liu Q, Wilkins BJ, Lee YJ, Ichijo H, Molkentin JD (2006) Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. Mol. Cell. Biol. 26(10);3785-97.
PMID:16680151 Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP (2006) Identification of a tumour suppressor network opposing nuclear Akt function. Nature 441(7092);523-7.
PMID:16847462 Engelman JA, Luo J, Cantley LC (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 7(8);606-19.
PMID:16868183 Stemmle LN, Fields TA, Casey PJ (2006) The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13. Mol. Pharmacol. 70(4);1461-8.
PMID:16969074 Boquoi A, Enders G (2006) Ubiquitination of Myc: flipping the switch. Cancer Biol. Ther. 5(8);907-8.
PMID:16998587 Dav– V, Childs T, Xu Y, Ikegami M, Besnard V, Maeda Y, Wert SE, Neilson JR, Crabtree GR, Whitsett JA (2006) Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J. Clin. Invest. 116(10);2597-609.
PMID:17030191 Chan DW, Chan CY, Yam JW, Ching YP, Ng IO (2006) Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer. Gastroenterology 131(4);1218-27.
PMID:17113272 Hoffmans R, Basler K (2006) BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. Mech. Dev. 124(1);59-67.
PMID:17127310 Hlubek F, Spaderna S, Schmalhofer O, Jung A, Kirchner T, Brabletz T (2006) Wnt/FZD signaling and colorectal cancer morphogenesis. Front. Biosci. 12;458-70.
PMID:17143292 Kimelman D, Xu W (2006) beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene 25(57);7482-91.
PMID:17158541 Mitra AP, Datar RH, Cote RJ (2006) Molecular pathways in invasive bladder cancer: new insights into mechanisms, progression, and target identification. J. Clin. Oncol. 24(35);5552-64.
PMID:17218262 Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y (2007) Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128(1);157-70.
PMID:17244647 Bryja V, Schulte G, Rawal N, Grahn A, Arenas E (2007) Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J. Cell. Sci. 120(Pt 4);586-95.
PMID:17293347 Moseley JB, Bartolini F, Okada K, Wen Y, Gundersen GG, Goode BL (2007) Regulated binding of adenomatous polyposis coli protein to actin. J. Biol. Chem. 282(17);12661-8.
PMID:17297457 Qian J, Steigerwald K, Combs KA, Barton MC, Groden J (2007) Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis. Oncogene 26(33);4872-6.
PMID:17374729 Salah Z, Maoz M, Pokroy E, Lotem M, Bar-Shavit R, Uziely B (2007) Protease-activated receptor-1 (hPar1), a survival factor eliciting tumor progression. Mol. Cancer Res. 5(3);229-40.
PMID:17430994 Johnston CA, Siderovski DP (2007) Receptor-mediated activation of heterotrimeric G-proteins: current structural insights. Mol. Pharmacol. 72(2);219-30.
PMID:17439715 Cui J, Zhang M, Zhang YQ, Xu ZH (2007) JNK pathway: diseases and therapeutic potential. Acta Pharmacol. Sin. 28(5);601-8.
PMID:17496910 McKay MM, Morrison DK (2007) Integrating signals from RTKs to ERK/MAPK. Oncogene 26(22);3113-21.
PMID:17535800 Lyons TR, Thorburn J, Ryan PW, Thorburn A, Anderson SM, Kassenbrock CK (2007) Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. J. Biol. Chem. 282(30);21987-97.
PMID:17588722 Kurzik-Dumke U, Czaja J (2007) Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC. Cell. Signal. 19(9);1973-85.
PMID:17593948 Wu HY, Tomizawa K, Matsui H (2007) Calpain-calcineurin signaling in the pathogenesis of calcium-dependent disorder. Acta Med. Okayama 61(3);123-37.
PMID:17613518 McKay MM, Morrison DK (2007) Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1. J. Biol. Chem. 282(36);26225-34.
PMID:17662023 Shioda N, Han F, Moriguchi S, Fukunaga K (2007) Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia. J. Neurochem. 102(5);1506-17.
PMID:17680028 Yang Q, Guan KL (2007) Expanding mTOR signaling. Cell Res. 17(8);666-81.
PMID:17684012 Ma L, Wang HY (2007) Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway. J. Biol. Chem. 282(39);28980-90.
PMID:17884187 Schulte G, Bryja V (2007) The Frizzled family of unconventional G-protein-coupled receptors. Trends Pharmacol. Sci. 28(10);518-25.
PMID:17928811 Bernardi R, Pandolfi PP (2007) Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat. Rev. Mol. Cell Biol. 8(12);1006-16.
PMID:17986005 Yamamoto H, Yoo SK, Nishita M, Kikuchi A, Minami Y (2007) Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 12(11);1215-23.
PMID:18000759 Ellenbroek SI, Collard JG (2007) Rho GTPases: functions and association with cancer. Clin. Exp. Metastasis 24(8);657-72.
PMID:18042541 Kuo YC, Huang KY, Yang CH, Yang YS, Lee WY, Chiang CW (2007) Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J. Biol. Chem. 283(4);1882-92.
PMID:18078995 Valdor R, Schreiber V, Saenz L, Mart–nez T, Mu–oz-Suano A, Dominguez-Villar M, Ram–rez P, Parrilla P, Aguado E, Garc–a-C–zar F, Y–lamos J (2007) Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells. Mol. Immunol. 45(7);1863-71.
PMID:18097445 Youle RJ, Strasser A (2007) The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9(1);47-59.
PMID:18187455 Bikkavilli RK, Feigin ME, Malbon CC (2008) G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells. J. Cell. Sci. 121(Pt 2);234-45.
PMID:18218901 Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF (2008) NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science 319(5862);476-81.
PMID:18235236 Medyouf H, Ghysdael J (2008) The calcineurin/NFAT signaling pathway: a novel therapeutic target in leukemia and solid tumors. Cell Cycle 7(3);297-303.
PMID:18256687 Tanegashima K, Zhao H, Dawid IB (2008) WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation. EMBO J. 27(4);606-17.
PMID:18285450 Sabath E, Negoro H, Beaudry S, Paniagua M, Angelow S, Shah J, Grammatikakis N, Yu AS, Denker BM (2008) Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly. J. Cell. Sci. 121(Pt 6);814-24.
PMID:18299389 Olabisi OA, Soto-Nieves N, Nieves E, Yang TT, Yang X, Yu RY, Suk HY, Macian F, Chow CW (2008) Regulation of transcription factor NFAT by ADP-ribosylation. Mol. Cell. Biol. 28(9);2860-71.
PMID:18372913 Arora P, Cuevas BD, Russo A, Johnson GL, Trejo J (2008) Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion. Oncogene 27(32);4434-45.
PMID:18481918 Obsilov– V, Silhan J, Boura E, Teisinger J, Obsil T (2008) 14-3-3 proteins: a family of versatile molecular regulators. Physiol Res 57 Suppl 3;S11-21.
PMID:18497258 Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ (2008) Beta-arrestin-mediated localization of smoothened to the primary cilium. Science 320(5884);1777-81.
PMID:18559511 Krauss S, Foerster J, Schneider R, Schweiger S (2008) Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3. Cancer Res. 68(12);4658-65.
PMID:18606138 Yamamoto S, Nishimura O, Misaki K, Nishita M, Minami Y, Yonemura S, Tarui H, Sasaki H (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15(1);23-36.
PMID:18636226 Vervoorts J, L–scher B (2008) Post-translational regulation of the tumor suppressor p27(KIP1). Cell. Mol. Life Sci. 65(20);3255-64.
PMID:18762249 Winkel A, Stricker S, Tylzanowski P, Seiffart V, Mundlos S, Gross G, Hoffmann A (2008) Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling. Cell. Signal. 20(11);2134-44.
PMID:18851840 Partovian C, Ju R, Zhuang ZW, Martin KA, Simons M (2008) Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells. Mol. Cell 32(1);140-9.
PMID:18855897 Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD (2008) MAP3Ks as central regulators of cell fate during development. Dev. Dyn. 237(11);3102-14.
PMID:18953287 Bryja V, Schambony A, Caj–nek L, Dominguez I, Arenas E, Schulte G (2008) Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. EMBO Rep. 9(12);1244-50.
PMID:18974774 Sombroek D, Hofmann TG (2008) How cells switch HIPK2 on and off. Cell Death Differ. 16(2);187-94.
PMID:19020754 Tickenbrock L, Hehn S, Sargin B, Choudhary C, B–umer N, Buerger H, Schulte B, M–ller O, Berdel WE, M–ller-Tidow C, Serve H (2008) Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4. Int. J. Oncol. 33(6);1215-21.
PMID:19027299 Morrison DK (2008) The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. Trends Cell Biol. 19(1);16-23.
PMID:19029934 Jeanes A, Gottardi CJ, Yap AS (2008) Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene 27(55);6920-9.
PMID:19056682 Bryja V, Andersson ER, Schambony A, Esner M, Bryjov– L, Biris KK, Hall AC, Kraft B, Cajanek L, Yamaguchi TP, Buckingham M, Arenas E (2008) The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol. Biol. Cell 20(3);924-36.
PMID:19072724 Williams BO, Insogna KL (2009) Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone. J. Bone Miner. Res. 24(2);171-8.
PMID:19131971 Arnold HK, Zhang X, Daniel CJ, Tibbitts D, Escamilla-Powers J, Farrell A, Tokarz S, Morgan C, Sears RC (2009) The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc. EMBO J. 28(5);500-12.
PMID:19136967 Liu Q, Busby JC, Molkentin JD (2009) Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nat. Cell Biol. 11(2);154-61.
PMID:19151919 Bosco EE, Mulloy JC, Zheng Y (2009) Rac1 GTPase: a "Rac" of all trades. Cell. Mol. Life Sci. 66(3);370-4.
PMID:19218564 Nayak A, Gl–ckner-Pagel J, Vaeth M, Schumann JE, Buttmann M, Bopp T, Schmitt E, Serfling E, Berberich-Siebelt F (2009) Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase. J. Biol. Chem. 284(16);10935-46.
PMID:19289794 Lu A, Tebar F, Alvarez-Moya B, L–pez-Alcal– C, Calvo M, Enrich C, Agell N, Nakamura T, Matsuda M, Bachs O (2009) A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes. J. Cell Biol. 184(6);863-79.
PMID:19352404 Schulman BA, Harper JW (2009) Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat. Rev. Mol. Cell Biol. 10(5);319-31.
PMID:19359428 van der Merwe JQ, Moreau F, MacNaughton WK (2009) Protease-activated receptor-2 stimulates intestinal epithelial chloride transport through activation of PLC and selective PKC isoforms. Am. J. Physiol. Gastrointest. Liver Physiol. 296(6);G1258-66.
PMID:19366350 Rayasam GV, Tulasi VK, Sodhi R, Davis JA, Ray A (2009) Glycogen synthase kinase 3: more than a namesake. Br. J. Pharmacol. 156(6);885-98.
PMID:19379695 Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, Sakuma R, Luga V, Roncari L, Attisano L, Wrana JL (2009) Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell 137(2);295-307.
PMID:19459846 Kitagawa K, Kotake Y, Kitagawa M (2009) Ubiquitin-mediated control of oncogene and tumor suppressor gene products. Cancer Sci. 100(8);1374-81.
PMID:19541618 McKay MM, Ritt DA, Morrison DK (2009) Signaling dynamics of the KSR1 scaffold complex. Proc. Natl. Acad. Sci. U.S.A. 106(27);11022-7.
PMID:19565474 Yao Z, Seger R (2010) The ERK signaling cascade–views from different subcellular compartments. Biofactors 35(5);407-16.
PMID:19568798 Gunn RM, Hailes HC (2009) Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules. J Chem Biol 1(1-4);49-62.
PMID:19577357 Cantrell VA, Jessen JR (2010) The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion. Cancer Lett. 287(1);54-61.
PMID:19608982 MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown JH, Sabri AK, Molkentin JD, Houser SR (2009) CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circ. Res. 105(4);316-25.
PMID:19619488 MacDonald BT, Tamai K, He X (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17(1);9-26.
PMID:19641503 Lomonosova E, Chinnadurai G (2009) BH3-only proteins in apoptosis and beyond: an overview. Oncogene 27 Suppl 1;S2-19.
PMID:19685005 Park J, Song WJ, Chung KC (2009) Function and regulation of Dyrk1A: towards understanding Down syndrome. Cell. Mol. Life Sci. 66(20);3235-40.
PMID:19701191 Suriben R, Kivim–e S, Fisher DA, Moon RT, Cheyette BN (2009) Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat. Genet. 41(9);977-85.
PMID:19725819 Al-Shanti N, Stewart CE (2010) Ca2+/calmodulin-dependent transcriptional pathways: potential mediators of skeletal muscle growth and development. Biol Rev Camb Philos Soc 84(4);637-52.
PMID:19853559 Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ (2009) Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Dev. Cell 17(4);443-58.
PMID:19900451 Qian J, Perchiniak EM, Sun K, Groden J (2010) The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis. Gastroenterology 138(4);1418-28.
PMID:19906679 Gosens R, Baarsma HA, Heijink IH, Oenema TA, Halayko AJ, Meurs H, Schmidt M (2010) De novo synthesis of {beta}-catenin via H-Ras and MEK regulates airway smooth muscle growth. FASEB J. 24(3);757-68.
PMID:19910923 Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A (2010) Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J. 29(1);41-54.
PMID:19928350 Etienne-Manneville S (2010) APC in cell migration. Adv. Exp. Med. Biol. 656;30-40.
PMID:19966784 Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, Ginty DD (2010) Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat. Cell Biol. 12(1);41-6; sup pp 1-8.
PMID:20006983 Gao C, Chen YG (2010) Dishevelled: The hub of Wnt signaling. Cell. Signal. 22(5);717-27.
PMID:20008297 Vemula S, Shi J, Hanneman P, Wei L, Kapur R (2010) ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Blood 115(9);1785-96.
PMID:20008353 Bleicken S, Classen M, Padmavathi PV, Ishikawa T, Zeth K, Steinhoff HJ, Bordignon E (2010) Molecular details of Bax activation, oligomerization, and membrane insertion. J. Biol. Chem. 285(9);6636-47.
PMID:20093472 Cruciat CM, Ohkawara B, Acebron SP, Karaulanov E, Reinhard C, Ingelfinger D, Boutros M, Niehrs C (2010) Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 327(5964);459-63.
PMID:20194509 Li M, Wang H, Huang T, Wang J, Ding Y, Li Z, Zhang J, Li L (2010) TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. J. Biol. Chem. 285(18);13397-404.
PMID:20214616 Carnero A (2010) The PKB/AKT pathway in cancer. Curr. Pharm. Des. 16(1);34-44.
PMID:20215527 Witte F, Bernatik O, Kirchner K, Masek J, Mahl A, Krejci P, Mundlos S, Schambony A, Bryja V, Stricker S (2010) Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2. FASEB J. 24(7);2417-26.
PMID:20223821 Turm H, Maoz M, Katz V, Yin YJ, Offermanns S, Bar-Shavit R (2010) Protease-activated receptor-1 (PAR1) acts via a novel Galpha13-dishevelled axis to stabilize beta-catenin levels. J. Biol. Chem. 285(20);15137-48.
PMID:20347994 Rezabkova L, Boura E, Herman P, Vecer J, Bourova L, Sulc M, Svoboda P, Obsilova V, Obsil T (2010) 14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3). J. Struct. Biol. 170(3);451-61.
PMID:20351293 Ju R, Cirone P, Lin S, Griesbach H, Slusarski DC, Crews CM (2010) Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 107(15);6906-11.
PMID:20398329 Wickenden JA, Watson CJ (2010) Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts. Breast Cancer Res. 12(2);202.
PMID:20452955 Lallemand-Breitenbach V, de Th– H (2010) PML nuclear bodies. Cold Spring Harb Perspect Biol 2(5);a000661.
PMID:20457807 Nishita M, Itsukushima S, Nomachi A, Endo M, Wang Z, Inaba D, Qiao S, Takada S, Kikuchi A, Minami Y (2010) Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization. Mol. Cell. Biol. 30(14);3610-9.
PMID:20506250 Gong X, Ming X, Deng P, Jiang Y (2010) Mechanisms regulating the nuclear translocation of p38 MAP kinase. J. Cell. Biochem. 110(6);1420-9.
PMID:20514436 Yang D, Ma S, Tan Y, Li D, Tang B, Zhang X, Sun M, Yang Y (2010) Increased expression of calpain and elevated activity of calcineurin in the myocardium of patients with congestive heart failure. Int. J. Mol. Med. 26(1);159-64.
PMID:20516082 Singh G, Singh SK, K–nig A, Reutlinger K, Nye MD, Adhikary T, Eilers M, Gress TM, Fernandez-Zapico ME, Ellenrieder V (2010) Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation. J. Biol. Chem. 285(35);27241-50.
PMID:20553968 Fukami K, Inanobe S, Kanemaru K, Nakamura Y (2011) Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance. Prog. Lipid Res. 49(4);429-37.
PMID:20558317 Hanif IM, Hanif IM, Shazib MA, Ahmad KA, Pervaiz S (2011) Casein Kinase II: an attractive target for anti-cancer drug design. Int. J. Biochem. Cell Biol. 42(10);1602-5.
PMID:20579883 Buechling T, Bartscherer K, Ohkawara B, Chaudhary V, Spirohn K, Niehrs C, Boutros M (2010) Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr. Biol. 20(14);1263-8.
PMID:20628572 Freisinger CM, Fisher RA, Slusarski DC (2010) Regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning. PLoS Genet. 6(7);e1001020.
PMID:20679392 Manfredi JJ (2010) The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev. 24(15);1580-9.
PMID:20699474 Niehrs C, Boutros M (2010) Trafficking, acidification, and growth factor signaling. Sci Signal 3(134);pe26.
PMID:20709625 Ghibelli L, Diederich M (2011) Multistep and multitask Bax activation. Mitochondrion 10(6);604-13.
PMID:20711444 Cox B, Briscoe J, Ulloa F (2010) SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors. PLoS ONE 5(8);e11996.
PMID:20930545 Tauriello DV, Maurice MM (2011) The various roles of ubiquitin in Wnt pathway regulation. Cell Cycle 9(18);3700-9.
PMID:20947020 Yu A, Xing Y, Harrison SC, Kirchhausen T (2011) Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure 18(10);1311-20.
PMID:20976471 Montenarh M (2011) Cellular regulators of protein kinase CK2. Cell Tissue Res. 342(2);139-46.
PMID:21069266 Yuan Y, Niu CC, Deng G, Li ZQ, Pan J, Zhao C, Yang ZL, Si WK (2011) The Wnt5a/Ror2 noncanonical signaling pathway inhibits canonical Wnt signaling in K562 cells. Int. J. Mol. Med. 27(1);63-9.
PMID:21078818 Grumolato L, Liu G, Mong P, Mudbhary R, Biswas R, Arroyave R, Vijayakumar S, Economides AN, Aaronson SA (2010) Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev. 24(22);2517-30.
PMID:21087212 Nguyen G (2011) Renin, (pro)renin and receptor: an update. Clin. Sci. 120(5);169-78.
PMID:21115349 Li H, Rao A, Hogan PG (2011) Interaction of calcineurin with substrates and targeting proteins. Trends Cell Biol. 21(2);91-103.
PMID:21233202 Hutchinson JA, Shanware NP, Chang H, Tibbetts RS (2011) Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. J. Biol. Chem. 286(10);8688-96.
PMID:21237163 Rooney B, O’Donovan H, Gaffney A, Browne M, Faherty N, Curran SP, Sadlier D, Godson C, Brazil DP, Crean J (2011) CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: implications for the pathogenesis of diabetic nephropathy. FEBS Lett. 585(3);531-8.
PMID:21262816 Li S, Esterberg R, Lachance V, Ren D, Radde-Gallwitz K, Chi F, Parent JL, Fritz A, Chen P (2011) Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity. Proc. Natl. Acad. Sci. U.S.A. 108(6);2264-9.
PMID:21262972 Chen H, Liu L, Ma B, Ma TM, Hou JJ, Xie GM, Wu W, Yang FQ, Chen YG (2011) Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation. J. Biol. Chem. 286(17);14870-80.
PMID:21266584 Azoulay-Alfaguter I, Yaffe Y, Licht-Murava A, Urbanska M, Jaworski J, Pietrokovski S, Hirschberg K, Eldar-Finkelman H (2011) Distinct molecular regulation of glycogen synthase kinase-3alpha isozyme controlled by its N-terminal region: functional role in calcium/calpain signaling. J. Biol. Chem. 286(15);13470-80.
PMID:21278340 Ishiguro K, Ando T, Maeda O, Watanabe O, Goto H (2011) Cutting edge: tubulin — functions as an adaptor in NFAT-importin — interaction. J. Immunol. 186(5);2710-3.
PMID:21303971 Schramp M, Thapa N, Heck J, Anderson R (2011) PIPKI– regulates —catenin transcriptional activity downstream of growth factor receptor signaling. Cancer Res. 71(4);1282-91.
PMID:21316585 Gao B, Song H, Bishop K, Elliot G, Garrett L, English MA, Andre P, Robinson J, Sood R, Minami Y, Economides AN, Yang Y (2011) Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev. Cell 20(2);163-76.
PMID:21376121 Suzuki YJ (2011) Cell signaling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis. Cell. Signal. 23(7);1094-9.
PMID:21380625 Hermle T, Petzoldt AG, Simons M (2011) The role of proton transporters in epithelial Wnt signaling pathways. Pediatr. Nephrol. 26(9);1523-7.
PMID:21386996 Kveiborg M, Instrell R, Rowlands C, Howell M, Parker PJ (2011) PKC– and PKC– regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways. PLoS ONE 6(2);e17168.
PMID:21397842 Ohkawara B, Glinka A, Niehrs C (2011) Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. Dev. Cell 20(3);303-14.
PMID:21406690 Wan M, Li J, Herbst K, Zhang J, Yu B, Wu X, Qiu T, Lei W, Lindvall C, Williams BO, Ma H, Zhang F, Cao X (2011) LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of G–(s). Sci Signal 4(164);ra15.
PMID:21414921 S–nchez-G–mez MV, Alberdi E, P–rez-Navarro E, Alberch J, Matute C (2011) Bax and calpain mediate excitotoxic oligodendrocyte death induced by activation of both AMPA and kainate receptors. J. Neurosci. 31(8);2996-3006.
PMID:21486225 Krishna S, Low IC, Pervaiz S (2011) Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2. Biochem. J. 435(3);545-51.
PMID:21506126 Ponce DP, Maturana JL, Cabello P, Yefi R, Niechi I, Silva E, Armisen R, Galindo M, Antonelli M, Tapia JC (2011) Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of —catenin transcriptional activity. J. Cell. Physiol. 226(7);1953-9.
PMID:21518267 Kikuchi A, Yamamoto H, Sato A, Matsumoto S (2012) Wnt5a: its signalling, functions and implication in diseases. Acta Physiol (Oxf) 204(1);17-33.
PMID:21619876 Raptis L, Arulanandam R, Geletu M, Turkson J (2011) The R(h)oads to Stat3: Stat3 activation by the Rho GTPases. Exp. Cell Res. 317(13);1787-95.
PMID:21640127 Thennes T, Mehta D (2012) Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function. Microvasc. Res. 83(1);31-44.
PMID:21642958 Lima-Fernandes E, Enslen H, Camand E, Kotelevets L, Boularan C, Achour L, Benmerah A, Gibson LC, Baillie GS, Pitcher JA, Chastre E, Etienne-Manneville S, Marullo S, Scott MG (2011) Distinct functional outputs of PTEN signalling are controlled by dynamic association with —arrestins. EMBO J. 30(13);2557-68.
PMID:21670566 Sorimachi H, Hata S, Ono Y (2011) Calpain chronicle–an enzyme family under multidisciplinary characterization. Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. 87(6);287-327.
PMID:21693646 Carmon KS, Gong X, Lin Q, Thomas A, Liu Q (2011) R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Proc. Natl. Acad. Sci. U.S.A. 108(28);11452-7.
PMID:21709260 Sharma S, Findlay GM, Bandukwala HS, Oberdoerffer S, Baust B, Li Z, Schmidt V, Hogan PG, Sacks DB, Rao A (2011) Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc. Natl. Acad. Sci. U.S.A. 108(28);11381-6.
PMID:21718540 Kivim–e S, Yang XY, Cheyette BN (2011) All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. BMC Biochem. 12;33.
PMID:21727895 de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H (2011) Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 476(7360);293-7.
PMID:21736902 Parrales A, L–pez E, L–pez-Colom– AM (2011) Thrombin activation of PI3K/PDK1/Akt signaling promotes cyclin D1 upregulation and RPE cell proliferation. Biochim. Biophys. Acta 1813(10);1758-66.
PMID:21738214 Cabon L, Gal–n-Malo P, Bouharrour A, Delavall–e L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA (2012) BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation. Cell Death Differ. 19(2);245-56.
PMID:21796133 Balakumar P, Jagadeesh G (2012) Potential cross-talk between (pro)renin receptors and Wnt/frizzled receptors in cardiovascular and renal disorders. Hypertens. Res. 34(11);1161-70.
PMID:21829496 Walker F, Zhang HH, Odorizzi A, Burgess AW (2011) LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. PLoS ONE 6(7);e22733.
PMID:21871017 Yiu GK, Kaunisto A, Chin YR, Toker A (2011) NFAT promotes carcinoma invasive migration through glypican-6. Biochem. J. 440(1);157-66.
PMID:21903638 De A (2012) Wnt/Ca2+ signaling pathway: a brief overview. Acta Biochim. Biophys. Sin. (Shanghai) 43(10);745-56.
PMID:21908588 Baarsma HA, Menzen MH, Halayko AJ, Meurs H, Kerstjens HA, Gosens R (2012) —Catenin signaling is required for TGF—1-induced extracellular matrix production by airway smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 301(6);L956-65.
PMID:21909076 Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat CM, Niehrs C (2012) LGR4 and LGR5 are R-spondin receptors mediating Wnt/—catenin and Wnt/PCP signalling. EMBO Rep. 12(10);1055-61.
PMID:21965663 Jung MS, Park JH, Ryu YS, Choi SH, Yoon SH, Kwen MY, Oh JY, Song WJ, Chung SH (2012) Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation. J. Biol. Chem. 286(46);40401-12.
PMID:21983832 Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ (2011) The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat. Immunol. 12(11);1063-70.
PMID:22007144 Tian X, Liu Z, Niu B, Zhang J, Tan TK, Lee SR, Zhao Y, Harris DC, Zheng G (2012) E-cadherin/—catenin complex and the epithelial barrier. J. Biomed. Biotechnol. 2011;567305.
PMID:22017973 Kikuchi A, Yamamoto H, Sato A, Matsumoto S (2012) New insights into the mechanism of Wnt signaling pathway activation. Int Rev Cell Mol Biol 291;21-71.
PMID:22037766 Daulat AM, Luu O, Sing A, Zhang L, Wrana JL, McNeill H, Winklbauer R, Angers S (2012) Mink1 regulates —catenin-independent Wnt signaling via Prickle phosphorylation. Mol. Cell. Biol. 32(1);173-85.
PMID:22088220 Li T, Kilic A, Wei X, Wu C, Schwartzbauer G, Yankey GK, DeFilippi C, Bond M, Wu ZJ, Griffith BP (2014) Regional imbalanced activation of the calcineurin/BAD apoptotic pathway and the PI3K/Akt survival pathway after myocardial infarction. Int. J. Cardiol. 166(1);158-65.
PMID:22094462 Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E (2012) Negative cross-talk between calcium-sensing receptor and —catenin signaling systems in colonic epithelium. J. Biol. Chem. 287(2);1158-67.
PMID:22275375 Zhang Y, Li Z, Sacks DB, Ames JB (2012) Structural basis for Ca2+-induced activation and dimerization of estrogen receptor — by calmodulin. J. Biol. Chem. 287(12);9336-44.
PMID:22399895 Jiao M, Lu G, Jing X, Li S, Li Y, Wang J (2010) A novel radar sensor for the non-contact detection of speech signals. Sensors (Basel) 10(5);4622-33.
PMID:22433869 Goel S, Chin EN, Fakhraldeen SA, Berry SM, Beebe DJ, Alexander CM (2012) Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. J. Biol. Chem. 287(20);16454-66.
PMID:22558232 Krejci P, Aklian A, Kaucka M, Sevcikova E, Prochazkova J, Masek JK, Mikolka P, Pospisilova T, Spoustova T, Weis M, Paznekas WA, Wolf JH, Gutkind JS, Wilcox WR, Kozubik A, Jabs EW, Bryja V, Salazar L, Vesela I, Balek L (2012) Receptor tyrosine kinases activate canonical WNT/—catenin signaling via MAP kinase/LRP6 pathway and direct —catenin phosphorylation. PLoS ONE 7(4);e35826.
PMID:22745173 Wu ZQ, Brabletz T, Fearon E, Willis AL, Hu CY, Li XY, Weiss SJ (2012) Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity. Proc. Natl. Acad. Sci. U.S.A. 109(28);11312-7.
PMID:22898821 Pfister AS, Hadjihannas MV, R–hrig W, Schambony A, Behrens J (2013) Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration. J. Biol. Chem. 287(42);35333-40.
PMID:23308069 Perchiniak EM, Groden J (2011) Mechanisms Regulating Microtubule Binding, DNA Replication, and Apoptosis are Controlled by the Intestinal Tumor Suppressor APC. Curr Colorectal Cancer Rep 7(2);145-151.
PMID:23343194 Kim W, Kim M, Jho EH (2013) Wnt/—catenin signalling: from plasma membrane to nucleus. Biochem. J. 450(1);9-21.

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