TXN

Protein TXN map

Identifiers
thioredoxin
HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599 GENECARDS:TXN REACTOME:66001 KEGG:7295 ATLASONC:TXNID44354ch9q31 WIKI:TXN

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / TNF_RESPONSE  map
 Survival  map  / MAPK  map

References
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12655147

TXN@Cytoplasm

Identifiers
CHEBI:15967 KEGGCOMPOUND:C00342 CAS:52500-60-4

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / TNF_RESPONSE  map

References
a_re1307:( Apoptosis  map ) PMID:10688666

TXN|​-S-S-@Cytoplasm

Identifiers
CHEBI:18191 KEGGCOMPOUND:C00343

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / TNF_RESPONSE  map


Modifications:
In compartment: Cytoplasm
  1. TXN@Cytoplasm map

  2. TXN|​-S-S-@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. ASK1*:​TXN@Cytoplasm map

  2. TXN:​TXNIP@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. rTXN@Nucleus map map TXN@Cytoplasm map

  2. purine ribonucleoside 5′-diphosphate@Cytoplasm map + TXN@Cytoplasm map map purine 2′-deoxyribonucleoside 5′-diphosphate@Cytoplasm map + TXN|​-S-S-@Cytoplasm map
  3. pyrimidine ribonucleoside 5′-diphosphate@Cytoplasm map + TXN@Cytoplasm map map pyrimidine 2′-deoxyribonucleoside 5′-diphosphate@Cytoplasm map + TXN|​-S-S-@Cytoplasm map
  4. TXN@Cytoplasm map + TXNIP@Cytoplasm map map TXN:​TXNIP@Cytoplasm map
  5. TXN@Cytoplasm map + ASK1*@Cytoplasm map map ASK1*:​TXN@Cytoplasm map
  6. TXN|​-S-S-@Cytoplasm map + NADPH@Cytoplasm map map TXN@Cytoplasm map + NADP_super_+_endsuper_@Cytoplasm map
  7. PRDX*|​-S-S-@Cytoplasm map + TXN@Cytoplasm map map PRDX*@Cytoplasm map + TXN|​-S-S-@Cytoplasm map
  8. s_s_mpk1_s1037 map MAP3K5@Cytoplasm map + TXN@Cytoplasm map

As Catalyser:

  1. Caspase3*@Cytoplasm map + NO@Cytoplasm map map Caspase3*|​-SNO@Cytoplasm map

  2. Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk@Cytoplasm map + NO@Cytoplasm map map Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk|​-SNO@Cytoplasm map

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