VEGFA

Protein VEGFA map

Identifiers
vascular endothelial growth factor A
HUGO:VEGFA HGNC:12680 ENTREZ:7422 UNIPROT:P15692 GENECARDS:VEGFA REACTOME:403002 KEGG:7422 ATLASONC:GC_VEGFA WIKI:VEGFA

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / HIF1  map

References
PMID:9157999
VEGF increased the level of ETS1 mRNA in human umbifical vein endothelial cells and lung microvascular endothelial cells over 5-fold.
Protein levels were shown to increase concordantly.
PMID:15111329
VEGF is a predominant angiogenic factor that mediates ocular neovascularization.
VEGF is increased by hypoxia, which is one of the primary stimuli for ocular neovascularization.
VEGF induces Ets-1 expression in bovine retinal endothelial cells and its expression is PKC/ERK pathway-dependent.
Ets-1 up-regulation is involved in the development of retinal neovascularization, and inhibition of Ets-1 may be beneficial in the treatment of ischemic ocular diseases
PMID:11166270
VEGF stands for the vascular Endothelial Growth Factor family of ligands and receptors is crucial for vascular development and neovascularization in physiological and pathological processes in both embryos, and in adults
PMID:13678960
VEGFs belong to a family of homodimeric glycoproteins that containts five members (VEGF-A, B, C, D, and Placenta growth factor PLGF).
VEGFs bind to 3 different VEGF-receptor tyrosine kinases (VEGFR-1, 2, 3).
Upon ligation, VEGF-receptors dimerize, autophosphorylate and, thereby transduce signals that direct cellular functions.
PMID:10022831
PMID:15501236
VEGFA is a homodimer that exists in five different isoforms comprising 121, 145, 165, 189, and 206 amino acids per chain.
The isoforms differ in their ability to bind heparan sulfate proteoglycans in the extracellular matrix (ECM).
In adult Endothelial cells, VEGFA exhibits high affinity binding to tyrosine kinase receptors, VEGFR1 and VEGFR2.
Although ECs express both receptors, recent findings suggest that only VEGFR2 is able to mediate angiogenic effects of VEGFA

VEGFA@Extracellular space

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:22349261
e_re353( EMT  map ):
PMID:9157999
VEGF increased the level of ETS1 mRNA in human umbifical vein endothelial cells and lung microvascular endothelial cells over 5-fold.
Protein levels were shown to increase concordantly.
PMID:15111329
VEGF induces Ets-1 expression in bovine retinal endothelial cells and its expression is PKC/ERK pathway-dependent.
Ets-1 up-regulation is involved in the development of retinal neovascularization, and inhibition of Ets-1 may be beneficial in the treatment of ischemic ocular diseases
PMID:12490555
Snail is able to induce the expression of Slug and all other neural crest markers (Zic5, FoxD3, Twist and Ets1)
PMID:16716598
PMID:11708773
Endothelin1 is target gene of HIF1
PMID:21041997
In cells induced to undergo EMT, TGFB also activates the expresion of ZEB1 and ZEB2 through upregulation of ETS1 expression, which then may cooperate with the bHLH transcription factor E47 (TCF3)
PMID:17615296
TGFB induces ETS1 transcriptional expression.
TGFB represses ID2 and ID3 transcriptional expression (PMID:15121845 and PMID:15181457)
ID2 may regulate the function of Ets1 to modulate the transcription of ZEB1 and ZEB2 without alteration of the transcription of Ets1.
Ets1 may act as an inducer of ZEB1 in collaboration with E47 (TCF3)

VEGFA@Cytoplasm

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:22349261


Modifications:
In compartment: Cytoplasm
  1. VEGFA@Cytoplasm map

In compartment: Extracellular space

  1. VEGFA@Extracellular space map

  2. VEGFA|​hm2@Extracellular space map

Participates in complexes:
In compartment: Cytoplasm

  1. VEGFA:​VEGFR2*|​hm2@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. VEGFA@Extracellular space map map VEGFA|​hm2@Extracellular space map

  2. rVEGFA@Nucleus map map VEGFA@Extracellular space map
  3. rVEGFA@Nucleus map map VEGFA@Cytoplasm map
  4. VEGFA@Extracellular space map map Angiogenesis@Nucleus map
  5. VEGFA@Cytoplasm map map VEGFA@Extracellular space map
  6. VEGFR2*@Cytoplasm map + VEGFA@Extracellular space map map VEGFA:​VEGFR2*|​hm2@Cytoplasm map

As Catalyser:

  1. gETS1@Nucleus map map rETS1@Nucleus map

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