VEGFA

RNA VEGFA map

Identifiers
vascular endothelial growth factor A
HUGO:VEGFA HGNC:12680 ENTREZ:7422 UNIPROT:P15692 GENECARDS:VEGFA REACTOME:403002 KEGG:7422 ATLASONC:GC_VEGFA WIKI:VEGFA

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / HIF1  map

References
PMID:9157999
VEGF increased the level of ETS1 mRNA in human umbifical vein endothelial cells and lung microvascular endothelial cells over 5-fold.
Protein levels were shown to increase concordantly.
PMID:11166270
VEGF stands for the vascular Endothelial Growth Factor family of ligands and receptors is crucial for vascular development and neovascularization in physiological and pathological processes in both embryos, and in adults
PMID:13678960
VEGFs belong to a family of homodimeric glycoproteins that containts five members (VEGF-A, B, C, D, and Placenta growth factor PLGF).
VEGFs bind to 3 different VEGF-receptor tyrosine kinases (VEGFR-1, 2, 3).
Upon ligation, VEGF-receptors dimerize, autophosphorylate and, thereby transduce signals that direct cellular functions.

rVEGFA@Nucleus

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map

References
PMID:22349261
e_re24( EMT  map ):
PMID:13130303
Keratin-14, 18, 19, Vimentin are putative direct HIF1 target genes
http://www.omicsonline.org/1948-5956/JCST-03-035.php
Genes induced by HIF-1 in cancer cells include KRT-14, 18, 19, Vimentin, VEGF
PMID:9278421
HIF1 target genes include TGFB3, VEGF
PMID:7768934
VEGF is induced by hypoxia in a HIF1-dependent way
PMID:11528470
Prokinecticin 1 (EG-VEGF) is induced by hypoxia through a potential HIF1-dependent mechanism indicates that this gene is in the same homeostatic cascade as VEGF, Flt1 and erythropoietinPMID:17987801 PMID:16716598


Modifications:
In compartment: Nucleus
  1. rVEGFA@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gVEGFA@Nucleus map map rVEGFA@Nucleus map

    2. rVEGFA@Nucleus map map VEGFA@Extracellular space map
    3. gVEGFA@Nucleus map map rVEGFA@Nucleus map
    4. rVEGFA@Nucleus map map VEGFA@Cytoplasm map

    As Catalyser:

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