WASF2

Protein WASF2 map

Identifiers
WAS protein family, member 2
HUGO:WASF2 HGNC:12733 ENTREZ:10163 UNIPROT:Q9Y6W5 GENECARDS:WASF2 REACTOME:67292 KEGG:10163 ATLASONC:GC_WASF2 WIKI:WASF2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

WASF2@Cytoplasm

References
e_re789( EMT  map ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
PMID:16702231
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
PMID:9843499
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
e_re791( EMT  map ):
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:14749719
PAK1 phosphorylates and activates ARP2_3 complex.


Modifications:
In compartment: Cytoplasm
  1. WASF2@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. Actin cytoskeletal*:​WASF2@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. WASF2@Cytoplasm map map WASF2@Cytoplasm map

  2. WASF2@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​WASF2@Cytoplasm map
  3. Actin cytoskeletal*:​WASF2@Cytoplasm map map Actin polymerization@Nucleus map

As Catalyser:

  1. ARP2_3*@Cytoplasm map map ARP2_3*@Cytoplasm map

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