WEE1

Protein WEE1 map

Identifiers
WEE1 homolog (S. pombe)
HUGO:WEE1 HGNC:12761 ENTREZ:7465 UNIPROT:P30291 GENECARDS:WEE1 REACTOME:104871 KEGG:7465 ATLASONC:GC_WEE1 WIKI:WEE1

Maps_Modules
 DNA repair  map  / G1_CC_PHASE  map
 DNA repair  map  / S_CC_PHASE  map
 DNA repair  map  / G2_CC_PHASE  map
 Cell cycle  map  / WEE  map

References
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786

WEE1|​CHEK1site_pho@Nucleus

References
d_re603( DNA repair  map ):
In response to DNA damage, CHEK1 phosphorylates and activates WEE1, blocks cell cycle and allows DNA repair
PMID:23897299, PMID:23508805
d_re273:( DNA repair  map ) Wee1 phosphorylation of CDC2 keeps the complex inactive

WEE1@Nucleus

References
d_re603( DNA repair  map ):
In response to DNA damage, CHEK1 phosphorylates and activates WEE1, blocks cell cycle and allows DNA repair
PMID:23897299, PMID:23508805

WEE1|​pho@Nucleus

References
c_re195( Cell cycle  map ):
phosphorylation and inactivation of Wee1 kinase
PMID:8515817, PMID:15070733, PMID:7681363 (yeast)
Cyclin B phosphorylates Myt1 in vitro
PMID:9268380


Modifications:
In compartment: Nucleus
  1. WEE1@Nucleus map

  2. WEE1|​pho@Nucleus map
  3. WEE1|​CHEK1site_pho@Nucleus map

In compartment: default

  1. WEE1|​pho@default map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. WEE1@Nucleus map map WEE1|​pho@Nucleus map

    2. WEE1|​CHEK1site_pho@Nucleus map map WEE1|​pho@default map
    3. WEE1|​pho@default map map degraded
    4. WEE1@Nucleus map map WEE1|​CHEK1site_pho@Nucleus map

    As Catalyser:

    1. CDK1|​Thr14_pho:​CyclinB*@Nucleus map map CDK1|​Tyr15_pho|​Thr14_pho:​CyclinB*@Nucleus map

    2. CDK1:​CyclinB*@Nucleus map map CDK1|​Tyr15_pho:​CyclinB*@Nucleus map
    3. CDK2:​CyclinE*@Nucleus map map CDK2|​Tyr14_pho|​Tyr15_pho:​CyclinE*@Nucleus map
    4. CDK1:​CyclinB1*@default map map CDK1|​Y14/15_pho:​CyclinB1*@default map
    5. CDK2:​CyclinE*@default map map CDK2|​Y14/15_pho:​CyclinE*@default map
    6. CDK4_6*:​CyclinD*@default map map CDK4_6*|​Y14_pho:​CyclinD*@default map
    7. CDK2:​CyclinA1*@default map map CDK2|​Y14/15_pho:​CyclinA1*@default map
    8. CDK1:​CyclinA1*@default map map CDK1|​Y14/15_pho:​CyclinA1*@default map

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