TRADD

Protein TRADD map

Identifiers
TNFRSF1A-associated via death domain
HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 GENECARDS:TRADD REACTOME:66377 KEGG:8717 ATLASONC:GC_TRADD WIKI:TRADD

Maps_Modules
 Apoptosis  map  / TNF_RESPONSE  map
 Survival  map  / MAPK  map

References
Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins.
PMID:11274345

TRADD@TNFRSF1 Receptor Complex

References
a_re1343( Apoptosis  map ):
PMID:17560373
PMID:19641494


Modifications:
In compartment: Cytoplasm
  1. TRADD@Cytoplasm map

In compartment: TNFRSF1 Receptor Complex

  1. TRADD@TNFRSF1 Receptor Complex map

Participates in complexes:
In compartment: Cytoplasm

  1. FADD:​RIPK1:​TRADD@Cytoplasm map

  2. DAB2IP|​S604_pho:​TRADD:​TRAF2@Cytoplasm map
  3. CFLAR:​FADD:​RIPK1:​TRADD@Cytoplasm map

In compartment: Plasma Membrane

  1. TNFRSF1A:​TRADD@Plasma Membrane map

  2. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  3. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. FADD:​RIPK1:​TRADD@Cytoplasm map + CFLAR@Cytoplasm map map CFLAR:​FADD:​RIPK1:​TRADD@Cytoplasm map

  2. TRADD@Cytoplasm map map TRADD@TNFRSF1 Receptor Complex map
  3. DAB2IP|​S604_pho@TNFRSF1 Receptor Complex map + TRAF2@TNFRSF1 Receptor Complex map + TRADD@TNFRSF1 Receptor Complex map map DAB2IP|​S604_pho:​TRADD:​TRAF2@Cytoplasm map
  4. TRADD@TNFRSF1 Receptor Complex map + RIPK1@TNFRSF1 Receptor Complex map + FADD@Cytoplasm map map FADD:​RIPK1:​TRADD@Cytoplasm map
  5. TNFRSF1A@Plasma Membrane map + TRADD@Cytoplasm map map TNFRSF1A:​TRADD@Plasma Membrane map
  6. TRAF2@Cytoplasm map + TNFRSF1A:​TRADD@Plasma Membrane map map TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  7. RIPK1@Cytoplasm map + TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  8. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + TAK1*@Cytoplasm map map s_s_mpk1_s1047
  9. MAP3K1@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1046
  10. MAP3K2_3*@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map s_s_mpk1_s1049
  11. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map map ROS@Cytoplasm map
  12. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map map s_s_mpk1_s1048

As Catalyser:

  1. RIPK1@Cytoplasm map map RIPK1@TNFRSF1 Receptor Complex map

  2. ASK1*|​unk|​S967_pho@Cytoplasm map map ASK1*@Cytoplasm map
  3. ASK1*@Cytoplasm map map ASK1*|​oligomer@Cytoplasm map
  4. RFK@Cytoplasm map map RFK@TNFRSF1 Receptor Complex map
  5. Caspase8*@Cytoplasm map map cleaved~Caspase8*@Cytoplasm map

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