VAV1,2 are GEFs for Rac1.
VAV2 is recruited by the CD19 co-receptor of the B cells and participates in the B cell receptor signaling.
in the T cell, VAV1 forms complex with LCP2.
This complex is involved in the T cell receptor and CD28 signaling cascades.
e_re966( EMT ):
FYN is required for VAV1 phosphorylation and thus activation.
tyrosine phosphorylation of beta3 integrin and aVb3-mediated adhesion are required for VAV1 assocaition and Rho activation.
Vav1 associates with aVb3 upon cell adhesion to vitronectin
In compartment: Cytoplasm
Participates in complexes:
Participates in reactions:
As Reactant or Product:
- Rac1_GEFs*@Cytoplasm → VAV1@Cytoplasm
- LCP2|pho@Cytoplasm → VAV1@Cytoplasm
- VAV1@Cytoplasm → VAV1@Cytoplasm