TP53BP1

Protein TP53BP1 map

Identifiers
tumor protein p53 binding protein 1
HUGO:TP53BP1 HGNC:11999 ENTREZ:7158 UNIPROT:Q12888 GENECARDS:TP53BP1 REACTOME:61176 KEGG:7158 ATLASONC:GC_TP53BP1 WIKI:TP53BP1

Maps_Modules
 Apoptosis  map  / MITOCH_METABOLISM  map

References
synonym:53BP1
PMID:9748285, PMID:11042216, PMID:20646866, PMID:11877378
53BP1* binds to DNA and stops DNA resection and therefore stops HR during cell cycle exept S-pthase, because 53BP1*
is phosphorylated by CDK1(CDC2) during S-phase, this phosphorylation inhibits 53BP1* activity
PMID:17243194

TP53BP1@Site of DNA damage

References
a_re1509:( Apoptosis  map ) influenceDelete: re to reactants
a_re1501( Apoptosis  map ):
influenceDelete: re to products
PMID:18087291
review

TP53BP1|​pho@default

References
d_re222( DNA repair  map ):
PMID:17243194
53BP1* binds to DNA and stops DNA resection and therefore stops HR during cell cycle except S-phase, because 53BP1* is phosphorylated by CDK1(CDC2) during S-phase, this phosphorylation inhibits 53BP1* activity.

TP53BP1@default

References
d_re71( DNA repair  map ):
For inactivation of EXO1 by 53BP1-mediated phosphorylation:
PMID:18756267, PMID:15867354
ATM and ATR phosphorylate EXO1 and lead to EXO1 ubiquitination and degradation:
PMID:18048416, PMID:11438669, PMID:20019063
d_re114( DNA repair  map ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833
d_re222( DNA repair  map ):
PMID:17243194
53BP1* binds to DNA and stops DNA resection and therefore stops HR during cell cycle except S-phase, because 53BP1* is phosphorylated by CDK1(CDC2) during S-phase, this phosphorylation inhibits 53BP1* activity.


Modifications:
In compartment: Site of DNA damage
  1. TP53BP1@Site of DNA damage map

In compartment: default

  1. TP53BP1@default map

  2. TP53BP1|​pho@default map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. TP53BP1@Site of DNA damage map map TP53BP1@Site of DNA damage map

    2. TP53BP1@Site of DNA damage map map TP53BP1@Site of DNA damage map
    3. TP53BP1@default map map TP53BP1|​pho@default map

    As Catalyser:

    1. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map

    2. EXO1@default map map EXO1|​S692_pho|​S372_pho|​S567_pho|​S587_pho@default map

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