VE-Cadherin*:_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*

Complex VE-Cadherin*:_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4* map


Complex composition:

  1. VE-Cadherin* map
  2. _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4* map




VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm

Identifiers
NAME:VE-Cadherin*:_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / DESMOSOMES  map

References
PMID:10685062
Adherens junctions are ubiquitously expressed in endothelia of all vascular beds?
Adherens junction in endothelila cells are formed by homofilic binding of VE-cahderin (cadherin-5)
Cadherins are cell adhesion molecules anchored by their cytoplasmic tails to a network of intracellular cytoplasmic proteins connected to the actin-based microfilament system.
Association with catenins is nessesary for cadherin-mediated cell adhesion.
PMID:12426320
VE-cadhein interacts with catenin delta 1 (p120-catenin, CTNND1)
VE-cadhein interacts with Plakophilin 4 (PKP4)
PMID:7962210
VE-cadhein interacts with catenin beta 1 (CTNNB1)
PKP4 and CTNND1 bind to the same region on the cytoplasmic tail of VE-cadherin.
Overexpression of PKP4 can displace CTNND1 from intercellular junctions.
PMID:9739078
VE-cadhein interacts with Plakoglobin (JUP)

Confidence
REF=3 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. VE-Cadherin*@Cytoplasm map + _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map

  2. VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map Desmosomes@Cytoplasm map

As Catalyser:

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