TSC1:TSC2

Complex TSC1:TSC2 map


Complex composition:

  1. TSC1 map
  2. TSC2 map




TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm

Identifiers
NAME:TSC1:TSC2

References
a_re351( Apoptosis  map ):
PMID:12150915
in NIH3T3
in HEK293
PMID:12172553
a_re354( Apoptosis  map ):
logical:re354_s2093=FALSE
PMID:18198340
DDIT4 mediated hypoxic signalling to mTPMID:12468542
14-3-3_beta_ forms a ternary complex with TSC1 and Akt-phosphorylated TSC2

Confidence
REF=3 FUNC=5

TSC1:​TSC2|​S1798_pho|​M1_unk@Cytoplasm

Identifiers
NAME:TSC1:TSC2

References
a_re356:( Apoptosis  map ) PMID:15342917

Confidence
REF=1 FUNC=5

TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytoplasm

Identifiers
NAME:TSC1:TSC2

References
a_re363( Apoptosis  map ):
PMID:16959574
in different murine cell lines, inhibited upon Wnt signalling
in HEK293

Confidence
REF=1 FUNC=5

TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytoplasm

Identifiers
NAME:TSC1:TSC2

References
a_re355:( Apoptosis  map ) PMID:17693255

Confidence
REF=1 FUNC=5

TSC1:​TSC2|​M1_unk@Cytoplasm

Identifiers
NAME:TSC1:TSC2

References
a_re351( Apoptosis  map ):
PMID:12150915
in NIH3T3
in HEK293
PMID:12172553
a_re352( Apoptosis  map ):
PMID:14651849
PMID:19339977
review
PMID:18692468
SESN2 promotes TSC2 phosphorylation, and interacts with both AMPK and TSC2.
a_re353:( Apoptosis  map ) PMID:15851026
a_re355:( Apoptosis  map ) PMID:17693255
a_re356:( Apoptosis  map ) PMID:15342917
a_re359( Apoptosis  map ):
reactionType:is.a
inferred from re259 and re260
a_re361( Apoptosis  map ):
PMID:18974095
in HEK293, in vitro
by DAPK1 (DAPK1 phosphorylation status not assessed)

Confidence
REF=5 FUNC=5

TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm

Identifiers
NAME:TSC1:TSC2

References
a_re352( Apoptosis  map ):
PMID:14651849
PMID:19339977
review
PMID:18692468
SESN2 promotes TSC2 phosphorylation, and interacts with both AMPK and TSC2.
a_re357:( Apoptosis  map ) reactionType:is.a
a_re363( Apoptosis  map ):
PMID:16959574
in different murine cell lines, inhibited upon Wnt signalling
in HEK293

Confidence
REF=3 FUNC=5

TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane

Identifiers
NAME:TSC1:TSC2

Confidence
REF=0 FUNC=5

TSC1:​TSC2@Endosome Membrane

Identifiers
NAME:TSC1:TSC2

References
s_akt1_re45( Survival  map ):
PMID:14551205
PMID:17693255
s_akt1_re37( Survival  map ):
PMID:16636147
ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN
s_akt1_re61:( Survival  map ) PMID:17604271

Confidence
REF=4 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. TSC1:​TSC2|​M1_unk@Cytoplasm map

  2. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map
  3. TSC1:​TSC2|​S1798_pho|​M1_unk@Cytoplasm map
  4. TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytoplasm map
  5. TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  6. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytoplasm map

In compartment: Endosome Membrane

  1. TSC1:​TSC2@Endosome Membrane map

  2. TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map

Participates in reactions:
As Reactant or Product:

  1. TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map map TSC1:​TSC2|​M1_unk@Cytoplasm map

  2. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  3. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map
  4. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1@Cytoplasm map + TSC2|​S664_pho|​M1_unk@Cytoplasm map
  5. 14-3-3*|​unk@Cytoplasm map + TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map map 14-3-3*|​unk:​TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  6. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytoplasm map
  7. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1798_pho|​M1_unk@Cytoplasm map
  8. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map map a_s2151
  9. TSC1:​TSC2|​M1_unk@Cytoplasm map map a_s2151
  10. TSC2|​M1_unk@Cytoplasm map + TSC1@Cytoplasm map map TSC1:​TSC2|​M1_unk@Cytoplasm map
  11. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1@Cytoplasm map + TSC2|​pho|​M1_unk@Cytoplasm map
  12. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytoplasm map
  13. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytoplasm map map a_s2151
  14. TSC1:​TSC2@Endosome Membrane map map TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  15. TSC1@Endosome Membrane map + TSC2@Cytoplasm map map TSC1:​TSC2@Endosome Membrane map
  16. TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map map TSC1@Endosome Membrane map + TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map

As Catalyser:

  1. RHEB|​pho@Endosome Membrane map map RHEB@Endosome Membrane map

  2. PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map + 14-3-3*@Cytoplasm map map 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map

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