WNT canonical pathway

Phenotype WNT canonical pathway map
WNT canonical pathway@Nucleus

References
s_shh2_re16:( Survival  map ) PMID:16328026 PMID:17035233
s_shh2_re23:( Survival  map ) PMID:19424602
s_shh2_re26:( Survival  map ) PMID:18813803

WNT canonical pathway@Cytoplasm

Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re29:( Survival  map ) PMID:12734397
s_wca2_re33:( Survival  map ) PMID:14747478
s_wca2_re57( Survival  map ):
This complex is able to activate target genes of the canonical wnt pathway
PMID:21536646
s_wca2_re61:( Survival  map ) continue with dvl puncta formation
s_wca2_re63( Survival  map ):
Ubiquination at this residue increases b-catenin protein stability and increased top-flash activity
PMID:22705350
s_wca2_re66:( Survival  map ) The destruction is part of the canonical wnt pathway when no WNT ligand is bound to the receptor. This complex makes sure that beta-catenin is degraded.
s_wca2_re71( Survival  map ):
Binding of CRIPTO-1 to LRP5/6 enhances Topflash activity
PMID:23022962
s_wnc1_re20( Survival  map ):
Association of LGR5 w/ Wnt-receptors leads to synergistic TOPFLASH reporter activity
PMID:21727895
LGR5 antagonises Wnt signalling
PMID:21829496
s_wnc1_re48:( Survival  map ) PMID:21237163
s_wnc1_re69( Survival  map ):
PMID:21069266
PMID:15388793
s_wnc1_re72( Survival  map ):
Rack1 inhibits canonical MODULE
PMID:2126816
s_wnc2_re75:( Survival  map ) PMID:18762249
s_wnc4_re6( Survival  map ):
Phosphorylation of LRP6 by ERKk and simultanious activation by Wnt3 gives a higher activation rate of the canoncical wnt pathway (synergetic effect)
PMID:22558232


Modifications:
In compartment: Cytoplasm
  1. WNT canonical pathway@Cytoplasm map

  2. WNT canonical pathway@Cytoplasm map
  3. WNT canonical pathway@Cytoplasm map
  4. WNT canonical pathway@Cytoplasm map

In compartment: Nucleus

  1. WNT canonical pathway@Nucleus map

  2. WNT canonical pathway@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. rWNT11@Nucleus map map WNT canonical pathway@Nucleus map

    2. rSFRP1@Nucleus map map WNT canonical pathway@Nucleus map
    3. rFOXA2@Nucleus map map WNT canonical pathway@Nucleus map
    4. rFOXC2@Nucleus map map WNT canonical pathway@Nucleus map
    5. rFOXL1@Nucleus map map WNT canonical pathway@Nucleus map
    6. rFOXF1@Nucleus map map WNT canonical pathway@Nucleus map
    7. rFOXE1@Nucleus map map WNT canonical pathway@Nucleus map
    8. s_s_wca2_s318 map WNT canonical pathway@Cytoplasm map
    9. s_s_wca2_s320 map WNT canonical pathway@Cytoplasm map
    10. FZD6@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    11. E-Cadherin*:​G_alpha_o*@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    12. CK1*:​LRP6|​T1479_pho|​S1490_pho|​T1493_pho:​TMEM198@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    13. DVL2|​S480_pho|​S298_pho:​LRP6:​RIPK4@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    14. _beta_-Catenin*|​K394_ubi@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    15. APC|​K63_ubi:​AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    16. CRIPTO-1*:​E-Cadherin*:​G_alpha_o*@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    17. WNT2B@Nucleus map map WNT canonical pathway@Nucleus map
    18. DKK3@Nucleus map map WNT canonical pathway@Nucleus map
    19. CK1_epsilon_*:​E-Cadherin*:​LGR5:​RSPO1-4*@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    20. CCN2*:​LRP6@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    21. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map WNT canonical pathway@Cytoplasm map
    22. s_s_wnc1_s396 map WNT canonical pathway@Cytoplasm map
    23. ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    24. _beta_-Catenin*@Cytoplasm map map WNT canonical pathway@Cytoplasm map
    25. LRP6|​pho|​T1572_pho@Cytoplasm map map WNT canonical pathway@Cytoplasm map

    As Catalyser:

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