Vinculin*

Protein Vinculin* map

Identifiers
vinculin
HUGO:VCL HGNC:12665 ENTREZ:7414 UNIPROT:P18206 GENECARDS:VCL REACTOME:67186 KEGG:7414 ATLASONC:GC_VCL WIKI:VCL

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

Vinculin*@Cytoplasm

References
e_re978( EMT  map ):
Autophosphorylation of PTK2:
PMID:7529872
PMID:19339212
PMID:7657702
PMID:16919435
FAK (PTK2) is first recruited to sites of integrin clustering via interactions wiith integrin-associated proteins such as talin, paxillin.
FAK binds to the cytoplasmic domain of b1 integrin via Paxillin (PXN) and Talin (TLN)
Binding to aVb3 or a5b1 integrins induces PTK2 (FAK1) autophosphorylation at Y397.
PMID:10545505
FAK associates with paxillin, vinculin, and p130cas (BCAR1) in the focal adhesion complex
Integrins control motile strategy through a Rho-cofilin pathway.
beta1 integrins promote random migration, whereas beta3 integrins promote persistent migration in the same epithelial cell background.
Adhesion to fibronectin by aVb3 supports actin cytoskeletal reorganization via cofilin, resulting in a single broad lamellipod with static cell-matrix adhesions at the leading edge.
Adhesion by a5b1 instead leads to the phosphorylation and thus inactivation of cofilin, and these cells fail to polarize their cytoskeleton but extend thin protrusions containing highly dynamic cell-matrix adhesions in multiple directions.
The activity of the small GTPase RhoA is particularly high in cells adhering by a5b1, and inhibition of Rho signaling causes a switch from a beta1 to a beta3-associated mode of migration, whereas increased Rho activity has the opposite effect.
Alterations in integrin expression profiles thus allow cells to modulate several critical aspects of the motile machinery through Rho GTPases.


Modifications:
In compartment: Cytoplasm
  1. Vinculin*@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map

  2. Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map
  3. Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​ZYX:​c-SRC*@Cytoplasm map
  4. ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. FAK1*|​Y_pho|​pho:​c-SRC*@Cytoplasm map + BCAR1@Cytoplasm map + Talin*@Cytoplasm map + PXN|​pho@Cytoplasm map + Vinculin*@Cytoplasm map map BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map

  2. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map + Actinin*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map map Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map
  3. Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map + ZYX@Cytoplasm map map Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​ZYX:​c-SRC*@Cytoplasm map
  4. ARP2_3*@Cytoplasm map + Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map map ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map
  5. ARP2_3*:​Actin cytoskeletal*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​Vinculin*:​c-SRC*@Cytoplasm map map Actin polymerization@Nucleus map

As Catalyser:

  1. FAK1*|​emp@Cytoplasm map map FAK1*|​pho@Cytoplasm map

Leave a Reply