UV

Unknown UV map
UV@Nucleus

Identifiers
Ultraviolet light or radiation (UV-A and UV-B)
Damage types are bulky adducts, 6-4 phosphoproducts, cyclobutane pyrimidinr dimer (CPD), pyrimidine dimer, thymidine dimer.
Causes direct damage, NER gap, stalled transcription and stalled replication fork or indirect damage by formation of free radicals

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / C_NHEJ  map
 DNA repair  map  / FANCONI  map
 DNA repair  map  / TLS  map
 DNA repair  map  / DR  map

References
http://dnatraffic.ibb.waw.pl/classification/dna_damages
PMID:22258607, PMID:19267553, PMID:18256616
For NER
PMID:22743272, PMID:22822215, PMID:22492724, PMID:22373527
For C_NHEJ
PMID:17293412, PMID:15367581
FOR HR
PMID:21646340, PMID:22987150, PMID:22860035
For TLS
PMID:22521143
For Fanconi
PMID:17145857
d_re513( DNA repair  map ):
For C_NHEJ activation by IR
PMID:20691907, PMID:23012265, PMID:21785230
For C_NHEJ activation by UV
Topoisomerate inhibitors bloch double strand DNA repair by HR, C_NHEJ and Fanconi pathways
PMID:23259582
PMID:22123462, PMID:20693240
PMID:21414716, PMID:23157317
For activation by Dbait
PMID:22068457, PMID:22815765, PMID:22042585, PMID:19621083
d_re515( DNA repair  map ):
FOR HR activation by IR
PMID:20723763
For HR activation by UV
PMID:21885354, PMID:22987150, PMID:20206282, PMID:19398948, PMID:1575062
Interstrand crosslinking agents activate HR
PMID:21701511
d_re516( DNA repair  map ):
For actovation of TLS by UV
For actIvation of TLS by interstrand crosslinking agents
PMID:20015866, PMID:15155842, PMID:22122464, PMID:23106263, PMID:21666254, PMID:20658647
d_re517( DNA repair  map ):
UV light causes bulky adducts damage in DNA that repared by NER pathway
For activation of NER by UV
Interstrand crosslinking agents induce NER
ROS activate NER for repating intrastrand crosslink
PMID:22581771
ROS activate NER for bulky adducts
PMID:18189366
d_re518( DNA repair  map ):
Damage caused by UV light pyrimidine dimers is repaired by DR
d_re519( DNA repair  map ):
PMID:22743272, PMID:22822215, PMID:22492724, NER:22373527
Transcription-dependent NER and damage by UV
PMID:20045328, PMID:14599741
d_re520( DNA repair  map ):
Fanconi is activated by interstrand crosslinking agents
PMID:23444773, PMID:21948210, PMID:21701511


Modifications:
In compartment: Nucleus
  1. UV@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

      As Catalyser:

      1. gIntact_DNA*@Nucleus map map gC_NHEJ_DNA_st1*@Nucleus map

      2. gIntact_DNA*@Nucleus map map gHR_DNA_st1*@Nucleus map
      3. gIntact_DNA*@Nucleus map map gTLS_DNA_st1*@Nucleus map
      4. gIntact_DNA*@Nucleus map map gGG-NER_DNA_st1*@Nucleus map
      5. gIntact_DNA*@Nucleus map map gDR_DNA_st1*@Nucleus map
      6. gIntact_DNA*@Nucleus map map gTC-NER_DNA_st1*@Nucleus map
      7. gIntact_DNA*@Nucleus map map gFanconi_DNA_st1*@Nucleus map

      Leave a Reply