VAV1

Protein VAV1 map

Identifiers
vav 1 guanine nucleotide exchange factor
HUGO:VAV1 HGNC:12657 ENTREZ:7409 UNIPROT:P15498 GENECARDS:VAV1 REACTOME:67134 KEGG:7409 ATLASONC:VAV1ID195ch19p13 WIKI:VAV1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
VAV1,2 are GEFs for Rac1.
PMID:11080163
VAV2 is recruited by the CD19 co-receptor of the B cells and participates in the B cell receptor signaling.
PMID:12165654
in the T cell, VAV1 forms complex with LCP2.
This complex is involved in the T cell receptor and CD28 signaling cascades.

VAV1@Cytoplasm

References
e_re966( EMT  map ):
PMID:9822663
FYN is required for VAV1 phosphorylation and thus activation.
PMID:15699036
tyrosine phosphorylation of beta3 integrin and aVb3-mediated adhesion are required for VAV1 assocaition and Rho activation.
Vav1 associates with aVb3 upon cell adhesion to vitronectin


Modifications:
In compartment: Cytoplasm
  1. VAV1@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. Rac1_GEFs*@Cytoplasm map map VAV1@Cytoplasm map

    2. LCP2|​pho@Cytoplasm map map VAV1@Cytoplasm map
    3. VAV1@Cytoplasm map map VAV1@Cytoplasm map

    As Catalyser:

      Leave a Reply