TSC2

Protein TSC2 map

Identifiers
tuberous sclerosis 2
HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2
P49815

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:17680028
PMID:16636147
PMID:20146692

TSC2|​S664_pho|​M1_unk@Cytoplasm

References
a_re353:( Apoptosis  map ) PMID:15851026

TSC2|​M1_unk@Cytoplasm

References
a_re1267( Apoptosis  map ):
reactionType:is.a
logical:re1266_s4082_re1267=FALSE

TSC2|​pho|​M1_unk@Cytoplasm

References
a_re361( Apoptosis  map ):
PMID:18974095
in HEK293, in vitro
by DAPK1 (DAPK1 phosphorylation status not assessed)

TSC2|​M1_ace@Cytoplasm

References
a_re1266( Apoptosis  map ):
PMID:20145209
in vitro, in HEK293T, ARD1/NAA10 _alpha_acetylation of TSC2
ARD1 ectopic expression and silencing affects TORC1 activity
relevance to cancer development
a_re1268:( Apoptosis  map ) reactionType:is.a

TSC2@Cytoplasm

References
a_re1266( Apoptosis  map ):
PMID:20145209
in vitro, in HEK293T, ARD1/NAA10 _alpha_acetylation of TSC2
ARD1 ectopic expression and silencing affects TORC1 activity
relevance to cancer development
a_re1267( Apoptosis  map ):
reactionType:is.a
logical:re1266_s4082_re1267=FALSE

TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane

References
s_akt1_re37( Survival  map ):
PMID:16636147
ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN
s_akt1_re169( Survival  map ):
Phosphorylation of S939 and S981 by Akt initiates binding of 14-3-3 protein to TSC2 leading to trans
s_s_akt1_re169( Survival  map ):


Modifications:
In compartment: Cytoplasm
  1. TSC2@Cytoplasm map

  2. TSC2|​ubi@Cytoplasm map
  3. TSC2|​M1_ace@Cytoplasm map
  4. TSC2|​M1_unk@Cytoplasm map
  5. TSC2|​pho|​M1_unk@Cytoplasm map
  6. TSC2|​S664_pho|​M1_unk@Cytoplasm map

In compartment: Endosome Membrane

  1. TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map

Participates in complexes:
In compartment: Cytoplasm

  1. E3*:​TSC2@Cytoplasm map

  2. PAM*:​TSC2@Cytoplasm map
  3. HERC1:​TSC2@Cytoplasm map
  4. TSC1:​TSC2|​M1_unk@Cytoplasm map
  5. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map
  6. TSC1:​TSC2|​S1798_pho|​M1_unk@Cytoplasm map
  7. TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytoplasm map
  8. TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  9. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytoplasm map
  10. 14-3-3*|​unk:​TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  11. CUL4*:​DCAF*:​FBW5*:​TSC2@Cytoplasm map
  12. 14-3-3*|​unk:​FOXO*|​pho|​pho:​TSC1:​TSC2|​S939_don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytoplasm map

In compartment: Endosome Membrane

  1. TSC1:​TSC2@Endosome Membrane map

  2. TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  3. 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map

Participates in reactions:
As Reactant or Product:

  1. rTSC2@Nucleus map map TSC2@Cytoplasm map

  2. TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map map TSC1:​TSC2|​M1_unk@Cytoplasm map
  3. TSC2@Cytoplasm map map TSC2|​M1_ace@Cytoplasm map
  4. TSC2@Cytoplasm map map TSC2|​M1_unk@Cytoplasm map
  5. TSC2|​M1_ace@Cytoplasm map map TSC2|​M1_unk@Cytoplasm map
  6. TSC2@Cytoplasm map map TSC2|​ubi@Cytoplasm map
  7. TSC2|​ubi@Cytoplasm map map degraded
  8. 14-3-3*|​unk@Cytoplasm map + FOXO*|​pho|​pho@Cytoplasm map map 14-3-3*|​unk:​FOXO*|​pho|​pho:​TSC1:​TSC2|​S939_don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytoplasm map
  9. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  10. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map
  11. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1@Cytoplasm map + TSC2|​S664_pho|​M1_unk@Cytoplasm map
  12. 14-3-3*|​unk@Cytoplasm map + TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map map 14-3-3*|​unk:​TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  13. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytoplasm map
  14. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1798_pho|​M1_unk@Cytoplasm map
  15. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map map a_s2151
  16. TSC1:​TSC2|​M1_unk@Cytoplasm map map a_s2151
  17. TSC2|​M1_unk@Cytoplasm map + TSC1@Cytoplasm map map TSC1:​TSC2|​M1_unk@Cytoplasm map
  18. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1@Cytoplasm map + TSC2|​pho|​M1_unk@Cytoplasm map
  19. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytoplasm map
  20. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytoplasm map map a_s2151
  21. 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map map s_s_akt1_s642
  22. TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map + 14-3-3*@Cytoplasm map map 14-3-3*:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  23. HERC1:​TSC2@Cytoplasm map map Ubiquitination@Cytoplasm map
  24. PAM*:​TSC2@Cytoplasm map map Ubiquitination@Cytoplasm map
  25. E3*:​TSC2@Cytoplasm map map Ubiquitination@Cytoplasm map
  26. CUL4*:​DCAF*:​FBW5*:​TSC2@Cytoplasm map map Ubiquitination@Cytoplasm map
  27. TSC1:​TSC2@Endosome Membrane map map TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  28. HERC1:​TSC2@Cytoplasm map map HERC1@Cytoplasm map + TSC2@Cytoplasm map
  29. TSC1@Endosome Membrane map + TSC2@Cytoplasm map map TSC1:​TSC2@Endosome Membrane map
  30. TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map map TSC1@Endosome Membrane map + TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  31. TSC2@Cytoplasm map + TSC1@Cytoplasm map map s_s_shh3_s120

As Catalyser:

  1. RHEB|​pho@Endosome Membrane map map RHEB@Endosome Membrane map

  2. PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map + 14-3-3*@Cytoplasm map map 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map

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