Complex Vitronectin*:aVb3*_aVb5* 
Complex composition:
Vitronectin*:aVb3*_aVb5*@Extracellular space
Identifiers
NAME:Vitronectin*:aVb3*_aVb5*
Maps_Modules
EMT / EMT_REGULATORS
EMT / ECM
EMT / CELL_MATRIX_ADHESIONS
References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.
e_re958( EMT ):
Laminin-8 interacts with integrins.
e_re966( EMT ):
PMID:9822663
FYN is required for VAV1 phosphorylation and thus activation.
PMID:15699036
tyrosine phosphorylation of beta3 integrin and aVb3-mediated adhesion are required for VAV1 assocaition and Rho activation.
Vav1 associates with aVb3 upon cell adhesion to vitronectin
Confidence
REF=5 FUNC=5
Modifications:
Participates in complexes:
In compartment: Extracellular space
Participates in reactions:
As Reactant or Product:
- aVb3*_aVb5*@Extracellular space + Vitronectin*@Extracellular space → Vitronectin*:aVb3*_aVb5*@Extracellular space
- Vitronectin*:aVb3*_aVb5*@Extracellular space → Cell-matrix adhesions@Extracellular space
As Catalyser: