TRAF2

Protein TRAF2 map

Identifiers
TNF receptor-associated factor 2
HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 GENECARDS:TRAF2 REACTOME:66371 KEGG:7186 ATLASONC:GC_TRAF2 WIKI:TRAF2

Maps_Modules
 Apoptosis  map  / TNF_RESPONSE  map
 Survival  map  / MAPK  map

References
TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2.
PMID:11274345


Modifications:
In compartment: Cytoplasm
  1. TRAF2@Cytoplasm map

In compartment: TNFRSF1 Receptor Complex

  1. TRAF2@TNFRSF1 Receptor Complex map

Participates in complexes:
In compartment: Cytoplasm

  1. DAB2IP|​S604_pho:​TRADD:​TRAF2@Cytoplasm map

In compartment: Plasma Membrane

  1. ERN1:​TRAF2@Plasma Membrane map

  2. TNFRSF1B:​TRAF2@Plasma Membrane map
  3. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  4. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. TRAF2@Cytoplasm map map TRAF2@TNFRSF1 Receptor Complex map

  2. DAB2IP|​S604_pho@TNFRSF1 Receptor Complex map + TRAF2@TNFRSF1 Receptor Complex map + TRADD@TNFRSF1 Receptor Complex map map DAB2IP|​S604_pho:​TRADD:​TRAF2@Cytoplasm map
  3. TRAF2@Cytoplasm map + TNFRSF1A:​TRADD@Plasma Membrane map map TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  4. RIPK1@Cytoplasm map + TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  5. TRAF2@Cytoplasm map + TNFRSF1B@Plasma Membrane map map TNFRSF1B:​TRAF2@Plasma Membrane map
  6. TRAF2@Cytoplasm map + ERN1@Plasma Membrane map map ERN1:​TRAF2@Plasma Membrane map
  7. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + TAK1*@Cytoplasm map map s_s_mpk1_s1047
  8. TNFRSF1B:​TRAF2@Plasma Membrane map + TAK1*@Cytoplasm map map TAK1*|​pho:​TNFRSF1B@Cytoplasm map
  9. MAP3K1@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1046
  10. MAP3K1@Cytoplasm map + TNFRSF1B:​TRAF2@Plasma Membrane map map MAP3K1|​pho:​TNFRSF1B@Cytoplasm map
  11. MAP3K2_3*@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1049
  12. MAP3K2_3*@Cytoplasm map + TNFRSF1B:​TRAF2@Plasma Membrane map map MAP3K2_3*|​pho:​TNFRSF1B@Cytoplasm map
  13. TNFRSF1B:​TRAF2@Plasma Membrane map map ROS@Cytoplasm map
  14. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map ROS@Cytoplasm map
  15. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map map s_s_mpk1_s1048
  16. TNFRSF1B:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map map MAP3K5|​pho:​TNFRSF1B@Cytoplasm map

As Catalyser:

  1. RIPK1@Cytoplasm map map RIPK1@TNFRSF1 Receptor Complex map

  2. cIAP*@Cytoplasm map map cIAP*@TNFRSF1 Receptor Complex map
  3. ASK1*|​unk|​S967_pho@Cytoplasm map map ASK1*@Cytoplasm map
  4. ASK1*@Cytoplasm map map ASK1*|​oligomer@Cytoplasm map

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