In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
Cell adhesion to components of the ECM is important in the angiogenesis
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.
e_re958( EMT ):
Laminin-8 interacts with integrins.
e_re966( EMT ):
FYN is required for VAV1 phosphorylation and thus activation.
tyrosine phosphorylation of beta3 integrin and aVb3-mediated adhesion are required for VAV1 assocaition and Rho activation.
Vav1 associates with aVb3 upon cell adhesion to vitronectin
Participates in complexes:
In compartment: Extracellular space
Participates in reactions:
As Reactant or Product:
- aVb3*_aVb5*@Extracellular space + Vitronectin*@Extracellular space → Vitronectin*:aVb3*_aVb5*@Extracellular space
- Vitronectin*:aVb3*_aVb5*@Extracellular space → Cell-matrix adhesions@Extracellular space