VE-Cadherin*

Protein VE-Cadherin* map

Identifiers
cadherin 5, type 2 (vascular endothelium)
HUGO:CDH5 HGNC:1764 ENTREZ:1003 UNIPROT:P33151 GENECARDS:CDH5 REACTOME:51218 KEGG:1003 ATLASONC:GC_CDH5 WIKI:CDH5

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map

References
PMID:10685062
Adherens junctions are ubiquitously expressed in endothelia of all vascular beds?
Adherens junction in endothelila cells are formed by homofilic binding of VE-cahderin (cadherin-5)
Cadherins are cell adhesion molecules anchored by their cytoplasmic tails to a network of intracellular cytoplasmic proteins connected to the actin-based microfilament system.
Association with catenins is nessesary for cadherin-mediated cell adhesion.
PMID:12426320
VE-cadhein interacts with catenin delta 1 (p120-catenin, CTNND1)
VE-cadhein interacts with Plakophilin 4 (PKP4)
PMID:7962210
VE-cadhein interacts with catenin beta 1 (CTNNB1)
PKP4 and CTNND1 bind to the same region on the cytoplasmic tail of VE-cadherin.
Overexpression of PKP4 can displace CTNND1 from intercellular junctions.
PMID:9739078
VE-cadhein interacts with Plakoglobin (JUP)

VE-Cadherin*@Cytoplasm

References
e_re1006( EMT  map ):
PMID:10685062
Adherens junctions are ubiquitously expressed in endothelia of all vascular beds?
Adherens junction in endothelila cells are formed by homofilic binding of VE-cahderin (cadherin-5)
Cadherins are cell adhesion molecules anchored by their cytoplasmic tails to a network of intracellular cytoplasmic proteins connected to the actin-based microfilament system.
Association with catenins is nessesary for cadherin-mediated cell adhesion.
PMID:12426320
VE-cadhein interacts with catenin delta 1 (p120-catenin, CTNND1)
VE-cadhein interacts with Plakophilin 4 (PKP4)
PMID:7962210
VE-cadhein interacts with catenin beta 1 (CTNNB1)
PKP4 and CTNND1 bind to the same region on the cytoplasmic tail of VE-cadherin.
Overexpression of PKP4 can displace CTNND1 from intercellular junctions.
PMID:9739078
VE-cadhein interacts with Plakoglobin (JUP)


Modifications:
In compartment: Cytoplasm
  1. VE-Cadherin*@Cytoplasm map

  2. VE-Cadherin*|​hm2@Cytoplasm map

In compartment: Extracellular space

  1. VE-Cadherin*@Extracellular space map

Participates in complexes:
In compartment: Cytoplasm

  1. VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. VE-Cadherin*@Cytoplasm map + _beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map

  2. VE-Cadherin*:​_beta_-Catenin*_p120*1_Plakoglobin*_Plakophilin4*@Cytoplasm map map Desmosomes@Cytoplasm map
  3. Plakoglobin binding partners*@Cytoplasm map map VE-Cadherin*@Cytoplasm map
  4. Cadherin*@Cytoplasm map map VE-Cadherin*@Cytoplasm map
  5. VE-Cadherin*@Extracellular space map + VE-Cadherin*@Cytoplasm map map VE-Cadherin*|​hm2@Cytoplasm map

As Catalyser:

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