TSC1

Protein TSC1 map

Identifiers
tuberous sclerosis 1
HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1
Q92574

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:17680028
PMID:16636147
PMID:20146692

TSC1@Cytoplasm

References
a_re353:( Apoptosis  map ) PMID:15851026
a_re361( Apoptosis  map ):
PMID:18974095
in HEK293, in vitro
by DAPK1 (DAPK1 phosphorylation status not assessed)

TSC1|​T417_pho|​S584_pho|​T1047_pho@Endosome Membrane

References
s_akt1_re170:( Survival  map ) PMID:14551205
s_akt1_re45( Survival  map ):
PMID:14551205
PMID:17693255

TSC1|​pho|​pho@Endosome Membrane

References
s_akt1_re171:( Survival  map ) PMID:17693255
s_akt1_re45( Survival  map ):
PMID:14551205
PMID:17693255


Modifications:
In compartment: Cytoplasm
  1. TSC1@Cytoplasm map

In compartment: Endosome Membrane

  1. TSC1@Endosome Membrane map

  2. TSC1|​pho|​pho@Endosome Membrane map
  3. TSC1|​T417_pho|​S584_pho|​T1047_pho@Endosome Membrane map

Participates in complexes:
In compartment: Cytoplasm

  1. TSC1:​TSC2|​M1_unk@Cytoplasm map

  2. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map
  3. TSC1:​TSC2|​S1798_pho|​M1_unk@Cytoplasm map
  4. TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytoplasm map
  5. TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  6. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytoplasm map
  7. 14-3-3*|​unk:​TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  8. 14-3-3*|​unk:​FOXO*|​pho|​pho:​TSC1:​TSC2|​S939_don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytoplasm map

In compartment: Endosome Membrane

  1. TSC1:​TSC2@Endosome Membrane map

  2. TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map

Participates in reactions:
As Reactant or Product:

  1. TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map map TSC1:​TSC2|​M1_unk@Cytoplasm map

  2. 14-3-3*|​unk@Cytoplasm map + FOXO*|​pho|​pho@Cytoplasm map map 14-3-3*|​unk:​FOXO*|​pho|​pho:​TSC1:​TSC2|​S939_don|​T1462_don|​S1345_don|​S1337_don|​S1341_don|​M1_unk@Cytoplasm map
  3. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  4. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map
  5. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1@Cytoplasm map + TSC2|​S664_pho|​M1_unk@Cytoplasm map
  6. 14-3-3*|​unk@Cytoplasm map + TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map map 14-3-3*|​unk:​TSC1:​TSC2|​S939_pho|​T1462_pho|​M1_unk@Cytoplasm map
  7. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytoplasm map
  8. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1798_pho|​M1_unk@Cytoplasm map
  9. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map map a_s2151
  10. TSC1:​TSC2|​M1_unk@Cytoplasm map map a_s2151
  11. TSC2|​M1_unk@Cytoplasm map + TSC1@Cytoplasm map map TSC1:​TSC2|​M1_unk@Cytoplasm map
  12. TSC1:​TSC2|​M1_unk@Cytoplasm map map TSC1@Cytoplasm map + TSC2|​pho|​M1_unk@Cytoplasm map
  13. TSC1:​TSC2|​S1345_pho|​M1_unk@Cytoplasm map map TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytoplasm map
  14. TSC1:​TSC2|​S1345_pho|​S1337_pho|​S1341_pho|​M1_unk@Cytoplasm map map a_s2151
  15. TSC1@Endosome Membrane map map TSC1|​T417_pho|​S584_pho|​T1047_pho@Endosome Membrane map
  16. TSC1@Endosome Membrane map map TSC1|​pho|​pho@Endosome Membrane map
  17. TSC1:​TSC2@Endosome Membrane map map TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  18. TSC1@Endosome Membrane map + TSC2@Cytoplasm map map TSC1:​TSC2@Endosome Membrane map
  19. TSC1:​TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map map TSC1@Endosome Membrane map + TSC2|​S981_pho|​S1130_pho|​pho|​S1132_pho|​pho|​S1088_pho|​S1086_pho@Endosome Membrane map
  20. TSC2@Cytoplasm map + TSC1@Cytoplasm map map s_s_shh3_s120

As Catalyser:

  1. RHEB|​pho@Endosome Membrane map map RHEB@Endosome Membrane map

  2. HERC1:​TSC2@Cytoplasm map map HERC1@Cytoplasm map + TSC2@Cytoplasm map
  3. TSC1@Endosome Membrane map + TSC2@Cytoplasm map map TSC1:​TSC2@Endosome Membrane map
  4. PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map + 14-3-3*@Cytoplasm map map 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map
  5. GDP:​RAC1@Cytoplasm map + GTP@Cytoplasm map map GTP:​RAC1@Cytoplasm map + GDP@Cytoplasm map

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