UAF1*:USP1

Complex UAF1*:USP1 map


Complex composition:

  1. UAF1* map
  2. USP1 map




UAF1*:​USP1|​pho@default

Identifiers
NAME:UAF1*:USP1

Maps_Modules
 DNA repair  map  / FANCONI  map

References
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process:
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559
d_re247( DNA repair  map ):
De-ubiquitination of PCNA serves a negative loop for inactivation of TLS
PMID:16531995

Confidence
REF=5 FUNC=2


Modifications:
Participates in complexes:
In compartment: default
  1. UAF1*:​USP1|​pho@default map

Participates in reactions:
As Reactant or Product:

  1. USP1|​pho@default map + UAF1*@default map map UAF1*:​USP1|​pho@default map

As Catalyser:

  1. FANCI|​K523_ubi|​pho@default map map FANCI|​pho@default map

  2. FANCD2|​K561_ubi|​pho@default map map FANCD2|​pho@default map
  3. PCNA|​K164_ubi@default map map PCNA@default map
  4. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  5. BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map

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